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Conserved domains on  [gi|1490347179|gb|RKZ99268|]
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hypothetical protein DRQ43_00075 [Gammaproteobacteria bacterium]

Protein Classification

putative bifunctional diguanylate cyclase/phosphodiesterase( domain architecture ID 11472025)

putative bifunctional diguanylate cyclase/phosphodiesterase may only contain one of the two functional domains (GGDEF diguanylate cyclase or EAL family cyclyc-guanylate-specific phosphodiesterase)

EC:  2.7.7.65
Gene Ontology:  GO:0005886|GO:0046872|GO:0005525|GO:0052621|GO:0071111
PubMed:  16045609|16530465|11557134|15306016

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5001 COG5001
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ...
 55-672 0e+00

Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];


:

Pssm-ID: 444025 [Multi-domain]  Cd Length: 678  Bit Score: 584.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  55 LIIIAISVFRIITSRRYLLNKTNLPAHLYSHVFLTFVTGTLWGYVAYMQMYTNDDVLRNLIFLINFGLIAASIATLSAWV 134
Cdd:COG5001    54 LLLLALLALLALLLLAAALLALALAALLLAALLAALLLLLLLLLALLVLLLLLLLLLALLALLAALLARALAALLLAAAS 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 135 YAYLAYMFPQSLAIFYVFLKLDNEYSLQMAGAFVIFTGVMIITSIRYSYRIKKEAELIHDLNNEIGMREEAQLQLQNSKQ 214
Cdd:COG5001   134 AALLAAALGAALLAALALALLLALARALLALLLLLLLALLLLLLLLLLLALLLLLLLALLLRLLLLLRGGRLLRLALRLL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 215 GLEDKVNERTKELVDMNSHLESVIDKKEQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRF 294
Cdd:COG5001   214 LGLLLLGLLLLLLLVAVLAIARLITERKRAEERLRHLAYHDPLTGLPNRRLFLDRLEQALARARRSGRRLALLFIDLDRF 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 295 KTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGGDEFVIVLDRMENTDDAIHVAKKVINSLTETFEIQAHKIHIGA 374
Cdd:COG5001   294 KEINDTLGHAAGDELLREVARRLRACLREGDTVARLGGDEFAVLLPDLDDPEDAEAVAERILAALAEPFELDGHELYVSA 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 375 SVGISIYPTDGKTSSILIRNADTAMYKAKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQPQVNCLTGE 454
Cdd:COG5001   374 SIGIALYPDDGADAEELLRNADLAMYRAKAAGRNRYRFFDPEMDERARERLELEADLRRALERGELELHYQPQVDLATGR 453

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 455 TTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRT---QPANHVTYSINLSVLQFNNYKFIDFVR 531
Cdd:COG5001   454 IVGAEALLRWQHPERGLVSPAEFIPLAEETGLIVPLGEWVLREACRQLAAwqdAGLPDLRVAVNLSARQLRDPDLVDRVR 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 532 NEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARLPIDVIKIDKSLVRNINEHK 611
Cdd:COG5001   534 RALAETGLPPSRLELEITESALLEDPEEALETLRALRALGVRIALDDFGTGYSSLSYLKRLPVDTLKIDRSFVRDLAEDP 613

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490347179 612 NLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDDIDHWLS 672
Cdd:COG5001   614 DDAAIVRAIIALAHSLGLEVVAEGVETEEQLEFLRELGCDYAQGYLFSRPLPAEELEALLR 674
 
Name Accession Description Interval E-value
COG5001 COG5001
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ...
 55-672 0e+00

Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];


Pssm-ID: 444025 [Multi-domain]  Cd Length: 678  Bit Score: 584.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  55 LIIIAISVFRIITSRRYLLNKTNLPAHLYSHVFLTFVTGTLWGYVAYMQMYTNDDVLRNLIFLINFGLIAASIATLSAWV 134
Cdd:COG5001    54 LLLLALLALLALLLLAAALLALALAALLLAALLAALLLLLLLLLALLVLLLLLLLLLALLALLAALLARALAALLLAAAS 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 135 YAYLAYMFPQSLAIFYVFLKLDNEYSLQMAGAFVIFTGVMIITSIRYSYRIKKEAELIHDLNNEIGMREEAQLQLQNSKQ 214
Cdd:COG5001   134 AALLAAALGAALLAALALALLLALARALLALLLLLLLALLLLLLLLLLLALLLLLLLALLLRLLLLLRGGRLLRLALRLL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 215 GLEDKVNERTKELVDMNSHLESVIDKKEQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRF 294
Cdd:COG5001   214 LGLLLLGLLLLLLLVAVLAIARLITERKRAEERLRHLAYHDPLTGLPNRRLFLDRLEQALARARRSGRRLALLFIDLDRF 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 295 KTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGGDEFVIVLDRMENTDDAIHVAKKVINSLTETFEIQAHKIHIGA 374
Cdd:COG5001   294 KEINDTLGHAAGDELLREVARRLRACLREGDTVARLGGDEFAVLLPDLDDPEDAEAVAERILAALAEPFELDGHELYVSA 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 375 SVGISIYPTDGKTSSILIRNADTAMYKAKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQPQVNCLTGE 454
Cdd:COG5001   374 SIGIALYPDDGADAEELLRNADLAMYRAKAAGRNRYRFFDPEMDERARERLELEADLRRALERGELELHYQPQVDLATGR 453

