NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1490707192|gb|RLC82353|]
View 

glycosyltransferase family 2 protein [Chloroflexi bacterium]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10118426)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  9445404|12691742
SCOP:  3000077

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 2-224 4.28e-61

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


:

Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 191.73  E-value: 4.28e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   2 NVAAVVPARDEERNVVNCLESLAWADRRVVFLDSRTSDRTAELARQAGAKVILHPFENFAQFHNAAMNAVEADWVFFVDG 81
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192  82 DERATPELAQEVRSVTDgSHEEVAWSVPRHNYIFGRLTLGAGWYPDYQSRLLLRDRARWE-RPVHEIIVADGPTGR-LKN 159
Cdd:cd02511    81 DERLTPELADEILALLA-TDDYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEdGRVHEQVVVDGGVGIvLKG 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490707192 160 PLIHYNYDNLPDFIARQERYTDVDAGILFEEGIRPRVYTPYsQAVRQFW---WRFVTLRGTRDGLHGL 224
Cdd:cd02511   160 DILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGL-LLGRPLLaflKMYILKRGFLDGRAGF 226
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 2-224 4.28e-61

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 191.73  E-value: 4.28e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   2 NVAAVVPARDEERNVVNCLESLAWADRRVVFLDSRTSDRTAELARQAGAKVILHPFENFAQFHNAAMNAVEADWVFFVDG 81
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192  82 DERATPELAQEVRSVTDgSHEEVAWSVPRHNYIFGRLTLGAGWYPDYQSRLLLRDRARWE-RPVHEIIVADGPTGR-LKN 159
Cdd:cd02511    81 DERLTPELADEILALLA-TDDYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEdGRVHEQVVVDGGVGIvLKG 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490707192 160 PLIHYNYDNLPDFIARQERYTDVDAGILFEEGIRPRVYTPYsQAVRQFW---WRFVTLRGTRDGLHGL 224
Cdd:cd02511   160 DILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGL-LLGRPLLaflKMYILKRGFLDGRAGF 226
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-93 1.94e-12

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 64.34  E-value: 1.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   1 MNVAAVVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQAGA-----KVILHPfENFAQFH--NAAMNA 70
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLaqtYPDFEIIVVDDGSTDGTAEILRELAAkdpriRVIRLE-RNRGKGAarNAGLAA 80

                          90       100
                  ....*....|....*....|...
gi 1490707192  71 VEADWVFFVDGDERATPELAQEV 93
Cdd:COG0463    81 ARGDYIAFLDADDQLDPEKLEEL 103
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-88 3.83e-07

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 48.55  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   6 VVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQA-----GAKVILHPfENF---AQFhNAAMNAVEAD 74
Cdd:pfam00535   3 IIPTYNEEKYLLETLESLLnqtYPNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLP-ENRgkaGAR-NAGLRAATGD 80

                          90
                  ....*....|....
gi 1490707192  75 WVFFVDGDERATPE 88
Cdd:pfam00535  81 YIAFLDADDEVPPD 94
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 1-53 6.16e-07

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 49.53  E-value: 6.16e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1490707192   1 MNVAAVVPARDEERNVVNCLESLAWADRR-----VVFLDSRTSDRTAELARQAGAKVI 53
Cdd:PRK13915   31 RTVSVVLPALNEEETVGKVVDSIRPLLMEplvdeLIVIDSGSTDATAERAAAAGARVV 88
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 2-224 4.28e-61

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 191.73  E-value: 4.28e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   2 NVAAVVPARDEERNVVNCLESLAWADRRVVFLDSRTSDRTAELARQAGAKVILHPFENFAQFHNAAMNAVEADWVFFVDG 81
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192  82 DERATPELAQEVRSVTDgSHEEVAWSVPRHNYIFGRLTLGAGWYPDYQSRLLLRDRARWE-RPVHEIIVADGPTGR-LKN 159
Cdd:cd02511    81 DERLTPELADEILALLA-TDDYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEdGRVHEQVVVDGGVGIvLKG 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490707192 160 PLIHYNYDNLPDFIARQERYTDVDAGILFEEGIRPRVYTPYsQAVRQFW---WRFVTLRGTRDGLHGL 224
Cdd:cd02511   160 DILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGL-LLGRPLLaflKMYILKRGFLDGRAGF 226
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-93 1.94e-12

