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Conserved domains on  [gi|1487323286|ref|XP_026525093|]
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nidogen-1 [Notechis scutatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 232-462 1.90e-106

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


:

Pssm-ID: 238158  Cd Length: 224  Bit Score: 331.19  E-value: 1.90e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  232 GSPQRVNGKVKGRIFVGnnPIPVVFENTDLHSYVVMNHGRAYTAISTIPETLGFSLLPLASIGGIIGWMFAVEQEGYQNG 311
Cdd:cd00255      1 GIPQRVNGKVSGNINVG--QSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  312 FSVTGGEFTRQAEVTFLSNNEKLIIKQKFSGIDEHGHLTISTELEGKVPEIPFGSSVHIEPYTELYHSSSSVI-TSSSTR 390
Cdd:cd00255     79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTR 158

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487323286  391 EYTVTEPerngvSPTYTVSYQWRQTISFDECIHDDshHSGSATQQLSVDSVFVLYNKEEQILRYAMSNSIGP 462
Cdd:cd00255    159 EYTVDEG-----GESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGP 223
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 650-716 4.33e-26

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 102.00  E-value: 4.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1487323286  650 CQREQEQILALGPRGHRPIGQFIPQCDIYGNYLPTQCHPSTGYCWCVDRDGNEMDGTRSGPGiQPPC 716
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG-DPDC 66
NIDO super family cl02648
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 96-164 5.86e-16

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


The actual alignment was detected with superfamily member smart00539:

Pssm-ID: 470642  Cd Length: 152  Bit Score: 75.93  E-value: 5.86e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487323286    96 PFYADLDTTGgRGNVYYRKDSSPETLQLAAKYIKRGFP-NTTFDPESVVIVTWDSVAPY--VGSSQDATLQV 164
Cdd:smart00539    1 PFWADADTEG-TGKVYYRETTDHAILDRATESVREGFTdMGGFRAKSVVIVTWENVAAYgsQSSDGTNTFQA 71
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 812-852 5.65e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 5.65e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1487323286   812 IVKTDLESPEGIALDPHGRTIFWTDSQLDRIEVAKVDGTHR 852
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 607-640 8.65e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 57.61  E-value: 8.65e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1487323286  607 CQSNR--CHPDAVCYNSPGSFSCQCKAGYHGDGFHC 640
Cdd:pfam12947    1 CSDNNggCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 853-897 1.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1487323286   853 RVLFDTELVNPRAIVADPVRGNLYWTDWNReaPKIETSYMDGTNR 897
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 474-510 4.45e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.60  E-value: 4.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1487323286  474 CYTGTHGCDINAVCRPgTGNQFTCECSVGFRGDGRTC 510
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1009-1033 8.24e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 8.24e-09
                           10        20
                   ....*....|....*....|....*
gi 1487323286 1009 CSVNNGGCTHLCLATPGGRSCRCPD 1033
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
714-927 2.56e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 2.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  714 PPCLGTVAPPVTIGPSVKPDAIPLPPGSHLLIAQSGKIDHVPLEGNVMRKSDAKALLYVPDKVVIGVAYDCLEKMVYWTD 793
Cdd:COG3391      7 LLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVAN 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  794 ISSPSISRASLGGGEPVSIVKTDlESPEGIALDPHGRTIFWTDSQLDRieVAKVDGTHRRVLFDTEL-VNPRAIVADPVR 872
Cdd:COG3391     87 SGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAVDPDG 163

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1487323286  873 GNLYWTDW-NREAPKIeTSYMDGTNRRILVKDNLG-LPNGLTLDTYSSLLCWVDAGT 927
Cdd:COG3391    164 KRLYVANSgSNTVSVI-VSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGS 219
EGF_CA smart00179
Calcium-binding EGF-like domain;
512-554 6.13e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 6.13e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1487323286   512 DVDECQEqPTVCGSNAVCNNQPGTFRCECLEGYQfsdDGRTCI 554
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 193-228 1.34e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.67  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1487323286  193 CTNNRHQCSVHAVCKDYPSGFCCSCIVGYKGNGRQC 228
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 563-601 2.31e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1487323286  563 CLMGSHTCDipQRARCIYSGGSsYICACIPGFSGDGRSC 601
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 232-462 1.90e-106

