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Conserved domains on  [gi|148922178|gb|AAI46760|]
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Slit homolog 3 (Drosophila) [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1188-1314 1.38e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.38e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  1188 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1265
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 148922178  1266 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1314
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-217 1.37e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 1.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   62 NAERLDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 141
Cdd:COG4886   114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  142 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 217
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
588-900 1.87e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.87e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  588 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 667
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  668 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 747
Cdd:COG4886   144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  748 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 824
Cdd:COG4886   176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  825 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
Cdd:COG4886   252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
326-666 2.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 2.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  326 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 405
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  406 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 485
Cdd:COG4886   162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  486 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 563
Cdd:COG4886   208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  564 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITT 643
Cdd:COG4886   257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         330       340
                  ....*....|....*....|...
gi 148922178  644 ITPGAFTTLVSLSTINLLSNPFN 666
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLN 357
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1074-1110 1.57e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.57e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148922178 1074 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1031 5.30e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 148922178  998 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 1031
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 956-994 3.56e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148922178  956 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 994
Cdd:cd00054     2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1123-1153 3.58e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.58e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148922178  1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1035-1072 4.37e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148922178 1035 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
Cdd:cd00054     2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 7.87e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.87e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 148922178     33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-250 9.99e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 9.99e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178   188 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 250
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1466-1521 3.47e-04

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 40.85  E-value: 3.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178   1466 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1521
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
LRRNT smart00013
Leucine rich repeat N-terminal domain;
280-311 1.40e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.40e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 148922178    280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 311
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1372-1400 3.03e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.03e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 148922178  1372 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1400
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1188-1314 1.38e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.38e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  1188 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1265
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 148922178  1266 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1314
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1181-1314 3.61e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.61e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   1181 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 1257
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 148922178   1258 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 1314
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1159-1312 3.77e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 3.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178 1159 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1234
Cdd:cd00110     1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148922178 1235 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 1312
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-217 1.37e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 1.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   62 NAERLDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 141
Cdd:COG4886   114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  142 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 217
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
588-900 1.87e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.87e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  588 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 667
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  668 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 747
Cdd:COG4886   144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  748 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 824
Cdd:COG4886   176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  825 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
Cdd:COG4886   252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
326-666 2.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 2.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  326 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 405
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  406 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 485
Cdd:COG4886   162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  486 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 563
Cdd:COG4886   208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  564 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITT 643
Cdd:COG4886   257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         330       340
                  ....*....|....*....|...
gi 148922178  644 ITPGAFTTLVSLSTINLLSNPFN 666
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLN 357
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-217 1.24e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 1.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   61 RNAERLDLDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQS------TPK 134
Cdd:cd21340    46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPrslaalSNS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  135 LTRLDLSenqiqgiprkafrgitdvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRL 212
Cdd:cd21340   122 LRVLNIS------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDL 175


                  ....*
gi 148922178  213 HSNHL 217
Cdd:cd21340   176 TGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
775-835 1.15e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 1.15e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178   775 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 835
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
557-617 7.09e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 7.09e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178   557 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI 617
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
159-217 4.07e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.07e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178   159 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 636-714 2.16e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 69.34  E-value: 2.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   636 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 712
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 148922178   713 GN 714
Cdd:TIGR00864   82 EE 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 734-860 1.64e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  734 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 812
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  813 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 859
Cdd:cd21340    82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                  .
gi 148922178  860 H 860
Cdd:cd21340   155 S 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
522-790 3.40e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  522 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 596
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  597 HGRVfrgLSGLKTLMLRSNLIGCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 676
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  677 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 756
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 148922178  757 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 790
Cdd:PRK15370  372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1074-1110 1.57e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.57e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148922178 1074 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
857-906 4.16e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 4.16e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 148922178    857 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 906
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
255-536 1.13e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  255 DVQKKEYVCPAPHSEPPScNANSISCPSPCTCSNNIVDCRGK-GLMEIPANLPEGIVEIRLEQNSIKAIPAGAftqYKKL 333
Cdd:PRK15370  147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  334 KRIDISKNQISDIA---PDAFQGLKsltslvLYGNKITEIAKGLfdgLVSLQLLLLNANKINCLRVNTFQDLQNlnlLSL 410
Cdd:PRK15370  223 KTLYANSNQLTSIPatlPDTIQEME------LSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRY---LSV 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  411 YDNKLQTISKGLfaPlQSIQTLHLAQN-----PFVCDCHLKWL-ADylqDNPIETSGArcSSPRRLANKRISQ----IKS 480
Cdd:PRK15370  291 YDNSIRTLPAHL--P-SGITHLNVQSNsltalPETLPPGLKTLeAG---ENALTSLPA--SLPPELQVLDVSKnqitVLP 362

