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Conserved domains on  [gi|148705385|gb|EDL37332|]
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solute carrier family 30 (zinc transporter), member 3, isoform CRA_a, partial [Mus musculus]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 1002352)

cation transporter of the cation diffusion facilitator (CDF) family that facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

Gene Ontology:  GO:0008324
PubMed:  25896018|17448255
TCDB:  2.A.4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDF super family cl36863
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
 80-187 1.20e-26

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR01297:

Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 101.91  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385   80 IFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGILLYLA 159
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80

                          90       100
                  ....*....|....*....|....*...
gi 148705385  160 FLRLLHSDYHIEAGAMLLTASIAVCANL 187
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNL 108
 
Name Accession Description Interval E-value
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
 80-187 1.20e-26

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 101.91  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385   80 IFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGILLYLA 159
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80

                          90       100
                  ....*....|....*....|....*...
gi 148705385  160 FLRLLHSDYHIEAGAMLLTASIAVCANL 187
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNL 108
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
66-187 1.09e-24

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 97.11  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385  66 QARRQLYAACAVCFIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASV 145
Cdd:COG1230   15 SSERRLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANA 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148705385 146 VSLWIVTGILLYLAFLRLLHSDyHIEAGAMLLTASIAVCANL 187
Cdd:COG1230   95 LLLLVVAGYILYEAIQRLFNPP-PVAGGGMLVVAVIGLVVNL 135
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
 80-187 2.79e-16

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 72.69  E-value: 2.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385   80 IFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGILLYLA 159
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80

                          90       100
                  ....*....|....*....|....*...
gi 148705385  160 FLRLLHSDYHIEAGAMLLTASIAVCANL 187
Cdd:pfam01545  81 IQRLLSPGEEIDPGLALILALVSLLVNL 108
PRK03557 PRK03557
CDF family zinc transporter ZitB;
45-187 1.07e-13

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 67.85  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385  45 MAFHHCHKDPVpqsglSPERVQARRqLYAACAVCFIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRP 124
Cdd:PRK03557   1 MAHSHSHTSSH-----LPEDNNARR-LLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRP 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148705385 125 ATRTMTFGWHRSETLGALASVVSLWIVTGILLYLAFLRLLHSdyHIEAGAMLLTASIA-VCANL 187
Cdd:PRK03557  75 PTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTP--RPVAGGMMMAIAVAgLLANI 136
 
Name Accession Description Interval E-value
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
 80-187 1.20e-26

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 101.91  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385   80 IFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGILLYLA 159
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEA 80

                          90       100
                  ....*....|....*....|....*...
gi 148705385  160 FLRLLHSDYHIEAGAMLLTASIAVCANL 187
Cdd:TIGR01297  81 IERLINPEPEIDGGTMLIVAIVGLIVNL 108
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
66-187 1.09e-24

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 97.11  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385  66 QARRQLYAACAVCFIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASV 145
Cdd:COG1230   15 SSERRLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAEILAALANA 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148705385 146 VSLWIVTGILLYLAFLRLLHSDyHIEAGAMLLTASIAVCANL 187
Cdd:COG1230   95 LLLLVVAGYILYEAIQRLFNPP-PVAGGGMLVVAVIGLVVNL 135
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
 80-187 2.79e-16

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 72.69  E-value: 2.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385   80 IFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGILLYLA 159
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVFLLYES 80

                          90       100
                  ....*....|....*....|....*...
gi 148705385  160 FLRLLHSDYHIEAGAMLLTASIAVCANL 187
Cdd:pfam01545  81 IQRLLSPGEEIDPGLALILALVSLLVNL 108
PRK03557 PRK03557
CDF family zinc transporter ZitB;
45-187 1.07e-13

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 67.85  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385  45 MAFHHCHKDPVpqsglSPERVQARRqLYAACAVCFIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRP 124
Cdd:PRK03557   1 MAHSHSHTSSH-----LPEDNNARR-LLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRP 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148705385 125 ATRTMTFGWHRSETLGALASVVSLWIVTGILLYLAFLRLLHSdyHIEAGAMLLTASIA-VCANL 187
Cdd:PRK03557  75 PTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTP--RPVAGGMMMAIAVAgLLANI 136
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
67-151 4.38e-10

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 57.04  E-value: 4.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148705385  67 ARRQLYAACAVCFIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALA--- 143
Cdd:COG0053    1 GRRAALASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGKAEYLASLIvav 80

                         90
                 ....*....|
gi 148705385 144 --SVVSLWIV 151
Cdd:COG0053   81 liLLAGLFIL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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