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Conserved domains on  [gi|1490718101|gb|RLC90867|]
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hypothetical protein DRI37_00225 [Chloroflexi bacterium]

Protein Classification

YidC/Oxa1 family membrane protein insertase( domain architecture ID 15331943)

YidC/Oxa1 family membrane protein insertase functions as a membrane protein chaperone and as an independent insertase for membrane proteins, such as mitochondrial inner membrane protein OXA1/OXA1L and bacterial membrane protein insertase YidC

Gene Ontology:  GO:0016020|GO:0032977

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
42-236 1.40e-52

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


:

Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 169.10  E-value: 1.40e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAasplq 121
Cdd:cd20070    17 PLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFIALYQVLRNSIE----- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsflsvsalvPLQSKFLW--LDLALPDPFFVLPVLVVVTTWLQQKLLTPPAsasadPQAQSMTQSMQV 199
Cdd:cd20070    92 ----------------------LRGAPFLWwiLDLSAPDPYYILPILMGVTMFLQQKLTPTPT-----DDQAPQQKMMMY 144
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1490718101 200 TMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRK 236
Cdd:cd20070   145 FMPVMFTFIFLSFPSGLVLYWLVSNLFSIIQQLIINK 181
 
Name Accession Description Interval E-value
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
42-236 1.40e-52

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 169.10  E-value: 1.40e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAasplq 121
Cdd:cd20070    17 PLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFIALYQVLRNSIE----- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsflsvsalvPLQSKFLW--LDLALPDPFFVLPVLVVVTTWLQQKLLTPPAsasadPQAQSMTQSMQV 199
Cdd:cd20070    92 ----------------------LRGAPFLWwiLDLSAPDPYYILPILMGVTMFLQQKLTPTPT-----DDQAPQQKMMMY 144
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1490718101 200 TMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRK 236
Cdd:cd20070   145 FMPVMFTFIFLSFPSGLVLYWLVSNLFSIIQQLIINK 181
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
42-233 2.64e-46

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 153.02  E-value: 2.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAASplq 121
Cdd:TIGR03592  19 PLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLRSIELR--- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsflsvsalvplQSKFLWL-DLALPDPFFVLPVLVVVTTWLQQKLLTppaSASADPQAQSMtqsMQVT 200
Cdd:TIGR03592  96 ------------------------HAPFLWIiDLSSPDPYYILPILMGVTMFLQQKLSP---KGPPDPAQQKM---MMYF 145
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1490718101 201 MPLFMGFISLNYATGLSVYFIVSNLAGILQFYL 233
Cdd:TIGR03592 146 MPLMFLFFFLSFPAGLVLYWVVSNLFTIIQQLI 178
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
42-238 3.91e-46

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 153.74  E-value: 3.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAAsplq 121
Cdd:COG0706    44 PLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIEL---- 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsflsvsalvpLQSKFLWL-DLALPDPFFVLPV-LVVVTTWLQQKLltppasaSADPQAQSMTQSMQV 199
Cdd:COG0706   120 -----------------------RHAPFLGIpDLSAPDPYYIFLPiLMGVTMFLQQKL-------NPAPAQDPQQKKMMY 169
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1490718101 200 TMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRKHY 238
Cdd:COG0706   170 IMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRL 208
60KD_IMP pfam02096
60Kd inner membrane protein;
42-236 6.60e-46

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 152.24  E-value: 6.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAiiralaasplq 121
Cdd:pfam02096  18 PLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIFIALYRV----------- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsFLSVSALVPLQSKFLWLDLALPDPFFVLPVLVV-----VTTWLQQKLLTPPAsasadPQAQSMTQS 196
Cdd:pfam02096  87 --------------LRNSIELRHAPFFLWIADLSAPDPISILHYYILpilmgVTMFLQQKLTPAPQ-----DQPPQMKMM 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1490718101 197 MQVTMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRK 236
Cdd:pfam02096 148 MLYFMPLMFLFFFLNFPAGLVLYWVVSNLLSIGQQLIINR 187
PRK01318 PRK01318
membrane protein insertase; Provisional
42-237 5.17e-35

