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Conserved domains on  [gi|149049136|gb|EDM01590|]
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phosphodiesterase 6H, cGMP-specific, cone, gamma, isoform CRA_b [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDE6_gamma super family cl04809
Retinal cGMP phosphodiesterase, gamma subunit; Retinal rod and cone cGMP phosphodiesterases ...
 2-51 6.20e-19

Retinal cGMP phosphodiesterase, gamma subunit; Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit, which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells.


The actual alignment was detected with superfamily member pfam04868:

Pssm-ID: 428163  Cd Length: 82  Bit Score: 73.44  E-value: 6.20e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 149049136   2 SDSPCLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGYHGDLP 51
Cdd:pfam04868  1 KPKSTLAAPARATGPTTPHKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIP 50
 
Name Accession Description Interval E-value
PDE6_gamma pfam04868
Retinal cGMP phosphodiesterase, gamma subunit; Retinal rod and cone cGMP phosphodiesterases ...
 2-51 6.20e-19

Retinal cGMP phosphodiesterase, gamma subunit; Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit, which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells.


Pssm-ID: 428163  Cd Length: 82  Bit Score: 73.44  E-value: 6.20e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 149049136   2 SDSPCLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGYHGDLP 51
Cdd:pfam04868  1 KPKSTLAAPARATGPTTPHKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIP 50
 
Name Accession Description Interval E-value
PDE6_gamma pfam04868
Retinal cGMP phosphodiesterase, gamma subunit; Retinal rod and cone cGMP phosphodiesterases ...
 2-51 6.20e-19

Retinal cGMP phosphodiesterase, gamma subunit; Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit, which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells.


Pssm-ID: 428163  Cd Length: 82  Bit Score: 73.44  E-value: 6.20e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 149049136   2 SDSPCLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGYHGDLP 51
Cdd:pfam04868  1 KPKSTLAAPARATGPTTPHKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIP 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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