NCBI Conserved Domain Search

Conserved domains on [gi|1490467430|gb|RLA99010|]

View

hypothetical protein DRG32_00010 [Deltaproteobacteria bacterium]

Protein Classification

nitrogen regulation protein NR(II)( domain architecture ID 11467505)

nitrogen regulation protein NR(II) (NtrB) is a PAS domain-containing sensor histidine kinase that is a member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation; NtrB autophosphorylates and transfers the phosphoryl group to NtrC during nitrogen limitation, and acts as a phosphatase that dephosphorylates and inactivates NtrC in the presence of nitrogen

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

194-539

7.24e-117

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 349.53 E-value: 7.24e-117

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 194 EYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE---LEAYLSEDRA-----HRVE 265
Cdd:COG3852     1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEdspLRELLERALAegqpvTERE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 266 VNYTKDPFTKLRLGLSFYPLRDHRGElSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQL 345
Cdd:COG3852    81 VTLRRKDGEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 346 LrEEKFSNPHAQRLMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIFfrTPQWNYGIRLIKEIEKGV- 424
Cdd:COG3852   160 L-ERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELL--RAEAPKNIRIVRDYDPSLp 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 425 VVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPAD--------NKVILRVTDTGKGISPDKVERIFDPFFTTKER 496
Cdd:COG3852   237 EVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1490467430 497 GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAEKG 539
Cdd:COG3852   317 GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359

Name

Accession

Description

Interval

E-value

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

194-539

7.24e-117

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 349.53 E-value: 7.24e-117

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 194 EYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE---LEAYLSEDRA-----HRVE 265
Cdd:COG3852     1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEdspLRELLERALAegqpvTERE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 266 VNYTKDPFTKLRLGLSFYPLRDHRGElSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQL 345
Cdd:COG3852    81 VTLRRKDGEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 346 LrEEKFSNPHAQRLMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIFfrTPQWNYGIRLIKEIEKGV- 424
Cdd:COG3852   160 L-ERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELL--RAEAPKNIRIVRDYDPSLp 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 425 VVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPAD--------NKVILRVTDTGKGISPDKVERIFDPFFTTKER 496
Cdd:COG3852   237 EVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1490467430 497 GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAEKG 539
Cdd:COG3852   317 GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359

PRK11360

two-component system sensor histidine kinase AtoS;

201-540

4.93e-97

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 306.89 E-value: 4.93e-97

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 201 FSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE-------LEAYLSEDRAHR-VEVNYTKDP 272
Cdd:PRK11360  263 LNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPntpfaspLLDTLEHGTEHVdLEISFPGRD 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 273 FTkLRLGLSFYPLRDHRGELSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKFS 352
Cdd:PRK11360  343 RT-IELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSD 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 353 NPHaQRLMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLeIFFRTPQWNYGIRLIKEIEKGV-VVECDPQ 431
Cdd:PRK11360  422 PPS-QEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVL-QLFQTAGVQARVDFETELDNELpPIWADPE 499

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 432 QMQQVLWNLLINAVEAMEGKGVLKVGLRREpADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQ 511
Cdd:PRK11360  500 LLKQVLLNILINAVQAISARGKIRIRTWQY-SDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINA 578

                         330       340
                  ....*....|....*....|....*....
gi 1490467430 512 HRGTITVLSKVGEGTTFNITMPLKAEKGG 540
Cdd:PRK11360  579 HGGDIEVESEPGVGTTFTLYLPINPQGNQ 607

T2SS_HK

NF038348

histidine kinase;

302-535

5.96e-43

histidine kinase;

Pssm-ID: 439642 [Multi-domain] Cd Length: 574 Bit Score: 161.27 E-value: 5.96e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 302 LTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLR-------------EEKFSNPHAQRLMEI------ 362
Cdd:NF038348  308 IHELEETHVQLLQSEKLASIGQLAAGVAHEINNPIGFVSANLNTLKgwvhslldviaaqEAATPAHAAQTRAPLaaagrd 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 363 ------------IVTES----NRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIFFRtpQWNYGIRLIKEIEKGVVV 426
Cdd:NF038348  388 adldyvrgdimtLIDESidgaMRVRRIVQDLRDFSRPSGDEWSFADLHAGLESTLNVVHN--ELKYKADVVREYGDLPLV 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 427 ECDPQQMQQVLWNLLINAVEAMEGKGVLKVglRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKE--RGTGLGLSI 504
Cdd:NF038348  466 ECNAAQLNQVFMNLLVNAAQAIPGRGTITI--RTTCDGDHASIAISDTGKGIPPDVMGRIFDPFFTTKPvgQGTGLGLSI 543

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1490467430 505 VHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:NF038348  544 SHGIVEHHRGRIDVASEPGRGSTFTITLPVR 574

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

429-535

1.91e-35

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 128.54 E-value: 1.91e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKER-----GTGLGLS 503
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERD--GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1490467430  504 IVHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

430-534

4.20e-35

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 127.15 E-value: 4.20e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 430 PQQMQQVLWNLLINAVEAMEGKGvlKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKE--RGTGLGLSIVHK 507
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGRG--RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYR 78

                          90       100
                  ....*....|....*....|....*..
gi 1490467430 508 IIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:cd16943    79 IIQKHGGTIRVASVPGGGTRFTIILPI 105

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

429-535

9.97e-31

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 115.54 E-value: 9.97e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRRepaDNKVILRVTDTGKGISPDKVERIFDPFFTTKER---GTGLGLSIV 505
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE---GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIV 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1490467430 506 HKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLPLA 108

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

199-310

2.95e-06

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 46.52 E-value: 2.95e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 199 EAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE-----LEAYLSEDRAHRVEVNYTKdpF 273
Cdd:TIGR00229   2 EERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEedreeVRERIERRLEGEPEPVSEE--R 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1490467430 274 TKLR-------LGLSFYPLRDHrGELSGKVVIFQDLTKMKDMEE 310
Cdd:TIGR00229  80 RVRRkdgseiwVEVSVSPIRTN-GGELGVVGIVRDITERKEAEE 122

Name

Accession

Description

Interval

E-value

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

194-539

7.24e-117

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 349.53 E-value: 7.24e-117

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 194 EYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE---LEAYLSEDRA-----HRVE 265
Cdd:COG3852     1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEdspLRELLERALAegqpvTERE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 266 VNYTKDPFTKLRLGLSFYPLRDHRGElSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQL 345
Cdd:COG3852    81 VTLRRKDGEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 346 LrEEKFSNPHAQRLMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIFfrTPQWNYGIRLIKEIEKGV- 424
Cdd:COG3852   160 L-ERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELL--RAEAPKNIRIVRDYDPSLp 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 425 VVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPAD--------NKVILRVTDTGKGISPDKVERIFDPFFTTKER 496
Cdd:COG3852   237 EVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1490467430 497 GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAEKG 539
Cdd:COG3852   317 GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

175-537

5.16e-107

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 326.53 E-value: 5.16e-107

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 175 GFLAEEVTKRSRQLSRTREEYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPELEA 254
Cdd:COG5000    65 GELARAFNRMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 255 Y--LSEDRAHRVEVNYTKDPFTKLRLGLSFYPLRDHrgelsGKVVIFQDLTKMKdmeesvkRSERLASVGQLAAGIAHEI 332
Cdd:COG5000   145 AelLREALERGWQEEIELTRDGRRTLLVRASPLRDD-----GYVIVFDDITELL-------RAERLAAWGELARRIAHEI 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 333 RNPLASISGAIQLLREeKFS------NPHAQRLMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEiFFR 406
Cdd:COG5000   213 KNPLTPIQLSAERLRR-KLAdkleedREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLA-LYE 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 407 TPQWNYGIRLIKEIEKGV-VVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVER 485
Cdd:COG5000   291 PALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE--DGRVRIEVSDNGPGIPEEVLER 368

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1490467430 486 IFDPFFTTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAE 537
Cdd:COG5000   369 IFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEE 420

PRK11360

two-component system sensor histidine kinase AtoS;

201-540

4.93e-97

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 306.89 E-value: 4.93e-97

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 201 FSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE-------LEAYLSEDRAHR-VEVNYTKDP 272
Cdd:PRK11360  263 LNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPntpfaspLLDTLEHGTEHVdLEISFPGRD 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 273 FTkLRLGLSFYPLRDHRGELSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKFS 352
Cdd:PRK11360  343 RT-IELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSD 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 353 NPHaQRLMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLeIFFRTPQWNYGIRLIKEIEKGV-VVECDPQ 431
Cdd:PRK11360  422 PPS-QEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVL-QLFQTAGVQARVDFETELDNELpPIWADPE 499

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 432 QMQQVLWNLLINAVEAMEGKGVLKVGLRREpADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQ 511
Cdd:PRK11360  500 LLKQVLLNILINAVQAISARGKIRIRTWQY-SDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINA 578

                         330       340
                  ....*....|....*....|....*....
gi 1490467430 512 HRGTITVLSKVGEGTTFNITMPLKAEKGG 540
Cdd:PRK11360  579 HGGDIEVESEPGVGTTFTLYLPINPQGNQ 607

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

171-535

6.15e-90

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 284.94 E-value: 6.15e-90

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 171 GYLTGFLA--EEVTKRSRqlsrTREEYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDV 248
Cdd:COG5809   114 GDIEGMLAisRDITERKR----MEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILEL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 249 FPELEAYLSEDRAHRV---------EVNY-TKDPFTKLrLGLSFYPLRDHrGELSGKVVIFQDLTKMKDMEESVKRSERL 318
Cdd:COG5809   190 IHSDDQENVAAFISQLlkdggiaqgEVRFwTKDGRWRL-LEASGAPIKKN-GEVDGIVIIFRDITERKKLEELLRKSEKL 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 319 ASVGQLAAGIAHEIRNPLASISGAIQLLREekfsNPHAQRLM--EIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKV 396
Cdd:COG5809   268 SVVGELAAGIAHEIRNPLTSLKGFIQLLKD----TIDEEQKTylDIMLSELDRIESIISEFLVLAKPQAIKYEPKDLNTL 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 397 VEDTLEIFfrTPQWN-YGIRLIKEIEKGVV-VECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPaDNKVILRVTDT 474
Cdd:COG5809   344 IEEVIPLL--QPQALlKNVQIELELEDDIPdILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAED-DDKVVISVTDE 420

