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Conserved domains on  [gi|1490909939|gb|RLE41329|]
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hypothetical protein DRJ23_00165 [Candidatus Acetothermia bacterium]

Protein Classification

sensor histidine kinase( domain architecture ID 11468388)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals, such as Bacillus subtilis thermosensor DesK which regulates the order of membrane lipids by controlling the expression of the gene encoding delta 5-acyl-lipid desaturase, oxygen sensor histidine kinase NreB which is involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen, sensor histidine kinase LiaS which is involved in sensing cell wall stress, and Staphylococcus aureus VraS which positively modulates cell wall biosynthesis

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10500846|10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
166-403 7.11e-63

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 202.54  E-value: 7.11e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 166 LTTILAGAAGVYGALSYTVRAFTEIYARKNRALRARERELSklsQRILSAQDEERRRIARVLHDELGQTLAAVKLEL--- 242
Cdd:COG4585     3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELA---ARAEEAREEERRRIARELHDGVGQSLSAIKLQLeaa 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 243 ---------AAGEDVTRAQGLIDRAISQTRDLAHSLRPPLLDDLGLGPSLRRLGRMVEEAGNVDVRVRVEITE-RLPQEH 312
Cdd:COG4585    80 rrlldadpeAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPdRLPPEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 313 EGLLFSAAQEALRNIEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP--GLGLRGIRERVEGIGGRMSVFSRPGE 390
Cdd:COG4585   160 ELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPggGLGLRGMRERAEALGGTLTIGSAPGG 239

                         250
                  ....*....|...
gi 1490909939 391 GTRLEVEVPYAGD 403
Cdd:COG4585   240 GTRVRATLPLAAA 252
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
166-403 7.11e-63

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 202.54  E-value: 7.11e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 166 LTTILAGAAGVYGALSYTVRAFTEIYARKNRALRARERELSklsQRILSAQDEERRRIARVLHDELGQTLAAVKLEL--- 242
Cdd:COG4585     3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELA---ARAEEAREEERRRIARELHDGVGQSLSAIKLQLeaa 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 243 ---------AAGEDVTRAQGLIDRAISQTRDLAHSLRPPLLDDLGLGPSLRRLGRMVEEAGNVDVRVRVEITE-RLPQEH 312
Cdd:COG4585    80 rrlldadpeAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPdRLPPEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 313 EGLLFSAAQEALRNIEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP--GLGLRGIRERVEGIGGRMSVFSRPGE 390
Cdd:COG4585   160 ELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPggGLGLRGMRERAEALGGTLTIGSAPGG 239

                         250
                  ....*....|...
gi 1490909939 391 GTRLEVEVPYAGD 403
Cdd:COG4585   240 GTRVRATLPLAAA 252
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
195-399 1.27e-33

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 131.25  E-value: 1.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 195 NRALRARERELSKLSQRILSAQDEERRRIARVLHDELGQTLAAVKLE------LAAGE-DVTRAQGLID----RAISQTR 263
Cdd:PRK11644  277 NQSLQKELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRTQagiikrLAADNaSVKQSAQLIEqlslGVYDTVR 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 264 DLAHSLRPPLLDDLGLGPSLRRLGRMVE-EAGNVDVRVRVEITER-LPQEHEGLLFSAAQEALRNIEAHAQARRVEIAVE 341
Cdd:PRK11644  357 RLLGRLRPRQLDDLTLEQAIRSLMREMElEDRGIVSHLDWRIDESaLSETQRVTLFRVCQEGLNNIVKHADASAVTLQGW 436

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1490909939 342 QREGAIVLVVTDDGIGFD-HAAVPGLGLRGIRERVEGIGGRMSVFSRPgeGTRLEVEVP 399
Cdd:PRK11644  437 QQDERLMLVIEDDGSGLPpGSGQQGFGLRGMRERVTALGGTLTISCTH--GTRLSVSLP 493
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 316-399 1.92e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 93.39  E-value: 1.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 316 LFSAAQEALRNIEAHAQARRVEIAVEQREGAIVLVVTDDGIGFD---HAAVPGLGLRGIRERVEGIGGRMSVFSRPGEGT 392
Cdd:cd16917     1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDgpaPPGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80


