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Conserved domains on  [gi|1490725949|gb|RLC97011|]
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hypothetical protein DRI40_01460 [Chloroflexi bacterium]

Protein Classification

protein jag( domain architecture ID 11448923)

SpoIIIJ-associated protein jag is necessary for the third stage of sporulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jag_EloR super family cl49528
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ...
 5-218 1.65e-71

RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB.


The actual alignment was detected with superfamily member NF041568:

Pssm-ID: 469453 [Multi-domain]  Cd Length: 203  Bit Score: 216.15  E-value: 1.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949   5 EASGRTVEEATQRALEQLGLSRDEVEVEVLKKGKPGFLGL-GAEDATVRVTPLPqqpkaqdDVATLAKGVLEDLLKLMKL 83
Cdd:NF041568    3 TATGKTVEEAVESALAELGVTRDRVEIEVLEEGSKGFLGLfGSKPAVVKVTLKP-------DPIEEAKEFLENVLEAMGI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949  84 DAKVELrasspegDSPRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKAKVPVAIDVEGYKQRRYLVLRDL 163
Cdd:NF041568   76 DEVEIE-------EEEDDDVIKFNLSGEKLGLLIGKRGQTLDALQYLTNLVANRYSDEYVRVILDAENYRERREETLEQL 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1490725949 164 ALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNPDVTTQSIGEGEVRKVAIIP 218
Cdd:NF041568  149 AERLADKVKRTKKPVVLEPMPSYERKIIHTALQNHPDVETYSEGEEPNRKVVIAP 203
 
Name Accession Description Interval E-value
Jag_EloR NF041568
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ...
 5-218 1.65e-71

RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB.


Pssm-ID: 469453 [Multi-domain]  Cd Length: 203  Bit Score: 216.15  E-value: 1.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949   5 EASGRTVEEATQRALEQLGLSRDEVEVEVLKKGKPGFLGL-GAEDATVRVTPLPqqpkaqdDVATLAKGVLEDLLKLMKL 83
Cdd:NF041568    3 TATGKTVEEAVESALAELGVTRDRVEIEVLEEGSKGFLGLfGSKPAVVKVTLKP-------DPIEEAKEFLENVLEAMGI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949  84 DAKVELrasspegDSPRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKAKVPVAIDVEGYKQRRYLVLRDL 163
Cdd:NF041568   76 DEVEIE-------EEEDDDVIKFNLSGEKLGLLIGKRGQTLDALQYLTNLVANRYSDEYVRVILDAENYRERREETLEQL 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1490725949 164 ALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNPDVTTQSIGEGEVRKVAIIP 218
Cdd:NF041568  149 AERLADKVKRTKKPVVLEPMPSYERKIIHTALQNHPDVETYSEGEEPNRKVVIAP 203
Jag COG1847
Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General ...
 71-220 2.26e-54

Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General function prediction only];


Pssm-ID: 441452 [Multi-domain]  Cd Length: 143  Bit Score: 170.68  E-value: 2.26e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949  71 KGVLEDLLKLMKLDAKVELRAsspegdspRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKAKVPVAIDVE 150
Cdd:COG1847     2 ADFLEELLDIMGLDGDIEIEV--------EGDRLTVDISGEDLGLLIGRRGETLDALQYLTNLAVNRKTGERSRVILDVE 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949 151 GYKQRRYLVLRDLALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNPDVTTQSIGEGEVRKVAIIPRR 220
Cdd:COG1847    74 GYRERREEELEELARRAAEKVKRTGKPVELEPMSPYERRIIHDALADDPGVETESEGEEPYRRVVISPKR 143
KH-II_Jag cd02414
type II K-homology (KH) RNA-binding domain found in protein Jag and similar proteins; Protein ...
 70-155 1.75e-22

type II K-homology (KH) RNA-binding domain found in protein Jag and similar proteins; Protein Jag, also called SpoIIIJ-associated protein, is associated with SpoIIIJ and is necessary for the third stage of sporulation. Members of this family are mainly from bacteria and contain only one canonical type II K-homology (KH) domain that has the signature motif GXXG (where X represents any amino acid).