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  481 KKFRCSGSEDYRSRfssECFMDLvcPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD 536
Cdd:PRK15370  363 ETLPPTITTLDVSR---NALTNL--PENLPAALQIMQASRNNLVRLPESLPHFRGE 413
EGF_CA smart00179
Calcium-binding EGF-like domain;
1074-1110 2.60e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.60e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148922178   1074 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 1110
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
52-217 2.76e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   52 LRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHledNQVSVIERGAFQDLKQLERLRlnkNKLQVLPELLFQS 131
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFH---NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  132 tpkLTRLDLSENQIQGIPRKAFRGItdvKNLQLDNNHISCIEDGAFRALRDLEIltlNNNnisRILVTSFNHMPKIRTLR 211
Cdd:PRK15370  306 ---ITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSLPASLPPELQVLDV---SKN---QITVLPETLPPTITTLD 373


                  ....*.
gi 148922178  212 LHSNHL 217
Cdd:PRK15370  374 VSRNAL 379
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1031 5.30e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 148922178  998 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 1031
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 410-473 2.22e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.22e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148922178   410 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 473
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1000-1029 3.21e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 148922178  1000 CEDNDCENNATCVDGINNYVCICPPNYTGE 1029
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 956-994 3.56e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148922178  956 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 994
Cdd:cd00054     2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1123-1153 3.58e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.58e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148922178  1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1078-1108 3.91e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.91e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148922178  1078 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1108
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1035-1072 4.37e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148922178 1035 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
Cdd:cd00054     2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 7.87e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.87e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 148922178     33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 8.23e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 8.23e-05
                           10        20
                   ....*....|....*....|....*...
gi 148922178    33 ACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-250 9.99e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 9.99e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178   188 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 250
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1027 1.79e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.79e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 148922178    998 DDCE-DNDCENNATCVDGINNYVCICPPNYT 1027
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-374 3.37e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSvieRGAFQDL-KQ--LERLRLNKNKLQ-VLPELLFQSTpKLT 136
Cdd:PLN00113  308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS---GEIPKNLgKHnnLTVLDLSTNNLTgEIPEGLCSSG-NLF 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  137 RLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNH 216
Cdd:PLN00113  384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  217 LYCDchlawLSDWLRQRRtvgqftlcmapvhLRGFNVADvqkkeyvcpaphseppscnaNSISCPSPctcsnnivdcrgK 296
Cdd:PLN00113  464 FFGG-----LPDSFGSKR-------------LENLDLSR--------------------NQFSGAVP------------R 493

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178  297 GLMeipaNLPEgIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-EIAKGL 374
Cdd:PLN00113  494 KLG----SLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1466-1521 3.47e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.85  E-value: 3.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178   1466 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1521
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
LRRCT smart00082
Leucine rich repeat C-terminal domain;
437-467 6.66e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 6.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 148922178    437 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 467
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1035-1072 7.10e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 7.10e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148922178   1035 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 1072
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
280-311 1.40e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.40e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 148922178    280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 311
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 280-306 1.71e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.71e-03
                           10        20
                   ....*....|....*....|....*..
gi 148922178   280 CPSPCTCSNNIVDCRGKGLMEIPANLP 306
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1372-1400 3.03e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.03e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 148922178  1372 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1400
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 959-992 3.62e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.62e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 148922178   959 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 992
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
962-994 4.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 148922178    962 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 994
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
133-155 6.24e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.24e-03
                            10        20
                    ....*....|....*....|...
gi 148922178    133 PKLTRLDLSENQIQGIPRKAFRG 155
Cdd:smart00369    2 PNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1188-1314 1.38e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.38e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  1188 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1265
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 148922178  1266 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1314
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1181-1314 3.61e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.61e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   1181 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 1257
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 148922178   1258 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 1314
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1159-1312 3.77e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 3.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178 1159 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1234
Cdd:cd00110     1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148922178 1235 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 1312
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-217 1.37e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 1.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   62 NAERLDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 141
Cdd:COG4886   114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  142 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 217
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-455 3.67e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 3.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQvsviergAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDL 140
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  141 SENQIQGIPrKAFRGITDVKNLQLDNNHISCIeDGAFRALRDLEILTLNNNNISRILvTSFNHMPKIRTLRLHSNHLYcd 220
Cdd:COG4886   144 SNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLT-- 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  221 chlawlsdwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpaphseppscnansiscpspctcsnnivdcrgkglmE 300
Cdd:COG4886   219 -------------------------------------------------------------------------------D 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  301 IPANLPE--GIVEIRLEQNSIKAIPagAFTQYKKLKRIDISKNQISDIAPDAfqGLKSLTSLVLYGNKITEIA-KGLFDG 377
Cdd:COG4886   220 LPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELELL 295