                  ....*..
gi 1490909939 393 RLEVEVP 399
Cdd:cd16917    81 RVTARLP 87
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 316-399 1.40e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 60.84  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 316 LFSAAQEALRN-IEAHAQARRVEIAVEqREGAIVLVVTDDGIGFDHAAVP-----------------GLGLRGIRERVEG 377
Cdd:pfam02518   6 LRQVLSNLLDNaLKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPrifepfstadkrggggtGLGLSIVRKLVEL 84

                          90       100
                  ....*....|....*....|..
gi 1490909939 378 IGGRMSVFSRPGEGTRLEVEVP 399
Cdd:pfam02518  85 LGGTITVESEPGGGTTVTLTLP 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 313-401 2.10e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.36  E-value: 2.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939  313 EGLLFSAAQEALRN-IEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP-------------------GLGLRGIR 372
Cdd:smart00387   3 PDRLRQVLSNLLDNaIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEkifepffrtdkrsrkiggtGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*....
gi 1490909939  373 ERVEGIGGRMSVFSRPGEGTRLEVEVPYA 401
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLPLE 111
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
166-403 7.11e-63

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 202.54  E-value: 7.11e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 166 LTTILAGAAGVYGALSYTVRAFTEIYARKNRALRARERELSklsQRILSAQDEERRRIARVLHDELGQTLAAVKLEL--- 242
Cdd:COG4585     3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELA---ARAEEAREEERRRIARELHDGVGQSLSAIKLQLeaa 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 243 ---------AAGEDVTRAQGLIDRAISQTRDLAHSLRPPLLDDLGLGPSLRRLGRMVEEAGNVDVRVRVEITE-RLPQEH 312
Cdd:COG4585    80 rrlldadpeAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPdRLPPEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 313 EGLLFSAAQEALRNIEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP--GLGLRGIRERVEGIGGRMSVFSRPGE 390
Cdd:COG4585   160 ELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPggGLGLRGMRERAEALGGTLTIGSAPGG 239

                         250
                  ....*....|...
gi 1490909939 391 GTRLEVEVPYAGD 403
Cdd:COG4585   240 GTRVRATLPLAAA 252
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 195-399 9.65e-38

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 142.45  E-value: 9.65e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 195 NRALRARERELSKLSQRILSAQDEERRRIARVLHDELGQTLAAVKLELAAGEDVTRAQGLIDRAIS----------QTRD 264
Cdd:COG3851   268 NQQLEQELRENRALARQLVSAEESERREIARELHDEIGQNITAIRTQASILKRLAPQPEIEQSAQSieslalriydTTRR 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 265 LAHSLRPPLLDDLGLGPSLRRLG-RMVEEAGNVDvrVRVEITERLPQEHEGL---LFSAAQEALRNIEAHAQARRVEIAV 340
Cdd:COG3851   348 LLDRLRPAVLDELGLEEALRELPrELAFEEPGIS--CQLDLRGDPSLLDDTLqltLYRLVQEALTNILKHAEASQIRISL 425

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 341 EQREGAIVLVVTDDGIGFD-HAAVPGLGLRGIRERVEGIGGRMSVFSRPGeGTRLEVEVP 399
Cdd:COG3851   426 SQDKRLLSLEIRDDGIGLPpELRAKGFGLRGMRERVRALGGDFRLSSAPK-GTRLSVLLP 484
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
195-399 1.27e-33

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 131.25  E-value: 1.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 195 NRALRARERELSKLSQRILSAQDEERRRIARVLHDELGQTLAAVKLE------LAAGE-DVTRAQGLID----RAISQTR 263
Cdd:PRK11644  277 NQSLQKELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRTQagiikrLAADNaSVKQSAQLIEqlslGVYDTVR 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 264 DLAHSLRPPLLDDLGLGPSLRRLGRMVE-EAGNVDVRVRVEITER-LPQEHEGLLFSAAQEALRNIEAHAQARRVEIAVE 341
Cdd:PRK11644  357 RLLGRLRPRQLDDLTLEQAIRSLMREMElEDRGIVSHLDWRIDESaLSETQRVTLFRVCQEGLNNIVKHADASAVTLQGW 436

