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Conserved domains on  [gi|1490012194|gb|AYJ71643|]
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thyroglobulin, partial [Sylvilagus brasiliensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TY super family cl00150
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 4-50 3.87e-06

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


The actual alignment was detected with superfamily member pfam00086:

Pssm-ID: 469630  Cd Length: 66  Bit Score: 39.59  E-value: 3.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 1490012194  4 CQLQAERAflga*qalLANSSTSAPLSSIHVPQCRADGEWSRVQCDG 50
Cdd:pfam00086  1 CERERARA--------LEQAASGRPASGLYIPNCDEDGFYKPVQCHG 39
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 4-50 3.87e-06

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 39.59  E-value: 3.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 1490012194  4 CQLQAERAflga*qalLANSSTSAPLSSIHVPQCRADGEWSRVQCDG 50
Cdd:pfam00086  1 CERERARA--------LEQAASGRPASGLYIPNCDEDGFYKPVQCHG 39
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 3-50 4.60e-06

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 39.37  E-value: 4.60e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1490012194  3 PCQLQAERAFlga*qallaNSSTSAPLSSIHVPQCRADGEWSRVQCDG 50
Cdd:cd00191    1 PCERERASAL---------ESLAGPKLSGLYVPQCDEDGNYEPVQCHG 39
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 4-50 3.87e-06

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 39.59  E-value: 3.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 1490012194  4 CQLQAERAflga*qalLANSSTSAPLSSIHVPQCRADGEWSRVQCDG 50
Cdd:pfam00086  1 CERERARA--------LEQAASGRPASGLYIPNCDEDGFYKPVQCHG 39
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 3-50 4.60e-06

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 39.37  E-value: 4.60e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1490012194  3 PCQLQAERAFlga*qallaNSSTSAPLSSIHVPQCRADGEWSRVQCDG 50
Cdd:cd00191    1 PCERERASAL---------ESLAGPKLSGLYVPQCDEDGNYEPVQCHG 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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