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148922178  378 LVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN 455
Cdd:COG4886   296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-450 9.10e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 9.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   62 NAERLDLDRNNitritkmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 141
Cdd:COG4886    97 NLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  142 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRiLVTSFNHMPKIRTLRLHSNHLYcdc 221
Cdd:COG4886   168 NNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLT--- 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  222 HLAWLsdwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpaphseppscnansiscpspctcsnnivdcrgkglmei 301
Cdd:COG4886   242 DLPEL--------------------------------------------------------------------------- 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  302 pANLPEgIVEIRLEQNSIKAIPAGAftQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAkgLFDGLVSL 381
Cdd:COG4886   247 -GNLTN-LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178  382 QLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLAD 450
Cdd:COG4886   321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
588-900 1.87e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.87e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  588 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 667
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  668 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 747
Cdd:COG4886   144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  748 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 824
Cdd:COG4886   176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  825 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
Cdd:COG4886   252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-837 2.03e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 2.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  535 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKikevregAFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRS 614
Cdd:COG4886    74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  615 NLIGCVSnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 694
Cdd:COG4886   146 NQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ------------------------------ 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  695 fLKEIPiqdvaiqdftcdgneessCQLSprcpeqctcmetvvrcsnkGLRALprgmpkdvTELYLEGNHLTAVPRELSAL 774
Cdd:COG4886   194 -ITDLP------------------EPLG-------------------NLTNL--------EELDLSGNQLTDLPEPLANL 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148922178  775 RHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIPVHAfnGLRSLRVLTLHGNDISS 837
Cdd:COG4886   228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
633-859 1.47e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 1.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  633 LLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQkpfFLKEIPIQDVAIQDFTCD 712
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDL---LLSSLLLLLSLLLLLLLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  713 GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALprgmpKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTN 792
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148922178  793 yTFSNMSHLSTLILSYNRLRCIPvHAFNGLRSLRVLTLHGNDISSVPEgSFNDLTSLSHLALGTNPL 859
Cdd:COG4886   154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
326-666 2.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 2.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  326 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 405
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  406 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 485
Cdd:COG4886   162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  486 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 563
Cdd:COG4886   208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  564 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITT 643
Cdd:COG4886   257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         330       340
                  ....*....|....*....|...
gi 148922178  644 ITPGAFTTLVSLSTINLLSNPFN 666
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-459 3.13e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 3.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  290 IVDCRGKGLMEIPANLPE--GIVEIRLEQNSIKAIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 367
Cdd:COG4886   117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  368 TEIAKGLfdglvslqllllnankinclrvntfQDLQNLNLLSLYDNKLQTISKGLfAPLQSIQTLHLAQN-----PFVCD 442
Cdd:COG4886   195 TDLPEPL-------------------------GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                         170
                  ....*....|....*...
gi 148922178  443 C-HLKWLadYLQDNPIET 459
Cdd:COG4886   249 LtNLEEL--DLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-482 4.04e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 4.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  107 DLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENqiqgiprKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEIL 186
Cdd:COG4886    70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKEL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  187 TLNNNNISRIlVTSFNHMPKIRTLRLHSNhlycdchlawlsdwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpap 266
Cdd:COG4886   142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNN--------------------------------------------------- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  267 hseppscnansiscpspctcsnnivdcrgkGLMEIP---ANLPEgIVEIRLEQNSIKAIPAgAFTQYKKLKRIDISKNQI 343
Cdd:COG4886   170 ------------------------------QLTDLPeelGNLTN-LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  344 SDIaPDAFQGLKSLTSLVLYGNKITEIAKglfdglvslqllllnankinclrvntFQDLQNLNLLSLYDNKLQTISKglF 423
Cdd:COG4886   218 TDL-PEPLANLTNLETLDLSNNQLTDLPE--------------------------LGNLTNLEELDLSNNQLTDLPP--L 268

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178  424 APLQSIQTLHLAQNPFVcDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKK 482
Cdd:COG4886   269 ANLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
Laminin_G_1 pfam00054
Laminin G domain;
1186-1317 7.97e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 81.21  E-value: 7.97e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  1186 VATDKDNGILLYKGDNDP---LALELYQGHVRLVYDsLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTP--- 1259
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARptg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178  1260 -KSLGKLQKQPAVGinsPLYLGGIPTSTglSALRQGTDRPlgGFHGCIHEVRINNELQD 1317
Cdd:pfam00054   80 eSPLGATTDLDVDG---PLYVGGLPSLG--VKKRRLAISP--SFDGCIRDVIVNGKPLD 131
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-217 1.24e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 1.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   61 RNAERLDLDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQS------TPK 134
Cdd:cd21340    46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPrslaalSNS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  135 LTRLDLSenqiqgiprkafrgitdvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRL 212
Cdd:cd21340   122 LRVLNIS------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDL 175