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1490909939 342 QREGAIVLVVTDDGIGFD-HAAVPGLGLRGIRERVEGIGGRMSVFSRPgeGTRLEVEVP 399
Cdd:PRK11644  437 QQDERLMLVIEDDGSGLPpGSGQQGFGLRGMRERVTALGGTLTISCTH--GTRLSVSLP 493
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 316-399 1.92e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 93.39  E-value: 1.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 316 LFSAAQEALRNIEAHAQARRVEIAVEQREGAIVLVVTDDGIGFD---HAAVPGLGLRGIRERVEGIGGRMSVFSRPGEGT 392
Cdd:cd16917     1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDgpaPPGGGGFGLLGMRERAELLGGTLTIGSRPGGGT 80


                  ....*..
gi 1490909939 393 RLEVEVP 399
Cdd:cd16917    81 RVTARLP 87
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
200-406 1.12e-16

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 82.03  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 200 ARERELSKLSQRILSaqdEERRRIARVLHDELGQTLAAVKLELAA----GEDVTRA-QGLIDR-------AISQTRDLAH 267
Cdd:PRK10600  345 ALERQQERQQQLIVM---EERATIARELHDSIAQSLSCMKMQVSClqmqGDALPESsRELLSQirnelnaSWRQLRELLT 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 268 SLRPPLlDDLGLGPSLRRLgrmVEEAG---NVDVRVRVEITERLPQEHEGL-LFSAAQEALRNIEAHAQARRVEIAVEQR 343
Cdd:PRK10600  422 TFRLQL-TEPGLRPALEAS---CEEFSarfGFPVKLDYQLPPRLVPSHQAIhLLQIAREALSNALKHAQASEVVVTVAQN 497

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490909939 344 EGAIVLVVTDDGIGF-DHAAVPG-LGLRGIRERVEGIGGRMSVFSRPGEGTrlEVEVPYAGDKNR 406
Cdd:PRK10600  498 QNQVKLSVQDNGCGVpENAERSNhYGLIIMRDRAQSLRGDCRVRRRESGGT--EVVVTFIPEKTF 560
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
218-399 1.62e-12

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 69.11  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 218 EERRRIARVLHDELGQTLAAVKLELA-----AGEDVTRAQGLI---DRAIS----QTRDLAHSLRPPLLD-DLGLGpslr 284
Cdd:PRK10935  362 EERATIARELHDSLAQVLSYLKIQLTllkrsLDEDNAKAQSIIaefDQALSdayrQLRELLTTFRLTIQEaNLGSA---- 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 285 rLGRMVEE-AGNVDVRVRVeiTERLPQehegLLFSAAQ---------EALRNIEAHAQARRVEI-AVEQREGAIVLVVTD 353
Cdd:PRK10935  438 -LEEMLDQlRNQTDAKITL--DCRLPS----QALDAQQqvhllqiirEATLNAIKHANASEIAVsCVTNPDGEHTVSIRD 510

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1490909939 354 DGIGFDHAAVPG--LGLRGIRERVEGIGGRMSVFSRPGEGTRLEVEVP 399
Cdd:PRK10935  511 DGIGIGELKEPEghYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFP 558
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 316-399 1.40e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 60.84  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 316 LFSAAQEALRN-IEAHAQARRVEIAVEqREGAIVLVVTDDGIGFDHAAVP-----------------GLGLRGIRERVEG 377
Cdd:pfam02518   6 LRQVLSNLLDNaLKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPrifepfstadkrggggtGLGLSIVRKLVEL 84

                          90       100
                  ....*....|....*....|..
gi 1490909939 378 IGGRMSVFSRPGEGTRLEVEVP 399
Cdd:pfam02518  85 LGGTITVESEPGGGTTVTLTLP 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 313-401 2.10e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.36  E-value: 2.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939  313 EGLLFSAAQEALRN-IEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP-------------------GLGLRGIR 372
Cdd:smart00387   3 PDRLRQVLSNLLDNaIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEkifepffrtdkrsrkiggtGLGLSIVK 82

                           90       100
                   ....*....|....*....|....*....
gi 1490909939  373 ERVEGIGGRMSVFSRPGEGTRLEVEVPYA 401
Cdd:smart00387  83 KLVELHGGEISVESEPGGGTTFTITLPLE 111
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 219-274 2.89e-11