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 455 TTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRT---QPANHVTYSINLSVLQFNNYKFIDFVR 531
Cdd:COG5001   454 IVGAEALLRWQHPERGLVSPAEFIPLAEETGLIVPLGEWVLREACRQLAAwqdAGLPDLRVAVNLSARQLRDPDLVDRVR 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 532 NEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARLPIDVIKIDKSLVRNINEHK 611
Cdd:COG5001   534 RALAETGLPPSRLELEITESALLEDPEEALETLRALRALGVRIALDDFGTGYSSLSYLKRLPVDTLKIDRSFVRDLAEDP 613

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490347179 612 NLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDDIDHWLS 672
Cdd:COG5001   614 DDAAIVRAIIALAHSLGLEVVAEGVETEEQLEFLRELGCDYAQGYLFSRPLPAEELEALLR 674
PRK10060 PRK10060
cyclic di-GMP phosphodiesterase;
238-671 7.80e-109

cyclic di-GMP phosphodiesterase;


Pssm-ID: 236645 [Multi-domain]  Cd Length: 663  Bit Score: 343.97  E-value: 7.80e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 238 IDKKEQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIktSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARL 317
Cdd:PRK10060  223 ITEERRAQERLRILANTDSITGLPNRNAIQELIDHAI--NAADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAI 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 318 HKILRSRDTLARNGGDEFvIVLdrMENTDDAI--HVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNA 395
Cdd:PRK10060  301 LSCLEEDQTLARLGGDEF-LVL--ASHTSQAAleAMASRILTRLRLPFRIGLIEVYTGCSIGIALAPEHGDDSESLIRSA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 396 DTAMYKAKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQPQVNcLTGETTGFEILLRWSNTTYGEIGPD 475
Cdd:PRK10060  378 DTAMYTAKEGGRGQFCVFSPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKIT-WRGEVRSLEALVRWQSPERGLIPPL 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 476 RFVPLLEETGLIYATGDWV----VTQVIDFiRTQPANhVTYSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITES 551
Cdd:PRK10060  457 EFISYAEESGLIVPLGRWVmldvVRQVAKW-RDKGIN-LRVAVNVSARQLADQTIFTALKQALQELNFEYCPIDVELTES 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 552 LLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTN 631
Cdd:PRK10060  535 CLIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQV 614

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1490347179 632 IFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDDIDHWL 671
Cdd:PRK10060  615 IAEGVETAKEDAFLTKNGVNERQGFLFAKPMPAVAFERWY 654
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 429-666 2.80e-94

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 291.37  E-value: 2.80e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 429 NELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRT--QP 506
Cdd:cd01948     1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARwqAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 507 ANHVTYSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSM 586
Cdd:cd01948    81 GPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 587 SYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDD 666
Cdd:cd01948   161 SYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPAEE 240
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 428-667 6.33e-85

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 267.16  E-value: 6.33e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  428 ENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRTQPA 507
Cdd:smart00052   1 ERELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  508 NHVTY---SINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYT 584
Cdd:smart00052  81 QGPPPlliSINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGYS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  585 SMSYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPiMP 664
Cdd:smart00052 161 SLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRP-LP 239


                   ...
gi 1490347179  665 DDI 667
Cdd:smart00052 240 LDD 242
EAL pfam00563
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 428-661 4.17e-78

EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


Pssm-ID: 425752 [Multi-domain]  Cd Length: 235  Bit Score: 249.16  E-value: 4.17e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 428 ENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRTQPA 507
Cdd:pfam00563   1 ARALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALADLAQLQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 508 NHVT-YSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSM 586
Cdd:pfam00563  81 GPDIkLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLLARLEALREVLKRLRALGIRIALDDFGTGYSSL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490347179 587 SYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKP 661
Cdd:pfam00563 161 SYLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
GGDEF TIGR00254
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by ...
 251-408 1.16e-40

diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other]


Pssm-ID: 272984 [Multi-domain]  Cd Length: 165  Bit Score: 145.94  E-value: 1.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 251 LAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARN 330
Cdd:TIGR00254   1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 331 GGDEFVIVLDRmENTDDAIHVA---KKVINSLTETFEIQAhKIHIGASVGISIYPTDGKTSSILIRNADTAMYKAKKSGG 407
Cdd:TIGR00254  81 GGEEFVVILPG-TPLEDALSKAerlRDAINSKPIEVAGSE-TLTVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGR 158


                  .
gi 1490347179 408 N 408
Cdd:TIGR00254 159 N 159
 
Name Accession Description Interval E-value
COG5001 COG5001
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ...
 55-672 0e+00

Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];


Pssm-ID: 444025 [Multi-domain]  Cd Length: 678  Bit Score: 584.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  55 LIIIAISVFRIITSRRYLLNKTNLPAHLYSHVFLTFVTGTLWGYVAYMQMYTNDDVLRNLIFLINFGLIAASIATLSAWV 134
Cdd:COG5001    54 LLLLALLALLALLLLAAALLALALAALLLAALLAALLLLLLLLLALLVLLLLLLLLLALLALLAALLARALAALLLAAAS 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 135 YAYLAYMFPQSLAIFYVFLKLDNEYSLQMAGAFVIFTGVMIITSIRYSYRIKKEAELIHDLNNEIGMREEAQLQLQNSKQ 214
Cdd:COG5001   134 AALLAAALGAALLAALALALLLALARALLALLLLLLLALLLLLLLLLLLALLLLLLLALLLRLLLLLRGGRLLRLALRLL 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 215 GLEDKVNERTKELVDMNSHLESVIDKKEQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRF 294
Cdd:COG5001   214 LGLLLLGLLLLLLLVAVLAIARLITERKRAEERLRHLAYHDPLTGLPNRRLFLDRLEQALARARRSGRRLALLFIDLDRF 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 295 KTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGGDEFVIVLDRMENTDDAIHVAKKVINSLTETFEIQAHKIHIGA 374
Cdd:COG5001   294 KEINDTLGHAAGDELLREVARRLRACLREGDTVARLGGDEFAVLLPDLDDPEDAEAVAERILAALAEPFELDGHELYVSA 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 375 SVGISIYPTDGKTSSILIRNADTAMYKAKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQPQVNCLTGE 454
Cdd:COG5001   374 SIGIALYPDDGADAEELLRNADLAMYRAKAAGRNRYRFFDPEMDERARERLELEADLRRALERGELELHYQPQVDLATGR 453