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 331.19  E-value: 1.90e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  232 GSPQRVNGKVKGRIFVGnnPIPVVFENTDLHSYVVMNHGRAYTAISTIPETLGFSLLPLASIGGIIGWMFAVEQEGYQNG 311
Cdd:cd00255      1 GIPQRVNGKVSGNINVG--QSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  312 FSVTGGEFTRQAEVTFLSNNEKLIIKQKFSGIDEHGHLTISTELEGKVPEIPFGSSVHIEPYTELYHSSSSVI-TSSSTR 390
Cdd:cd00255     79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTR 158

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487323286  391 EYTVTEPerngvSPTYTVSYQWRQTISFDECIHDDshHSGSATQQLSVDSVFVLYNKEEQILRYAMSNSIGP 462
Cdd:cd00255    159 EYTVDEG-----GESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGP 223
G2F smart00682
G2 nidogen domain and fibulin;
230-474 8.47e-93

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 294.74  E-value: 8.47e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286   230 AEGSPQRVNGKVKGRIFVGNnpIPVVFENTDLHSYVVMNHGRAYTAISTIPETLGFSLLPLASIGGIIGWMFAVEQEGYQ 309
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGE--FPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286   310 NGFSVTGGEFTRQAEVTFlSNNEKLIIKQKFSGIDEHGHLTISTELEGKVPEIPFGSSVHIEPYTELYHSSSS-VITSSS 388
Cdd:smart00682   79 NGFQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPgVLTTSS 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286   389 TREYTVteperngvsPTYTVSYQWRQTISFDECIHDDSHHsgSATQQLSVDSVFVLYNKEEQILRYAMSNSIGPIDgsgd 468
Cdd:smart00682  158 TREYTV---------DNQTHSYTVDQTITFEECQHRDAFP--PTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGD---- 222


                    ....*.
gi 1487323286   469 vSRNPC 474
Cdd:smart00682  223 -ESNQC 227
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 232-425 3.25e-80

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 259.06  E-value: 3.25e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  232 GSPQRVNGKVKGRIfvgnnpIPVVFENTDLHSYVVMNHGRAYTAISTIPETLGFSLLPLASIGGIIGWMFAVEQEGYQNG 311
Cdd:pfam07474    1 GVPQRVNGKVSGTI------NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNG 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  312 FSVTGGEFTRQAEVTFLSNNEKLIIKQKFSGIDEHGHLTISTELEGKVPEIPFGSSVHIEPYTELYHSSSSVI-TSSSTR 390
Cdd:pfam07474   75 FSLTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGElTSSSTR 154

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1487323286  391 EYTVTEPERngvspTYTVSYQWRQTISFDECIHDD 425
Cdd:pfam07474  155 TYTVDGEGN-----TRTISYTVNQTITYQECRHAE 184
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 650-716 4.33e-26

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 102.00  E-value: 4.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1487323286  650 CQREQEQILALGPRGHRPIGQFIPQCDIYGNYLPTQCHPSTGYCWCVDRDGNEMDGTRSGPGiQPPC 716
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 649-716 5.27e-22

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 90.22  E-value: 5.27e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487323286  649 KCQREQEQILALGPRGHRPiGQFIPQCDIYGNYLPTQCHPSTGYCWCVDRDGNEMDGTRSGPGiQPPC 716
Cdd:cd00191      1 PCERERASALESLAGPKLS-GLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
96-164 5.86e-16