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 58.79  E-value: 2.89e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490909939 219 ERRRIARVLHDELGQTLAAVKLEL------------AAGEDVTRAQGLIDRAISQTRDLAHSLRPPLL 274
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLelarrlldrdpeEAREQLDAIRELAREALQELRRLLGDLRPPAL 68
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 99-399 7.38e-10

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 60.20  E-value: 7.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939  99 SEWIGVIFYVFTVIYANFFLPELQGYLITGLVVLLYSSLVILEYFGVIPHRSLFPPYEAPYRNLAYNLTTILAGAAGVYG 178
Cdd:COG4191     3 RLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 179 ALSYTVRAFTEIYARKNRALRARERELSKLSQRILSAQDEERRRiaRVLHDELGQT--LAAVKlELAAG----------- 245
Cdd:COG4191    83 GLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEEL--RELQEQLVQSekLAALG-ELAAGiaheinnplaa 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 246 ------------------EDVTRAQGLIDRAISQTRDLAHSLR------PPLLDDLGLGPSLRRLGRMVE-EAGNVDVRV 300
Cdd:COG4191   160 ilgnaellrrrledepdpEELREALERILEGAERAAEIVRSLRafsrrdEEEREPVDLNELIDEALELLRpRLKARGIEV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 301 RVEITERLPQ--EHEGLLfsaaQEALRN-----IEA--HAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP------- 364
Cdd:COG4191   240 ELDLPPDLPPvlGDPGQL----EQVLLNllinaIDAmeEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLErifepff 315

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1490909939 365 ---------GLGL---RGIrerVEGIGGRMSVFSRPGEGTRLEVEVP 399
Cdd:COG4191   316 ttkpvgkgtGLGLsisYGI---VEKHGGRIEVESEPGGGTTFTITLP 359
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
111-401 1.15e-09

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 59.15  E-value: 1.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 111 VIYANFFLPELQGYLITGLVVLLYSSLVILEYFGVIPHRSLFPPYEAPYRNLAYNLTTILAGAAGVYGALSYTVRAFTEI 190
Cdd:COG0642     2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 191 YARKNRALRARERELSKLSQRILSAQDEERRRIARVLHdELGQTLAAVK--LELAAGEDVTRAQGLIDRAISQTRDLAHs 268
Cdd:COG0642    82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSH-ELRTPLTAIRgyLELLLEELDEEQREYLETILRSADRLLR- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 269 lrppLLDDL---------GLGPSLRR--LGRMVEE--------AGNVDVRVRVEITERLPQEH--EGLLfsaaQEALRN- 326
Cdd:COG0642   160 ----LINDLldlsrleagKLELEPEPvdLAELLEEvvelfrplAEEKGIELELDLPDDLPTVRgdPDRL----RQVLLNl 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 327 ----IEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP------------------GLGL---RGIrerVEGIGGR 381
Cdd:COG0642   232 lsnaIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLErifepffrtdpsrrgggtGLGLaivKRI---VELHGGT 308

                         330       340
                  ....*....|....*....|
gi 1490909939 382 MSVFSRPGEGTRLEVEVPYA 401
Cdd:COG0642   309 IEVESEPGKGTTFTVTLPLA 328
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 239-403 3.18e-09

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 58.43  E-value: 3.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 239 KLELAAGEDVTRAQGLIDRAISQTRDLAH---------SLRPPLLDDLGLGPSLRRLGRMVEEA-GNVDVRVRVEITERL 308
Cdd:COG5000   229 KLADKLEEDREDLERALDTIIRQVDRLKRivdefldfaRLPEPQLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDL 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 309 PQehegLLFSAAQ--EALRN-----IEAHAQARRVEIAVEQREGAIVLVVTDDGIGF-----DHAAVP---------GLG 367
Cdd:COG5000   309 PE----VLADRDQleQVLINllknaIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIpeevlERIFEPffttkpkgtGLG 384

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1490909939 368 L---RGIrerVEGIGGRMSVFSRPGEGTRLEVEVPYAGD 403
Cdd:COG5000   385 LaivKKI---VEEHGGTIELESRPGGGTTFTIRLPLAEE 420
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
217-401 5.28e-08