                  ....*
gi 148922178  213 HSNHL 217
Cdd:cd21340   176 TGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
336-665 9.58e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 9.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  336 IDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 415
Cdd:COG4886    46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  416 QTISKGLfAPLQSIQTLHLAQNpfvcdchlkwladylqdnpietsgarcssprrlankRISQIKSkkfrcsgsedyrsrf 495
Cdd:COG4886   126 TDLPEEL-ANLTNLKELDLSNN------------------------------------QLTDLPE--------------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  496 ssecfmdlvcpekcrcegTIVDCSNqklvripshlpeyVTDLRLNDNEVSVLEATgiFKKLPNLRKINLSNNKIKEVREg 575
Cdd:COG4886   154 ------------------PLGNLTN-------------LKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITDLPE- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  576 AFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRSNLIGCVSNdtFAGLSSVRLLSLYDNRITTITPGAftTLVSL 655
Cdd:COG4886   200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNL 274

                         330
                  ....*....|
gi 148922178  656 STINLLSNPF 665
Cdd:COG4886   275 KTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
775-835 1.15e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 1.15e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178   775 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 835
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
557-617 7.09e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 7.09e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178   557 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI 617
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
582-641 1.22e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.08  E-value: 1.22e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   582 SVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRI 641
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
159-217 4.07e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.07e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178   159 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
61-121 4.36e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.36e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178    61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 121
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
133-193 4.67e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.67e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178   133 PKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNI 193
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
311-367 6.97e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 6.97e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 148922178   311 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 367
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
799-859 1.75e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.75e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178   799 SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-145 1.83e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.83e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178    86 NLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQI 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
605-665 1.85e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.85e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148922178   605 SGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPF 665
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-169 1.94e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.94e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   110 QLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI 169
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 636-714 2.16e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 69.34  E-value: 2.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   636 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 712
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 148922178   713 GN 714
Cdd:TIGR00864   82 EE 83
LRR_8 pfam13855
Leucine rich repeat;
534-593 2.40e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 2.40e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   534 VTDLRLNDNEVSVLEAtGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQL 593
Cdd:pfam13855    3 LRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
754-811 5.61e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 5.61e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178   754 VTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 811
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 734-860 1.64e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  734 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 812
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  813 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 859
Cdd:cd21340    82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                  .
gi 148922178  860 H 860
Cdd:cd21340   155 S 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
522-790 3.40e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  522 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 596
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  597 HGRVfrgLSGLKTLMLRSNLIGCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 676
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  677 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 756
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 148922178  757 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 790
Cdd:PRK15370  372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 830-915 4.68e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.64  E-value: 4.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   830 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQCk 906
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80


                   ....*....
gi 148922178   907 gpvDINIVA 915
Cdd:TIGR00864   81 ---DEEYVA 86
PLN03150 PLN03150
hypothetical protein; Provisional
 767-860 8.75e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.21  E-value: 8.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  767 VPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR-CIPvHAFNGLRSLRVLTLHGNDISS-VPEgsfn 844
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIP-ESLGQLTSLRILNLNGNSLSGrVPA---- 508

                          90
                  ....*....|....*.
gi 148922178  845 dltslshlALGTNPLH 860
Cdd:PLN03150  509 --------ALGGRLLH 516
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
697-859 1.13e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  697 KEIPIQDVAIQDF-TCDGNEESSCQLS--------PRCPEQCTcmeTVVrCSNKGLRALPRGMPKDVTELYLEGNHLTAV 767
Cdd:PRK15370  160 KEAANREEAVQRMrDCLKNNKTELRLKilglttipACIPEQIT---TLI-LDNNELKSLPENLQGNIKTLYANSNQLTSI 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  768 PRELSALrhLTLIDLSNNSISMLTNYTfsnMSHLSTLILSYNRLRCIPVHAFNGLRSLRVltlHGNDISSVPEgsfNDLT 847
Cdd:PRK15370  236 PATLPDT--IQEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRYLSV---YDNSIRTLPA---HLPS 304

                         170
                  ....*....|..
gi 148922178  848 SLSHLALGTNPL 859
Cdd:PRK15370  305 GITHLNVQSNSL 316
LRR_8 pfam13855
Leucine rich repeat;
332-377 2.22e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 2.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 148922178   332 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDG 377
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-203 4.93e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 4.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   52 LRAVPRGIPR--NAERLDLDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIerGAFQDLKQLERLRLNKNK-----LQVL 124
Cdd:COG4886   217 LTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQltdlkLKEL 292

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178  125 PELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNH 203
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 540-859 6.19e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 6.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  540 NDNEVSVLEATG---------IFKKLPNLRKINLSNNKIK-EVREGAFDGAASVQELMLTGNQLEtvhGRVFRG-LSGLK 608
Cdd:PLN00113   67 NSSRVVSIDLSGknisgkissAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsIPNLE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  609 TLMLRSNLI-GCVSNDtFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNC----------NCHLAWLG-- 675
Cdd:PLN00113  144 TLDLSNNMLsGEIPND-IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqiprelgqmkSLKWIYLGyn 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  676 -------------KWLRKRRIVSGNPRCQKP-----------FFLKE------IPIQDVAIQDF-TCDGNEESscqLSPR 724
Cdd:PLN00113  223 nlsgeipyeigglTSLNHLDLVYNNLTGPIPsslgnlknlqyLFLYQnklsgpIPPSIFSLQKLiSLDLSDNS---LSGE 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  725 CPE---QCTCMETVVRCSNK-------GLRALPRgmpkdVTELYLEGNHLTA-VPRELSALRHLTLIDLSNNSISMLTNY 793
Cdd:PLN00113  300 IPElviQLQNLEILHLFSNNftgkipvALTSLPR-----LQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTGEIPE 374