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 75.93  E-value: 5.86e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487323286    96 PFYADLDTTGgRGNVYYRKDSSPETLQLAAKYIKRGFP-NTTFDPESVVIVTWDSVAPY--VGSSQDATLQV 164
Cdd:smart00539    1 PFWADADTEG-TGKVYYRETTDHAILDRATESVREGFTdMGGFRAKSVVIVTWENVAAYgsQSSDGTNTFQA 71
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 672-717 1.08e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 66.25  E-value: 1.08e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1487323286   672 IPQCDIYGNYLPTQCHPSTGYCWCVDRDGNEMDGTRSgPGIQPPCL 717
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRT-EGGDPDCP 45
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 812-852 5.65e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 5.65e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1487323286   812 IVKTDLESPEGIALDPHGRTIFWTDSQLDRIEVAKVDGTHR 852
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 607-640 8.65e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 57.61  E-value: 8.65e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1487323286  607 CQSNR--CHPDAVCYNSPGSFSCQCKAGYHGDGFHC 640
Cdd:pfam12947    1 CSDNNggCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 853-897 1.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1487323286   853 RVLFDTELVNPRAIVADPVRGNLYWTDWNReaPKIETSYMDGTNR 897
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
603-641 2.70e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.40  E-value: 2.70e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1487323286   603 DIDECQS-NRCHPDAVCYNSPGSFSCQCKAGYHgDGFHCV 641
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 474-510 4.45e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.60  E-value: 4.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1487323286  474 CYTGTHGCDINAVCRPgTGNQFTCECSVGFRGDGRTC 510
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1009-1033 8.24e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 8.24e-09
                           10        20
                   ....*....|....*....|....*
gi 1487323286 1009 CSVNNGGCTHLCLATPGGRSCRCPD 1033
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 603-641 1.02e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1487323286  603 DIDECQS-NRCHPDAVCYNSPGSFSCQCKAGYHGDgfHCV 641
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 873-914 1.28e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.28e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1487323286  873 GNLYWTDWNREApKIETSYMDGTNRRILVKDNLGLPNGLTLD 914
Cdd:pfam00058    1 GRLYWTDSSLRA-SISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
714-927 2.56e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 2.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  714 PPCLGTVAPPVTIGPSVKPDAIPLPPGSHLLIAQSGKIDHVPLEGNVMRKSDAKALLYVPDKVVIGVAYDCLEKMVYWTD 793
Cdd:COG3391      7 LLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVAN 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  794 ISSPSISRASLGGGEPVSIVKTDlESPEGIALDPHGRTIFWTDSQLDRieVAKVDGTHRRVLFDTEL-VNPRAIVADPVR 872
Cdd:COG3391     87 SGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAVDPDG 163

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1487323286  873 GNLYWTDW-NREAPKIeTSYMDGTNRRILVKDNLG-LPNGLTLDTYSSLLCWVDAGT 927
Cdd:COG3391    164 KRLYVANSgSNTVSVI-VSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGS 219
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 830-870 3.18e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.62  E-value: 3.18e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1487323286  830 RTIFWTDSQLD-RIEVAKVDGTHRRVLFDTELVNPRAIVADP 870
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 898-940 5.91e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 5.91e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1487323286   898 RILVKDNLGLPNGLTLDTYSSLLCWVDAGTKSVECMDLNQHSR 940
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
512-554 6.13e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 6.13e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1487323286   512 DVDECQEqPTVCGSNAVCNNQPGTFRCECLEGYQfsdDGRTCI 554
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 512-554 6.93e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 6.93e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1487323286  512 DVDECqEQPTVCGSNAVCNNQPGTFRCECLEGYQfsddGRTCI 554
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 193-228 1.34e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.67  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1487323286  193 CTNNRHQCSVHAVCKDYPSGFCCSCIVGYKGNGRQC 228
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 516-553 1.78e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 1.78e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1487323286  516 CQEQPTVCGSNAVCNNQPGTFRCECLEGYQFsdDGRTC 553
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 789-827 2.47e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.23  E-value: 2.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1487323286  789 VYWTDISS-PSISRASLGGGEPVSIVKTDLESPEGIALDP 827
Cdd:pfam00058    3 LYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 563-601 2.31e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1487323286  563 CLMGSHTCDipQRARCIYSGGSsYICACIPGFSGDGRSC 601
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 816-918 9.00e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.39  E-value: 9.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  816 DLESPEGIALDPHGRtIFWTDSQLDRIEVAKVDGTHRRVL-----FDTELVNPRAIVADPVrGNLYWTDWNreapkiets 890
Cdd:cd05819    100 EFNGPRGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTG--------- 168

                           90       100
                   ....*....|....*....|....*...
gi 1487323286  891 ymdgtNRRILVKDnlglPNGLTLDTYSS 918
Cdd:cd05819    169 -----NHRIQVFD----PDGNFLTTFGS 187
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 817-901 1.68e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 1.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  817 LESPEGIALDPHGRtIFWTDSQLDRIEVAKVDGTHRRV-----LFDTELVNPRAIVADPvRGNLYWTDWNreapkietsy 891
Cdd:cd05819     54 FNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTG---------- 121

