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Conserved domains on  [gi|1490960372|gb|RLE82096|]
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MAG: hypothetical protein DRJ52_02775 [Thermoprotei archaeon]

Protein Classification

SPFH domain-containing protein( domain architecture ID 11556246)

uncharacterized SPFH (stomatin, prohibitin, flotillin, and HflK/C) domain-containing protein with a C-terminal DZR (zinc-ribbon) domain

CATH:  3.30.479.30
Gene Ontology:  GO:0016020|GO:0046872
PubMed:  17766116|10542406
SCOP:  4003722

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPFH_like_u1 cd03408
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
 15-215 7.62e-48

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


:

Pssm-ID: 259806  Cd Length: 217  Bit Score: 160.41  E-value: 7.62e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  15 IIWKYPDEEIEWGSQLIVREHEVAVFFRDGKVYDVLGPGRHTLTTLNLPLltraLSSIMGFDKI---PFRASVIFVSMKR 91
Cdd:cd03408     2 IRWKGPDNEIKNGSQLIVREGQAAIFVNEGKVADVFGPGGHTLTTNNIPF----LTTLKGWKFGfesPFKAEVYFVNTKE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  92 FQG-KFGGRTQTI-------ELAPLMFHGTFWFKVSDPRLFITEIVGGRSIYETSDVSRFLRGYFNENLMKYLSTYSI-F 162
Cdd:cd03408    78 ILDiKWGTPNPIPyrdpeygIPVRLRAFGTYSFRVTDPALFLTEVVGTQGTFTTDEIEEQLRSEIVQALKDAIAELSIsG 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1490960372 163 DVYQS---LDRVSMEVKVKLLADFRRIGLELVDLKFEGVDTTGEWREKIFWLRQTG 215
Cdd:cd03408   158 LDLALeanLDELSAALKEKLAPEFEKYGLELTSFGIESISLPEEVQKRIDKRASMA 213
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 275-320 1.64e-18

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


:

Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 77.80  E-value: 1.64e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1490960372 275 CPRCGNRNPPNAKFCMYCGAPLGGtKTCPACGRTVPVSAKFCPYCG 320
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPLKP-DRCPNCGAPVPPNARFCPYCG 45
 
Name Accession Description Interval E-value
SPFH_like_u1 cd03408
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
 15-215 7.62e-48

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259806  Cd Length: 217  Bit Score: 160.41  E-value: 7.62e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  15 IIWKYPDEEIEWGSQLIVREHEVAVFFRDGKVYDVLGPGRHTLTTLNLPLltraLSSIMGFDKI---PFRASVIFVSMKR 91
Cdd:cd03408     2 IRWKGPDNEIKNGSQLIVREGQAAIFVNEGKVADVFGPGGHTLTTNNIPF----LTTLKGWKFGfesPFKAEVYFVNTKE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  92 FQG-KFGGRTQTI-------ELAPLMFHGTFWFKVSDPRLFITEIVGGRSIYETSDVSRFLRGYFNENLMKYLSTYSI-F 162
Cdd:cd03408    78 ILDiKWGTPNPIPyrdpeygIPVRLRAFGTYSFRVTDPALFLTEVVGTQGTFTTDEIEEQLRSEIVQALKDAIAELSIsG 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1490960372 163 DVYQS---LDRVSMEVKVKLLADFRRIGLELVDLKFEGVDTTGEWREKIFWLRQTG 215
Cdd:cd03408   158 LDLALeanLDELSAALKEKLAPEFEKYGLELTSFGIESISLPEEVQKRIDKRASMA 213
YdjI COG4260
Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain ...
 4-307 3.04e-42

Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443402 [Multi-domain]  Cd Length: 337  Bit Score: 149.23  E-value: 3.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372   4 VIQWVNPREDEIIWKYPDE--EIEWGSQLIVREHEVAVFFRDGKVYDVLGPGRHTLTTLNLPLltraLSSIMGFDK---I 78
Cdd:COG4260    14 VIEWTDDSPDTLVYRFPGYdnEIKNGSKLTVREGQGAIFVNEGKIADVFEPGRYTLDTSNLPS----LTTLKRWKFgfeS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  79 PFRASVIFVSMKRFQG-KFGGRTqtielaPLMF-------------HGTFWFKVSDPRLFITEIVGGRSIYETSDVSRFL 144
Cdd:COG4260    90 PFKQEVYFVNTKEITDnKWGTPN------PITFrdpefgapvrlraFGTYSYRIVDPLLFYKEVVGTDGVFTTDEIDEQL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372 145 RGYFNENLMKYLST--YSIFDVYQSLDRVSMEVKVKLLADFRRIGLELVDLKFEGVDTTGEWREKIFWLRQ---TGQAAY 219
Cdd:COG4260   164 RSEIVTALSDALAEsgIRYLDLAANTDELAQALNEALAPDFEERGLEITSFGIENISLPEEVQKAIDKRSSmaaLGDLNA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372 220 VLQMQTLK--EVAkelGKSPGAATGTGLVLLPQLMQPQQQQPSPPPPPSQPVPSGVVCPRCGNRNPPnaKFCMYCGAPLG 297
Cdd:COG4260   244 YVQYQAAEamEAA---ASNEGGAAGAGMGMGMGMAMGGMMAQALQQPGQPQQQQPAAAAAAPAQDPG--KFCAQLGELLD 318

                         330
                  ....*....|
gi 1490960372 298 GTKTCPACGR 307
Cdd:COG4260   319 AGKFCPECGD 328
Band_7_1 pfam13421
SPFH domain-Band 7 family;
16-198 9.20e-20

SPFH domain-Band 7 family;


Pssm-ID: 433193  Cd Length: 211  Bit Score: 85.92  E-value: 9.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  16 IWKYP--DEEIEWGSQLIVREHEVAVFFRDGKVYDVLGPGRHTLTTLNLPLLTRALSSIMGFDKiPFRASVIFVSMKRFQ 93
Cdd:pfam13421   1 VWRFPryNNEIKNGAKLIVREGQTAVFVNEGQIADVFGPGTYTLTTRNLPILTTLKGWKYGFDS-PFKAEVYFVNTRQFT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  94 G-KFGGRTQTI----ELAPLMF--HGTFWFKVSDPRLFITEIVGGRSIYETSDVSRFLRGY----FNENLMKylSTYSIF 162
Cdd:pfam13421  80 DlKWGTPNPVTlrdpEFGPVRVraFGTYSVRVVDPATFLREIVGTDGNFTTDEISELLRSLivtrFSDMLGE--SGIPVL 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1490960372 163 DVYQSLDRVSMEVKVKLLADFRRIGLELVDLKFEGV 198
Cdd:pfam13421 158 DLAANQRELGEMLRERIAPEFAEYGLALPKFYIENI 193
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 275-320 1.64e-18

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 77.80  E-value: 1.64e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1490960372 275 CPRCGNRNPPNAKFCMYCGAPLGGtKTCPACGRTVPVSAKFCPYCG 320
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPLKP-DRCPNCGAPVPPNARFCPYCG 45
PRK14559 PRK14559
serine/threonine phosphatase;
273-321 2.34e-11

serine/threonine phosphatase;


Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 64.69  E-value: 2.34e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1490960372 273 VVCPRCGNRNPPNAKFCMYCGAPLgGTKTCPACGRTVPVSAKFCPYCGA 321
Cdd:PRK14559    2 LICPQCQFENPNNNRFCQKCGTSL-THKPCPQCGTEVPVDEAHCPNCGA 49
COG2888 COG2888
Predicted RNA-binding protein involved in translation, contains Zn-ribbon domain, DUF1610 ...
 274-324 2.51e-06

Predicted RNA-binding protein involved in translation, contains Zn-ribbon domain, DUF1610 family [General function prediction only];


Pssm-ID: 442134 [Multi-domain]  Cd Length: 52  Bit Score: 43.95  E-value: 2.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490960372 274 VCPRCGNR---NPPNAKFCMYCGAPLGGTktCPACGRTVPVSaKFCPYCGAKLE 324
Cdd:COG2888     2 VCPSCGREiapEGGVAFYCPNCGEALIIR--CPKCRKQSNAL-YFCPKCGFEGP 52
PHB smart00244
prohibitin homologues; prohibitin homologues
 31-194 2.40e-03

prohibitin homologues; prohibitin homologues


Pssm-ID: 214581 [Multi-domain]  Cd Length: 160  Bit Score: 38.03  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372   31 IVREHEVAVFFRDGKVYDVLGPGRHTlttlnlplltralssimgfdKIPFRASVIFVSMKrfQGKFGGRTQTI---ELAP 107
Cdd:smart00244   5 VVGEGERGVVERLGRVLRVLGPGLHF--------------------LIPFIDDVKKVDLR--AQTDDVPPQETitkDNVK 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  108 LMFHGTFWFKVSDPRlfiteivggRSIYETSDVSRF-LRGYFNENLMKYLSTYSIFDVYQSL-DRVSMEVKVKLLADFRR 185
Cdd:smart00244  63 VSVDAVVYYRVLDPL---------RAVYRVLDADYAvIEQLAQTTLRSVIGKRTLDELLTDQrEKISENIREELNEAAEA 133