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 64.34  E-value: 1.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   1 MNVAAVVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQAGA-----KVILHPfENFAQFH--NAAMNA 70
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLaqtYPDFEIIVVDDGSTDGTAEILRELAAkdpriRVIRLE-RNRGKGAarNAGLAA 80

                          90       100
                  ....*....|....*....|...
gi 1490707192  71 VEADWVFFVDGDERATPELAQEV 93
Cdd:COG0463    81 ARGDYIAFLDADDQLDPEKLEEL 103
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-117 4.33e-09

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 54.05  E-value: 4.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   5 AVVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQAGAK---VILHPFE---NFAQFHNAAMNAVEADW 75
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLaqtYPNFEVIVVDDGSTDGTLEILEEYAKKdprVIRVINEenqGLAAARNAGLKAARGEY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1490707192  76 VFFVDGDERATPELAQEVRSVTDGSHEEVAWSvPRHNYIFGR 117
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADAVG-GPGNLLFRR 121
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 3-87 1.18e-08

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 54.36  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   3 VAAVVPARDEERNVVNCLESLAWADR-----RVVFLDSRTSDRTAELARQAGAK------VILHPFENFAQFHNAAMNAV 71
Cdd:COG1215    31 VSVIIPAYNEEAVIEETLRSLLAQDYpkeklEVIVVDDGSTDETAEIARELAAEyprvrvIERPENGGKAAALNAGLKAA 110

                          90
                  ....*....|....*.
gi 1490707192  72 EADWVFFVDGDERATP 87
Cdd:COG1215   111 RGDIVVFLDADTVLDP 126
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 6-82 1.54e-08

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 53.00  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   6 VVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQAGA-----KVILHPFENF--AQFHNAAMNAVEADW 75
Cdd:cd06423     2 IVPAYNEEAVIERTIESLLaldYPKLEVIVVDDGSTDDTLEILEELAAlyirrVLVVRDKENGgkAGALNAGLRHAKGDI 81


                  ....*..
gi 1490707192  76 VFFVDGD 82
Cdd:cd06423    82 VVVLDAD 88
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-88 4.29e-08

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 51.92  E-value: 4.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   1 MNVAAVVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQ---AGAKVILHPfEN--FAQFHNAAMNAVE 72
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLaqtYPPFEVIVVDNGSTDGTAELLAAlafPRVRVIRNP-ENlgFAAARNLGLRAAG 81

                          90
                  ....*....|....*.
gi 1490707192  73 ADWVFFVDGDERATPE 88
Cdd:COG1216    82 GDYLLFLDDDTVVEPD 97
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-82 3.14e-07

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 49.11  E-value: 3.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   6 VVPARDEERNVVNCLESL-----AWADRRVVFLDSRTSDRTAELARQAGA-----KVILHPfENFAQFH--NAAMNAVEA 73
Cdd:cd04179     2 VIPAYNEEENIPELVERLlavleEGYDYEIIVVDDGSTDGTAEIARELAArvprvRVIRLS-RNFGKGAavRAGFKAARG 80


                  ....*....
gi 1490707192  74 DWVFFVDGD 82
Cdd:cd04179    81 DIVVTMDAD 89
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-88 3.83e-07

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 48.55  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   6 VVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQA-----GAKVILHPfENF---AQFhNAAMNAVEAD 74
Cdd:pfam00535   3 IIPTYNEEKYLLETLESLLnqtYPNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLP-ENRgkaGAR-NAGLRAATGD 80

                          90
                  ....*....|....
gi 1490707192  75 WVFFVDGDERATPE 88
Cdd:pfam00535  81 YIAFLDADDEVPPD 94
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 1-53 6.16e-07

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 49.53  E-value: 6.16e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1490707192   1 MNVAAVVPARDEERNVVNCLESLAWADRR-----VVFLDSRTSDRTAELARQAGAKVI 53
Cdd:PRK13915   31 RTVSVVLPALNEEETVGKVVDSIRPLLMEplvdeLIVIDSGSTDATAERAAAAGARVV 88
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 3-87 3.67e-05