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 455 TTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRT---QPANHVTYSINLSVLQFNNYKFIDFVR 531
Cdd:COG5001   454 IVGAEALLRWQHPERGLVSPAEFIPLAEETGLIVPLGEWVLREACRQLAAwqdAGLPDLRVAVNLSARQLRDPDLVDRVR 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 532 NEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARLPIDVIKIDKSLVRNINEHK 611
Cdd:COG5001   534 RALAETGLPPSRLELEITESALLEDPEEALETLRALRALGVRIALDDFGTGYSSLSYLKRLPVDTLKIDRSFVRDLAEDP 613

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490347179 612 NLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDDIDHWLS 672
Cdd:COG5001   614 DDAAIVRAIIALAHSLGLEVVAEGVETEEQLEFLRELGCDYAQGYLFSRPLPAEELEALLR 674
EAL COG2200
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ...
 109-671 5.34e-113

EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];


Pssm-ID: 441802 [Multi-domain]  Cd Length: 576  Bit Score: 352.16  E-value: 5.34e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 109 DVLRNLIFLINFGLIAASIATLSAWVYAYLAYMFPQSLAIFYVFLKLDNEYSLQMAGAFVIFTGVMIITSIRYSYRIKKE 188
Cdd:COG2200    12 LLLLLLALLAEALALLLLLALLLLALASALLLAVAALLAALLAALLLLLALALLLLLLLLLLLLLLLLLLLLALLLLLLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 189 AELIHDLNNEIGMREEAQLQLQNSKQGLEDKVNERTKELVDMNSHLESVIDKKEQAEKSLHYLAYHDELTGLPNKNLLVD 268
Cdd:COG2200    92 LLLLLLLLLLLLALLLAALLALLLLLLLLLLLLLLSLLLLLVLVLLRLALELLLALLLLALLALLDLLLLLLLRRLLLLL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 269 RINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGGDEFVIVLDRMENTDDA 348
Cdd:COG2200   172 LLLLLLLLLALALLALLLLLLLLLLLLLDNDGLGGAGLLLLLLLALLLLLLLARLLLALLGGGGGGFLLLLLLLAAAAAA 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 349 IHVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNADTAMYKAKKSGGNQLQFYNESMSnQLRDRLVLE 428
Cdd:COG2200   252 AAALRLLLLLLLEPLLLGGGLVVVASSGGGAAAPDDGADAALLLAAAAAAAAAAAGGGRGRVVFFAAAEA-RARRRLALE 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 429 NELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRTQPAN 508
Cdd:COG2200   331 SELREALEEGELRLYYQPIVDLRTGRVVGYEALLRWRHPDGGLISPAEFIPAAERSGLIVELDRWVLERALRQLARWPER 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 509 H--VTYSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSM 586
Cdd:COG2200   411 GldLRLSVNLSARSLLDPDFLERLLELLAEYGLPPERLVLEITESALLEDLEAAIELLARLRALGVRIALDDFGTGYSSL 490

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 587 SYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDD 666
Cdd:COG2200   491 SYLKRLPPDYLKIDRSFVRDIARDPRDQAIVRAIVALAHRLGLKVVAEGVETEEQLEALRELGCDYAQGYLFGRPLPLEE 570


                  ....*
gi 1490347179 667 IDHWL 671
Cdd:COG2200   571 LEALL 575
PRK10060 PRK10060
cyclic di-GMP phosphodiesterase;
238-671 7.80e-109

cyclic di-GMP phosphodiesterase;


Pssm-ID: 236645 [Multi-domain]  Cd Length: 663  Bit Score: 343.97  E-value: 7.80e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 238 IDKKEQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIktSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARL 317
Cdd:PRK10060  223 ITEERRAQERLRILANTDSITGLPNRNAIQELIDHAI--NAADNNQVGIVYLDLDNFKKVNDAYGHMFGDQLLQDVSLAI 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 318 HKILRSRDTLARNGGDEFvIVLdrMENTDDAI--HVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNA 395
Cdd:PRK10060  301 LSCLEEDQTLARLGGDEF-LVL--ASHTSQAAleAMASRILTRLRLPFRIGLIEVYTGCSIGIALAPEHGDDSESLIRSA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 396 DTAMYKAKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQPQVNcLTGETTGFEILLRWSNTTYGEIGPD 475
Cdd:PRK10060  378 DTAMYTAKEGGRGQFCVFSPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKIT-WRGEVRSLEALVRWQSPERGLIPPL 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 476 RFVPLLEETGLIYATGDWV----VTQVIDFiRTQPANhVTYSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITES 551
Cdd:PRK10060  457 EFISYAEESGLIVPLGRWVmldvVRQVAKW-RDKGIN-LRVAVNVSARQLADQTIFTALKQALQELNFEYCPIDVELTES 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 552 LLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTN 631
Cdd:PRK10060  535 CLIENEELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQV 614

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1490347179 632 IFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDDIDHWL 671
Cdd:PRK10060  615 IAEGVETAKEDAFLTKNGVNERQGFLFAKPMPAVAFERWY 654
PRK11359 PRK11359
cyclic-di-GMP phosphodiesterase; Provisional
 207-676 4.54e-95