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490467430 475 GKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:COG5809   421 GCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

154-535

7.32e-84

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 269.29 E-value: 7.32e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 154 LYLFYKLFLTILSLFLAGYLTGFLAEEVTKRSRQLSRTREEYSRLeafsknvLQSLQSGLITVDLTGRITFVNAAGERIL 233
Cdd:COG5805   118 IYVEVKLFPIYNQNGQAAILALRDITKKKKIEEILQEQEERLQTL-------IENSPDLICVIDTDGRILFINESIERLF 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 234 GLKR-----TSLRNLFLSDVFPELEAYLSEDRAHRVEVNYTKDPFTK----LRLGLSFYPLRDHRGELSGKVVIFQDLTK 304
Cdd:COG5805   191 GAPReeligKNLLELLHPCDKEEFKERIESITEVWQEFIIEREIITKdgriRYFEAVIVPLIDTDGSVKGILVILRDITE 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 305 MKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKFSNPHaqrLMEIIVTESNRLNRLINEFLLYAQPP 384
Cdd:COG5805   271 KKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEE---YFDIMLSELDRIESIISEFLALAKPQ 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 385 KATKKKVELDKVVEDTleIFFRTPQWN-YGIRLIKE-IEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLrrEP 462
Cdd:COG5805   348 AVNKEKENINELIQDV--VTLLETEAIlHNIQIRLElLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHT--EE 423

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490467430 463 ADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:COG5805   424 EDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

300-535

1.15e-82

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 261.66 E-value: 1.15e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 300 QDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLR---EEKFSNPHAQRLMEIIVTESNRLNRLINE 376
Cdd:COG4191   121 RAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRrrlEDEPDPEELREALERILEGAERAAEIVRS 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 377 FLLYAQPPKATKKKVELDKVVEDTLEIFfrTPQWNY-GIRLIKEIEKGV-VVECDPQQMQQVLWNLLINAVEAMEGK--G 452
Cdd:COG4191   201 LRAFSRRDEEEREPVDLNELIDEALELL--RPRLKArGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGegG 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 453 VLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKE--RGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNI 530
Cdd:COG4191   279 RITISTRRE--GDYVVISVRDNGPGIPPEVLERIFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTI 356


                  ....*
gi 1490467430 531 TMPLK 535
Cdd:COG4191   357 TLPLA 361

KinC

COG5807

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...

203-535

2.49e-82

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 260.87 E-value: 2.49e-82

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 203 KNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRtslrNLFLSDVFPELEAYLS------EDRAHRVEVNYTKDPFTkl 276
Cdd:COG5807    30 KQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQ----NEYIGKTFVEEKCILKdeqlynKEAFDRIEISYLTKNGE-- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 277 rLGLSFYPLRDHRGELSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKfSNPHA 356
Cdd:COG5807   104 -FDEIIYPIYYKDGVILGLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESR-EDSER 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 357 QRLMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIFfrTPQW-NYGIRLIKEIE-KGVVVECDPQQMQ 434
Cdd:COG5807   182 EEYFNIIISEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALL--STEAiLKNISIKYDLAdDEPVINGDKNQLK 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 435 QVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRG 514
Cdd:COG5807   260 QVFINLIKNAIEAMETGGNITIKTYVE--GDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNG 337

                         330       340
                  ....*....|....*....|.
gi 1490467430 515 TITVLSKVGEGTTFNITMPLK 535
Cdd:COG5807   338 TIEVESKPGKGTTFTIYLPLY 358

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

213-534

1.48e-65

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 215.93 E-value: 1.48e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 213 LITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPELEAYLSEDRAHRVEVNYTKDPFTKLRLGLSFYPLRDHRGEL 292
Cdd:COG0642     2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 293 SGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKfsNPHAQRLMEIIVTESNRLNR 372
Cdd:COG0642    82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLLR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 373 LINEFLLYA----QPPKATKKKVELDKVVEDTLEIFfRTPQWNYGIRLIKEIEKGVV-VECDPQQMQQVLWNLLINAVEA 447
Cdd:COG0642   160 LINDLLDLSrleaGKLELEPEPVDLAELLEEVVELF-RPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 448 MEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKE----RGTGLGLSIVHKIIEQHRGTITVLSKVG 523
Cdd:COG0642   239 TPEGGTVTVSVRRE--GDRVRISVEDTGPGIPPEDLERIFEPFFRTDPsrrgGGTGLGLAIVKRIVELHGGTIEVESEPG 316

                         330
                  ....*....|.
gi 1490467430 524 EGTTFNITMPL 534
Cdd:COG0642   317 KGTTFTVTLPL 327

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

296-535

3.86e-65

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 217.43 E-value: 3.86e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 296 VVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKFSNPHAQRLMEIIVTESNRLNRLIN 375
Cdd:COG5806   176 VYLIENLIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIIT 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 376 EFLLYAQPPKATKKKVELDKVVEDTLEIFfrTPQWN-YGIRLIKEIEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVL 454
Cdd:COG5806   256 DYLTFAKPQPEKLEKIDVSEELEHVIDVL--SPYANmNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTL 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 455 KVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:COG5806   334 TIDVSID--KNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411


                  .
gi 1490467430 535 K 535
Cdd:COG5806   412 A 412

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

154-537

4.28e-63

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 211.72 E-value: 4.28e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 154 LYLFYKLFLTILSLFLAGYLTGFLAEEVTKRSRQLSRTREEYSRL-EAFSKNVLQSLQSGLITVDLTGRITFVNAAGERI 232
Cdd:COG5002     6 LLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLlLALLLLLLLLLLLLLALLLLLLLLLLLLALALLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 233 LGLKRTSLRNLFLSDVFPELEAYLSEDRAHRVEVNYTKDPFTKLRLGLSFYPLRDHRGELSGKVVIFQDLTKMKDMEEsV 312
Cdd:COG5002    86 LALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQ-M 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 313 KRserlasvgQLAAGIAHEIRNPLASISGAIQLLREEKFSNPH-AQRLMEIIVTESNRLNRLINEFLLYAQ----PPKAT 387
Cdd:COG5002   165 RR--------EFVANVSHELRTPLTSIRGYLELLLDGAADDPEeRREYLEIILEEAERLSRLVNDLLDLSRlesgELKLE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 388 KKKVELDKVVEDTLEIFfrTPQW-NYGIRLIKEI-EKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREpaDN 465
Cdd:COG5002   237 KEPVDLAELLEEVVEEL--RPLAeEKGIELELDLpEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREE--DD 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490467430 466 KVILRVTDTGKGISPDKVERIFDPFFTT------KERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAE 537
Cdd:COG5002   313 QVRISVRDTGIGIPEEDLPRIFERFYRVdksrsrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

304-537

3.46e-62

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 203.99 E-value: 3.46e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 304 KMKDMEESVKRSERLASvgQLAAGIAHEIRNPLASISGAIQLLRE-EKFSNPHAQRLMEIIVTESNRLNRLINEFLLYAQ 382
Cdd:COG2205     1 ELEEALEELEELERLKS--EFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 383 ----PPKATKKKVELDKVVEDTLEIFFRTPQwNYGIRLIKEI-EKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVG 457
Cdd:COG2205    79 lesgKLSLELEPVDLAELLEEAVEELRPLAE-EKGIRLELDLpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITIS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 458 LRREpaDNKVILRVTDTGKGISPDKVERIFDPFF----TTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:COG2205   158 ARRE--GDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235


                  ....
gi 1490467430 534 LKAE 537
Cdd:COG2205   236 LAES 239

PRK10364

two-component system sensor histidine kinase ZraS;

308-538

1.73e-60

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 206.56 E-value: 1.73e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 308 MEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKFSNPHAQRLMEIIVTESNRLNRLINEFLLYAQPPKAT 387
Cdd:PRK10364  224 LQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLA 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 388 KKKVELDKVVEDTLEIFFRTPQwNYGIRLIKEIEKGV-VVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRRepADNK 466
Cdd:PRK10364  304 LQAVDLNDLINHSLQLVSQDAN-SREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASE--SGAG 380

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490467430 467 VILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAEK 538
Cdd:PRK10364  381 VKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITR 452

KinD

COG5808

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...