                           90
                   ....*....|
gi 1487323286  892 mdgtNRRILV 901
Cdd:cd05819    122 ----NHRIQK 127
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 812-881 3.40e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.38  E-value: 3.40e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1487323286  812 IVKTDLESPEGIALDPHGrTIFWTDSQLDRIEVAKVDGTHR-----RVLFDTELVNPRAIVADPvRGNLYWTDWN 881
Cdd:cd05819    190 TGPGQFNYPTGIAVDSDG-NIYVADSGNNRVQVFDPDGAGFggngnFLGSDGQFNRPSGLAVDS-DGNLYVADTG 262
 
Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 232-462 1.90e-106

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 331.19  E-value: 1.90e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  232 GSPQRVNGKVKGRIFVGnnPIPVVFENTDLHSYVVMNHGRAYTAISTIPETLGFSLLPLASIGGIIGWMFAVEQEGYQNG 311
Cdd:cd00255      1 GIPQRVNGKVSGNINVG--QSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  312 FSVTGGEFTRQAEVTFLSNNEKLIIKQKFSGIDEHGHLTISTELEGKVPEIPFGSSVHIEPYTELYHSSSSVI-TSSSTR 390
Cdd:cd00255     79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTR 158

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487323286  391 EYTVTEPerngvSPTYTVSYQWRQTISFDECIHDDshHSGSATQQLSVDSVFVLYNKEEQILRYAMSNSIGP 462
Cdd:cd00255    159 EYTVDEG-----GESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGP 223
G2F smart00682
G2 nidogen domain and fibulin;
230-474 8.47e-93

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 294.74  E-value: 8.47e-93
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286   230 AEGSPQRVNGKVKGRIFVGNnpIPVVFENTDLHSYVVMNHGRAYTAISTIPETLGFSLLPLASIGGIIGWMFAVEQEGYQ 309
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGE--FPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286   310 NGFSVTGGEFTRQAEVTFlSNNEKLIIKQKFSGIDEHGHLTISTELEGKVPEIPFGSSVHIEPYTELYHSSSS-VITSSS 388
Cdd:smart00682   79 NGFQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPgVLTTSS 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286   389 TREYTVteperngvsPTYTVSYQWRQTISFDECIHDDSHHsgSATQQLSVDSVFVLYNKEEQILRYAMSNSIGPIDgsgd 468
Cdd:smart00682  158 TREYTV---------DNQTHSYTVDQTITFEECQHRDAFP--PTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGD---- 222


                    ....*.
gi 1487323286   469 vSRNPC 474
Cdd:smart00682  223 -ESNQC 227
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 232-425 3.25e-80

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 259.06  E-value: 3.25e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  232 GSPQRVNGKVKGRIfvgnnpIPVVFENTDLHSYVVMNHGRAYTAISTIPETLGFSLLPLASIGGIIGWMFAVEQEGYQNG 311
Cdd:pfam07474    1 GVPQRVNGKVSGTI------NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNG 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  312 FSVTGGEFTRQAEVTFLSNNEKLIIKQKFSGIDEHGHLTISTELEGKVPEIPFGSSVHIEPYTELYHSSSSVI-TSSSTR 390
Cdd:pfam07474   75 FSLTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGElTSSSTR 154

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1487323286  391 EYTVTEPERngvspTYTVSYQWRQTISFDECIHDD 425
Cdd:pfam07474  155 TYTVDGEGN-----TRTISYTVNQTITYQECRHAE 184
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 650-716 4.33e-26

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 102.00  E-value: 4.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1487323286  650 CQREQEQILALGPRGHRPIGQFIPQCDIYGNYLPTQCHPSTGYCWCVDRDGNEMDGTRSGPGiQPPC 716
Cdd:pfam00086    1 CERERARALEQAASGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 649-716 5.27e-22

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 90.22  E-value: 5.27e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487323286  649 KCQREQEQILALGPRGHRPiGQFIPQCDIYGNYLPTQCHPSTGYCWCVDRDGNEMDGTRSGPGiQPPC 716
Cdd:cd00191      1 PCERERASALESLAGPKLS-GLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
96-164 5.86e-16