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183097 [Multi-domain]  Cd Length: 799  Bit Score: 311.32  E-value: 4.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 207 LQLQNSKQGLEDKVNERtkeLVDMNSHLESVIDKKEQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIKTSsrdnQKIAI 286
Cdd:PRK11359  334 LQIKTSSGAETSAFIER---VADISQHLAALALEQEKSRQHIEQLIQFDPLTGLPNRNNLHNYLDDLVDKA----VSPVV 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 287 LFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGGDEFVIVLDRMEnTDDAIHVAKKVINSLTETFEIQ 366
Cdd:PRK11359  407 YLIGVDHFQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLEND-VSNITQIADELRNVVSKPIMID 485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 367 AHKIHIGASVGISIypTDGKTSSILIRNADTAMYKAKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQP 446
Cdd:PRK11359  486 DKPFPLTLSIGISY--DVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKERLVLGAALKEAISNNQLKLVYQP 563

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 447 QVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQV---IDFIRTQPANHVTYSINLSVLQFNN 523
Cdd:PRK11359  564 QIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWVIAEAcrqLAEWRSQNIHIPALSVNLSALHFRS 643

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 524 YKFIDFVRNEIDKAGIDPAQIEFEITESLLIndfEKTHDFLSELH---SLGCSIALDDFGTGYTSMSYLARLPIDVIKID 600
Cdd:PRK11359  644 NQLPNQVSDAMQAWGIDGHQLTVEITESMMM---EHDTEIFKRIQilrDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID 720

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490347179 601 KSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDDIDHWLSLAQD 676
Cdd:PRK11359  721 KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEEIPGWMSSVLP 796
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 429-666 2.80e-94

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 291.37  E-value: 2.80e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 429 NELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRT--QP 506
Cdd:cd01948     1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARwqAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 507 ANHVTYSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSM 586
Cdd:cd01948    81 GPDLRLSVNLSARQLRDPDFLDRLLELLAETGLPPRRLVLEITESALIDDLEEALATLRRLRALGVRIALDDFGTGYSSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 587 SYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIMPDD 666
Cdd:cd01948   161 SYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPAEE 240
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 428-667 6.33e-85

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 267.16  E-value: 6.33e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  428 ENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRTQPA 507
Cdd:smart00052   1 ERELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  508 NHVTY---SINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYT 584
Cdd:smart00052  81 QGPPPlliSINLSARQLISPDLVPRVLELLEETGLPPQRLELEITESVLLDDDESAVATLQRLRELGVRIALDDFGTGYS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  585 SMSYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPiMP 664
Cdd:smart00052 161 SLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRP-LP 239


                   ...
gi 1490347179  665 DDI 667
Cdd:smart00052 240 LDD 242
EAL pfam00563
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 428-661 4.17e-78

EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


Pssm-ID: 425752 [Multi-domain]  Cd Length: 235  Bit Score: 249.16  E-value: 4.17e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 428 ENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRTQPA 507
Cdd:pfam00563   1 ARALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALADLAQLQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 508 NHVT-YSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSM 586
Cdd:pfam00563  81 GPDIkLSINLSPASLADPGFLELLRALLKQAGPPPSRLVLEITESDLLARLEALREVLKRLRALGIRIALDDFGTGYSSL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490347179 587 SYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKP 661
Cdd:pfam00563 161 SYLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 246-667 1.85e-68

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 243.04  E-value: 1.85e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  246 KSLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRD 325
Cdd:PRK09776   659 RQLSYSASHDALTHLANRASFEKQLRRLLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSD 738

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  326 TLARNGGDEFVIVLDRMeNTDDAIHVAKKVINSLTE---TFEIQAHKihIGASVGISIYPTDGKTSSILIRNADTAMYKA 402
Cdd:PRK09776   739 VLARLGGDEFGLLLPDC-NVESARFIATRIISAINDyhfPWEGRVYR--VGASAGITLIDANNHQASEVMSQADIACYAA 815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  403 KKSGGNQLQFYNESMSNQLRDR--LVLENELHSALEKDEFyLMYQPQVNCLTGETTGF-EILLR-WsnTTYGE-IGPDRF 477
Cdd:PRK09776   816 KNAGRGRVTVYEPQQAAAHSEHraLSLAEQWRMIKENQLM-MLAHGVASPRIPEARNHwLISLRlW--DPEGEiIDEGAF 892

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  478 VPLLEETGLIYATGDWVVTQV-IDFIRTQPANHVTYSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLIND 556
Cdd:PRK09776   893 RPAAEDPALMHALDRRVIHEFfRQAAKAVASKGLSIALPLSVAGLSSPTLLPFLLEQLENSPLPPRLLHLEITETALLNH 972

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  557 FEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARLPIDVIKIDKSLVRNIneHKNL--KSIVKAIVTMSESLGMTNIFE 634
Cdd:PRK09776   973 AESASRLVQKLRLAGCRVVLSDFGRGLSSFNYLKAFMADYLKLDGELVANL--HGNLmdEMLISIIQGHAQRLGMKTIAG 1050

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1490347179  635 GVETKEELAVIQSMKGNIIQGYLFSKPiMPDDI 667
Cdd:PRK09776  1051 PVELPLVLDTLSGIGVDLAYGYAIARP-QPLDL 1082
PRK13561 PRK13561
putative diguanylate cyclase; Provisional
 242-674 9.74e-68

putative diguanylate cyclase; Provisional


Pssm-ID: 184143 [Multi-domain]  Cd Length: 651  Bit Score: 234.22  E-value: 9.74e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 242 EQAEKSLHYlayhdELTGLPNKNLLVDRINQSIktssRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKIL 321
Cdd:PRK13561  226 EQSRNATRF-----PVSDLPNKALLMALLEQVV----ARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVL 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 322 RSRDTLARNGGDEFVIVLDRMENTDDAIHVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDgKTSSILIRNADTAMYK 401
Cdd:PRK13561  297 SPRMVLAQISGYDFAIIANGVKEPWHAITLGQQVLTIINERLPIQRIQLRPSCSIGIAMFYGD-LTAEQLYSRAISAAFT 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 402 AKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLL 481
Cdd:PRK13561  376 ARRKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPEGLIDRI 455