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 53.37  E-value: 5.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 217 DEERRRIARVLHDElgqtlaavklelaagedVTRAQGLIDRAISQTRDLAHSLRPPL----LDDLgLGPSLRRLGRMVEE 292
Cdd:COG2205    49 PEERRELLEIIRES-----------------AERLLRLIEDLLDLSRLESGKLSLELepvdLAEL-LEEAVEELRPLAEE 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 293 AGnvdVRVRVEITERLP--QEHEGLLFSAAQEALRN-IEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP----- 364
Cdd:COG2205   111 KG---IRLELDLPPELPlvYADPELLEQVLANLLDNaIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELErifer 187

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1490909939 365 -------------GLGL---RGIrerVEGIGGRMSVFSRPGEGTRLEVEVPYA 401
Cdd:COG2205   188 fyrgdnsrgeggtGLGLaivKRI---VEAHGGTIWVESEPGGGTTFTVTLPLA 237
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 246-403 2.56e-07

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 52.16  E-value: 2.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 246 EDVTRAQGLIDRAISQTRDLAHSLRPPLLDDLglgpslrrLGRMVEEAGNVDVRVRVEITERLPQEHE---------GLL 316
Cdd:COG3290   218 EALEYIDEISEELQELIDSLLSRIGNPVLAAL--------LLGKAARARERGIDLTIDIDSDLPDLPLsdtdlvtilGNL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 317 FSAAQEALRNIEAhaQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP---------------GLGLRGIRERVEGIGGR 381
Cdd:COG3290   290 LDNAIEAVEKLPE--EERRVELSIRDDGDELVIEVEDSGPGIPEELLEkifergfstklgegrGLGLALVKQIVEKYGGT 367

                         170       180
                  ....*....|....*....|..
gi 1490909939 382 MSVFSRPGEGTRLEVEVPYAGD 403
Cdd:COG3290   368 IEVESEEGEGTVFTVRLPKEGE 389
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
327-400 4.24e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 51.94  E-value: 4.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 327 IEAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP-------------GLGLRGIRERVE---GIGGRMSVFSRPGE 390
Cdd:COG2972   353 IEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEklleelsskgegrGIGLRNVRERLKlyyGEEYGLEIESEPGE 432

                          90
                  ....*....|
gi 1490909939 391 GTRLEVEVPY 400
Cdd:COG2972   433 GTTVTIRIPL 442
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
347-399 1.59e-06

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 50.45  E-value: 1.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490909939 347 IVLVVTDDGIGFDHAAVP--------------GLGLRGIRERVEGIGGRMSVFSRPGEGTRLEVEVP 399
Cdd:PRK13837  608 VLLRVSDTGAGIDEAVLPhifepffttraggtGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
319-399 4.31e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 45.67  E-value: 4.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 319 AAQEALRNIEAHAQAR----RVEIAVEQREGAIVLVVTDDGIGFDHAAVP---------GLGLRGIRERVEgiggRMSVF 385
Cdd:COG2172    38 AVSEAVTNAVRHAYGGdpdgPVEVELELDPDGLEIEVRDEGPGFDPEDLPdpystlaegGRGLFLIRRLMD----EVEYE 113

                          90
                  ....*....|....
gi 1490909939 386 SRPGeGTRLEVEVP 399
Cdd:COG2172   114 SDPG-GTTVRLVKR 126
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 327-406 5.36e-06

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 48.37  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 327 IEAHAQA--RRVEIAVEQREGAIVLVVTDDGIGFDHAAVP--------------GLGLRGIRERVEGIGGRMSVFSRPGE 390
Cdd:PRK11086  446 LEAVGGEegGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDaifdkgystkgsnrGVGLYLVKQSVENLGGSIAVESEPGV 525