302-537

3.25e-59

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 203.06 E-value: 3.25e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 302 LTKMKDMEESVKR---SERLASVGQLAAGIAHEIRNPLASISGAIQLLrEEKFSNPHAQRLMEIIVTESNRLNRLINEFL 378
Cdd:COG5808   219 LLKRKTLLERVIQeinTQKLELIGTFAASTAHEIRNPLTSIKGFIQLL-QEKYPELEDQKYFDIIQEEIQRINQIVSEFL 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 379 LYAQPPKATKKKVELDKVVEDTLEIFFRTPQwNYGIRL-IKEIEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVG 457
Cdd:COG5808   298 VLGKPTAKKLELDDLNELIEEILSIIDSEAN-LKNIRVeKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTIS 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 458 LrrEPADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAE 537
Cdd:COG5808   377 I--ENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLKKE 454

PRK13837

two-component system VirA-like sensor kinase;

292-543

1.29e-49

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 183.34 E-value: 1.29e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 292 LSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKFSNPHAQRLMEIIVTESNRLN 371
Cdd:PRK13837  421 LAHAIERRRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARAR 500

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 372 RLINEFLLYAQPPKATKKKVELDKVVEDTLEIF-FRTPQwnyGIRLI-KEIEKGVVVECDPQQMQQVLWNLLINAVEAME 449
Cdd:PRK13837  501 LIIDQILAFGRKGERNTKPFDLSELVTEIAPLLrVSLPP---GVELDfDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMD 577

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 450 GKGVLKVGLRRE-------------PADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRGTI 516
Cdd:PRK13837  578 GAGRVDISLSRAklrapkvlshgvlPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYI 657

                         250       260
                  ....*....|....*....|....*..
gi 1490467430 517 TVLSKVGEGTTFNITMPLKAEKGGGSR 543
Cdd:PRK13837  658 DVQSTVGRGTRFDVYLPPSSKVPVAPQ 684

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

128-537

4.33e-43

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 158.09 E-value: 4.33e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 128 ISYGILINLEYYLIIPPLYPQYLYESLYLFYKLFLTILSLFLAGYLTGFLAEEVTKRSRQLSRTREEYSRLEAFSKNVLQ 207
Cdd:COG3290    12 LILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLVEEREAVLE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 208 SLQSGLITVDLTGRITFVNAAGERILGLkrtSLRNLFLSDVFPELEAYLSEDRAHRVEvnytkdpftKLRLGLSFYPLRD 287
Cdd:COG3290    92 SIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLAEVLETGERDEEILLN---------GRVLVVNRVPIRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 288 HrGELSGKVVIFQDLTKMKDMEESVKRSERLASVgqLAAgIAHEIRNPLASISGAIQLLREEKfsnphAQRLMEIIVTES 367
Cdd:COG3290   160 D-GRVVGAVATFRDRTELERLEEELEGVKELAEA--LRA-QRHDFRNHLHTISGLLQLGEYDE-----ALEYIDEISEEL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 368 NRL---------NRLINEFLLYAQPpKATKKKVELDKVVEDTLEiffrtpqwnygirlikeiekgvVVECDPQQMQQVLW 438
Cdd:COG3290   231 QELidsllsrigNPVLAALLLGKAA-RARERGIDLTIDIDSDLP----------------------DLPLSDTDLVTILG 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 439 NLLINAVEAMEG----KGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTK-ERGTGLGLSIVHKIIEQHR 513
Cdd:COG3290   288 NLLDNAIEAVEKlpeeERRVELSIRDD--GDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYG 365

                         410       420
                  ....*....|....*....|....
gi 1490467430 514 GTITVLSKVGEGTTFNITMPLKAE 537
Cdd:COG3290   366 GTIEVESEEGEGTVFTVRLPKEGE 389

T2SS_HK

NF038348

histidine kinase;

302-535

5.96e-43

histidine kinase;

Pssm-ID: 439642 [Multi-domain] Cd Length: 574 Bit Score: 161.27 E-value: 5.96e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 302 LTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLR-------------EEKFSNPHAQRLMEI------ 362
Cdd:NF038348  308 IHELEETHVQLLQSEKLASIGQLAAGVAHEINNPIGFVSANLNTLKgwvhslldviaaqEAATPAHAAQTRAPLaaagrd 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 363 ------------IVTES----NRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIFFRtpQWNYGIRLIKEIEKGVVV 426
Cdd:NF038348  388 adldyvrgdimtLIDESidgaMRVRRIVQDLRDFSRPSGDEWSFADLHAGLESTLNVVHN--ELKYKADVVREYGDLPLV 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 427 ECDPQQMQQVLWNLLINAVEAMEGKGVLKVglRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKE--RGTGLGLSI 504
Cdd:NF038348  466 ECNAAQLNQVFMNLLVNAAQAIPGRGTITI--RTTCDGDHASIAISDTGKGIPPDVMGRIFDPFFTTKPvgQGTGLGLSI 543

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1490467430 505 VHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:NF038348  544 SHGIVEHHRGRIDVASEPGRGSTFTITLPVR 574

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

70-537

5.33e-42

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 157.64 E-value: 5.33e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  70 ITRLLYFLIATDILIITGMIYLTGGGTSPFSPLYFLAVLEGGAILERRGGIMAASMSSISYGILINLEYYLIIPPLYPQY 149
Cdd:COG4251    28 LLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 150 LYESLYLFYKLFLTILSLFLAGYLTGFLAEEVTKRSRQLSRTREEYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAag 229
Cdd:COG4251   108 LLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLL-- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 230 ERILGLKRTSLRNLFLSDVFPELEAYLSEDRAHRVEVNYTKDPFTKLRLGLSFYPLRDHRGELSGKVVIFQDLTKMKDME 309
Cdd:COG4251   186 LVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELE 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 310 ESVK-RSERLASV----GQLAAGIAHEIRNPLASISGAIQLLrEEKFS---NPHAQRLMEIIVTESNRLNRLINEFLLYA 381
Cdd:COG4251   266 EELEeRTAELERSneelEQFAYVASHDLREPLRKISGFSQLL-EEDYGdklDEEGREYLERIRDAAERMQALIDDLLAYS 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 382 QPPKA--TKKKVELDKVVEDTLEIFFRTPQwNYGIRLikEIEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLR 459
Cdd:COG4251   345 RVGRQelEFEPVDLNELLEEVLEDLEPRIE-ERGAEI--EVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIG 421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 460 REPADNKVILRVTDTGKGISPDKVERIFDPFFTTKER----GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:COG4251   422 AEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRdeyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501


                  ..
gi 1490467430 536 AE 537
Cdd:COG4251   502 PA 503

PRK13557

histidine kinase; Provisional

222-533

1.23e-38

histidine kinase; Provisional

Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 148.67 E-value: 1.23e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 222 ITFVNAAGERILGLKRTSL--RNL-FLS--DVFPELEAYLSEDRAHRVEV-----NYTKDpftklrlGLSFY------PL 285
Cdd:PRK13557   55 IVFANRAFLEMTGYAAEEIigNNCrFLQgpETDRATVAEVRDAIAERREIateilNYRKD-------GSSFWnalfvsPV 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 286 RDHRGELsgkVVIFQ---DLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLL----REEKFSNPHAQR 358
Cdd:PRK13557  128 YNDAGDL---VYFFGsqlDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIqaalSHPDADRGRMAR 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 359 LMEIIVTESNRLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIFFRTpqWNYGIRLIKEIEKGV-VVECDPQQMQQVL 437
Cdd:PRK13557  205 SVENIRAAAERAATLTQQLLAFARKQRLEGRVLNLNGLVSGMGELAERT--LGDAVTIETDLAPDLwNCRIDPTQAEVAL 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 438 WNLLINAVEAMEGKGVLKVGLR-REPADNK------------VILRVTDTGKGISPDKVERIFDPFFTTKE--RGTGLGL 502
Cdd:PRK13557  283 LNVLINARDAMPEGGRVTIRTRnVEIEDEDlamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGL 362

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1490467430 503 SIVHKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:PRK13557  363 SMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

429-535

1.91e-35

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 128.54 E-value: 1.91e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKER-----GTGLGLS 503
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERD--GDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1490467430  504 IVHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

430-534

4.20e-35

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 127.15 E-value: 4.20e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 430 PQQMQQVLWNLLINAVEAMEGKGvlKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKE--RGTGLGLSIVHK 507
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGRG--RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYR 78

                          90       100
                  ....*....|....*....|....*..
gi 1490467430 508 IIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:cd16943    79 IIQKHGGTIRVASVPGGGTRFTIILPI 105

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

429-535

9.97e-31

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 115.54 E-value: 9.97e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRRepaDNKVILRVTDTGKGISPDKVERIFDPFFTTKER---GTGLGLSIV 505
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE---GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIV 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1490467430 506 HKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTLPLA 108

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-533

4.84e-29

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 110.56 E-value: 4.84e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEAMEGKGVLK--VGLRREPADNK-VILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIVHKII 509
Cdd:cd16920     1 IQQVLINLVRNGIEAMSEGGCERreLTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80

                          90       100
                  ....*....|....*....|....
gi 1490467430 510 EQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16920    81 EAHGGRLSVESPAGGGATFQFTLP 104

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

433-533

6.79e-27

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 105.15 E-value: 6.79e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEAMEGKGVLKVGLRREPAD-------------NKVILRVTDTGKGISPDKVERIFDPFFTTKE--RG 497
Cdd:cd16919     1 LELAILNLAVNARDAMPEGGRLTIETSNQRVDadyalnyrdlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1490467430 498 TGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16919    81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

433-534

9.55e-27

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 104.50 E-value: 9.55e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAV---EamEGKGVLKVGLRREPAD-NKVILRVTDTGKGISPDKVERIFDPF------FTTKERGTGLGL 502
Cdd:cd16922     1 LRQILLNLLGNAIkftE--EGEVTLRVSLEEEEEDgVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGL 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1490467430 503 SIVHKIIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:cd16922    79 AISKKLVELMGGDISVESEPGQGSTFTFTLPL 110

glnL

PRK11073

nitrogen regulation protein NR(II);

200-535

1.55e-26

nitrogen regulation protein NR(II);

Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 110.56 E-value: 1.55e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 200 AFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLkrtSLRNLFlSDVFPELEAYLSEDRAHRVEVNYTKDPFTKLRLG 279
Cdd:PRK11073    7 PDAGQILNSLINSILLLDDDLAIHYANPAAQQLLAQ---SSRKLF-GTPLPELLSYFSLNIELMRESLQAGQGFTDNEVT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 280 LSFYPlRDHRGELSGKVVIFQD-LTKMKDMEESVKRS-ERLASVGQLAA-----GIAHEIRNPLASISGAIQLLrEEKFS 352
Cdd:PRK11073   83 LVIDG-RSHILSLTAQRLPEGMiLLEMAPMDNQRRLSqEQLQHAQQVAArdlvrGLAHEIKNPLGGLRGAAQLL-SKALP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 353 NPHAQRLMEIIVTESNRLNRLINEfLLYAQPPkATKKKVELDKVVED-----TLEIffrtpqwNYGIRLIKEIEKGVV-V 426
Cdd:PRK11073  161 DPALTEYTKVIIEQADRLRNLVDR-LLGPQRP-GTHVTESIHKVAERvvqlvSLEL-------PDNVRLIRDYDPSLPeL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 427 ECDPQQMQQVLWNLLINAVEAMEGKGVlKVGLRREPADNKVI----------LRVTDTGKGISPDKVERIFDPFFTTKER 496
Cdd:PRK11073  232 AHDPDQIEQVLLNIVRNALQALGPEGG-TITLRTRTAFQLTLhgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGREG 310