                   ....*....
gi 1490960372  186 IGLELVDLK 194
Cdd:smart00244 134 WGIKVEDVE 142
 
Name Accession Description Interval E-value
SPFH_like_u1 cd03408
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
 15-215 7.62e-48

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259806  Cd Length: 217  Bit Score: 160.41  E-value: 7.62e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  15 IIWKYPDEEIEWGSQLIVREHEVAVFFRDGKVYDVLGPGRHTLTTLNLPLltraLSSIMGFDKI---PFRASVIFVSMKR 91
Cdd:cd03408     2 IRWKGPDNEIKNGSQLIVREGQAAIFVNEGKVADVFGPGGHTLTTNNIPF----LTTLKGWKFGfesPFKAEVYFVNTKE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  92 FQG-KFGGRTQTI-------ELAPLMFHGTFWFKVSDPRLFITEIVGGRSIYETSDVSRFLRGYFNENLMKYLSTYSI-F 162
Cdd:cd03408    78 ILDiKWGTPNPIPyrdpeygIPVRLRAFGTYSFRVTDPALFLTEVVGTQGTFTTDEIEEQLRSEIVQALKDAIAELSIsG 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1490960372 163 DVYQS---LDRVSMEVKVKLLADFRRIGLELVDLKFEGVDTTGEWREKIFWLRQTG 215
Cdd:cd03408   158 LDLALeanLDELSAALKEKLAPEFEKYGLELTSFGIESISLPEEVQKRIDKRASMA 213
YdjI COG4260
Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain ...
 4-307 3.04e-42

Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443402 [Multi-domain]  Cd Length: 337  Bit Score: 149.23  E-value: 3.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372   4 VIQWVNPREDEIIWKYPDE--EIEWGSQLIVREHEVAVFFRDGKVYDVLGPGRHTLTTLNLPLltraLSSIMGFDK---I 78
Cdd:COG4260    14 VIEWTDDSPDTLVYRFPGYdnEIKNGSKLTVREGQGAIFVNEGKIADVFEPGRYTLDTSNLPS----LTTLKRWKFgfeS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  79 PFRASVIFVSMKRFQG-KFGGRTqtielaPLMF-------------HGTFWFKVSDPRLFITEIVGGRSIYETSDVSRFL 144
Cdd:COG4260    90 PFKQEVYFVNTKEITDnKWGTPN------PITFrdpefgapvrlraFGTYSYRIVDPLLFYKEVVGTDGVFTTDEIDEQL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372 145 RGYFNENLMKYLST--YSIFDVYQSLDRVSMEVKVKLLADFRRIGLELVDLKFEGVDTTGEWREKIFWLRQ---TGQAAY 219
Cdd:COG4260   164 RSEIVTALSDALAEsgIRYLDLAANTDELAQALNEALAPDFEERGLEITSFGIENISLPEEVQKAIDKRSSmaaLGDLNA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372 220 VLQMQTLK--EVAkelGKSPGAATGTGLVLLPQLMQPQQQQPSPPPPPSQPVPSGVVCPRCGNRNPPnaKFCMYCGAPLG 297
Cdd:COG4260   244 YVQYQAAEamEAA---ASNEGGAAGAGMGMGMGMAMGGMMAQALQQPGQPQQQQPAAAAAAPAQDPG--KFCAQLGELLD 318

                         330
                  ....*....|
gi 1490960372 298 GTKTCPACGR 307
Cdd:COG4260   319 AGKFCPECGD 328
Band_7_1 pfam13421
SPFH domain-Band 7 family;
16-198 9.20e-20

SPFH domain-Band 7 family;