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 75.93  E-value: 5.86e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487323286    96 PFYADLDTTGgRGNVYYRKDSSPETLQLAAKYIKRGFP-NTTFDPESVVIVTWDSVAPY--VGSSQDATLQV 164
Cdd:smart00539    1 PFWADADTEG-TGKVYYRETTDHAILDRATESVREGFTdMGGFRAKSVVIVTWENVAAYgsQSSDGTNTFQA 71
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 672-717 1.08e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 66.25  E-value: 1.08e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1487323286   672 IPQCDIYGNYLPTQCHPSTGYCWCVDRDGNEMDGTRSgPGIQPPCL 717
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRT-EGGDPDCP 45
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 812-852 5.65e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 5.65e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1487323286   812 IVKTDLESPEGIALDPHGRTIFWTDSQLDRIEVAKVDGTHR 852
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 607-640 8.65e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 57.61  E-value: 8.65e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1487323286  607 CQSNR--CHPDAVCYNSPGSFSCQCKAGYHGDGFHC 640
Cdd:pfam12947    1 CSDNNggCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 853-897 1.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1487323286   853 RVLFDTELVNPRAIVADPVRGNLYWTDWNReaPKIETSYMDGTNR 897
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
603-641 2.70e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.40  E-value: 2.70e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1487323286   603 DIDECQS-NRCHPDAVCYNSPGSFSCQCKAGYHgDGFHCV 641
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 474-510 4.45e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.60  E-value: 4.45e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1487323286  474 CYTGTHGCDINAVCRPgTGNQFTCECSVGFRGDGRTC 510
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1009-1033 8.24e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 8.24e-09
                           10        20
                   ....*....|....*....|....*
gi 1487323286 1009 CSVNNGGCTHLCLATPGGRSCRCPD 1033
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 603-641 1.02e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1487323286  603 DIDECQS-NRCHPDAVCYNSPGSFSCQCKAGYHGDgfHCV 641
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 873-914 1.28e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.28e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1487323286  873 GNLYWTDWNREApKIETSYMDGTNRRILVKDNLGLPNGLTLD 914
Cdd:pfam00058    1 GRLYWTDSSLRA-SISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
714-927 2.56e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 2.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  714 PPCLGTVAPPVTIGPSVKPDAIPLPPGSHLLIAQSGKIDHVPLEGNVMRKSDAKALLYVPDKVVIGVAYDCLEKMVYWTD 793
Cdd:COG3391      7 LLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVAN 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  794 ISSPSISRASLGGGEPVSIVKTDlESPEGIALDPHGRTIFWTDSQLDRieVAKVDGTHRRVLFDTEL-VNPRAIVADPVR 872
Cdd:COG3391     87 SGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAVDPDG 163

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1487323286  873 GNLYWTDW-NREAPKIeTSYMDGTNRRILVKDNLG-LPNGLTLDTYSSLLCWVDAGT 927
Cdd:COG3391    164 KRLYVANSgSNTVSVI-VSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGS 219
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 830-870 3.18e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.62  E-value: 3.18e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1487323286  830 RTIFWTDSQLD-RIEVAKVDGTHRRVLFDTELVNPRAIVADP 870
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 898-940 5.91e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 5.91e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1487323286   898 RILVKDNLGLPNGLTLDTYSSLLCWVDAGTKSVECMDLNQHSR 940
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
512-554 6.13e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 6.13e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1487323286   512 DVDECQEqPTVCGSNAVCNNQPGTFRCECLEGYQfsdDGRTCI 554
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 512-554 6.93e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 6.93e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1487323286  512 DVDECqEQPTVCGSNAVCNNQPGTFRCECLEGYQfsddGRTCI 554
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 193-228 1.34e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.67  E-value: 1.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1487323286  193 CTNNRHQCSVHAVCKDYPSGFCCSCIVGYKGNGRQC 228
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 516-553 1.78e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 1.78e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1487323286  516 CQEQPTVCGSNAVCNNQPGTFRCECLEGYQFsdDGRTC 553
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 789-827 2.47e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.23  E-value: 2.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1487323286  789 VYWTDISS-PSISRASLGGGEPVSIVKTDLESPEGIALDP 827
Cdd:pfam00058    3 LYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA pfam07645
Calcium-binding EGF domain;
512-543 6.42e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 6.42e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1487323286  512 DVDECQEQPTVCGSNAVCNNQPGTFRCECLEG 543
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 789-1006 8.91e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 48.35  E-value: 8.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  789 VYWTDISSPSISRASLGGGEpVSIVKTDLESPEGIALDPHGRtiFWTDSQLDRIEVAKVDGTHRRVL---FDTELVNPRA 865
Cdd:COG3386     21 LYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGR--LLVADHGRGLVRFDPADGEVTVLadeYGKPLNRPND 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  866 IVADPvRGNLYWTDWNREAPKIETSYMDGTNRRILVKDNLGLPNGLTLDTYSSLLCWVDAGTKSVECMDLNQH---SRRK 942
Cdd:COG3386     98 GVVDP-DGRLYFTDMGEYLPTGALYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADgtlGNRR 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  943 IL----EGIQYP--FSITSYGkNLFYTDWKRDAVVAVD------RTISKENDN-----FQPYKRTRLYgITTAWAQCPSG 1005
Cdd:COG3386    177 VFadlpDGPGGPdgLAVDADG-NLWVALWGGGGVVRFDpdgellGRIELPERRptnvaFGGPDLRTLY-VTTARSLPLAG 254