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 131.53  E-value: 5.17e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQaiiralaasplq 121
Cdd:PRK01318  340 PLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYK------------ 407
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsFLSVSalVPLQSK--FLWL-DLALPDPFFVLPVLVV-----VTTWLQQKLLTPPasasADPQAQSM 193
Cdd:PRK01318  408 --------------VLLVS--IELRHApfIGWIhDLSAPDPYFILHIGLLpilmgITMFLQQKLNPTP----TDPMQAKI 467
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1490718101 194 tqsMQVtMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRKH 237
Cdd:PRK01318  468 ---MKF-MPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRR 507
 
Name Accession Description Interval E-value
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
42-236 1.40e-52

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 169.10  E-value: 1.40e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAasplq 121
Cdd:cd20070    17 PLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFIALYQVLRNSIE----- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsflsvsalvPLQSKFLW--LDLALPDPFFVLPVLVVVTTWLQQKLLTPPAsasadPQAQSMTQSMQV 199
Cdd:cd20070    92 ----------------------LRGAPFLWwiLDLSAPDPYYILPILMGVTMFLQQKLTPTPT-----DDQAPQQKMMMY 144
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1490718101 200 TMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRK 236
Cdd:cd20070   145 FMPVMFTFIFLSFPSGLVLYWLVSNLFSIIQQLIINK 181
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
42-233 2.64e-46

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 153.02  E-value: 2.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAASplq 121
Cdd:TIGR03592  19 PLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLRSIELR--- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsflsvsalvplQSKFLWL-DLALPDPFFVLPVLVVVTTWLQQKLLTppaSASADPQAQSMtqsMQVT 200
Cdd:TIGR03592  96 ------------------------HAPFLWIiDLSSPDPYYILPILMGVTMFLQQKLSP---KGPPDPAQQKM---MMYF 145
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1490718101 201 MPLFMGFISLNYATGLSVYFIVSNLAGILQFYL 233
Cdd:TIGR03592 146 MPLMFLFFFLSFPAGLVLYWVVSNLFTIIQQLI 178
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
42-238 3.91e-46

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 153.74  E-value: 3.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAAsplq 121
Cdd:COG0706    44 PLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIEL---- 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsflsvsalvpLQSKFLWL-DLALPDPFFVLPV-LVVVTTWLQQKLltppasaSADPQAQSMTQSMQV 199
Cdd:COG0706   120 -----------------------RHAPFLGIpDLSAPDPYYIFLPiLMGVTMFLQQKL-------NPAPAQDPQQKKMMY 169
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1490718101 200 TMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRKHY 238
Cdd:COG0706   170 IMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRL 208
60KD_IMP pfam02096
60Kd inner membrane protein;
42-236 6.60e-46

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 152.24  E-value: 6.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAiiralaasplq 121
Cdd:pfam02096  18 PLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIFIALYRV----------- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsFLSVSALVPLQSKFLWLDLALPDPFFVLPVLVV-----VTTWLQQKLLTPPAsasadPQAQSMTQS 196
Cdd:pfam02096  87 --------------LRNSIELRHAPFFLWIADLSAPDPISILHYYILpilmgVTMFLQQKLTPAPQ-----DQPPQMKMM 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1490718101 197 MQVTMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRK 236
Cdd:pfam02096 148 MLYFMPLMFLFFFLNFPAGLVLYWVVSNLLSIGQQLIINR 187
PRK01318 PRK01318
membrane protein insertase; Provisional
42-237 5.17e-35