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  794 TFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Cdd:PLN00113  375 GLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
LRR_8 pfam13855
Leucine rich repeat;
387-439 6.34e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 6.34e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 148922178   387 NANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPF 439
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1074-1110 1.57e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.57e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148922178 1074 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1110
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
857-906 4.16e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 4.16e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 148922178    857 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 906
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
255-536 1.13e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  255 DVQKKEYVCPAPHSEPPScNANSISCPSPCTCSNNIVDCRGK-GLMEIPANLPEGIVEIRLEQNSIKAIPAGAftqYKKL 333
Cdd:PRK15370  147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  334 KRIDISKNQISDIA---PDAFQGLKsltslvLYGNKITEIAKGLfdgLVSLQLLLLNANKINCLRVNTFQDLQNlnlLSL 410
Cdd:PRK15370  223 KTLYANSNQLTSIPatlPDTIQEME------LSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRY---LSV 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  411 YDNKLQTISKGLfaPlQSIQTLHLAQN-----PFVCDCHLKWL-ADylqDNPIETSGArcSSPRRLANKRISQ----IKS 480
Cdd:PRK15370  291 YDNSIRTLPAHL--P-SGITHLNVQSNsltalPETLPPGLKTLeAG---ENALTSLPA--SLPPELQVLDVSKnqitVLP 362

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  481 KKFRCSGSEDYRSRfssECFMDLvcPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD 536
Cdd:PRK15370  363 ETLPPTITTLDVSR---NALTNL--PENLPAALQIMQASRNNLVRLPESLPHFRGE 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-220 1.45e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   49 GLGLRAVPRGIPRNA--ERLDLDRNNITRITKMDFAGL---KNLRVLHLEDNQVSV----IERGAFQDLK-QLERLRLNK 118
Cdd:cd00116    67 PRGLQSLLQGLTKGCglQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrLLAKGLKDLPpALEKLVLGR 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  119 NKLQVLP----ELLFQSTPKLTRLDLSENQI--QGIPR--KAFRGITDVKNLQLDNNHISCIED----GAFRALRDLEIL 186
Cdd:cd00116   147 NRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVL 226

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 148922178  187 TLNNNNIS----RILVTSFNHM-PKIRTLRLHSNHLYCD 220
Cdd:cd00116   227 NLGDNNLTdagaAALASALLSPnISLLTLSLSCNDITDD 265
EGF_CA smart00179
Calcium-binding EGF-like domain;
1074-1110 2.60e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.60e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148922178   1074 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 1110
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
52-217 2.76e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   52 LRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHledNQVSVIERGAFQDLKQLERLRlnkNKLQVLPELLFQS 131
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFH---NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  132 tpkLTRLDLSENQIQGIPRKAFRGItdvKNLQLDNNHISCIEDGAFRALRDLEIltlNNNnisRILVTSFNHMPKIRTLR 211
Cdd:PRK15370  306 ---ITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSLPASLPPELQVLDV---SKN---QITVLPETLPPTITTLD 373


                  ....*.
gi 148922178  212 LHSNHL 217
Cdd:PRK15370  374 VSRNAL 379
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1031 5.30e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 148922178  998 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 1031
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 755-839 1.14e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  755 TELYLE------GNHLTAVPRELSALRH-LTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIP--VHAFNGLRSL 825
Cdd:cd21340    93 EELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSL 170

                          90
                  ....*....|....
gi 148922178  826 RVLTLHGNDISSVP 839
Cdd:cd21340   171 RELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 134-666 1.74e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  134 KLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISC-IEDGAFRALRDLEILTLNNNNISRILVTSFnhMPKIRTLRL 212
Cdd:PLN00113   70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  213 HSNHLYCDCHLawlsdwlrqrrTVGQFTlcmapvhlrGFNVADVQKKEYVCPAPHSEppscnANSISCPSPCTCSNNIVD 292
Cdd:PLN00113  148 SNNMLSGEIPN-----------DIGSFS---------SLKVLDLGGNVLVGKIPNSL-----TNLTSLEFLTLASNQLVG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  293 crgkglmEIPANLPE--GIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-E 369
Cdd:PLN00113  203 -------QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  370 IAKGLFDglvslqllllnankinclrvntfqdLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCdchlkwla 449
Cdd:PLN00113  276 IPPSIFS-------------------------LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG-------- 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  450 dylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRfSSECFMDLvcpEKCRCEGTIVD--CSNQKLVR-- 525
Cdd:PLN00113  323 --------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH-NNLTVLDL---STNNLTGEIPEglCSSGNLFKli 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  526 -----IPSHLPEYVTD------LRLNDNEVSVlEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLE 594
Cdd:PLN00113  387 lfsnsLEGEIPKSLGAcrslrrVRLQDNSFSG-ELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF 465