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 482 EETGLIYATGDWVVTQVIDFIRTQPANHVT--YSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEK 559
Cdd:PRK13561  456 ESCGLMVTVGHWVLEESCRLLAAWQERGIMlpLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHA 535

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 560 THDFLSELHSLGCSIALDDFGTGYTSMSYLAR---LPIDVIKIDKSLVRNINEHknlKSIVKAIVTMSESLGMTNIFEGV 636
Cdd:PRK13561  536 AVAILRPLRNAGVRVALDDFGMGYAGLRQLQHmksLPIDVLKIDKMFVDGLPED---DSMVAAIIMLAQSLNLQVIAEGV 612

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1490347179 637 ETKEELAVIQSMKGNIIQGYLFSKPIMPDDI-DHWLSLA 674
Cdd:PRK13561  613 ETEAQRDWLLKAGVGIAQGFLFARALPIEIFeERYLEEK 651
YjcC COG4943
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ...
 421-671 9.54e-66

Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];


Pssm-ID: 443970 [Multi-domain]  Cd Length: 528  Bit Score: 225.95  E-value: 9.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 421 LRDRLVLENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVI- 499
Cdd:COG4943   266 LRRRLSPRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWRDPDGSVISPDIFIPLAEQSGLISPLTRQVIEQVFr 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 500 ---DFIRTQPANHVtySINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLInDFEKTHDFLSELHSLGCSIAL 576
Cdd:COG4943   346 dlgDLLAADPDFHI--SINLSASDLLSPRFLDDLERLLARTGVAPQQIVLEITERGFI-DPAKARAVIAALREAGHRIAI 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 577 DDFGTGYTSMSYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGY 656
Cdd:COG4943   423 DDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMAKTLNLDVVAEGVETEEQADYLRARGVQYGQGW 502

                         250
                  ....*....|....*
gi 1490347179 657 LFSKPIMPDDIDHWL 671
Cdd:COG4943   503 LFAKPLPAEEFIAWL 517
PRK11829 PRK11829
biofilm formation regulator HmsP; Provisional
 242-662 5.49e-65

biofilm formation regulator HmsP; Provisional


Pssm-ID: 183329 [Multi-domain]  Cd Length: 660  Bit Score: 227.13  E-value: 5.49e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 242 EQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKiAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKIL 321
Cdd:PRK11829  222 ADAYADMGRISHRFPVTELPNRSLFISLLEKEIASSTRTDHF-HLLVIGIETLQEVSGAMSEAQHQQLLLTIVQRIEQCI 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 322 RSRDTLARNGGDEFVIVLDRMENTDDAIHVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNADTAMYK 401
Cdd:PRK11829  301 DDSDLLAQLSKTEFAVLARGTRRSFPAMQLARRIMSQVTQPLFFDEITLRPSASIGITRYQAQQDTAESMMRNASTAMMA 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 402 AKKSGGNQLQFYNESMSNQLRDRLVLENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLL 481
Cdd:PRK11829  381 AHHEGRNQIMVFEPHLIEKTHKRLTQENDLLQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGFVHFA 460

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 482 EETGLIYATGDWVVTQVIDFIRTQPANHVT--YSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEK 559
Cdd:PRK11829  461 EEEGMMVPLGNWVLEEACRILADWKARGVSlpLSVNISGLQVQNKQFLPHLKTLISHYHIDPQQLLLEITETAQIQDLDE 540

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 560 THDFLSELHSLGCSIALDDFGTGYTSMSYL---ARLPIDVIKIDKSLVRNINEHKNLKSIVKAIvtmSESLGMTNIFEGV 636
Cdd:PRK11829  541 ALRLLRELQGLGLLIALDDFGIGYSSLRYLnhlKSLPIHMIKLDKSFVKNLPEDDAIARIISCV---SDVLKVRVMAEGV 617

                         410       420
                  ....*....|....*....|....*.
gi 1490347179 637 ETKEELAVIQSMKGNIIQGYLFSKPI 662
Cdd:PRK11829  618 ETEEQRQWLLEHGIQCGQGFLFSPPL 643
GGDEF COG2199
GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants ...
 238-413 3.81e-59

GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms];


Pssm-ID: 441801 [Multi-domain]  Cd Length: 275  Bit Score: 200.59  E-value: 3.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 238 IDKKEQAEKSLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARL 317
Cdd:COG2199   100 ITELRRLEERLRRLATHDPLTGLPNRRAFEERLERELARARREGRPLALLLIDLDHFKRINDTYGHAAGDEVLKEVARRL 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 318 HKILRSRDTLARNGGDEFVIVLDRMeNTDDAIHVAKKVINSLTET-FEIQAHKIHIGASVGISIYPTDGKTSSILIRNAD 396
Cdd:COG2199   180 RASLRESDLVARLGGDEFAVLLPGT-DLEEAEALAERLREALEQLpFELEGKELRVTVSIGVALYPEDGDSAEELLRRAD 258

                         170
                  ....*....|....*..
gi 1490347179 397 TAMYKAKKSGGNQLQFY 413
Cdd:COG2199   259 LALYRAKRAGRNRVVVY 275
GGDEF cd01949
Diguanylate-cyclase (DGC) or GGDEF domain; Diguanylate-cyclase (DGC) or GGDEF domain: ...
 253-411 5.51e-59

Diguanylate-cyclase (DGC) or GGDEF domain; Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.