                          90
                  ....*....|....*.
gi 1490909939 391 GTRLEVEVPYAGDKNR 406
Cdd:PRK11086  526 GTQFFVQIPWDGERSN 541
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
74-403 1.27e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 46.85  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939  74 LHWAHAGFFIAEIVLITALIHLMGGSEWIGVIFYVFTVIYANFFLPELQGYLITGLVVLLYSSLVILEYFGVIPHRSLFP 153
Cdd:COG5002     8 LLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 154 PYEAPYRNLAYNLTTILAGAAGVYGALSYTVRAFTEIYARKNRALRARERELSKLSQRILSA----------QDEERRR- 222
Cdd:COG5002    88 LLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAaverditeleRLEQMRRe 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 223 -IARVLHdELGQTLAAVK-----LELAAGEDVTRAQGLIDRAISQTRDLAHslrppLLDDL-----------GLGPSLRR 285
Cdd:COG5002   168 fVANVSH-ELRTPLTSIRgylelLLDGAADDPEERREYLEIILEEAERLSR-----LVNDLldlsrlesgelKLEKEPVD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 286 LGRMVEE--------AGNVDVRVRVEITERLPQEH--EGLLfsaaQEALRN-----IEAHAQARRVEIAVEQREGAIVLV 350
Cdd:COG5002   242 LAELLEEvveelrplAEEKGIELELDLPEDPLLVLgdPDRL----EQVLTNlldnaIKYTPEGGTITVSLREEDDQVRIS 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490909939 351 VTDDGIGFDHAAVP--------------------GLGL---RGIrerVEGIGGRMSVFSRPGEGTRLEVEVPYAGD 403
Cdd:COG5002   318 VRDTGIGIPEEDLPriferfyrvdksrsretggtGLGLaivKHI---VEAHGGRIWVESEPGKGTTFTITLPLARE 390
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
240-399 3.84e-05

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 45.94  E-value: 3.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 240 LELAAGEDVTRAQGLIDRAISQTRDLAHSLR--PpllddlgLGPSLRRLGRMVEEAG---NVDVRVRVE---------IT 305
Cdd:COG0643   203 LEDESLRELEEALEQLSRLTRELQDGVMRLRmvP-------ISTVFNRFPRMVRDLArelGKEVELVIEgeeteldrtVL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 306 ERL--PQEHegllfsaaqeALRN-----IEAhAQARR---------VEIAVEQREGAIVLVVTDDGIGFDHAAV------ 363
Cdd:COG0643   276 ERLgdPLVH----------LVRNavdhgIET-PEERLaagkpetgtITLSAYHEGGRVVIEVSDDGRGLDLEKIrakaie 344

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490909939 364 -----------------------PGL----------GlRGI-----RERVEGIGGRMSVFSRPGEGTRLEVEVP 399
Cdd:COG0643   345 kglitaeeaaalsdeellelifaPGFstaeevtdlsG-RGVgmdvvKTNIEALGGTIEIESEPGKGTTFTLRLP 417
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 2-399 6.10e-05

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 45.16  E-value: 6.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939   2 VSDPDFAELKATVIKTVMARRITLGAFSAIALIVILLTKISYLNPLFYAPLVWFLLTFPFKYLIERQTNPTGLHWAHAGF 81
Cdd:COG4251    65 LLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLR 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939  82 FIAEIVLITALIHLMGGSEWIGVIFYVFTVIYANFFLPELQGYLITGLVVLLYSSLVILEYFGVIPHRSLFPPYEAPYRN 161
Cdd:COG4251   145 LALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGG 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 162 LAYNLTTILAGAAGVYGALSYTVRAFTEIYARKNRALRARERELSKLSQRiLSAQDEERRRIARVL-HDeLGQTLAAVK- 239
Cdd:COG4251   225 LGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAE-LERSNEELEQFAYVAsHD-LREPLRKISg 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 240 -----LELAAGEDVTRAQGLIDRAISQTRDLAHslrppLLDDLglgpsLR--RLGRMVEEAGNVDVR-----VRVEITER 307
Cdd:COG4251   303 fsqllEEDYGDKLDEEGREYLERIRDAAERMQA-----LIDDL-----LAysRVGRQELEFEPVDLNelleeVLEDLEPR 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 308 LPQEH--------------EGLLFSAAQEALRN-IEAHAQAR--RVEIAVEQREGAIVLVVTDDGIGFD----------- 359
Cdd:COG4251   373 IEERGaeievgplptvrgdPTLLRQVFQNLISNaIKYSRPGEppRIEIGAEREGGEWVFSVRDNGIGIDpeyaekifeif 452