Pssm-ID: 411785  Cd Length: 79  Bit Score: 86.81  E-value: 1.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949  70 AKGVLEDLLKLMKLDAKVELrasspegdSPRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKAKVPVAIDV 149
Cdd:cd02414     2 AKEFLEELLDAMGIEAEVEV--------EEEEGTVKLNIDGEDPGLLIGKHGETLDALQYLANLVLNKEFGKRVRVVLDV 73


                  ....*.
gi 1490725949 150 EGYKQR 155
Cdd:cd02414    74 EGYRER 79
Jag_N pfam14804
Jag N-terminus; This domain is found at the N-terminus of proteins containing pfam13083 and ...
 7-55 6.33e-16

Jag N-terminus; This domain is found at the N-terminus of proteins containing pfam13083 and pfam01424, including the jag proteins.


Pssm-ID: 464324  Cd Length: 50  Bit Score: 68.94  E-value: 6.33e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490725949   7 SGRTVEEATQRALEQLGLSRDEVEVEVLKKGKPGFLGL-GAEDATVRVTP 55
Cdd:pfam14804   1 EGKTVEEAIEKALKELGVSRDEVEIEVLEEGSKGFLGLfGKKPAKVRVTV 50
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
143-219 9.84e-11

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 56.15  E-value: 9.84e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490725949  143 VPVAIDVEGYKQRRYLVLRDLALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNpDVTTQSIGEGEVRKVAIIPR 219
Cdd:smart00393   4 LPVTLDALSYRPRRREELIELELEIARFVKSTKESVELPPMNSYERKIVHELAEKY-GLESESFGEGPKRRVVISKK 79
 
Name Accession Description Interval E-value
Jag_EloR NF041568
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ...
 5-218 1.65e-71

RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB.


Pssm-ID: 469453 [Multi-domain]  Cd Length: 203  Bit Score: 216.15  E-value: 1.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949   5 EASGRTVEEATQRALEQLGLSRDEVEVEVLKKGKPGFLGL-GAEDATVRVTPLPqqpkaqdDVATLAKGVLEDLLKLMKL 83
Cdd:NF041568    3 TATGKTVEEAVESALAELGVTRDRVEIEVLEEGSKGFLGLfGSKPAVVKVTLKP-------DPIEEAKEFLENVLEAMGI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949  84 DAKVELrasspegDSPRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKAKVPVAIDVEGYKQRRYLVLRDL 163
Cdd:NF041568   76 DEVEIE-------EEEDDDVIKFNLSGEKLGLLIGKRGQTLDALQYLTNLVANRYSDEYVRVILDAENYRERREETLEQL 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1490725949 164 ALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNPDVTTQSIGEGEVRKVAIIP 218
Cdd:NF041568  149 AERLADKVKRTKKPVVLEPMPSYERKIIHTALQNHPDVETYSEGEEPNRKVVIAP 203
Jag COG1847
Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General ...
 71-220 2.26e-54

Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General function prediction only];


Pssm-ID: 441452 [Multi-domain]  Cd Length: 143  Bit Score: 170.68  E-value: 2.26e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949  71 KGVLEDLLKLMKLDAKVELRAsspegdspRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKAKVPVAIDVE 150
Cdd:COG1847     2 ADFLEELLDIMGLDGDIEIEV--------EGDRLTVDISGEDLGLLIGRRGETLDALQYLTNLAVNRKTGERSRVILDVE 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949 151 GYKQRRYLVLRDLALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNPDVTTQSIGEGEVRKVAIIPRR 220
Cdd:COG1847    74 GYRERREEELEELARRAAEKVKRTGKPVELEPMSPYERRIIHDALADDPGVETESEGEEPYRRVVISPKR 143
KH-II_Jag cd02414
type II K-homology (KH) RNA-binding domain found in protein Jag and similar proteins; Protein ...
 70-155 1.75e-22

type II K-homology (KH) RNA-binding domain found in protein Jag and similar proteins; Protein Jag, also called SpoIIIJ-associated protein, is associated with SpoIIIJ and is necessary for the third stage of sporulation. Members of this family are mainly from bacteria and contain only one canonical type II K-homology (KH) domain that has the signature motif GXXG (where X represents any amino acid).