                   .
gi 1487323286 1006 R 1006
Cdd:COG3386    255 A 255
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
788-879 9.97e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.48  E-value: 9.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  788 MVYWTDISSPSISRASLGGGEPVSIVKTDLESPEGIALDPHGRtIFWTDSQLDRI-EVAKVDGTHRRVLFDTELVNPRAI 866
Cdd:COG4257     29 AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGN-LWFTDNGNNRIgRIDPKTGEITTFALPGGGSNPHGI 107

                           90
                   ....*....|...
gi 1487323286  867 VADPvRGNLYWTD 879
Cdd:COG4257    108 AFDP-DGNLWFTD 119
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 606-641 1.85e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 42.46  E-value: 1.85e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1487323286  606 ECQ-SNRCHPDAVCYNSPGSFSCQCKAGYHGDgFHCV 641
Cdd:cd00053      1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGD-RSCE 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 767-808 2.10e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 2.10e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1487323286   767 KALLYVPDKVVIGVAYDCLEKMVYWTDISSPSISRASLGGGE 808
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 563-601 2.31e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1487323286  563 CLMGSHTCDipQRARCIYSGGSsYICACIPGFSGDGRSC 601
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
603-632 6.96e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 6.96e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1487323286  603 DIDECQS--NRCHPDAVCYNSPGSFSCQCKAG 632
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 816-918 9.00e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 45.39  E-value: 9.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  816 DLESPEGIALDPHGRtIFWTDSQLDRIEVAKVDGTHRRVL-----FDTELVNPRAIVADPVrGNLYWTDWNreapkiets 890
Cdd:cd05819    100 EFNGPRGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTG--------- 168

                           90       100
                   ....*....|....*....|....*...
gi 1487323286  891 ymdgtNRRILVKDnlglPNGLTLDTYSS 918
Cdd:cd05819    169 -----NHRIQVFD----PDGNFLTTFGS 187
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 779-943 1.43e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.89  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  779 GVAYDCLEKmVYWTDISSPSISRASLGGGEpVSIVKTD----LESPEGIALDPHGRtIFWTDSQLDRIEVAKVDGTHRRV 854
Cdd:cd14962     16 GVAADGRGR-IYVADTGRGAVFVFDLPNGK-VFVIGNAgpnrFVSPIGVAIDANGN-LYVSDAELGKVFVFDRDGKFLRA 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  855 LFDTELVN-PRAIVADPVRGNLYWTDwnREAPKIETSYMDGTNRRILVKDNLG-----LPNGLTLDTYSSLLCwVDAGTK 928
Cdd:cd14962     93 IGAGALFKrPTGIAVDPAGKRLYVVD--TLAHKVKVFDLDGRLLFDIGKRGSGpgefnLPTDLAVDRDGNLYV-TDTMNF 169

                          170
                   ....*....|....*
gi 1487323286  929 SVECMDLNQHSRRKI 943
Cdd:cd14962    170 RVQIFDADGKFLRSF 184
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 817-901 1.68e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 1.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  817 LESPEGIALDPHGRtIFWTDSQLDRIEVAKVDGTHRRV-----LFDTELVNPRAIVADPvRGNLYWTDWNreapkietsy 891
Cdd:cd05819     54 FNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTG---------- 121