Pssm-ID: 433193  Cd Length: 211  Bit Score: 85.92  E-value: 9.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  16 IWKYP--DEEIEWGSQLIVREHEVAVFFRDGKVYDVLGPGRHTLTTLNLPLLTRALSSIMGFDKiPFRASVIFVSMKRFQ 93
Cdd:pfam13421   1 VWRFPryNNEIKNGAKLIVREGQTAVFVNEGQIADVFGPGTYTLTTRNLPILTTLKGWKYGFDS-PFKAEVYFVNTRQFT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  94 G-KFGGRTQTI----ELAPLMF--HGTFWFKVSDPRLFITEIVGGRSIYETSDVSRFLRGY----FNENLMKylSTYSIF 162
Cdd:pfam13421  80 DlKWGTPNPVTlrdpEFGPVRVraFGTYSVRVVDPATFLREIVGTDGNFTTDEISELLRSLivtrFSDMLGE--SGIPVL 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1490960372 163 DVYQSLDRVSMEVKVKLLADFRRIGLELVDLKFEGV 198
Cdd:pfam13421 158 DLAANQRELGEMLRERIAPEFAEYGLALPKFYIENI 193
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 275-320 1.64e-18

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 77.80  E-value: 1.64e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1490960372 275 CPRCGNRNPPNAKFCMYCGAPLGGtKTCPACGRTVPVSAKFCPYCG 320
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPLKP-DRCPNCGAPVPPNARFCPYCG 45
Band_7 pfam01145
SPFH domain / Band 7 family; This family has been called SPFH, Band 7 or PHB domain. Recent ...
 31-232 1.43e-17

SPFH domain / Band 7 family; This family has been called SPFH, Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.


Pssm-ID: 426078 [Multi-domain]  Cd Length: 177  Bit Score: 78.90  E-value: 1.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  31 IVREHEVAVFFRDGKVYDVLGPGRHTlttlnlplltralssimgfdKIPFRASVIFVSMKRFQGKFGGRT-QTIELAPLM 109
Cdd:pfam01145   2 IVPPGEVGVVTRFGKLSRVLEPGLHF--------------------IIPFIQRVVTVDVRVQTLEVSVQTvLTKDGVPVN 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372 110 FHGTFWFKV--SDPRLFITEIVGGrsiyetSDVSRFLRGYFNENLMKYLSTYSIFDVYQSLDRVSMEVKVKLLADFRRIG 187
Cdd:pfam01145  62 VDVTVIYRVnpDDPPKLVQNVFGS------DDLQELLRRVLESALREIIARYTLEELLSNREELAEEIKNALQEELAKYG 135

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1490960372 188 LELVDLKFEGVDTTGEWREKIfwlrqtgQAAYVLQMQTLKEVAKE 232
Cdd:pfam01145 136 VEIIDVQITDIDPPPEIAEAI-------EAKQTAEQEAEAEIARA 173
PRK14559 PRK14559
serine/threonine phosphatase;
273-321 2.34e-11

serine/threonine phosphatase;


Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 64.69  E-value: 2.34e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1490960372 273 VVCPRCGNRNPPNAKFCMYCGAPLgGTKTCPACGRTVPVSAKFCPYCGA 321
Cdd:PRK14559    2 LICPQCQFENPNNNRFCQKCGTSL-THKPCPQCGTEVPVDEAHCPNCGA 49
HflC COG0330
Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational ...
 31-199 1.34e-07

Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440099 [Multi-domain]  Cd Length: 279  Bit Score: 52.15  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  31 IVREHEVAVFFRDGKVYDVLGPGRHtlttlnlplltralssimgFdKIPFRASVIFVSMKRFQGKF-GGRTQTIELAPLM 109
Cdd:COG0330    23 IVPQGERGVVLRFGKYVRTLEPGLH-------------------F-KIPFIDRVRKVDVREQVLDVpPQEVLTKDNNIVD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372 110 FHGTFWFKVSDPRLFiteivggrsIYETSDVSRFLRGYFNENLMKYLSTYSIFDVY-QSLDRVSMEVKVKLLADFRRIGL 188
Cdd:COG0330    83 VDAVVQYRITDPAKF---------LYNVENAEEALRQLAESALREVIGKMTLDEVLsTGRDEINAEIREELQEALDPYGI 153

                         170
                  ....*....|.
gi 1490960372 189 ELVDLKFEGVD 199
Cdd:COG0330   154 EVVDVEIKDID 164
zinc_ribbon_15 pfam17032
zinc-ribbon family; This zinc-ribbon region is found on a set of largely ...
 273-320 3.65e-07

zinc-ribbon family; This zinc-ribbon region is found on a set of largely microsporidia-specific proteins.


