NCBI Conserved Domain Search

Conserved domains on [gi|148695531|gb|EDL27478|]

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olfactory receptor 1270 [Mus musculus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

1.68e-164

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 457.83 E-value: 1.68e-164

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

1.68e-164

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 457.83 E-value: 1.68e-164

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-299

1.89e-45

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 154.97 E-value: 1.89e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531   29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  189 DTFVESVIVMansgLIALCSF----LVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:pfam13853 161 DIKVNNIYGL----FVVTSTFgidsLLIVLSYGLILrTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 148695531  264 TEDKLVAVF----YTVITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:pfam13853 237 NVPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

1.68e-164

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 457.83 E-value: 1.68e-164

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

24-289

2.23e-144

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 406.97 E-value: 2.23e-144

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 148695531 264 TEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

24-289

8.41e-141

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 398.01 E-value: 8.41e-141

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd13954    2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd13954   82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd13954  162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 148695531 263 FT--EDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd13954  242 YSsdLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-296

2.28e-132

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 376.80 E-value: 2.28e-132

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15225    4 FVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15225   84 GGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15225  164 ACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15225  244 peTDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

24-289

2.39e-126

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 361.27 E-value: 2.39e-126

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15936   82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:cd15936  162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                        250       260
                 ....*....|....*....|....*.
gi 148695531 264 TEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15936  242 PMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-289

3.01e-126

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 361.06 E-value: 3.01e-126

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15230    4 FVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15230   84 GTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15230  164 SCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15230  244 ldQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-289

9.23e-123

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 352.13 E-value: 9.23e-123

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15940    4 FMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15940   84 ACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFTE 265
Cdd:cd15940  164 ACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSE 243

                        250       260
                 ....*....|....*....|....
gi 148695531 266 DKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15940  244 DKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

9-299

3.22e-119

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 344.35 E-value: 3.22e-119

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531   9 ELIITGLFQDPNVQKVCFVLFLPVYLATVLGN-GLIVAMVIVSKsLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKV 87
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNlGMIVLIRLDSR-LHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAEN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  88 KTISLKGCLAQIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFC 167
Cdd:cd15943   80 KTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 168 GPNVIDHYFCDLQPLFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVV 246
Cdd:cd15943  160 GSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVT 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148695531 247 LFFGPAIFLYMRPSSTFTE--DKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:cd15943  240 IFYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-296

4.64e-118

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 340.73 E-value: 4.64e-118

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15229    4 FLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15229   84 AGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPS--ST 262
Cdd:cd15229  164 SCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIhIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNsaSS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15229  244 SVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-289

6.61e-117

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 337.15 E-value: 6.61e-117

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15912    4 FLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15912   84 GTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDT-FVESVIVMANSGLIaLCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:cd15912  164 SCSDTrLIELLDFILASVVL-LGSLLLTIVSYIyIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSS 242

                        250       260
                 ....*....|....*....|....*...
gi 148695531 264 TED--KLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15912  243 SLDlnKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

22-296

7.11e-116

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 334.96 E-value: 7.11e-116

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  22 QKVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFF 101
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 102 FHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQP 181
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 182 LFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPS 260
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 148695531 261 STF--TEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15235  241 SSYsaDKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-289

3.77e-115

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 332.91 E-value: 3.77e-115

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15911    4 FLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15911   84 AATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15911  164 SCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 ED--KLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15911  244 RDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

26-296

5.10e-114

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 330.38 E-value: 5.10e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15231    4 FLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15231   84 VGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15231  164 SCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15231  244 ldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-298

1.95e-113

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 328.83 E-value: 1.95e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15417    4 FVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15417   84 GLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15417  164 SCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15417  244 qdQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-289

7.87e-113

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 326.87 E-value: 7.87e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15431    4 FVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLiSIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15431   84 GITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVL-TMPLHFCGPNVINHFFCEVQALLKL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15431  163 ACSDTSLNEILMFATSIFTLLLPFSFILVSYIrIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSS 242