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 131.53  E-value: 5.17e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQaiiralaasplq 121
Cdd:PRK01318  340 PLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYK------------ 407
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpahiyrwlpsFLSVSalVPLQSK--FLWL-DLALPDPFFVLPVLVV-----VTTWLQQKLLTPPasasADPQAQSM 193
Cdd:PRK01318  408 --------------VLLVS--IELRHApfIGWIhDLSAPDPYFILHIGLLpilmgITMFLQQKLNPTP----TDPMQAKI 467
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1490718101 194 tqsMQVtMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRKH 237
Cdd:PRK01318  468 ---MKF-MPLIFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRR 507
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
42-236 4.87e-33

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 120.23  E-value: 4.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYqaiiralaasplq 121
Cdd:PRK00145   48 PLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPLGGCLPLLIQWPILIALY------------- 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lldlpaHIYRWLPSFLSVSalvplqskFLWL-DLALPDPFFVLPVLVVVTTWLQQKLLTPPasasaDPQAQSMTQSMQVT 200
Cdd:PRK00145  115 ------YVFNNLTGINGVS--------FLWIkDLAKPDITWILPILSGATTYLSGYLMTKA-----DSSQAGQMKTMNIG 175
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1490718101 201 MPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFRK 236
Cdd:PRK00145  176 MSIFMGVMSWKFKSALVLYWVIGNLIQIIQTYFIKK 211
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
2-235 1.32e-24

YidC family membrane integrase SpoIIIJ;


Pssm-ID: 179508  Cd Length: 255  Bit Score: 98.69  E-value: 1.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101   2 WDLLVVDPITNLMLVFYKLLGNQTILAVALLTLLVRLALTPLTLNQQKTMRKQQELQPKLKEIQEKYKGD----KEKLTQ 77
Cdd:PRK02944   36 WNEYFVYPLSQLITYFANLFGSNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYSSKdqatQQKLQQ 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  78 AQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAASplqlldlpahiyrwlpsflsvsalvplQSKFLWLDLALP 157
Cdd:PRK02944  116 EMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEIS---------------------------KHSFLWFDLGQA 168
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490718101 158 DPFFVLPVLVVVTTWLQQKLLTpPASASADPQAQSMTQSMQVTMPLFmgfiSLNYATGLSVYFIVSNLAGILQFYLFR 235
Cdd:PRK02944  169 DPYYILPIVAGITTFIQQKLMM-AGTAGQNPQMAMMLWLMPIMILIF----AINFPAALSLYWVVGNIFMIAQTYLIK 241
PRK01315 PRK01315
putative inner membrane protein translocase component YidC; Provisional
42-235 1.37e-23

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234941  Cd Length: 329  Bit Score: 97.50  E-value: 1.37e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRALAAsplq 121
Cdd:PRK01315   59 PLFVKQIKSQRNMQEIQPKMKKIQEKYKGDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAASR---- 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 122 lLDLPAHIYRWLPSFLSVSAL--VPLQSKFLwldLALPDPFFVLPVLVVVTTWL--------QQKLLTP--PASASADPQ 189
Cdd:PRK01315  135 -GDGIGPINPPLLESFRHAHIfgAPLAATFL---QALNAGNTAVQVVAAVLIILmsasqfitQLQLMTKnmPPEAKTGPM 210
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1490718101 190 AQsMTQSMQVTMPLFMGFISLNYATGLSVYFIVSNLAGI-LQFYLFR 235
Cdd:PRK01315  211 AQ-QQKMLLYLFPLMFLVSGIAFPVGVLFYWLTSNVWTMgQQFYVIR 256
PRK03449 PRK03449
putative inner membrane protein translocase component YidC; Provisional
44-108 7.18e-23

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 179580  Cd Length: 304  Bit Score: 95.13  E-value: 7.18e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490718101  44 TLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLY 108
Cdd:PRK03449   51 FVRQIRTTRKMQELQPQIKALQKKYGNDRQKMALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLF 115
PRK01622 PRK01622
membrane protein insertase YidC;
2-238 2.07e-20

membrane protein insertase YidC;