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490909939 360 -----HAAVPGLGL-----RGIrerVEGIGGRMSVFSRPGEGTRLEVEVP 399
Cdd:COG4251   453 qrlhsRDEYEGTGIglaivKKI---VERHGGRIWVESEPGEGATFYFTLP 499
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 284-399 7.26e-05

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 43.34  E-value: 7.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 284 RRLGRMVE-EAGNVDVRVRVEITERL--PQEHegLLFSAAQEALRNIEAHAQAR-----RVEIAVEQREGAIVLVVTDDG 355
Cdd:cd16916    14 RELGKQVElVVEGEDTELDKSVLEKLadPLTH--LLRNAVDHGIEAPEERLAAGkppegTITLRAEHQGNQVVIEVSDDG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 356 IGFDHAAV-----------------------------P--------------GLGLRGIRERVEGIGGRMSVFSRPGEGT 392
Cdd:cd16916    92 RGIDREKIrekaierglitadeaatlsddevlnlifaPgfstaeqvtdvsgrGVGMDVVKRSIESLGGTIEVESEPGQGT 171


                  ....*..
gi 1490909939 393 RLEVEVP 399
Cdd:cd16916   172 TFTIRLP 178
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
319-381 1.73e-04

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 41.12  E-value: 1.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490909939 319 AAQEALRNIEAHAQ----ARRVEIAVEQREGAIVLVVTDDGIGFDHAAVPGLGLRGIRERvEGIGGR 381
Cdd:pfam13581  35 AVGEACTNAVEHAYregpEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEPDED-RKEGGR 100
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 316-399 2.44e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 40.21  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 316 LFSAAQEAlrnIEAHAQAR-RVEIAVE-QREGAIVLVVTDDGIGF--------------DHAAVPGLGLRGIRERVEGIG 379
Cdd:cd16944    12 ILKNAAEA---IEGRPSDVgEVRIRVEaDQDGRIVLIVCDNGKGFpremrhratepyvtTRPKGTGLGLAIVKKIMEEHG 88

                          90       100
                  ....*....|....*....|
gi 1490909939 380 GRMSVFSRPGEGTRLEVEVP 399
Cdd:cd16944    89 GRISLSNREAGGACIRIILP 108
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 335-399 2.91e-04

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 42.97  E-value: 2.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490909939 335 RVEIAVEQREGAIVLVVTDDGIGFDHAAVP----GLGLRGIRERVEGIGGRMSVfsRPGEGTRLEVEVP 399
Cdd:COG3920   423 RIRVSWRREDGRLRLTVSDNGVGLPEDVDPparkGLGLRLIRALVRQLGGTLEL--DRPEGTRVRITFP 489
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-399 3.25e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 39.73  E-value: 3.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490909939 335 RVEIAVEQREGAIVLVVTDDGIGFDHAA--------VPGLGLRGIRERVEGIGGR---MSVFSRPGEGTRLEVEVP 399
Cdd:cd16956    26 RVEITARLDGQHLLLEVEDNGGGMDPDTlarilirsSNGLGLNLVDKRLRQAFGNdygLDIECAPGEGTRITIRLP 101
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 289-399 3.71e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 40.09  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 289 MVEEAGNVDVRVRVEI-TERLPQEHEGLLFSAAQEALRNIEAHAQARR----VEIAVEQREGAIVLVVTDDGIGFDHAAV 363
Cdd:cd16951    12 INAIHAVGDIRINITGdTGPVSSEVATAIGLVVNELLQNALKHAFSDReggtITIRSVVDGDYLRITVIDDGVGLPQDED 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1490909939 364 P----GLGLRGIRERVEGIGGRMSVFSRPGEGTRLEVEVP 399
Cdd:cd16951    92 WpnkgSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
PRK13560 PRK13560
hypothetical protein; Provisional
 224-399 4.66e-04