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1490467430 497 GTGLGLSIVHKIIEQHRGTITVLSKVGEgTTFNITMPLK 535
Cdd:PRK11073  311 GTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-528

7.86e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 101.38 E-value: 7.86e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEAMEGKGVLKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKE--RGTGLGLSIVHKIIE 510
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVE 80

                          90
                  ....*....|....*...
gi 1490467430 511 QHRGTITVLSKVGEGTTF 528
Cdd:cd16976    81 EHGGRLSVANEEGAGARF 98

PRK11100

sensory histidine kinase CreC; Provisional

329-536

1.06e-25

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 110.32 E-value: 1.06e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 329 AHEIRNPLASISGAIQLLREEKfsnPHA--QRLMEIIVTESNRLNRLINEFLLYA----QPPKATKKKVELDKVVEDTLE 402
Cdd:PRK11100  264 THELKSPLAAIRGAAELLQEDP---PPEdrARFTGNILTQSARLQQLIDRLLELArleqRQELEVLEPVALAALLEELVE 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 403 IffRTPQWNY-GIRLIKEIEkGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLrrEPADNKVILRVTDTGKGIsPD 481
Cdd:PRK11100  341 A--REAQAAAkGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSA--EVDGEQVALSVEDQGPGI-PD 414

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490467430 482 -KVERIFDPFFT-----TKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKA 536
Cdd:PRK11100  415 yALPRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

429-533

9.42e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 96.07 E-value: 9.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAMEGK--GVLKVGLRREP-ADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLSIV 505
Cdd:cd16944     1 DTTQISQVLTNILKNAAEAIEGRpsDVGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80

                          90       100
                  ....*....|....*....|....*...
gi 1490467430 506 HKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16944    81 KKIMEEHGGRISLSNREAGGACIRIILP 108

PRK15347

two component system sensor kinase;

300-536

1.13e-22

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 102.41 E-value: 1.13e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 300 QDLTKMKDMEE--SVKRSERLASvgqlaagIAHEIRNPLASISGAIQLLREEKfSNPHAQRLMEIIVTESNRLNRLINEF 377
Cdd:PRK15347  382 QALAEAKQRAEqaNKRKSEHLTT-------ISHEIRTPLNGVLGALELLQNTP-LTAEQMDLADTARQCTLSLLAIINNL 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 378 LLYAqppkatkkKVELDKVV--EDTLEIFFRTPQWNYGIRLiKEIEKGVVVEC------------DPQQMQQVLWNLLIN 443
Cdd:PRK15347  454 LDFS--------RIESGQMTlsLEETALLPLLDQAMLTIQG-PAQSKSLTLRTfvgahvplylhlDSLRLRQILVNLLGN 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 444 AVEAMEGKGVLkvgLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTT--KERGTGLGLSIVHKIIEQHRGTITVLSK 521
Cdd:PRK15347  525 AVKFTETGGIR---LRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGELTLFST 601

                         250
                  ....*....|....*
gi 1490467430 522 VGEGTTFNITMPLKA 536
Cdd:PRK15347  602 PGVGSCFSLVLPLNE 616

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-533

2.42e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 89.00 E-value: 2.42e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEAMEGKG---VLK------VGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGTGLGLS 503
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGSGgeiILRtrtqrqVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1490467430 504 IVHKIIEQHRGTITVLSKVGEgTTFNITMP 533
Cdd:cd16918    81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109

PRK09303

histidine kinase;

315-533

3.54e-21

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 95.40 E-value: 3.54e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 315 SERLASVGQLAAGIAHEIRNPLASISGAIQLLR--EEKFSNP-----------HAQRLMEIIvtesnrlNRLINEfLLYA 381
Cdd:PRK09303  145 LEQLKFKDRVLAMLAHDLRTPLTAASLALETLElgQIDEDTElkpalieqlqdQARRQLEEI-------ERLITD-LLEV 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 382 QPPKATK-----KKVELDKVVEDTLEIFfrTPQW-NYGIRLIKEIEKGV-VVECDPQQMQQVLWNLLINAVEAMEGKGVL 454
Cdd:PRK09303  217 GRTRWEAlrfnpQKLDLGSLCQEVILEL--EKRWlAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTI 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 455 KV-GLRRepADNKVILRVTDTGKGISPDKVERIFDPFFTTK----ERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFN 529
Cdd:PRK09303  295 TLsMLHR--TTQKVQVSICDTGPGIPEEEQERIFEDRVRLPrdegTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFH 372


                  ....
gi 1490467430 530 ITMP 533
Cdd:PRK09303  373 FTLP 376

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

291-520

1.98e-20

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 95.14 E-value: 1.98e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 291 ELSGKVVIFQDLtkmKDMEESVKRSERLASVGQLAAGIAHEIRNPLASISGAIQLLRE--EKFSNPHAQRLMEIIVTESN 368
Cdd:COG4192   406 EIEERKRIEKNL---RQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKalEQENYAQLPTSLDKIEGLIE 482

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 369 RLNRLINEFLLYAQPPKATKKKVELDKVVEDTLEIF---FRTPQwnygirLIKEIEKGVVVECDPQQMQQVLWNLLINAV 445
Cdd:COG4192   483 RMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVesrAKPQQ------ITLHIPDDLMVQGDQVLLEQVLVNLLVNAL 556

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490467430 446 EAMEGKGVLKVGLRREpaDNKVILRVTDTGKGIspDKVERIFDPFFTTKERGTGLGLSIVHKIIEQHRGTITVLS 520
Cdd:COG4192   557 DAVATQPQISVDLLSN--AENLRVAISDNGNGW--PLVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLAS 627

PRK11086

sensory histidine kinase DcuS; Provisional

206-537

2.58e-20

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 94.21 E-value: 2.58e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 206 LQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVfpelEAYLSEDRAHRV----------EVNytkdpFTK 275
Cdd:PRK11086  227 LQSIKEGVIAVDDRGEVTLINDEAKRLFNYKKGLEDDPLGTDV----ESWMPVSRLKEVlrtgtprrdeEIN-----ING 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 276 LRLGLSFYPLRDhRGELSGKVVIFQDLTKMKdmeesvKRSERLASVGQLAAGI---AHEIRNPLASISGAIQLLREEKFS 352
Cdd:PRK11086  298 RLLLTNTVPVRV-NGEIIGAIATFRDKTEVR------QLAQRLDGMVNYADALraqSHEFMNKLHVILGLLHLKSYDQLE 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 353 NphaqrlmEIIVTESNR---LNRLINE--------FLLYAQPpKATKKKVELDkVVEDTLeiffrtpqwnygirlIKEIE 421
Cdd:PRK11086  371 D-------YILKTANNYqeeIGSLLGKikspviagFLLGKIS-RARELGITLI-ISEDSQ---------------LPDSG 426

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 422 kgvvvecDPQQMQQ---VLWNLLINAVEAMEGKGVLKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKERGT 498
Cdd:PRK11086  427 -------DEDQVHElitILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNR 499

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1490467430 499 GLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKAE 537
Cdd:PRK11086  500 GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGE 538

PRK10604

sensor protein RstB; Provisional

318-535

2.52e-19

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 90.43 E-value: 2.52e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 318 LASVGQLAAGIAHEIRNPLASISgaiqlLREEKFSNPHAQRLMEIivtesNR----LNRLINEFLLYAQ--PPKATKKKV 391
Cdd:PRK10604  209 IASKKQLIDGIAHELRTPLVRLR-----YRLEMSDNLSAAESQAL-----NRdigqLEALIEELLTYARldRPQNELHLS 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 392 ELDkvvedtleiffrTPQWnYGIRL--IKEIEKGVVVECDPQQ-----------MQQVLWNLLINAVEAMEGKgvLKVGL 458
Cdd:PRK10604  279 EPD------------LPAW-LSTHLadIQAVTPEKTVRLDTPHqgdygaldmrlMERVLDNLLNNALRYAHSR--VRVSL 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 459 RREpaDNKVILRVTDTGKGISPDKVERIFDPFF---TTKERGTG---LGLSIVHKIIEQHRGTITVLSKVGEGTTFNITM 532
Cdd:PRK10604  344 LLD--GNQACLIVEDDGPGIPPEERERVFEPFVrldPSRDRATGgcgLGLAIVHSIALAMGGSVNCDESELGGARFSFSW 421


                  ...
gi 1490467430 533 PLK 535
Cdd:PRK10604  422 PVW 424

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-533

8.51e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 81.60 E-value: 8.51e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEAMEGKGVLKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKER----GTGLGLSIVHKI 508
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeyeGTGVGLAIVRKI 80

                          90       100
                  ....*....|....*....|....*
gi 1490467430 509 IEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16921    81 IERHGGRIWLESEPGEGTTFYFTLP 105

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

284-534

8.87e-19

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 90.00 E-value: 8.87e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 284 PLRDHRGELSGKVVIFQDLTKMKDMEESVKRSERlaSVGQLAAGIAHEIRNPLASISGAIQLLREEKFsNPHAQRLMEII 363
Cdd:PRK11091  248 PFYDRVGKRHGLMGFGRDITERKRYQDALEKASR--DKTTFISTISHELRTPLNGIVGLSRILLDTEL-TAEQRKYLKTI 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 364 ----VTESNRLNRLINEfllyaqpPKATKKKVELDK-------VVEDtLEIFFRTPQWNYGIRLIKEIEKGV--VVECDP 430
Cdd:PRK11091  325 hvsaITLGNIFNDIIDM-------DKMERRKLQLDNqpidftdFLAD-LENLSGLQAEQKGLRFDLEPLLPLphKVITDG 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 431 QQMQQVLWNLLINAVEAMEgKGVLKVGLRREPADnKVILRVTDTGKGISPDKVERIFDPFFTTKER-------GTGLGLS 503
Cdd:PRK11091  397 TRLRQILWNLISNAVKFTQ-QGGVTVRVRYEEGD-MLTFEVEDSGIGIPEDELDKIFAMYYQVKDShggkpatGTGIGLA 474