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148922178  595 TVHGRVFRGlSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 666
Cdd:PLN00113  466 GGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 410-473 2.22e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.22e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148922178   410 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 473
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-180 2.66e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   62 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLS 141
Cdd:PLN00113  476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 148922178  142 ENQIQGIPRKAFRGITDVKNLQLDNNHI--SCIEDGAFRAL 180
Cdd:PLN00113  556 QNQLSGEIPKNLGNVESLVQVNISHNHLhgSLPSTGAFLAI 596
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1000-1029 3.21e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 148922178  1000 CEDNDCENNATCVDGINNYVCICPPNYTGE 1029
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 956-994 3.56e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148922178  956 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 994
Cdd:cd00054     2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1123-1153 3.58e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.58e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148922178  1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1078-1108 3.91e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.91e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148922178  1078 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1108
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1035-1072 4.37e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148922178 1035 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
Cdd:cd00054     2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-222 4.52e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 4.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   60 PRNAERLDLDRNNIT-----RITKMdFAGLKNLRVLHLEDNQVSviERGA------FQDLKQLERLRLNKNKLQV----- 123
Cdd:COG5238   263 NTTVETLYLSGNQIGaegaiALAKA-LQGNTTLTSLDLSVNRIG--DEGAialaegLQGNKTLHTLNLAYNGIGAqgaia 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  124 LPELLfQSTPKLTRLDLSENQIQGIPRKAF----RGITDVKNLQLDNNHISciEDGAfRALRDLeiltLNNNnisrilvt 199
Cdd:COG5238   340 LAKAL-QENTTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIG--KQGA-EALIDA----LQTN-------- 403

                         170       180
                  ....*....|....*....|...
gi 148922178  200 sfnhmpKIRTLRLHSNHLYCDCH 222
Cdd:COG5238   404 ------RLHTLILDGNLIGAEAQ 420
LRRCT smart00082
Leucine rich repeat C-terminal domain;
663-712 7.14e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 7.14e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 148922178    663 NPFNCNCHLAWLGKWLRKRRIVSG--NPRCQKPFFLKEiPIQDVAIQDFTCD 712
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 7.87e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.87e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 148922178     33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 8.23e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 8.23e-05
                           10        20
                   ....*....|....*....|....*...
gi 148922178    33 ACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-250 9.99e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 9.99e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178   188 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 250
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
LRRNT smart00013
Leucine rich repeat N-terminal domain;
725-756 1.43e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.43e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 148922178    725 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 756
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 65-215 1.65e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   65 RLDLDRNNITRI-TKMDFAGLKNLRVLHLEDNQVSVIE----RGAFQDLKQLERLRLNKNKLQVLPELL------FQSTP 133
Cdd:cd00116     2 QLSLKGELLKTErATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  134 KLTRLDLSEN--QIQGIPR-KAFRGITDVKNLQLDNN--------------------------------HISCIE-DGAF 177
Cdd:cd00116    82 GLQELDLSDNalGPDGCGVlESLLRSSSLQELKLNNNglgdrglrllakglkdlppaleklvlgrnrleGASCEAlAKAL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 148922178  178 RALRDLEILTLNNNNIS----RILVTSFNHMPKIRTLRLHSN 215
Cdd:cd00116   162 RANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNN 203
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1081-1110 1.71e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.15  E-value: 1.71e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 148922178 1081 HKCRHGAQCVDTINGYTCTCPQGFSGPF-CE 1110
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1027 1.79e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.79e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 148922178    998 DDCE-DNDCENNATCVDGINNYVCICPPNYT 1027
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1164-1311 2.14e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 43.14  E-value: 2.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  1164 GKDSYVELASAKVRPQAN-ISLQVATDKDNG---ILLYKGDNDPLALELYQ-GHVRLVYDSLSSPPTTVYSVETVNDGQF 1238
Cdd:pfam13385    2 GGSDYVTLPDALLPTSDFtVSAWVKPDSLPGwarAIISSSGGGGYSLGLDGdGRLRFAVNGGNGGWDTVTSGASVPLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148922178  1239 HSVeLVTLN-QTLNLVVDkGTPKSLGKLQKQPAVGINSPLYLGGiptstglsalRQGTDRPlggFHGCIHEVRI 1311
Cdd:pfam13385   82 THV-AVTYDgGTLRLYVN-GVLVGSSTLTGGPPPGTGGPLYIGR----------SPGGDDY---FNGLIDEVRI 140
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1083-1104 2.55e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.62  E-value: 2.55e-04
                           10        20
                   ....*....|....*....|..
gi 148922178  1083 CRHGAQCVDTINGYTCTCPQGF 1104
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-374 3.37e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   61 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSvieRGAFQDL-KQ--LERLRLNKNKLQ-VLPELLFQSTpKLT 136
Cdd:PLN00113  308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS---GEIPKNLgKHnnLTVLDLSTNNLTgEIPEGLCSSG-NLF 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  137 RLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNH 216
Cdd:PLN00113  384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  217 LYCDchlawLSDWLRQRRtvgqftlcmapvhLRGFNVADvqkkeyvcpaphseppscnaNSISCPSPctcsnnivdcrgK 296
Cdd:PLN00113  464 FFGG-----LPDSFGSKR-------------LENLDLSR--------------------NQFSGAVP------------R 493