                           90
                   ....*....|
gi 1487323286  892 mdgtNRRILV 901
Cdd:cd05819    122 ----NHRIQK 127
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 816-914 3.34e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.82  E-value: 3.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  816 DLESPEGIALDPHGRtIFWTDSQLDRIEVAKVDGTHRRVL-----FDTELVNPRAIVADPvRGNLYWTDwnREAPKIETS 890
Cdd:cd14963    146 ELSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGKFIKELngspdGKSGFVNPRGIAVDP-DGNLYVVD--NLSHRVYVF 221

                           90       100
                   ....*....|....*....|....*....
gi 1487323286  891 YMDGTNRRILVK-----DNLGLPNGLTLD 914
Cdd:cd14963    222 DEQGKELFTFGGrgkddGQFNLPNGLFID 250
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 529-553 3.48e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 3.48e-04
                           10        20
                   ....*....|....*....|....*
gi 1487323286  529 CNNQPGTFRCECLEGYQFSDDGRTC 553
Cdd:pfam14670   12 CLNTPGGYTCSCPEGYELQDDGRTC 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 607-636 9.21e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 9.21e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1487323286  607 CQSNRCHPDAVCYNSPGSFSCQCKAGYHGD 636
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 817-974 1.61e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  817 LESPEGIALDPHGrTIFWTDSQLDRIEVAKVDGTHRRVL-----FDTELVNPRAIVADPvRGNLYWTD-WNREAPKI--E 888
Cdd:cd05819      7 LNNPQGIAVDSSG-NIYVADTGNNRIQVFDPDGNFITSFgsfgsGDGQFNEPAGVAVDS-DGNLYVADtGNHRIQKFdpD 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  889 TSYMDGTNRRILVKDNLGLPNGLTLDTYSSLlcWV-DAGTKSVECMDLNQHSRRKI------LEGIQYPFSITSYGKNLF 961
Cdd:cd05819     85 GNFLASFGGSGDGDGEFNGPRGIAVDSSGNI--YVaDTGNHRIQKFDPDGEFLTTFgsggsgPGQFNGPTGVAVDSDGNI 162

                          170
                   ....*....|....
gi 1487323286  962 Y-TDWKRDAVVAVD 974
Cdd:cd05819    163 YvADTGNHRIQVFD 176
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 507-552 2.88e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.45  E-value: 2.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1487323286  507 GRTCYDVDECQEQPTVCgsNAVCNNQPGTFRCECLEGYQFSDDGRT 552
Cdd:cd01475    181 GKICVVPDLCATLSHVC--QQVCISTPGSYLCACTEGYALLEDNKT 224
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 812-881 3.40e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.38  E-value: 3.40e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1487323286  812 IVKTDLESPEGIALDPHGrTIFWTDSQLDRIEVAKVDGTHR-----RVLFDTELVNPRAIVADPvRGNLYWTDWN 881
Cdd:cd05819    190 TGPGQFNYPTGIAVDSDG-NIYVADSGNNRVQVFDPDGAGFggngnFLGSDGQFNRPSGLAVDS-DGNLYVADTG 262
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 779-930 5.27e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 39.94  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  779 GVAYDCLEKMVYWTDISSPSISRASLGGGEPVSIvktDLESPEG-IALDPHGRTIFwTDSqlDRIEVAKVDGTHRRVLFD 857
Cdd:pfam08450    4 GPVWDEEEGALYWVDILGGRIHRLDPATGKETVW---DTPGPVGaIAPRDDGGLIV-ALK--DGVALLDLATGELTPLAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487323286  858 TELVNPRAI-----VADPvRGNLYWTD-WNREAPKIETS---YMDGTNRRILVKDNLGLPNGLTLDTYSSLLCWVDAGTK 928
Cdd:pfam08450   78 PEDDDWPLNrfndgKVDP-DGRFWFGTmGDDEAPGGDPGalyRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPAR 156


                   ..
gi 1487323286  929 SV 930
Cdd:pfam08450  157 KI 158
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 537-557 5.82e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 5.82e-03
                           10        20
                   ....*....|....*....|.
gi 1487323286  537 RCECLEGYQFSDDGRTCIAVD 557
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDID 21
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 515-545 7.46e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 7.46e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1487323286  515 ECQeQPTVCGSNAVCNNQPGTFRCECLEGYQ 545
Cdd:cd00053      1 ECA-ASNPCSNGGTCVNTPGSYRCVCPPGYT 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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