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 42.35  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 224 ARVLHDELGQTLaavkleLAAGEDVTRAQGLIDRAISQTRDLAhslrpplldDLGLGPSLRRLGRMVEEA-----GNVDV 298
Cdd:PRK13560  631 AEKLHDEEAKCA------FAESQDRICAMALAHEKLYQSEDLA---------DIDFLDYIESLTAHLKNSfaidfGRIDC 695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 299 RVRV-----EITERLPQeheGLLFSaaqEALRNIEAHA------QARRVEIAvEQREGAIVLVVTDDGIG----FDHAAV 363
Cdd:PRK13560  696 KIDAddgclDIDKAIPC---GLIIS---ELLSNALKHAfpdgaaGNIKVEIR-EQGDGMVNLCVADDGIGlpagFDFRAA 768

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1490909939 364 PGLGLRGIRERVEGIGGRMSVFSRpgEGTRLEVEVP 399
Cdd:PRK13560  769 ETLGLQLVCALVKQLDGEIALDSR--GGARFNIRFP 802
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 335-399 1.06e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 38.24  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 335 RVE-IAVEQREGAIVLVVTDDGIGFDHAAVP--------------------GLGLRGIRERVEGIGGRMSVFSRPGEGTR 393
Cdd:cd16922    24 RVSlEEEEEDGVQLRFSVEDTGIGIPEEQQArlfepfsqadssttrkyggtGLGLAISKKLVELMGGDISVESEPGQGST 103


                  ....*.
gi 1490909939 394 LEVEVP 399
Cdd:cd16922   104 FTFTLP 109
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
243-409 1.51e-03

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 40.54  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 243 AAGEDVTRAQGLI------DRAISQTRDLAH----SLRPPLLDDLgLGPSLRRLGRMVEEAGnVDVRVRV-EITERLPQE 311
Cdd:PRK10364  268 AGGEAHQLAQVMAkeadrlNRVVSELLELVKpthlALQAVDLNDL-INHSLQLVSQDANSRE-IQLRFTAnDTLPEIQAD 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 312 HEGLLFSAAQEALRNIEAHAQARRVEIAVEQREGAIVLVVTDDGIG-----FDHAAVP---------GLGLRGIRERVEG 377
Cdd:PRK10364  346 PDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGiaadqLEAIFTPyfttkaegtGLGLAVVHNIVEQ 425

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1490909939 378 IGGRMSVFSRPGEGTRLEVEVPYAGDKNRDRR 409
Cdd:PRK10364  426 HGGTIQVASQEGKGATFTLWLPVNITRRDPQG 457
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
246-399 1.75e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 40.21  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 246 EDVTRAQGLIDRAISQTRDlahslRPPLLDDLGLGPSLRRLGRMVEEAGNVDVRVRVEITERLPQehegLLFSAAQ--EA 323
Cdd:COG3852   178 EEADRLNNLVDRLLSFSRP-----RPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPE----VLGDPDQliQV 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 324 LRNI-----EA----------HAQARRVEIAVEQREGAIVLVVTDDGIG---------FDhaavP---------GLGL-- 368
Cdd:COG3852   249 LLNLvrnaaEAmpeggtitirTRVERQVTLGGLRPRLYVRIEVIDNGPGipeeildriFE----PffttkekgtGLGLai 324

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1490909939 369 -RGIrerVEGIGGRMSVFSRPGEGTRLEVEVP 399
Cdd:COG3852   325 vQKI---VEQHGGTIEVESEPGKGTTFRIYLP 353
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 319-381 2.01e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 37.25  E-value: 2.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490909939 319 AAQEALRNIEAHAQA----RRVEIAVEQREGAIVLVVTDDGIGFDHAAVPGlglrgiRERVEGIGGR 381
Cdd:cd16936     4 AVSEAVTNAVRHAYRhdgpGPVRLELDLDPDRLRVEVTDSGPGFDPLRPAD------PDAGLREGGR 64
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 328-399 2.98e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 36.88  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490909939 328 EAHAQARRVEIAVEQREGAIVLVVTDDGIGFDHAAVP---------------GLGLRGIRERVEGIGGRMSVFSRPGEGT 392
Cdd:cd16915    18 ATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDkvfergvstkgqgerGIGLALVRQSVERLGGSITVESEPGGGT 97


                  ....*..
gi 1490909939 393 RLEVEVP 399
Cdd:cd16915    98 TFSIRIP 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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