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1490467430 504 IVHKIIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:PRK11091  475 VSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505

envZ

PRK09467

osmolarity sensor protein; Provisional

324-536

1.73e-18

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 88.04 E-value: 1.73e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 324 LAAGIAHEIRNPLASISGAIQLLREEKfsnphaQRLMEIIVTESNRLNRLINEFLLYAQP-PKATKKKVELDKVVEDTLE 402
Cdd:PRK09467  232 LMAGVSHDLRTPLTRIRLATEMMSEED------GYLAESINKDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEVIA 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 403 IffrtpQWNYGirliKEIEKGVV-----VECDPQQMQQVLWNLLINAveAMEGKGVLKVGLRREPadNKVILRVTDTGKG 477
Cdd:PRK09467  306 A-----ESGYE----REIETALQpgpieVPMNPIAIKRALANLVVNA--ARYGNGWIKVSSGTEG--KRAWFQVEDDGPG 372

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490467430 478 ISPDKVERIFDPFfTTKER-----GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLKA 536
Cdd:PRK09467  373 IPPEQLKHLFQPF-TRGDSargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

436-533

2.06e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 80.41 E-value: 2.06e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 436 VLWNLLINAVEAM----EGKGVLKVGLRREPADnkVILRVTDTGKGISPDKVERIFDPFFTTKE-RGTGLGLSIVHKIIE 510
Cdd:cd16915     4 IVGNLIDNALDALaatgAPNKQVEVFLRDEGDD--LVIEVRDTGPGIAPELRDKVFERGVSTKGqGERGIGLALVRQSVE 81

                          90       100
                  ....*....|....*....|...
gi 1490467430 511 QHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16915    82 RLGGSITVESEPGGGTTFSIRIP 104

PRK09959

acid-sensing system histidine kinase EvgS;

157-535

4.36e-18

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 88.25 E-value: 4.36e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  157 FYklFLTILSLFLAG--YLTGFLAEEVTKRSRQLSRTREEYSrleAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILg 234
Cdd:PRK09959   536 FY--IVTTLSVLLVGssLLWGFYLLRSVRRRKVIQGDLENQI---SFRKALSDSLPNPTYVVNWQGNVISHNSAFEHYF- 609

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  235 lKRTSLRNLFL---------SDVFP---ELEAYLSEDRAHRVEVNYTKDPFTKLRLG----LSFYPLRDHRGELSGkvvi 298
Cdd:PRK09959   610 -TADYYKNAMLplensdspfKDVFSnahEVTAETKENRTIYTQVFEIDNGIEKRCINhwhtLCNLPASDHAVYICG---- 684

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  299 FQDLTKMKDMEES--VKRSERL-ASVG--QLAAGIAHEIRNPLASISGAIQLLREEKFSNPHAQRLMEIIVTESNRLNRL 373
Cdd:PRK09959   685 WQDITETRDLIHAleVERNKAInATVAksQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGL 764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  374 INEFLlyaqppkatkkkvELDKVVEDTLEIffrTPQWNYGIRLIKEI---------EKGVVVEC------------DPQQ 432
Cdd:PRK09959   765 IGEIL-------------DVDKIESGNYQL---QPQWVDIPTLVQNTchsfgaiaaSKSIALSCsstfpdhylvkiDPQA 828

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  433 MQQVLWNLLINAVEaMEGKGVLKVGLRR-EPADNKVILRVT--DTGKGISPDKVERIFDPFFTT----KERGTGLGLSIV 505
Cdd:PRK09959   829 FKQVLSNLLSNALK-FTTEGAVKITTSLgHIDDNHAVIKMTimDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMIC 907

                          410       420       430
                   ....*....|....*....|....*....|
gi 1490467430  506 HKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:PRK09959   908 KELIKNMQGDLSLESHPGIGTTFTITIPVE 937

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

429-533

8.17e-18

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 79.07 E-value: 8.17e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPAdNKVILRVTDTGKGISPDKVERIFDPF------FTTKERGTGLGL 502
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRL-NRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1490467430 503 SIVHKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16925    80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110

PRK11466

hybrid sensory histidine kinase TorS; Provisional

326-535

3.33e-17

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 85.34 E-value: 3.33e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 326 AGIAHEIRNPLASISGAIQLLREEKFSnPHAQRLMEIIVTESNRLNRLINEFLLYAQPpKATKKKVELD-------KVVE 398
Cdd:PRK11466  449 AAMSHEIRTPLYGILGTAQLLADNPAL-NAQRDDLRAITDSGESLLTILNDILDYSAI-EAGGKNVSVSdepfeprPLLE 526

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 399 DTLEIFFRTPQwNYGIRLIKEIEKGV--VVECDPQQMQQVLWNLLINAVEAMEgKGVLKVGLRREpaDNKVILRVTDTGK 476
Cdd:PRK11466  527 STLQLMSGRVK-GRPIRLATDIADDLptALMGDPRRIRQVITNLLSNALRFTD-EGSIVLRSRTD--GEQWLVEVEDSGC 602

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490467430 477 GISPDKVERIFDPF--FTTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:PRK11466  603 GIDPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663

PRK10841

two-component system sensor histidine kinase RcsC;

308-534

3.79e-17

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 85.03 E-value: 3.79e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 308 MEESVkrsERLASVGQLA--------AGIAHEIRNPLASISGAIQLLREeKFSNPHAQRLMEIIVTESNRLNRLINEFL- 378
Cdd:PRK10841  429 MEESL---QEMAQAAEQAsqsksmflATVSHELRTPLYGIIGNLDLLQT-KELPKGVDRLVTAMNNSSSLLLKIISDILd 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 379 --------LYAQPPKATKKKV-------ELDKVVEDTLEIffrtpqWNYgirlikeIEKGV--VVECDPQQMQQVLWNLL 441
Cdd:PRK10841  505 fskieseqLKIEPREFSPREVinhitanYLPLVVKKRLGL------YCF-------IEPDVpvALNGDPMRLQQVISNLL 571

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 442 INAVEAME-GKGVLKVGLRrepaDNKVILRVTDTGKGISPDKVERIFDPFF---TTKER---GTGLGLSIVHKIIEQHRG 514
Cdd:PRK10841  572 SNAIKFTDtGCIVLHVRVD----GDYLSFRVRDTGVGIPAKEVVRLFDPFFqvgTGVQRnfqGTGLGLAICEKLINMMDG 647

                         250       260
                  ....*....|....*....|
gi 1490467430 515 TITVLSKVGEGTTFNITMPL 534
Cdd:PRK10841  648 DISVDSEPGMGSQFTIRIPL 667

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

318-382

6.44e-17

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 74.94 E-value: 6.44e-17

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490467430 318 LASVGQLAAGIAHEIRNPLASISGAIQLLREEKFSNPHAQRLMEIIVTESNRLNRLINEFLLYAQ 382
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

429-516

1.61e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 75.58 E-value: 1.61e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPADnkVILRVTDTGKGISPDKVERIFDPFF---TTKER---GTGLGL 502
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQE--VRLDVEDSAPGVSDDQLARLFERFYrveSSRNRasgGSGLGL 78

                          90
                  ....*....|....
gi 1490467430 503 SIVHKIIEQHRGTI 516
Cdd:cd16946    79 AICHNIALAHGGTI 92

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

325-533

6.18e-16

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 80.20 E-value: 6.18e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 325 AAGIAHEIRNPLASISGAIQLLreekFSNPHAQRLMEIIV----TESNRLNRLINEFLLYAQppkATKKKVELDKVVED- 399
Cdd:PRK09835  266 SADIAHEIRTPITNLITQTEIA----LSQSRSQKELEDVLysnlEELTRMAKMVSDMLFLAQ---ADNNQLIPEKKMLDl 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 400 ---TLEIFFRTPQW--NYGIRLiKEIEKGVVVECDPQQMQQVLWNLLINAVEAM-EGKGVLkvgLRREPADNKVILRVTD 473
Cdd:PRK09835  339 adeVGKVFDFFEAWaeERGVEL-RFVGDPCQVAGDPLMLRRAISNLLSNALRYTpAGEAIT---VRCQEVDHQVQLVVEN 414

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490467430 474 TGKGISPDKVERIFDPFFTT------KERGTGLGLSIVHKIIEQHRGTITVLSKVgEGTTFNITMP 533
Cdd:PRK09835  415 PGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

435-534

1.98e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 71.97 E-value: 1.98e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 435 QVLWNLLINAVEAMEGKgvLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKER------GTGLGLSIVHKI 508
Cdd:cd16949     3 RALENVLRNALRYSPSK--ILLDISQD--GDQWTITITDDGPGVPEDQLEQIFLPFYRVDSArdresgGTGLGLAIAERA 78

                          90       100
                  ....*....|....*....|....*.
gi 1490467430 509 IEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:cd16949    79 IEQHGGKIKASNRKPGGLRVRIWLPA 104

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

464-533

2.07e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 72.32 E-value: 2.07e-15

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490467430 464 DNKVILRVTDTGKGISPDKVERIFDPFFTTK-----ERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16948    35 EQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109

PRK11107

hybrid sensory histidine kinase BarA; Provisional

429-534

2.34e-15

hybrid sensory histidine kinase BarA; Provisional

Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 79.51 E-value: 2.34e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAME-GKGVLKVGLRREpADNKVILR--VTDTGKGISPDKVERIFDPF------FTTKERGTG 499
Cdd:PRK11107  405 DPLRLQQIITNLVGNAIKFTEsGNIDILVELRAL-SNTKVQLEvqIRDTGIGISERQQSQLFQAFrqadasISRRHGGTG 483