Pssm-ID: 143635 [Multi-domain]  Cd Length: 158  Bit Score: 195.85  E-value: 5.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 253 YHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGG 332
Cdd:cd01949     1 YTDPLTGLPNRRAFEERLERLLARARRSGRPLALLLIDIDHFKQINDTYGHAAGDEVLKEVAERLRSSLRESDLVARLGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490347179 333 DEFVIVLDRMeNTDDAIHVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNADTAMYKAKKSGGNQLQ 411
Cdd:cd01949    81 DEFAILLPGT-DLEEAEALAERLREAIEEPFFIDGQEIRVTASIGIATYPEDGEDAEELLRRADEALYRAKRSGRNRVV 158
GGDEF pfam00990
Diguanylate cyclase, GGDEF domain; This domain is found linked to a wide range of ...
 252-409 9.13e-53

Diguanylate cyclase, GGDEF domain; This domain is found linked to a wide range of non-homologous domains in a variety of bacteria. It has been shown to be homologous to the adenylyl cyclase catalytic domain and has diguanylate cyclase activity. This observation correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. In the WspR protein of Pseudomonas aeruginosa, the GGDEF domain acts as a diguanylate cyclase, PDB:3bre, when the whole molecule appears to form a tetramer consisting of two symmetrically-related dimers representing a biological unit. The active site is the GGD/EF motif, buried in the structure, and the cyclic dimeric guanosine monophosphate (c-di-GMP) bind to the inhibitory-motif RxxD on the surface. The enzyme thus catalyzes the cyclization of two guanosine triphosphate (GTP) molecules to one c-di-GMP molecule.


Pssm-ID: 425976 [Multi-domain]  Cd Length: 160  Bit Score: 178.99  E-value: 9.13e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 252 AYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARNG 331
Cdd:pfam00990   1 AAHDPLTGLPNRRYFEEQLEQELQRALREGSPVAVLLIDLDNFKRINDTYGHSVGDEVLQEVAQRLSSSLRRSDLVARLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 332 GDEFVIVLDR--MENTDDAIHVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNADTAMYKAKKSGGNQ 409
Cdd:pfam00990  81 GDEFAILLPEtsLEGAQELAERIRRLLAKLKIPHTVSGLPLYVTISIGIAAYPNDGEDPEDLLKRADTALYQAKQAGRNR 160
GGDEF smart00267
diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria.
 250-413 1.05e-50

diguanylate cyclase; Diguanylate cyclase, present in a variety of bacteria.


Pssm-ID: 128563 [Multi-domain]  Cd Length: 163  Bit Score: 173.59  E-value: 1.05e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  250 YLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLAR 329
Cdd:smart00267   1 RLAFRDPLTGLPNRRYFEEELEQELQRAQRQGSPFALLLIDLDNFKDINDTYGHAVGDELLQEVAQRLSSCLRPGDLLAR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179  330 NGGDEFVIVLDRmENTDDAIHVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNADTAMYKAKKSGGNQ 409
Cdd:smart00267  81 LGGDEFALLLPE-TSLEEAIALAERILQQLREPIIIHGIPLYLTISIGVAAYPNPGEDAEDLLKRADTALYQAKKAGRNQ 159


                   ....
gi 1490347179  410 LQFY 413
Cdd:smart00267 160 VAVY 163
GGDEF TIGR00254
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by ...
 251-408 1.16e-40

diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other]


Pssm-ID: 272984 [Multi-domain]  Cd Length: 165  Bit Score: 145.94  E-value: 1.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 251 LAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARN 330
Cdd:TIGR00254   1 QAVRDPLTGLYNRRYLEEMLDSELKRARRFQRSFSVLMIDIDNFKKINDTLGHDVGDEVLREVARILQSSVRGSDVVGRY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 331 GGDEFVIVLDRmENTDDAIHVA---KKVINSLTETFEIQAhKIHIGASVGISIYPTDGKTSSILIRNADTAMYKAKKSGG 407
Cdd:TIGR00254  81 GGEEFVVILPG-TPLEDALSKAerlRDAINSKPIEVAGSE-TLTVTVSIGVACYPGHGLTLEELLKRADEALYQAKKAGR 158


                  .
gi 1490347179 408 N 408
Cdd:TIGR00254 159 N 159
PRK10551 PRK10551
cyclic di-GMP phosphodiesterase;
421-672 1.11e-35

cyclic di-GMP phosphodiesterase;


Pssm-ID: 182541 [Multi-domain]  Cd Length: 518  Bit Score: 141.67  E-value: 1.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 421 LRDRLVLENELHSALEKDEFYLMYQPQVNCLTGETTGFEILLRWSNTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVID 500
Cdd:PRK10551  258 LSLRMRPGKEILTGIKRGQFYVEYQPVVDTQTLRVTGLEALLRWRHPTAGEIPPDAFINYAEAQKLIVPLTQHLFELIAR 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 501 ----FIRTQPANhVTYSINLSVLQFNNYKFIDFVRNEIDKAGIDPAQIEFEITESLLINDFEKTHDFlSELHSLGCSIAL 576
Cdd:PRK10551  338 daaeLQKVLPVG-AKLGINISPAHLHSDSFKADVQRLLASLPADHFQIVLEITERDMVQEEEATKLF-AWLHSQGIEIAI 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 577 DDFGTGYTSMSYLARLPIDVIKIDKSLVRNINEHKNLKSIVKAIVTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGY 656
Cdd:PRK10551  416 DDFGTGHSALIYLERFTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRLNMLTVAEGVETPEQARWLRERGVNFLQGY 495