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178  297 GLMeipaNLPEgIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-EIAKGL 374
Cdd:PLN00113  494 KLG----SLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1466-1521 3.47e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.85  E-value: 3.47e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178   1466 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1521
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 331-370 4.83e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 4.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148922178   331 KKLKRIDISKNQISDIapDAFQGLKSLTSLVLYGN-KITEI 370
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDL 39
LRRCT smart00082
Leucine rich repeat C-terminal domain;
437-467 6.66e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 6.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 148922178    437 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 467
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1035-1072 7.10e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 7.10e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 148922178   1035 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 1072
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-218 7.39e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 7.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   66 LDLDRNNIT-RITKMDFAgLKNLRVLHLEDNQVSvierGAFQDL---KQLERLRLNKNKLQVLPELLFQSTPKLTRLDLS 141
Cdd:PLN00113  433 LDISNNNLQgRINSRKWD-MPSLQMLSLARNKFF----GGLPDSfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148922178  142 ENQIQG-IPRKaFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLY 218
Cdd:PLN00113  508 ENKLSGeIPDE-LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 324-456 8.03e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  324 AGAFTQYKKLKRIDISKNQISD-----IApDAFQGLKSLTSLVLYGNKITE-----IAKGLfDGLVSLQLLLLNANKI-- 391
Cdd:COG5238   229 AEALKGNKSLTTLDLSNNQIGDegviaLA-EALKNNTTVETLYLSGNQIGAegaiaLAKAL-QGNTTLTSLDLSVNRIgd 306

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148922178  392 -------NCLRVNtfqdlQNLNLLSLYDNKLQTI-SKGLFAPLQ---SIQTLHLAQNPfVCDCHLKWLADYLQDNP 456
Cdd:COG5238   307 egaialaEGLQGN-----KTLHTLNLAYNGIGAQgAIALAKALQentTLHSLDLSDNQ-IGDEGAIALAKYLEGNT 376
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 535-665 8.37e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 8.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  535 TDLRLNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVrEGaFDGAASVQELMLTGNQLE-----TVHGRVFRGLSG-LK 608
Cdd:cd21340    49 THLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLR 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148922178  609 TLMLRSNLIGCVSNdtFAGLSSVRLLSLYDNRITTITP--GAFTTLVSLSTINLLSNPF 665
Cdd:cd21340   124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-415 9.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 9.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   55 VPR--GIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELLFqS 131
Cdd:PLN00113  204 IPRelGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-S 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  132 TPKLTRLDLSENQIQG-IPRKafrgITDVKNLQ---LDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKI 207
Cdd:PLN00113  283 LQKLISLDLSDNSLSGeIPEL----VIQLQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  208 RTLRLHSNHL-------YCDC-HLawlsdwlrqrrtvgqFTLCMAPVHLRGfnvaDVQKKEYVCPAPHSEPPSCNANSIS 279
Cdd:PLN00113  359 TVLDLSTNNLtgeipegLCSSgNL---------------FKLILFSNSLEG----EIPKSLGACRSLRRVRLQDNSFSGE 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  280 CPSPCT----------CSNNIVDCRGKGLMEIPAnlpegIVEIRLEQNSIKA-IPAgaFTQYKKLKRIDISKNQISDIAP 348
Cdd:PLN00113  420 LPSEFTklplvyfldiSNNNLQGRINSRKWDMPS-----LQMLSLARNKFFGgLPD--SFGSKRLENLDLSRNQFSGAVP 492

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148922178  349 DAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 415
Cdd:PLN00113  493 RKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRRNT smart00013
Leucine rich repeat N-terminal domain;
280-311 1.40e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.40e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 148922178    280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 311
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 280-306 1.71e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.71e-03
                           10        20
                   ....*....|....*....|....*..
gi 148922178   280 CPSPCTCSNNIVDCRGKGLMEIPANLP 306
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
505-535 2.02e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 2.02e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 148922178    505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVT 535
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRR smart00370
Leucine-rich repeats, outliers;
556-579 2.43e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.43e-03
                            10        20
                    ....*....|....*....|....
gi 148922178    556 LPNLRKINLSNNKIKEVREGAFDG 579
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
556-579 2.43e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.43e-03
                            10        20
                    ....*....|....*....|....
gi 148922178    556 LPNLRKINLSNNKIKEVREGAFDG 579
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1001-1029 2.46e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*....
gi 148922178 1001 EDNDCENNATCVDGINNYVCICPPNYTGE 1029
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 725-751 2.69e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.69e-03
                           10        20
                   ....*....|....*....|....*..
gi 148922178   725 CPEQCTCMETVVRCSNKGLRALPRGMP 751
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1005-1024 2.96e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 2.96e-03
                           10        20
                   ....*....|....*....|
gi 148922178  1005 CENNATCVDGINNYVCICPP 1024
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1372-1400 3.03e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.03e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 148922178  1372 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1400
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1071-1106 3.04e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 3.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 148922178  1071 CETDNDDCVAHkcrhgAQCVDTINGYTCTCPQGFSG 1106
Cdd:pfam12947    1 CSDNNGGCHPN-----ATCTNTGGSFTCTCNDGYTG 31
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-567 3.39e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   55 VPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL--QVLPELLFQST 132
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRELGQMKS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  133 PKLtrLDLSENQIQG-IPrKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLR 211
Cdd:PLN00113  214 LKW--IYLGYNNLSGeIP-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLD 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  212 LHSNHLYCDchlawLSDWLRQRRTvgqftlcMAPVHLRGFNVADvQKKEYVCPAPHSEPPSCNANSISCpspctcsnniv 291
Cdd:PLN00113  291 LSDNSLSGE-----IPELVIQLQN-------LEILHLFSNNFTG-KIPVALTSLPRLQVLQLWSNKFSG----------- 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  292 dcrgkglmEIPANLPEgiveirleQNSikaipagaftqykkLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI-TEI 370
Cdd:PLN00113  347 --------EIPKNLGK--------HNN--------------LTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLeGEI 396

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  371 AKGLFDGLVSLQLLLLNaNKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDchlkwLAD 450
Cdd:PLN00113  397 PKSLGACRSLRRVRLQD-NSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG-----LPD 470

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178  451 YLQDNPIETsgarcsspRRLANKRISQIKSKKFRcSGSEDYRSRFSSECFMDLVCPEKCRCEGTI-VDCSNQKLV-RIPS 528
Cdd:PLN00113  471 SFGSKRLEN--------LDLSRNQFSGAVPRKLG-SLSELMQLKLSENKLSGEIPDELSSCKKLVsLDLSHNQLSgQIPA 541

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 148922178  529 HLPEY--VTDLRLNDNEVSVlEATGIFKKLPNLRKINLSNN 567
Cdd:PLN00113  542 SFSEMpvLSQLDLSQNQLSG-EIPKNLGNVESLVQVNISHN 581
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 71-177 3.50e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 3.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178    71 NNITRITKMDFAGLKNLRVLHLEDNqVSVIERGAFQDLKqLERLRLNKNkLQVLPELLFQSTPKLTRLDLSENqIQGIPR 150
Cdd:pfam13306   20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                           90       100
                   ....*....|....*....|....*..
gi 148922178   151 KAFRGiTDVKNLQLDNNHIScIEDGAF 177
Cdd:pfam13306   96 YAFSN-CSLKSITIPSSVTT-IGSYAF 120
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 959-992 3.62e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.62e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 148922178   959 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 992
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
962-994 4.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 148922178    962 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 994
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
LRR_9 pfam14580
Leucine-rich repeat;
539-622 5.74e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 5.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148922178   539 LNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGrvFRGLSGLKTLMLRSNLIG 618
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGD--LDPLASLKKLTFLSLLRN 123


                   ....
gi 148922178   619 CVSN 622
Cdd:pfam14580  124 PVTN 127
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
133-155 6.24e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.24e-03
                            10        20
                    ....*....|....*....|...
gi 148922178    133 PKLTRLDLSENQIQGIPRKAFRG 155
Cdd:smart00369    2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
133-155 6.24e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.24e-03
                            10        20
                    ....*....|....*....|...
gi 148922178    133 PKLTRLDLSENQIQGIPRKAFRG 155
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
822-845 6.89e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.89e-03
                            10        20
                    ....*....|....*....|....
gi 148922178    822 LRSLRVLTLHGNDISSVPEGSFND 845
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
822-845 6.89e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.89e-03
                            10        20
                    ....*....|....*....|....
gi 148922178    822 LRSLRVLTLHGNDISSVPEGSFND 845
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 85-121 7.55e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 7.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 148922178    85 KNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKL 121
Cdd:pfam12799    1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 133-174 9.01e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 9.01e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 148922178   133 PKLTRLDLSENQIQGIPrkAFRGITDVKNLQL-DNNHISCIED 174
Cdd:pfam12799    1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLsGNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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