Pssm-ID: 411785  Cd Length: 79  Bit Score: 86.81  E-value: 1.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490725949  70 AKGVLEDLLKLMKLDAKVELrasspegdSPRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKAKVPVAIDV 149
Cdd:cd02414     2 AKEFLEELLDAMGIEAEVEV--------EEEEGTVKLNIDGEDPGLLIGKHGETLDALQYLANLVLNKEFGKRVRVVLDV 73


                  ....*.
gi 1490725949 150 EGYKQR 155
Cdd:cd02414    74 EGYRER 79
R3H_jag cd02644
R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with ...
 153-219 2.55e-21

R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100073  Cd Length: 67  Bit Score: 83.68  E-value: 2.55e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490725949 153 KQRRYLVLRDLALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNPDVTTQSIGEGEVRKVAIIPR 219
Cdd:cd02644     1 RERREETLIRLAERAAEKVRRTGKPVKLEPMNAYERRIIHDALANDEDVETESEGEGPYRRVVISPK 67
Jag_N pfam14804
Jag N-terminus; This domain is found at the N-terminus of proteins containing pfam13083 and ...
 7-55 6.33e-16

Jag N-terminus; This domain is found at the N-terminus of proteins containing pfam13083 and pfam01424, including the jag proteins.


Pssm-ID: 464324  Cd Length: 50  Bit Score: 68.94  E-value: 6.33e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490725949   7 SGRTVEEATQRALEQLGLSRDEVEVEVLKKGKPGFLGL-GAEDATVRVTP 55
Cdd:pfam14804   1 EGKTVEEAIEKALKELGVSRDEVEIEVLEEGSKGFLGLfGKKPAKVRVTV 50
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 160-218 3.56e-13

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 62.12  E-value: 3.56e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1490725949 160 LRDLALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNPdVTTQSIGEGEVRKVAIIP 218
Cdd:pfam01424   3 LEQLAEKLAEFVKDTGKSLELPPMSSYERRIIHELAQKYG-LESESEGEEPNRRVVVYK 60
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
143-219 9.84e-11

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 56.15  E-value: 9.84e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490725949  143 VPVAIDVEGYKQRRYLVLRDLALRLAQKVKATGRSTTLEPMPPDERRVVHLALSVNpDVTTQSIGEGEVRKVAIIPR 219
Cdd:smart00393   4 LPVTLDALSYRPRRREELIELELEIARFVKSTKESVELPPMNSYERKIVHELAEKY-GLESESFGEGPKRRVVISKK 79
KH_4 pfam13083
KH domain;
71-147 1.90e-10

KH domain;


Pssm-ID: 463779  Cd Length: 73  Bit Score: 55.18  E-value: 1.90e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490725949  71 KGVLEDLLKLMkLDAKVELRASSPEGDspRQRSVALEVNGEDLGILIGRRGETLASLQYIVRLIVARHEKaKVPVAI 147
Cdd:pfam13083   1 KELVEDILKAL-VDDPEEVSVTEEEEE--KTVVLELNVAGEDMGKVIGKQGRTLDALRTLVSAAANKDGK-RVRVEI 73
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 153-218 3.66e-08

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 48.38  E-value: 3.66e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490725949 153 KQRRYLVLRDLALRLAqkvkatGRSTTLEPMPPDERRVVHLALSVNpDVTTQSIGEGEVRKVAIIP 218
Cdd:cd02325     1 REEREEELEAFAKDAA------GKSLELPPMNSYERKLIHDLAEYY-GLKSESEGEGPNRRVVITK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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