                         250
                  ....*....|....*.
gi 1490347179 657 LFSKPIMPDDIDHWLS 672
Cdd:PRK10551  496 WISRPLPLEDFVRWLK 511
pleD PRK09581
response regulator PleD; Reviewed
 251-409 7.50e-28

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 117.31  E-value: 7.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 251 LAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARN 330
Cdd:PRK09581  291 MAVTDGLTGLHNRRYFDMHLKNLIERANERGKPLSLMMIDIDHFKKVNDTYGHDAGDEVLREFAKRLRNNIRGTDLIARY 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 331 GGDEFVIVldrMENTD--DAIHVA---KKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNADTAMYKAKKS 405
Cdd:PRK09581  371 GGEEFVVV---MPDTDieDAIAVAeriRRKIAEEPFIISDGKERLNVTVSIGVAELRPSGDTIEALIKRADKALYEAKNT 447


                  ....
gi 1490347179 406 GGNQ 409
Cdd:PRK09581  448 GRNR 451
PRK09894 PRK09894
diguanylate cyclase; Provisional
 255-416 8.85e-27

diguanylate cyclase; Provisional


Pssm-ID: 182133 [Multi-domain]  Cd Length: 296  Bit Score: 110.93  E-value: 8.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 255 DELTGLPNKNLLVDRINQSIKtsSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGGDE 334
Cdd:PRK09894  132 DVLTGLPGRRVLDESFDHQLR--NREPQNLYLALLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGEE 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 335 FVIVLDRmeNTDDAIHVAKKVINSLTETFEIQA--HKIHIGASVGISIYpTDGKTSSILIRNADTAMYKAKKSGGNQLQF 412
Cdd:PRK09894  210 FIICLKA--ATDEEACRAGERIRQLIANHAITHsdGRINITATFGVSRA-FPEETLDVVIGRADRAMYEGKQTGRNRVMF 286


                  ....
gi 1490347179 413 YNES 416
Cdd:PRK09894  287 IDEQ 290
PRK15426 PRK15426
cellulose biosynthesis regulator YedQ;
247-409 5.16e-23

cellulose biosynthesis regulator YedQ;


Pssm-ID: 237964 [Multi-domain]  Cd Length: 570  Bit Score: 103.56  E-value: 5.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 247 SLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSRDT 326
Cdd:PRK15426  393 SLQWQAWHDPLTRLYNRGALFEKARALAKRCQRDQQPFSVIQLDLDHFKSINDRFGHQAGDRVLSHAAGLISSSLRAQDV 472

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 327 LARNGGDEFVIVLDRMeNTDDAIHVAKKVINSLTETfEIQAHK---IHIGASVGISIYPTDGK-TSSILIRNADTAMYKA 402
Cdd:PRK15426  473 AGRVGGEEFCVVLPGA-SLAEAAQVAERIRLRINEK-EILVAKsttIRISASLGVSSAEEDGDyDFEQLQSLADRRLYLA 550


                  ....*..
gi 1490347179 403 KKSGGNQ 409
Cdd:PRK15426  551 KQAGRNR 557
PRK11059 PRK11059
regulatory protein CsrD; Provisional
 252-662 1.43e-19

regulatory protein CsrD; Provisional


Pssm-ID: 236833 [Multi-domain]  Cd Length: 640  Bit Score: 93.00  E-value: 1.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 252 AYHDELTGLPNKnLLVDriNQsIKTSSRDNQKIA----ILFLDLDRFKTINDSLGHTIGDILIKKASARLHKIL-RSRDT 326
Cdd:PRK11059  228 AFQDAKTGLGNR-LFFD--NQ-LATLLEDQEMVGahgvVMLIRLPDFDLLQEEWGESQVEELLFELINLLSTFVmRYPGA 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 327 -LARNGGDEFVIVLDRMeNTDDAIHVAKKVINSL----------TETFeiqahkIHIGASvgisiYPTDGKTSSILIRNA 395
Cdd:PRK11059  304 lLARYSRSDFAVLLPHR-SLKEADSLASQLLKAVdalpppkmldRDDF------LHIGIC-----AYRSGQSTEQVMEEA 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 396 DTAMYKAKKSGGNqlqfyNESMSNQLRD----------RLVLENelhsALEKDEFYLMYQPQVNCLtGETTGFEILLRWS 465
Cdd:PRK11059  372 EMALRSAQLQGGN-----GWFVYDKAQLpekgrgsvrwRTLLEQ----TLVRGGPRLYQQPAVTRD-GKVHHRELFCRIR 441

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 466 NTTYGEIGPDRFVPLLEETGLIYATGDWVVTQVIDFIRTQPanHVTYSINLSVLQFNNYKFIDFVRNEI---DKAgiDPA 542
Cdd:PRK11059  442 DGQGELLSAELFMPMVQQLGLSEQYDRQVIERVLPLLRYWP--EENLSINLSVDSLLSRAFQRWLRDTLlqcPRS--QRK 517

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 543 QIEFEITESLLINDFEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARLPIDVIKIDKSLVRNINE-HKN---LKSIVk 618
Cdd:PRK11059  518 RLIFELAEADVCQHISRLRPVLRMLRGLGCRLAVDQAGLTVVSTSYIKELNVELIKLHPSLVRNIHKrTENqlfVRSLV- 596