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1490467430 500 LGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:PRK11107  484 LGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

320-382

4.70e-15

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 69.93 E-value: 4.70e-15

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490467430 320 SVGQLAAGIAHEIRNPLASISGAIQLLREEKfSNPHAQRLMEIIVTESNRLNRLINEFLLYAQ 382
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEK-LDEEQREYLETILRSAERLLRLINDLLDLSR 62

PRK10490

sensor protein KdpD; Provisional

308-536

1.16e-14

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 77.00 E-value: 1.16e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 308 MEESVK-RSERLASVGQLAAGIAHEIRNPLASISGAIQLLREEKFS--NPHAQRLMEI---IVTESnrlnRLINEFLLYA 381
Cdd:PRK10490  650 SEEQARlASEREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASegSPHARQASEIrqqVLNTT----RLVNNLLDMA 725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 382 QPPKA----TKKKVELDKVVEDTLEiffrtpQWNYG-------IRLIKEIekgVVVECDPQQMQQVLWNLLINAVE-AME 449
Cdd:PRK10490  726 RIQSGgfnlRKEWLTLEEVVGSALQ------MLEPGlsghpinLSLPEPL---TLIHVDGPLFERVLINLLENAVKyAGA 796

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 450 GKgvlKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFT-TKER---GTGLGLSIVHKIIEQHRGTITVLSKVGEG 525
Cdd:PRK10490  797 QA---EIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARgNKESaipGVGLGLAICRAIVEVHGGTIWAENRPEGG 873

                         250
                  ....*....|.
gi 1490467430 526 TTFNITMPLKA 536
Cdd:PRK10490  874 ACFRVTLPLET 884

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

308-516

1.33e-14

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 76.12 E-value: 1.33e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 308 MEESVkrsERLASVGQ-LAAGIAHEIRNPLASISGAIQLLREEKFSNPHAQRlmeiIVTESNRLNRLINEFL-LYAQPPK 385
Cdd:PRK09470  232 MVTAL---ERMMTSQQrLLSDISHELRTPLTRLQLATALLRRRQGESKELER----IETEAQRLDSMINDLLvLSRNQQK 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 386 A--TKKKVELDKVVEDTLE-IFFRTPQwnYGIRL-IKEIEKGVVVECDPQQMQQVLWNLLINAVEAmeGKGVLKVGLRre 461
Cdd:PRK09470  305 NhlERETFKANSLWSEVLEdAKFEAEQ--MGKSLtVSAPPGPWPINGNPNALASALENIVRNALRY--SHTKIEVAFS-- 378

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490467430 462 pADNK-VILRVTDTGKGISPDKVERIFDPFF---TTKER---GTGLGLSIVHKIIEQHRGTI 516
Cdd:PRK09470  379 -VDKDgLTITVDDDGPGVPEEEREQIFRPFYrvdEARDResgGTGLGLAIVENAIQQHRGWV 439

COG3920

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...

47-536

1.49e-14

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];

Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 76.10 E-value: 1.49e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  47 TLLYATTLLFFGSLYFKEIPEKDITRLLYFLIATDILIITGMIYLTGGGTSPFSPLYFLAVLEGGAILERRGGIMAASMS 126
Cdd:COG3920    23 LLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 127 SISYGILINLEYYLIIPPLYPQYLYESLYLFYKLFLTILSLFLAGYLTGFLAEEVTKRSRQLSRTREEYSRLEAFSKNVL 206
Cdd:COG3920   103 LLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 207 QSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPELEAYLSEDRAHRVEVNYTKDPFTKLRLGLSFYPLR 286
Cdd:COG3920   183 ALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 287 DHRGELSGKVVIFQDLTKMKDMEESVKRSERLASVgqLAAGIAHEIRNPLASISGAIQLlREEKFSNPHAQRLMEIIvte 366
Cdd:COG3920   263 LLRALLLLAAGIRLVITERKRAEEELEASLEEKEL--LLRELHHRVKNNLQVVSSLLRL-QARRADDPEAREALEES--- 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 367 SNRLN--RLINEfLLYAQPpkaTKKKVELDKVVEDTLEIFFRTPQwNYGIRLIKEIEKgvvVECDPQQMQQ---VLWNLL 441
Cdd:COG3920   337 QNRIQalALVHE-LLYQSE---DWEGVDLRDYLRELLEPLRDSYG-GRGIRIELDGPD---VELPADAAVPlglILNELV 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 442 INAVE--AMEG-KGVLKVGLRREpaDNKVILRVTDTGKGISPDkveriFDPffttkERGTGLGLSIVHKIIEQHRGTITV 518
Cdd:COG3920   409 TNALKhaFLSGeGGRIRVSWRRE--DGRLRLTVSDNGVGLPED-----VDP-----PARKGLGLRLIRALVRQLGGTLEL 476

                         490
                  ....*....|....*...
gi 1490467430 519 LSkvGEGTTFNITMPLKA 536
Cdd:COG3920   477 DR--PEGTRVRITFPLAE 492

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

320-382

2.35e-14

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 67.59 E-value: 2.35e-14

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490467430  320 SVGQLAAGIAHEIRNPLASISGAIQLLREEKFSNPHAQRLmEIIVTESNRLNRLINEFLLYAQ 382
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYL-ETILREAERLLRLINDLLDLSR 62

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

301-535

2.58e-14

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 75.05 E-value: 2.58e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 301 DLTKMKDMEESvkRSERLASVgqlaagiAHEIRNPLASISGAIQLLREEKFSNPHAQRLMEIIVTESNRLNRLINEFLLY 380
Cdd:PRK11006  193 DVTQMHQLEGA--RRNFFANV-------SHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 381 AQPPKATKkkVELDKVVE--DTLEIFFRTPQW----NYGIRLikEIEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVL 454
Cdd:PRK11006  264 SKIEAAPT--IDLNEKVDvpMMLRVLEREAQTlsqgKHTITF--EVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHI 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 455 KVGLRREPADNKviLRVTDTGKGISPDKVERIFDPFF-TTKER-----GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTF 528
Cdd:PRK11006  340 TVRWQRVPQGAE--FSVEDNGPGIAPEHIPRLTERFYrVDKARsrqtgGSGLGLAIVKHALSHHDSRLEIESEVGKGTRF 417


                  ....*..
gi 1490467430 529 NITMPLK 535
Cdd:PRK11006  418 SFVLPER 424

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-533

4.52e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 65.49 E-value: 4.52e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVE-AMEGKgvlKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFF----TTKERGTGLGLSIVHK 507
Cdd:cd16923     1 LQRVFSNLLSNAIKySPENT---RIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKA 77

                          90       100
                  ....*....|....*....|....*.
gi 1490467430 508 IIEQHRGTITVLSKvGEGTTFNITMP 533
Cdd:cd16923    78 IIELHGGSASAEYD-DNHDLFKVRLP 102

PAS

COG2202

PAS domain [Signal transduction mechanisms];

190-437

7.08e-13

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 68.90 E-value: 7.08e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 190 RTREEYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFP---------ELEAYLSEDR 260
Cdd:COG2202     1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPpedddefleLLRAALAGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 261 AHRVEV-NYTKDpFTKLRLGLSFYPLRDHRGELSGKVVIFQDLTKMKDMEESVKRSERLASVGQLAAGIAHEIRNPLASI 339
Cdd:COG2202    81 VWRGELrNRRKD-GSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 340 SgaiqllreekFSNPHAQRLMEIivTESNRLNRLINEFLLYAQPPKATKkkvELDKVVEDTLEIFFRTPQWNYGIRLIKE 419
Cdd:COG2202   160 L----------YVNPAAEELLGY--SPEELLGKSLLDLLHPEDRERLLE---LLRRLLEGGRESYELELRLKDGDGRWVW 224

                         250
                  ....*....|....*...
gi 1490467430 420 IEKGVVVECDPQQMQQVL 437
Cdd:COG2202   225 VEASAVPLRDGGEVIGVL 242

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

420-526

7.64e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 65.12 E-value: 7.64e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 420 IEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPADNkviLRVTDTGKGISPDKVERIFDPFF---TTKER 496
Cdd:cd16940     1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV---IRVEDNGPGIDEEELEALFERFYrsdGQNYG 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1490467430 497 GTGLGLSIVHKIIEQHRGTITVLSKVGEGT 526
Cdd:cd16940    78 GSGLGLSIVKRIVELHGGQIFLGNAQGGGL 107

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-533

1.23e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.01 E-value: 1.23e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEamegKGVLKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFT-TKER---GTGLGLSIVHKI 508
Cdd:cd16950     1 LKRVLSNLVDNALR----YGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRgDNARgtsGTGLGLAIVQRI 76

                          90       100
                  ....*....|....*....|....*
gi 1490467430 509 IEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16950    77 SDAHGGSLTLANRAGGGLCARIELP 101

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

194-317

1.92e-12

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 69.41 E-value: 1.92e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 194 EYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPELEAY--LSEDRAHRVEVNYTKD 271
Cdd:COG3829     5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLevLKTGKPVTGVIQKTGG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1490467430 272 pfTKLRLGLSFYPLRDHrGELSGKVVIFQDLTKMKDMEESVKRSER 317
Cdd:COG3829    85 --KGKTVIVTAIPIFED-GEVIGAVETFRDITELKRLERKLREEEL 127

HATPase_CheA-like

cd16916

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...

419-533

1.92e-12

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.

Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 65.68 E-value: 1.92e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 419 EIEKGVVVEC-DPqqmqqvLWNLLINAV-------EAMEGKGVLKVG---LRREPADNKVILRVTDTGKGISPDKVER-- 485
Cdd:cd16916    30 ELDKSVLEKLaDP------LTHLLRNAVdhgieapEERLAAGKPPEGtitLRAEHQGNQVVIEVSDDGRGIDREKIREka 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490467430 486 ----------------------IFDPFFTTKER-----GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16916   104 ierglitadeaatlsddevlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

429-518

2.56e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 63.25 E-value: 2.56e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFT-----TKERGTGLGLS 503
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEAD--TEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLA 78

                          90
                  ....*....|....*
gi 1490467430 504 IVHKIIEQHRGTITV 518
Cdd:cd16945    79 FVQEVAQLHGGRITL 93

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

424-537

3.05e-12

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 68.51 E-value: 3.05e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 424 VVVECDPQQMQQVLWNLLI-----NAV----EAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPfFTTK 494
Cdd:COG2972   323 VEIEIDEELLDLLIPKLILqplveNAIehgiEPKEGGGTIRISIRKE--GDRLVITVEDNGVGMPEEKLEKLLEE-LSSK 399

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1490467430 495 ERGTGLGLSIVHKIIEQHRG---TITVLSKVGEGTTFNITMPLKAE 537
Cdd:COG2972   400 GEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPLEEE 445

CheA

COG0643

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

385-534

4.08e-12

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 68.67 E-value: 4.08e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 385 KATKKKVELDKVVEDTleiffrtpqwnygirlikEIEKGVVvecdpQQMQQVLWNLLINAV----EAME-----GK---G 452
Cdd:COG0643   253 RELGKEVELVIEGEET------------------ELDRTVL-----ERLGDPLVHLVRNAVdhgiETPEerlaaGKpetG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 453 VLKVGLRREpaDNKVILRVTDTGKGISPDK-----VER-------------------IFDPFFTTKER-----GTGLGLS 503
Cdd:COG0643   310 TITLSAYHE--GGRVVIEVSDDGRGLDLEKirakaIEKglitaeeaaalsdeellelIFAPGFSTAEEvtdlsGRGVGMD 387

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1490467430 504 IVHKIIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:COG0643   388 VVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418

PRK10549

two-component system sensor histidine kinase BaeS;

326-540

4.25e-12

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 68.12 E-value: 4.25e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 326 AGIAHEIRNPLASISG---AIQllreEKFSNPHAQRLMEIIvTESNRLNRLINEF----------LLYaqppkatkKKVE 392
Cdd:PRK10549  245 ADISHELRTPLAVLRGeleAIQ----DGVRKFTPESVASLQ-AEVGTLTKLVDDLhqlslsdegaLAY--------RKTP 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 393 LDKVveDTLEIF---FRTPQWNYGIRLIKEIEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVIL 469
Cdd:PRK10549  312 VDLV--PLLEVAggaFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQR--DKTLRL 387

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490467430 470 RVTDTGKGISPDKVERIFDPFFTT---KER---GTGLGLSIVHKIIEQHRGTITVL-SKVGeGTTFNITMPLKAEKGG 540
Cdd:PRK10549  388 TFADSAPGVSDEQLQKLFERFYRTegsRNRasgGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELPLERDLQR 464

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

421-532

1.73e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 61.38 E-value: 1.73e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 421 EKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPADnkVILRVTDTGKGISPDKVERIFDPFFTTKE----- 495
Cdd:cd16947     9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKH--VYIDIWDKGKGISETEKDHVFERLYTLEDsrnsa 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1490467430 496 -RGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITM 532
Cdd:cd16947    87 kQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

439-533

3.48e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 60.29 E-value: 3.48e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 439 NLLINAVEAMEGKGVLKVGLRREPADNKviLRVTDTGKGISPDKVERIFDPFF-TTKER-----GTGLGLSIVHKIIEQH 512
Cdd:cd16952     7 NLVSNAVKYTPPSDTITVRWSQEESGAR--LSVEDTGPGIPPEHIPRLTERFYrVDIERcrntgGTGLGLAIVKHVMSRH 84

                          90       100
                  ....*....|....*....|.
gi 1490467430 513 RGTITVLSKVGEGTTFNITMP 533
Cdd:cd16952    85 DARLLIASELGKGSRFTCLFP 105

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

435-517

3.85e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 60.28 E-value: 3.85e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 435 QVLWNLLINAVEAMEGKGVlKVGLRREPADNKVILRVTDTGKGISPDKVERIFDPFFTTKERG------TGLGLSIVHKI 508
Cdd:cd16953     3 QVLRNLIGNAISFSPPDTG-RITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQI 81


                  ....*....
gi 1490467430 509 IEQHRGTIT 517
Cdd:cd16953    82 IEAHGGISV 90

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-534

1.82e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 57.83 E-value: 1.82e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEAMEGKgvLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFF---TTKERGT---GLGLSIVH 506
Cdd:cd16939     1 MARALDNLLRNALRYAHRT--VRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVrldPSRDRATggfGLGLAIVH 76

                          90       100
                  ....*....|....*....|....*....
gi 1490467430 507 KIIEQHRGTITVL-SKVGeGTTFNITMPL 534
Cdd:cd16939    77 RVALWHGGHVECDdSELG-GACFRLTWPR 104

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

413-531

3.83e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 58.03 E-value: 3.83e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 413 GIRLIKEIEKGVVVECDPQQMQQVLWNLLINAveameGKGVLK-VGLRREPADNKVILRVTDTGKGISPDKVERIFdpff 491
Cdd:cd16954    18 GVSISLDISPELRFPGERNDLMELLGNLLDNA-----CKWCLEfVEVTARQTDGGLHLIVDDDGPGVPESQRSKIF---- 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1490467430 492 ttkERGT---------GLGLSIVHKIIEQHRGTITVLSKVGEGTTFNIT 531
Cdd:cd16954    89 ---QRGQrldeqrpgqGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVV 134

PAS_4

pfam08448

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

206-303

3.15e-09

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 54.73 E-value: 3.15e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 206 LQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE---------LEAYLSEDRAHRVEVNYTKDPftKL 276
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPedaarleraLRRALEGEEPIDFLEELLLNG--EE 78

                          90       100
                  ....*....|....*....|....*...
gi 1490467430 277 R-LGLSFYPLRDHRGELSGKVVIFQDLT 303
Cdd:pfam08448  79 RhYELRLTPLRDPDGEVIGVLVISRDIT 106

PRK10337

sensor protein QseC; Provisional

329-512

1.39e-08

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 56.97 E-value: 1.39e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 329 AHEIRNPLASI---SGAIQL------LREEKFSNPH-----AQRLMEIIVTESnRLNRLINefLLYAQPpkatkkkVELD 394
Cdd:PRK10337  245 AHELRSPLAALkvqTEVAQLsdddpqARKKALLQLHagidrATRLVDQLLTLS-RLDSLDN--LQDVAE-------IPLE 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 395 KVVEDTLEIFFRTPQwNYGIRLIKEIE-KGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLrrepadNKVILRVTD 473
Cdd:PRK10337  315 DLLQSAVMDIYHTAQ-QAGIDVRLTLNaHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL------NARNFTVRD 387

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1490467430 474 TGKGISPDKVERIFDPFFT---TKERGTGLGLSIVHKIIEQH 512
Cdd:PRK10337  388 NGPGVTPEALARIGERFYRppgQEATGSGLGLSIVRRIAKLH 429

PRK10755

two-component system sensor histidine kinase PmrB;

323-514

1.38e-07

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 53.82 E-value: 1.38e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 323 QLAAGIAHEIRNPLASISGAIQLLreEKFSNPHAQRLMEIIvtesNRLNRLINEFLLYAQPPKA----TKKKVELDKVVE 398
Cdd:PRK10755  139 LFTADVAHELRTPLAGIRLHLELL--EKQHHIDVAPLIARL----DQMMHTVEQLLQLARAGQSfssgHYQTVKLLEDVI 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 399 DTLEIFFRTPQWNYGIRLI-KEIEKGVVVECDPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREPADnkVILRVTDTGKG 477
Cdd:PRK10755  213 LPSQDELSEMLEQRQQTLLlPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGG--AVLAVEDEGPG 290

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1490467430 478 ISPDKVERIFDPFFTTKER--GTGLGLSIVHKIIEQHRG 514
Cdd:PRK10755  291 IDESKCGELSKAFVRMDSRygGIGLGLSIVSRITQLHHG 329

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

203-301

3.57e-07

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 48.95 E-value: 3.57e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 203 KNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE----------LEAYLSEDRAHRVEVNYTKDP 272
Cdd:pfam00989   4 RAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEeddaevaellRQALLQGEESRGFEVSFRVPD 83

                          90       100
                  ....*....|....*....|....*....
gi 1490467430 273 FTKLRLGLSFYPLRDHRGELSGKVVIFQD 301
Cdd:pfam00989  84 GRPRHVEVRASPVRDAGGEILGFLGVLRD 112

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

456-537

7.03e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 50.77 E-value: 7.03e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 456 VGLRREpaDNKVILRVTDTGKGISPDKVerifdpffttkeRGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPLK 535
Cdd:COG4585   185 VTLEVD--DGELTLTVRDDGVGFDPEAA------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250


                  ..
gi 1490467430 536 AE 537
Cdd:COG4585   251 AA 252

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

204-251

1.76e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 45.47 E-value: 1.76e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1490467430  204 NVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE 251
Cdd:smart00091   5 AILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHP 52

dpiB

PRK15053

sensor histidine kinase DpiB; Provisional

160-533

2.39e-06

sensor histidine kinase DpiB; Provisional

Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 50.22 E-value: 2.39e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 160 LFLTILSLFLAGYLtgflaeevtkRSRQLSRTREEYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTS 239
Cdd:PRK15053  192 GILMLLSWFFAAHI----------RRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSPG 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 240 LRNL--FLSDVFPELEAYLSEDRAHRVEVNYTKDpftklrlGLSFYPLRD---HRGELSGKVVIFQD----------LTK 304
Cdd:PRK15053  262 RQWLgkPIAEVVRPADFFTEQIDEKRQDVVANFN-------GLSVIANREairSGDDLLGAIISFRSkdeistlnaqLTQ 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 305 MKDMEESVKRserlasvgqlaagIAHEIRNPLASISGaiqLLREEKFSnphaqRLMEIIVTESNRLNRLINEF------- 377
Cdd:PRK15053  335 IKQYVESLRT-------------LRHEHLNWMSTLNG---LLQMKEYD-----RVLEMVQGESQAQQQLIDSLreafadr 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 378 ----LLYAQPPKATKKKVELDKVVEDTLEiffrtpQWNYGIrlikeiekgvvvecDPQQMQQVLWNLLINAVEAM----E 449
Cdd:PRK15053  394 qvagLLFGKVQRARELGLKMVIVPGSQLS------QLPPGL--------------DSTEFAAIVGNLLDNAFEASlrsdE 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 450 GKGVLKVGLRREPADnkVILRVTDTGKGISPDKVERIFDPFFTTK--ERGT-GLGLSIVHKIIEQHRGTITVLSKVGEGT 526
Cdd:PRK15053  454 GNKIVELFLSDEGDD--VVIEVADQGCGVPESLRDKIFEQGVSTRadEPGEhGIGLYLIASYVTRCGGVITLEDNDPCGT 531