Pssm-ID: 465334 [Multi-domain]  Cd Length: 73  Bit Score: 46.90  E-value: 3.65e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490960372 273 VVCPRCGNRNPPNA-------KFCM----------------YCGAPLG--GTKTCPACGRTVPVSAKFCPYCG 320
Cdd:pfam17032   1 ILCPRCGTLSRAVYvkkykyfTLFFipvfkwgkskpylacsCCGSLYGdsKVKICPNCGTVVEPDFRYCPRCG 73
zinc_ribbon_2 pfam13240
zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as ...
 275-294 1.64e-06

zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.


Pssm-ID: 433054 [Multi-domain]  Cd Length: 21  Bit Score: 43.65  E-value: 1.64e-06
                          10        20
                  ....*....|....*....|
gi 1490960372 275 CPRCGNRNPPNAKFCMYCGA 294
Cdd:pfam13240   2 CPNCGAENPDGAKFCPKCGA 21
UPF0547 pfam10571
Uncharacterized protein family UPF0547; This domain contains a zinc-ribbon motif.
 300-320 2.06e-06

Uncharacterized protein family UPF0547; This domain contains a zinc-ribbon motif.


Pssm-ID: 402278 [Multi-domain]  Cd Length: 26  Bit Score: 43.72  E-value: 2.06e-06
                          10        20
                  ....*....|....*....|.
gi 1490960372 300 KTCPACGRTVPVSAKFCPYCG 320
Cdd:pfam10571   1 KKCPECDAIVPIAAKICPHCG 21
COG2888 COG2888
Predicted RNA-binding protein involved in translation, contains Zn-ribbon domain, DUF1610 ...
 274-324 2.51e-06

Predicted RNA-binding protein involved in translation, contains Zn-ribbon domain, DUF1610 family [General function prediction only];


Pssm-ID: 442134 [Multi-domain]  Cd Length: 52  Bit Score: 43.95  E-value: 2.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490960372 274 VCPRCGNR---NPPNAKFCMYCGAPLGGTktCPACGRTVPVSaKFCPYCGAKLE 324
Cdd:COG2888     2 VCPSCGREiapEGGVAFYCPNCGEALIIR--CPKCRKQSNAL-YFCPKCGFEGP 52
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 302-324 4.81e-06

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 43.13  E-value: 4.81e-06
                          10        20
                  ....*....|....*....|...
gi 1490960372 302 CPACGRTVPVSAKFCPYCGAKLE 324
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPLK 23
zinc_ribbon_2 pfam13240
zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as ...
 302-321 1.13e-04

zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.


Pssm-ID: 433054 [Multi-domain]  Cd Length: 21  Bit Score: 38.64  E-value: 1.13e-04
                          10        20
                  ....*....|....*....|
gi 1490960372 302 CPACGRTVPVSAKFCPYCGA 321
Cdd:pfam13240   2 CPNCGAENPDGAKFCPKCGA 21
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 273-293 1.56e-04

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 1.56e-04
                          10        20
                  ....*....|....*....|.
gi 1490960372 273 VVCPRCGNRNPPNAKFCMYCG 293
Cdd:pfam12773  25 DRCPNCGAPVPPNARFCPYCG 45
zf-ribbon_3 pfam13248
zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as ...
 299-323 2.98e-04

zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. pfam12773.


Pssm-ID: 404185 [Multi-domain]  Cd Length: 25  Bit Score: 37.56  E-value: 2.98e-04
                          10        20
                  ....*....|....*....|....*
gi 1490960372 299 TKTCPACGRTVPVSAKFCPYCGAKL 323
Cdd:pfam13248   1 TVRCPNCGAPVSPDDNVCPYCGTKL 25
Nob1 COG1439
rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis];
300-324 7.19e-04

rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441048 [Multi-domain]  Cd Length: 155  Bit Score: 39.45  E-value: 7.19e-04
                          10        20
                  ....*....|....*....|....*
gi 1490960372 300 KTCPACGRTVPVSAKFCPYCGAKLE 324
Cdd:COG1439   126 YRCTGCGREFDEPEEECPICGSPLK 150
SPFH_eoslipins_u2 cd13438
Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging ...
 32-128 8.30e-04

Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial SLPs remain uncharacterized.


Pssm-ID: 259816 [Multi-domain]  Cd Length: 215  Bit Score: 40.21  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  32 VREHEVAVFFRDGKVYDVLGPGRHtlttlnlplltralssimGFDKIPFRASVIFVSMkrfqgkfggRTQTIELAP---- 107
Cdd:cd13438     1 VPPGERGLLYRDGKLVRTLEPGRY------------------AFWKFGRKVQVELVDL---------REQLLEVSGqeil 53

                          90       100
                  ....*....|....*....|....*..
gi 1490960372 108 ------LMFHGTFWFKVSDPRLFITEI 128
Cdd:cd13438    54 tadkvaLRVNLVATYRVVDPVKAVETV 80
PHB smart00244
prohibitin homologues; prohibitin homologues
 31-194 2.40e-03

prohibitin homologues; prohibitin homologues


Pssm-ID: 214581 [Multi-domain]  Cd Length: 160  Bit Score: 38.03  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372   31 IVREHEVAVFFRDGKVYDVLGPGRHTlttlnlplltralssimgfdKIPFRASVIFVSMKrfQGKFGGRTQTI---ELAP 107
Cdd:smart00244   5 VVGEGERGVVERLGRVLRVLGPGLHF--------------------LIPFIDDVKKVDLR--AQTDDVPPQETitkDNVK 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490960372  108 LMFHGTFWFKVSDPRlfiteivggRSIYETSDVSRF-LRGYFNENLMKYLSTYSIFDVYQSL-DRVSMEVKVKLLADFRR 185
Cdd:smart00244  63 VSVDAVVYYRVLDPL---------RAVYRVLDADYAvIEQLAQTTLRSVIGKRTLDELLTDQrEKISENIREELNEAAEA 133


                   ....*....
gi 1490960372  186 IGLELVDLK 194
Cdd:smart00244 134 WGIKVEDVE 142
RPL40A COG1552
Ribosomal protein L40E [Translation, ribosomal structure and biogenesis]; Ribosomal protein ...
 274-293 2.43e-03

Ribosomal protein L40E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L40E is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441161 [Multi-domain]  Cd Length: 50  Bit Score: 35.68  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|
gi 1490960372 274 VCPRCGNRNPPNAKFCMYCG 293
Cdd:COG1552    17 ICMRCGARNPIRATRCRKCG 36
DZR_2 pfam18912
Double zinc ribbon domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 283-326 2.76e-03

Double zinc ribbon domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00156. This entry corresponds to two zinc ribbon motifs. This domain is found at the N-terminus of the ComF operon protein 3.


Pssm-ID: 465906 [Multi-domain]  Cd Length: 56  Bit Score: 35.34  E-value: 2.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1490960372 283 PPNakfCMYCGAPLGGTKT-CPAC-GRTVPVSAKFCPYCGAKLEGG 326
Cdd:pfam18912   7 PPR---CPLCGAIVAEGGGlCAACwAELPFITEPRCPRCGKPLEEG 49
YvbJ COG4640
Uncharacterized protein YvbJ, contains N-terminal Zn ribbon domain [Function unknown];
300-325 5.42e-03

Uncharacterized protein YvbJ, contains N-terminal Zn ribbon domain [Function unknown];


Pssm-ID: 443678 [Multi-domain]  Cd Length: 445  Bit Score: 38.21  E-value: 5.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 1490960372 300 KTCPACGRTVPVSAKFCPYCGAKLEG 325
Cdd:COG4640     2 KFCPNCGHKLEDGVKFCPNCGTPLTS 27
PknG_rubred pfam16919
Protein kinase G rubredoxin domain; This rubredoxin domain is found at the N-terminus of ...
 282-321 6.45e-03

Protein kinase G rubredoxin domain; This rubredoxin domain is found at the N-terminus of protein kinase G, and is essential for kinase activity.


Pssm-ID: 435653  Cd Length: 139  Bit Score: 36.64  E-value: 6.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1490960372 282 NP--PNAK-FCMYCGAPLG-GTKTCPAcgrtvpVSAKFCPYCGA 321
Cdd:pfam16919  85 NPvvPESKrFCWNCGRPVGrSTGEGPG------RSEGWCPHCGS 122
PRK07418 PRK07418
acetolactate synthase large subunit;
301-323 7.39e-03

acetolactate synthase large subunit;


Pssm-ID: 236014 [Multi-domain]  Cd Length: 616  Bit Score: 38.11  E-value: 7.39e-03
                          10        20
                  ....*....|....*....|...
gi 1490960372 301 TCPACGRTVPVSAKFCPYCGAKL 323
Cdd:PRK07418  594 YCSNCGAKNPSTHRFCPECGTKL 616
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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