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490347179 619 aivtmsESLGMTN---IFEGVETKEELaviQSMKGNII---QGYLFSKPI 662
Cdd:PRK11059  597 ------GACAGTEtqvFATGVESREEW---QTLQELGVsggQGDFFAESQ 637
PRK09966 PRK09966
diguanylate cyclase DgcN;
221-403 4.39e-16

diguanylate cyclase DgcN;


Pssm-ID: 182171 [Multi-domain]  Cd Length: 407  Bit Score: 80.82  E-value: 4.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 221 NERTKELVDMNSHLESVIDKKE------QAEKS-LHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKiAILFLDLDR 293
Cdd:PRK09966  210 EERIAEFHRFALDFNSLLDEMEewqlrlQAKNAqLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTS-ALLFLDGDN 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 294 FKTINDSLGHTIGDILIKKASARLHKILRSRDTLARNGGDEFVIVLDRMENTDDAIHVAKKVINSLTETFEIQ-AHKIHI 372
Cdd:PRK09966  289 FKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHnGHQTTM 368

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1490347179 373 GASVGISIyPTDGKTSSILIRNADTAMYKAK 403
Cdd:PRK09966  369 TLSIGYAM-TIEHASAEKLQELADHNMYQAK 398
adrA PRK10245
diguanylate cyclase AdrA; Provisional
 245-409 1.04e-15

diguanylate cyclase AdrA; Provisional


Pssm-ID: 182329 [Multi-domain]  Cd Length: 366  Bit Score: 79.49  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 245 EKSLHYLAYHDELTGLPNKNLLVDRINQSIKTSSRDNQKIAILFLDLDRFKTINDSLGHTIGDILIKKASARLHKILRSR 324
Cdd:PRK10245  198 KRRLQVMSTRDGMTGVYNRRHWETLLRNEFDNCRRHHRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGS 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 325 DTLARNGGDEFVIVldrMENT--DDAIHVAKKVINSLTETFEIQAHKIHIGASVGISIYPTDGKTSSILIRNADTAMYKA 402
Cdd:PRK10245  278 DVIGRFGGDEFAVI---MSGTpaESAITAMSRVHEGLNTLRLPNAPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKA 354


                  ....*..
gi 1490347179 403 KKSGGNQ 409
Cdd:PRK10245  355 KNAGRNR 361
PRK11596 PRK11596
cyclic-di-GMP phosphodiesterase; Provisional
 544-661 3.47e-08

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183222 [Multi-domain]  Cd Length: 255  Bit Score: 55.01  E-value: 3.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 544 IEFEITESLLINDFEKTHDfLSELHSLGcsiaLDDFGTGYTSMSYLARLPIDVIKIDKSL---VRNINEHKNLKSivkAI 620
Cdd:PRK11596  130 LRFELVEHIRLPKDSPFAS-MCEFGPLW----LDDFGTGMANFSALSEVRYDYIKVARELfimLRQSEEGRNLFS---QL 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1490347179 621 VTMSESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKP 661
Cdd:PRK11596  202 LHLMNRYCRGVIVEGVETPEEWRDVQRSPAFAAQGYFLSRP 242
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 319-403 5.05e-08

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 53.37  E-value: 5.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 319 KILRSR-DTLARNGGDEFVIVLDRMeNTDDAIHVAKKVINSLTETFEiqahkIHIGASVGISIyptdgktsSILIRNADt 397
Cdd:COG3706   109 EELLARvDLVARYGGEEFAILLPGT-DLEGALAVAERIREAVAELPS-----LRVTVSIGVAG--------DSLLKRAD- 173


                  ....*.
gi 1490347179 398 AMYKAK 403
Cdd:COG3706   174 ALYQAR 179
YuxH COG3434
c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction ...
 438-663 1.04e-07

c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction mechanisms];


Pssm-ID: 442660 [Multi-domain]  Cd Length: 407  Bit Score: 54.81  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 438 DEFYLMYQPQVNcLTGETTGFEILLRWSNT-TYGEIGPDRfvplleetgliyATGDWVVTQVIDfirtqpanhvtysINL 516
Cdd:COG3434     2 MDVFVARQPILD-RDQRVVGYELLFRSGLEnSAPDVDGDQ------------ATARVLLNAFLE-------------IGL 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 517 SVLQFNNYKFIDFVRNEIDK---AGIDPAQIEFEITESLLINdfEKTHDFLSELHSLGCSIALDDFGTGYTSMSYLARlp 593
Cdd:COG3434    56 DRLLGGKLAFINFTEELLLSdlpELLPPERVVLEILEDVEPD--EELLEALKELKEKGYRIALDDFVLDPEWDPLLPL-- 131

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 594 IDVIKIDkslVRNINEHKnLKSIVKAIvtmsESLGMTNIFEGVETKEELAVIQSMKGNIIQGYLFSKPIM 663
Cdd:COG3434   132 ADIIKID---VLALDLEE-LAELVARL----KRYGIKLLAEKVETREEFELCKELGFDLFQGYFFSKPEI 193
Nucleotidyl_cyc_III cd07556
Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse ...
 284-379 2.54e-06

Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.


Pssm-ID: 143637 [Multi-domain]  Cd Length: 133  Bit Score: 47.35  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490347179 284 IAILFLDLDRFKTINDSLGHTIGDILIKKASARL-HKILRSRDTLARNGGDEFVIVLDRMEnTDDAIHVAKKVINSLTet 362
Cdd:cd07556     2 VTILFADIVGFTSLADALGPDEGDELLNELAGRFdSLIRRSGDLKIKTIGDEFMVVSGLDH-PAAAVAFAEDMREAVS-- 78

                          90
                  ....*....|....*...
gi 1490347179 363 fEIQAHKI-HIGASVGIS 379
Cdd:cd07556    79 -ALNQSEGnPVRVRIGIH 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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