Pssm-ID: 179310  Cd Length: 256  Bit Score: 87.50  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101   2 WDLLVVDPITNLMLVFYKLLGNQTILAVALLTLLVRLALTPLTLNQQKTMRKQQE----LQPKLKEIQEKYKGDKEKLTQ 77
Cdd:PRK01622   37 FDHYFVYPFSFLIQFVAHHIGGSYGIAIIIVTLIIRSLMIPLAVSQYKSQRGMQEkmavMKPELDKIQAKLKVTKDLEKQ 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  78 AQ-----MSLYKEMGINPMG-GCLPMLIQLPLMFGLYQAIiralaasplqlldlpahiyRWLPSFLSvsalvplqSKFLW 151
Cdd:PRK01622  117 KEyqkemMELYKSGNINPLAmGCLPLLIQMPILSAFYYAI-------------------RRTEEIAS--------HSFLW 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 152 LDLALPDpfFVLPVLVVVTTWLQQKLLTppaSASADPQAQSMTQSMQVTMPLFMGFISLNYATGLSVYFIVSNLAGILQF 231
Cdd:PRK01622  170 FNLGHAD--HILPIIAGLTYFIQMKVSQ---SNGTSPEQVQMLKIQGIMMPAMILFMSFAAPSALVLYWITGGLFLMGQT 244

                  ....*..
gi 1490718101 232 YLFRKHY 238
Cdd:PRK01622  245 IVLRKVM 251
5TM_YidC_Oxa1_Alb3 cd19751
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ...
42-233 1.68e-19

Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410992 [Multi-domain]  Cd Length: 189  Bit Score: 83.76  E-value: 1.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEK------LTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRAl 115
Cdd:cd19751    17 PLTLKQQKSMRKMQVIRPEMEAIREKYKEKASKdkvqqeMQKEMLGLYKKHGVNPMAGCLPLFIQLPIFMAFYFAIMRT- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 116 aasplqlldlpahiyrwlPSFlsvsalvpLQSKFLWL-DLALPDPFFVLPVLVVVTTWLQQKLltPPASASADPQAQSMT 194
Cdd:cd19751    96 ------------------EEI--------RYHTFLWFfDLGQPDYLYILPFVAGITTYFQFKM--TMSHQQQMQMMQMQM 147
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1490718101 195 QSMQVTMPLFMGFISLNYATGLSVYFIVSNLAGILQFYL 233
Cdd:cd19751   148 KVMLYVMPVMIIIAGLSFPSALSLYWIISNLFMIIQTYF 186
PRK01001 PRK01001
putative inner membrane protein translocase component YidC; Provisional
42-230 1.50e-18

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234887 [Multi-domain]  Cd Length: 795  Bit Score: 85.24  E-value: 1.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGINPMGGCLPMLIQLPL---MFGLYQA--IIRALA 116
Cdd:PRK01001  593 PLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFliaMFDLLKSsfLLRGAS 672
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 117 ASPLQLLDL--PAHIYRW-LPSFLsvsalvpLQSKFLWLDLALpdpffvlpvlvVVTTWLQQKLLtppASASADP--QAQ 191
Cdd:PRK01001  673 FIPGWIDNLtaPDVLFSWeTPIWF-------IGNEFHLLPILL-----------GVVMFAQQKIS---SLKRKGPvtDQQ 731
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1490718101 192 SMTQSMQVTMPLFMGFISLNYATGLSVYFIVSNLAGILQ 230
Cdd:PRK01001  732 RQQEAMGTMMALLFTFMFYNFPSGLNIYWLSSMLLGVIQ 770
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
42-235 1.80e-16

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 75.64  E-value: 1.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYK-----GDKEKLTQAQ---MSLYKEMGINPMGGCLPMLIQLPLMFGLYQAiIR 113
Cdd:cd20069    21 PLVIKSQRNAARMANLQPELQKLQEKLKearasGDQLEAAEARkelKELMKKHNVNPLKSLLLPLVQAPVFISFFFA-LR 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 114 ALAASPlqlldlpahiyrwLPSFLSvsalvplqSKFLWL-DLALPDPFFVLPVLVVVTTWLQQKlLTPPASASADPQAQS 192
Cdd:cd20069   100 KMANLP-------------VPSFKT--------GGLLWFtDLTVPDPYYILPILTSLTFLATIE-LGAETGTSGSPQSKT 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1490718101 193 MTQSMQVtMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFR 235
Cdd:cd20069   158 MKNVFRG-LPVLMIPFTANFPSAVFLYWITSNLFSLAQNLLLR 199
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
42-128 8.59e-16