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 43.76  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   3 VAAVVPARDEERNVVNCLESLAWADR-----RVVFLDSRTSDRTAELARQAGAKvilhpFENFAQFHN------AAMN-A 70
Cdd:cd02525     2 VSIIIPVRNEEKYIEELLESLLNQSYpkdliEIIVVDGGSTDGTREIVQEYAAK-----DPRIRLIDNpkriqsAGLNiG 76

                          90       100
                  ....*....|....*....|
gi 1490707192  71 VE---ADWVFFVDGDERATP 87
Cdd:cd02525    77 IRnsrGDIIIRVDAHAVYPK 96
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-82 5.21e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 42.55  E-value: 5.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   6 VVPARDEERNVVNCLESLAWADR---RVVFLDSRTSDRTAELARQAGAKVILHPFE---NFAQFHNAAMNAVEADWVFFV 79
Cdd:cd04186     2 IIVNYNSLEYLKACLDSLLAQTYpdfEVIVVDNASTDGSVELLRELFPEVRLIRNGenlGFGAGNNQGIREAKGDYVLLL 81


                  ...
gi 1490707192  80 DGD 82
Cdd:cd04186    82 NPD 84
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 6-106 8.08e-05

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 42.56  E-value: 8.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   6 VVPARDEERNVVNCLESLA---WADRRVVFLDSRTSDRTAELARQAGAKVILHPFENFAQFHNAAMNAvEADWVFFVDGD 82
Cdd:cd02522     4 IIPTLNEAENLPRLLASLRrlnPLPLEIIVVDGGSTDGTVAIARSAGVVVISSPKGRARQMNAGAAAA-RGDWLLFLHAD 82

                          90       100
                  ....*....|....*....|....
gi 1490707192  83 ERATPELAQEVRSvTDGSHEEVAW 106
Cdd:cd02522    83 TRLPPDWDAAIIE-TLRADGAVAG 105
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-109 1.99e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 41.51  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   6 VVPARDEERNVVNCLESLAWADR-----RVVFLDSRTSDRTAELARQAGAKVILHPFE-NFAQFH-----NAAMNAVEA- 73
Cdd:cd04192     2 VIAARNEAENLPRLLQSLSALDYpkekfEVILVDDHSTDGTVQILEFAAAKPNFQLKIlNNSRVSisgkkNALTTAIKAa 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1490707192  74 --DWVFFVDGDERATPELAQE-VRSVTDGSHEEVAWSVP 109
Cdd:cd04192    82 kgDWIVTTDADCVVPSNWLLTfVAFIQKEQIGLVAGPVI 120
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 6-53 2.56e-04

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 40.66  E-value: 2.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1490707192   6 VVPARDEERNVVNCLESLAWAD-----RRVVFLDSRTSDRTAELARQAGAKVI 53
Cdd:cd06438     2 LIPAHNEEAVIGNTVRSLKAQDyprelYRIFVVADNCTDDTAQVARAAGATVL 54
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 3-153 4.67e-03

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 37.56  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192   3 VAAVVPARDEERNVV----NCLESLAWADRR--VVFLDSRTsDRTAELARQAGAK-VILHPFENF---AQFHNAAMNAVE 72
Cdd:cd06439    31 VTIIIPAYNEEAVIEakleNLLALDYPRDRLeiIVVSDGST-DGTAEIAREYADKgVKLLRFPERrgkAAALNRALALAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490707192  73 ADWVFFVDGDERATPE-LAQEVRSVTDgsheevawsvPRHNYIFGRLTL--------GAGWYPDYQSRLllrdrARWERP 143
Cdd:cd06439   110 GEIVVFTDANALLDPDaLRLLVRHFAD----------PSVGAVSGELVIvdgggsgsGEGLYWKYENWL-----KRAESR 174

                         170
                  ....*....|
gi 1490707192 144 VHEIIVADGP 153
Cdd:cd06439   175 LGSTVGANGA 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH