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Conserved domains on  [gi|148913019|ref|YP_001293333|]
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hypothetical protein GTPV_gp135 [Goatpox virus Pellor]

Protein Classification

PHA03043 family protein( domain architecture ID 10010378)

PHA03043 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03043 PHA03043
hypothetical protein; Provisional
 1-135 1.06e-62

hypothetical protein; Provisional


:

Pssm-ID: 165336  Cd Length: 130  Bit Score: 187.73  E-value: 1.06e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148913019   1 MGNKKNDDIKNIIKEYIRWRGNSekNICEERKLNIFFNKLKKIDSFVKKKIKESnndEYDIIKSMKLSLDDGPRMDKLPE 80
Cdd:PHA03043   1 MGNKKNDYIKDIIKEYIRWRGNS--DICEEHPLNIFFEKLMKFDSFAKKKIGES---DYDFIKSMKLSLDDGPRLDKLPT 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148913019  81 YLLDGLNAEEILGLCSIISEKVVSATYKVNWDRVYESLFNILDEKDLNYIKNKIM 135
Cdd:PHA03043  76 NLLDGLNAEEIIGLCGILAEKVVHSTYTVNWDRVFESLFNILDEKDLNYIKTKIM 130
 
Name Accession Description Interval E-value
PHA03043 PHA03043
hypothetical protein; Provisional
 1-135 1.06e-62

hypothetical protein; Provisional


Pssm-ID: 165336  Cd Length: 130  Bit Score: 187.73  E-value: 1.06e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148913019   1 MGNKKNDDIKNIIKEYIRWRGNSekNICEERKLNIFFNKLKKIDSFVKKKIKESnndEYDIIKSMKLSLDDGPRMDKLPE 80
Cdd:PHA03043   1 MGNKKNDYIKDIIKEYIRWRGNS--DICEEHPLNIFFEKLMKFDSFAKKKIGES---DYDFIKSMKLSLDDGPRLDKLPT 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148913019  81 YLLDGLNAEEILGLCSIISEKVVSATYKVNWDRVYESLFNILDEKDLNYIKNKIM 135
Cdd:PHA03043  76 NLLDGLNAEEIIGLCGILAEKVVHSTYTVNWDRVFESLFNILDEKDLNYIKTKIM 130
Poxv_Bcl-2-like pfam06227
Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins ...
 5-129 2.57e-14

Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins that function as immunomodulators to evade the host innate immune response through the inhibition of apoptosis or blocking the activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-kappaB (NF-kappaB). These proteins have low sequence identity but high structural similarity to the eukaryotic Bcl-2 protein family. They have a Bcl-2 fold which comprises a central hydrophobic alpha-helix that is surrounded by an additional layer of 6-7 amphipathic alpha-helices. Included in this family are proteins B14, A52, A46, C6, K7, N1, and N2. Protein N1 has the unusual dual ability of modulating apoptosis and inflammatory signalling. Protein K7, in addition to its anti-inflammatory activity, forms a complex with RNA helicase DDX3 and antagonizes interferon-beta promoter induction.


Pssm-ID: 368802  Cd Length: 145  Bit Score: 65.03  E-value: 2.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148913019    5 KNDDIKNIIKEYIRWRGNSEKNICeerKLNIFFNKLKKIDSFVKKKIKEsnnDEYDIIKSMKLS--LDDGPRMDKLPEYL 82
Cdd:pfam06227  23 DDDSIKDILEEYFRWRGNIGRNRD---SAGKLFKELMKFDDDAIKKYGG---DLITLIKNLLLDsdIYNFKLFIKLKINI 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 148913019   83 L--DGLNAEEILGLCSIISEKVVSATYKVNWDRVYESLFNILDEKDLNY 129
Cdd:pfam06227  97 DndNIEECKAIIGLCAILSEYWGKEDPTKNSLNILYLFFKNLSDDDLNK 145
 
Name Accession Description Interval E-value
PHA03043 PHA03043
hypothetical protein; Provisional
 1-135 1.06e-62

hypothetical protein; Provisional


Pssm-ID: 165336  Cd Length: 130  Bit Score: 187.73  E-value: 1.06e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148913019   1 MGNKKNDDIKNIIKEYIRWRGNSekNICEERKLNIFFNKLKKIDSFVKKKIKESnndEYDIIKSMKLSLDDGPRMDKLPE 80
Cdd:PHA03043   1 MGNKKNDYIKDIIKEYIRWRGNS--DICEEHPLNIFFEKLMKFDSFAKKKIGES---DYDFIKSMKLSLDDGPRLDKLPT 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148913019  81 YLLDGLNAEEILGLCSIISEKVVSATYKVNWDRVYESLFNILDEKDLNYIKNKIM 135
Cdd:PHA03043  76 NLLDGLNAEEIIGLCGILAEKVVHSTYTVNWDRVFESLFNILDEKDLNYIKTKIM 130
Poxv_Bcl-2-like pfam06227
Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins ...
 5-129 2.57e-14

Poxvirus Bcl-2-like proteins; This family represents a group of Poxvirus Bcl-2-like proteins that function as immunomodulators to evade the host innate immune response through the inhibition of apoptosis or blocking the activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-kappaB (NF-kappaB). These proteins have low sequence identity but high structural similarity to the eukaryotic Bcl-2 protein family. They have a Bcl-2 fold which comprises a central hydrophobic alpha-helix that is surrounded by an additional layer of 6-7 amphipathic alpha-helices. Included in this family are proteins B14, A52, A46, C6, K7, N1, and N2. Protein N1 has the unusual dual ability of modulating apoptosis and inflammatory signalling. Protein K7, in addition to its anti-inflammatory activity, forms a complex with RNA helicase DDX3 and antagonizes interferon-beta promoter induction.


Pssm-ID: 368802  Cd Length: 145  Bit Score: 65.03  E-value: 2.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148913019    5 KNDDIKNIIKEYIRWRGNSEKNICeerKLNIFFNKLKKIDSFVKKKIKEsnnDEYDIIKSMKLS--LDDGPRMDKLPEYL 82
Cdd:pfam06227  23 DDDSIKDILEEYFRWRGNIGRNRD---SAGKLFKELMKFDDDAIKKYGG---DLITLIKNLLLDsdIYNFKLFIKLKINI 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 148913019   83 L--DGLNAEEILGLCSIISEKVVSATYKVNWDRVYESLFNILDEKDLNY 129
Cdd:pfam06227  97 DndNIEECKAIIGLCAILSEYWGKEDPTKNSLNILYLFFKNLSDDDLNK 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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