                  ....*..
gi 1490467430 527 TFNITMP 533
Cdd:PRK15053  532 LFSIFIP 538

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

199-310

2.95e-06

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 46.52 E-value: 2.95e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 199 EAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPE-----LEAYLSEDRAHRVEVNYTKdpF 273
Cdd:TIGR00229   2 EERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEedreeVRERIERRLEGEPEPVSEE--R 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1490467430 274 TKLR-------LGLSFYPLRDHrGELSGKVVIFQDLTKMKDMEE 310
Cdd:TIGR00229  80 RVRRkdgseiwVEVSVSPIRTN-GGELGVVGIVRDITERKEAEE 122

PAS_9

pfam13426

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...

220-304

3.07e-06

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 45.53 E-value: 3.07e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 220 GRITFVNAAGERILGLKR-----TSLRNLFLSDVFPE-LEAYLSEDR-AHRVEVNYTKDPFTKLRLGLSFYPLRDHRGEL 292
Cdd:pfam13426   2 GRIIYVNDAALRLLGYTReellgKSITDLFAEPEDSErLREALREGKaVREFEVVLYRKDGEPFPVLVSLAPIRDDGGEL 81

                          90
                  ....*....|..
gi 1490467430 293 SGKVVIFQDLTK 304
Cdd:pfam13426  82 VGIIAILRDITE 93

HATPase_SpoIIAB-like

cd16942

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...

439-531

3.10e-06

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.

Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 46.76 E-value: 3.10e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 439 NLLINAVEAmEGKGVLKVGLRREpaDNKVILRVTDTGKGIsPDkVERIFDPFFTTK---ERgTGLGLSIVHKIIEQhrgt 515
Cdd:cd16942    49 NAIIHGYNN-DPNGIVSISVIIE--DGVVHLTVRDEGVGI-PD-IEEARQPLFTTKpelER-SGMGFTIMENFMDE---- 118

                          90
                  ....*....|....*.
gi 1490467430 516 ITVLSKVGEGTTFNIT 531
Cdd:cd16942   119 VIVESEVNKGTTVYLK 134

PAS

COG2202

PAS domain [Signal transduction mechanisms];

190-310

3.57e-06

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 48.48 E-value: 3.57e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 190 RTREEYSRLEAFSKNVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFPELEAYL----------SED 259
Cdd:COG2202   127 RAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERllellrrlleGGR 206

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1490467430 260 RAHRVEVNYTKDPFTKLRLGLSFYPLRDhRGELSGKVVIFQDLTKMKDMEE 310
Cdd:COG2202   207 ESYELELRLKDGDGRWVWVEASAVPLRD-GGEVIGVLGIVRDITERKRAEE 256

PRK10815

two-component system sensor histidine kinase PhoQ;

463-518

5.95e-06

two-component system sensor histidine kinase PhoQ;

Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 48.86 E-value: 5.95e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1490467430 463 ADNKVILRVTDTGKGISPDKVERIFD--PFFTTKERGTGLGLSIVHKIIEQHRGTITV 518
Cdd:PRK10815  405 TDEHLHIVVEDDGPGIPESKRELIFDrgQRADTLRPGQGLGLSVAREITEQYEGKISA 462

HATPase_YpdA-like

cd16955

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-506

7.43e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 44.76 E-value: 7.43e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490467430 433 MQQVLWNLLINAVEAMEGKGVLKVGLRREPaDNKVILRVTDTGKGISPDKVERIF-DPFFTTKergtgLGLSIVH 506
Cdd:cd16955     6 IQPLVENAIVHGIQEKKGKGVVKISVKKQL-KNRLHIAVEDNGIGISPKVIERVEqDEMPGNK-----IGLLNVH 74

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

429-518

4.83e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 42.45 E-value: 4.83e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIFDPFFTTKERGT-----GLGLS 503
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDE--EEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLY 78

                          90
                  ....*....|....*
gi 1490467430 504 IVHKIIEQHRGTITV 518
Cdd:cd16975    79 IAKNLVEKHGGSLII 93

RsbW

COG2172

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

440-508

6.25e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 42.59 E-value: 6.25e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490467430 440 LLINAVE---AMEGKGVLKVGLRREPadNKVILRVTDTGKGISPDKVErifDPFFTTKERgtGLGLSIVHKI 508
Cdd:COG2172    42 AVTNAVRhayGGDPDGPVEVELELDP--DGLEIEVRDEGPGFDPEDLP---DPYSTLAEG--GRGLFLIRRL 106

HATPase_Phy-like

cd16932

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ...

429-516

9.69e-05

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.

Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 41.87 E-value: 9.69e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 429 DPQQMQQVLWNLLINAVE---AMEGKGVLKVGLRREPADNKVIL-----RVTDTGKGISPDKVERIFDPF-FTTKErgtG 499
Cdd:cd16932     3 DQIRLQQVLADFLLNAVRftpSPGGWVEIKVSPTKKQIGDGVHVihlefRITHPGQGLPEELVQEMFEENqWTTQE---G 79

                          90
                  ....*....|....*..
gi 1490467430 500 LGLSIVHKIIEQHRGTI 516
Cdd:cd16932    80 LGLSISRKLVKLMNGDV 96

HATPase_YpdA-YehU-LytS-like

cd16924

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

433-533

9.83e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 41.66 E-value: 9.83e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 433 MQQVLWNLLINAVEAMEGKGVLKVGLRREpaDNKVILRVTDTGKGISPDKVERIfdpfFTTKERGTGLGLSIVHKIIEQH 512
Cdd:cd16924     6 LQPLVENAIQHGLSPLTDKGVVTISALKE--DNHVMIEVEDNGRGIDPKVLNIL----GKKPKEGNGIGLYNVHQRLILL 79

                          90       100
                  ....*....|....*....|....
gi 1490467430 513 RG---TITVLSKVGEGTTFNITMP 533
Cdd:cd16924    80 FGedyGIHIASEPDKGTRITFTIP 103

PAS

cd00130

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

212-302

1.17e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 41.46 E-value: 1.17e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430 212 GLITVDLTGRITFVNAAGERILGLKR-----TSLRNLFLSDVFPELEAYLSEDRAHRVEVNY-----TKDPfTKLRLGLS 281
Cdd:cd00130     4 GVIVLDLDGRILYANPAAEQLLGYSPeeligKSLLDLIHPEDREELRERLENLLSGGEPVTLevrlrRKDG-SVIWVLVS 82

                          90       100
                  ....*....|....*....|.
gi 1490467430 282 FYPLRDHRGELSGKVVIFQDL 302
Cdd:cd00130    83 LTPIRDEGGEVIGLLGVVRDI 103

HATPase_UhpB-NarQ-NarX-like

cd16917

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

463-533

1.84e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.

Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 40.23 E-value: 1.84e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490467430 463 ADNKVILRVTDTGKGISPDkverifdpfftTKERGTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMP 533
Cdd:cd16917    28 TADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTARLP 87

PAS_8

pfam13188

PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...

203-260

8.50e-04

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 37.91 E-value: 8.50e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1490467430 203 KNVLQSLQSGLITVDLTGRITFVNAAGERILGLkrtSLRNLFLSDVFPELEAYLSEDR 260
Cdd:pfam13188   4 RALFESSPDGILVLDEGGRIIYVNPAALELLGY---ELLGELLGELLDLLDPLLEDAL 58

PRK10547

chemotaxis protein CheA; Provisional

486-534

9.13e-04

chemotaxis protein CheA; Provisional

Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 42.02 E-value: 9.13e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490467430 486 IFDPFFTTKER-----GTGLGLSIVHKIIEQHRGTITVLSKVGEGTTFNITMPL 534
Cdd:PRK10547  470 IFAPGFSTAEQvtdvsGRGVGMDVVKRNIQEMGGHVEIQSKQGKGTTIRILLPL 523

PRK09776

putative diguanylate cyclase; Provisional

186-315

4.16e-03

putative diguanylate cyclase; Provisional

Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 40.04 E-value: 4.16e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490467430  186 RQLSRT-REEYSRLEAfsknVLQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVF--------PELE--- 253
Cdd:PRK09776   525 RQLNEAlFQEKERLHI----TLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLhitfgdngPLMEniy 600

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490467430  254 --------AYLSED------RAHRVEVNYtkdpftklrlglSFYPLRDHRGELSGKVVIFQDLTKMKDMEESVKRS 315
Cdd:PRK09776   601 scltsrsaAYLEQDvvlhcrSGGSYDVHY------------SITPLSTLDGENIGSVLVIQDVTESRKMLRQLSYS 664

TyrR

COG3283

Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ...

206-267

5.24e-03

Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];

Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 39.40 E-value: 5.24e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490467430 206 LQSLQSGLITVDLTGRITFVNAAGERILGLKRTSLRNLFLSDVFP--ELEAYLSED----RAHRVEVN 267
Cdd:COG3283    86 LEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLKgfNFSRWLESNeprpQSERVVIN 153

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01