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 76.43  E-value: 8.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQELQPKLKEIQEKYKG--DKE---KLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAIIRalA 116
Cdd:PRK00247   49 PFTWQQYKSGRTAAHIRPKRKALREEYKGktDEAsirELQQKQKDLNKEYGYNPLAGCVPALIQIPVFLGLYQVLLR--M 126
                          90
                  ....*....|..
gi 1490718101 117 ASPLQLLDLPAH 128
Cdd:PRK00247  127 ARPEGGLENPVH 138
PRK02654 PRK02654
putative inner membrane protein translocase component YidC; Provisional
42-108 3.32e-15

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235058  Cd Length: 375  Bit Score: 74.63  E-value: 3.32e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490718101  42 PLTLNQQKTMRK----QQELQPKLKEIQEKYKGDKEKLTQAQMSLYKEMGiNPMGGCLPMLIQLPLMFGLY 108
Cdd:PRK02654   44 PLSAGSIRNMRRmkiaQPVMQKRQAEIQERYKNDPQKQQEEMGKLMKEFG-NPLAGCLPLLVQMPILFALF 113
PRK02463 PRK02463
OxaA-like protein precursor; Provisional
42-230 2.47e-12

OxaA-like protein precursor; Provisional


Pssm-ID: 235040  Cd Length: 307  Bit Score: 65.52  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  42 PLTLNQQKTMRKQQE----LQPKLKEIQEKYKGDK---EKLT--QAQMSLYKEMGINPMG--GCLPMLIQLPLMFGLYQA 110
Cdd:PRK02463   77 PLGLYQSWKATYQSEkmayLKPVFEPINERLKNATtqeEKMAaqTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFA 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 111 IiralaasplqlldlpahiyRWLPSFLSvsalvplqSKFLWLDLALPDPFFVLPVLVVvttWLQQKLLTppASASADPQA 190
Cdd:PRK02463  157 A-------------------QYTKGVST--------STFLGIDLGSPSLVLTAIIGVL---YFFQSWLS--MMGVPEEQR 204
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1490718101 191 QSMtQSMQVTMPLFMGFISLNYATGLSVYFIVSNLAGILQ 230
Cdd:PRK02463  205 EQM-KAMMYMMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQ 243
PRK02201 PRK02201
putative inner membrane protein translocase component YidC; Provisional
43-238 2.56e-12

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235012  Cd Length: 357  Bit Score: 65.80  E-value: 2.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101  43 LTLNQQKTMRKQQELQPKLKEIQEKYKGD------KEKLTQAQMSLYKEMGINPMGGCLPMLIQLPLMFGLYQAI--IR- 113
Cdd:PRK02201  151 ITFKSTFNQEKQEELQGKKAKIDAKYKDYkkdkqmKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVqsLPs 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490718101 114 ---------ALAASPLQLLDLPAHIYRWlpsFLSVSALVPLQSKFLwldlalpdpffvlpvlvvvTTWLQQKLLTPPASA 184
Cdd:PRK02201  231 ikvttwlgiDLSATSWQEIFAGNWIYLP---ILIIVVPVQALSQLL-------------------PQILNKKKNKERTLN 288
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490718101 185 SADPQAQSMTQSMQVTMPLFMGFISLNYATGLSVYFIVSNLAGILQFYLFrkHY 238
Cdd:PRK02201  289 VKEKEALKKQNKTQNIISIVFIFFGVIFAAGVQIYWIIGGIWTILQTLGI--HY 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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