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15431  243 sdQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

11-293

9.60e-113

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 327.36 E-value: 9.60e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  11 IITGLFQDPNVQKVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTI 90
Cdd:cd15408    2 ILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  91 SLKGCLAQIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPN 170
Cdd:cd15408   82 SFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGSN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 171 VIDHYFCDLQPLFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFF 249
Cdd:cd15408  162 VINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLFY 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 148695531 250 GPAIFLYMRPSSTFTE--DKLVAVFYTVITPMLNPIIYTLRNAEVK 293
Cdd:cd15408  242 GSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-295

5.80e-112

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 324.89 E-value: 5.80e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15421    4 FSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15421   84 GGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15421  164 SCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHS 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15421  244 peQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

11-299

2.15e-111

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 324.23 E-value: 2.15e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  11 IITGLFQDPNVQKVCFVLFLPVYLATVLGN-GLIVAMVIVSKsLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKT 89
Cdd:cd15410    2 ILLGFTDYPELQVPLFLVFLAIYGITLLGNlGMIVLIKIDPK-LHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  90 ISLKGCLAQIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGP 169
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 170 NVIDHYFCDLQPLFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLF 248
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTiLRIRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148695531 249 FGPAIFLYMRPSSTFT--EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:cd15410  241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

26-289

2.45e-111

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 323.07 E-value: 2.45e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15237    4 FILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15237   84 GVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15237  164 ACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 E--DKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15237  244 PdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-289

1.06e-110

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 321.44 E-value: 1.06e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15938    4 FALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15938   84 GAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRkhSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFTE 265
Cdd:cd15938  164 ACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPV 241

                        250       260
                 ....*....|....*....|....
gi 148695531 266 DKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15938  242 DKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

24-289

2.26e-110

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 320.55 E-value: 2.26e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15227    2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15227   82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15227  162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                        250       260
                 ....*....|....*....|....*....
gi 148695531 263 F--TEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15227  242 SpsLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-298

1.61e-109

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 318.87 E-value: 1.61e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15419    4 FLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15419   84 GTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15419  164 SCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15419  244 peQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

26-289

6.44e-109

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 317.25 E-value: 6.44e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15918    4 FGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15918   84 GDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15918  164 SCSDTHLNELVILVLGGLVGLVPFLCILVSYVrIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15918  244 asKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

26-298

1.15e-108

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 316.95 E-value: 1.15e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15411    4 FVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15411   84 ATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15411  164 SCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 E--DKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15411  244 LgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

24-289

8.14e-107

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 311.93 E-value: 8.14e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15915    2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15915   82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRK--HSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSS 261
Cdd:cd15915  162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLkvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 148695531 262 --TFTEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15915  242 gdSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

24-289

3.62e-106

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 310.13 E-value: 3.62e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                        250       260
                 ....*....|....*....|....*.
gi 148695531 264 TEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15937  242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-298

7.25e-106

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 309.72 E-value: 7.25e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15409    4 FLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15409   84 ATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15409  164 SCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15409  244 ldQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-295

1.11e-105

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 309.33 E-value: 1.11e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15429    4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15429   84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCS-FLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15429  164 ACVDTSLNEVAILVSSVVVLLTPcFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15429  244 alQEKMISLFYAVVTPMLNPLIYSLRNKEVKGA 276

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-289

6.86e-104

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 304.38 E-value: 6.86e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSL-HSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHF 104
Cdd:cd15935    4 FVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 105 LGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFK 184
Cdd:cd15935   84 LGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 185 LACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15935  164 LACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSS 243

                        250       260
                 ....*....|....*....|....*
gi 148695531 265 EDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15935  244 VDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

25-298

1.84e-103

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 303.47 E-value: 1.84e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  25 CFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHF 104
Cdd:cd15413    3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 105 LGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFK 184
Cdd:cd15413   83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 185 LACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST- 262
Cdd:cd15413  163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSh 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 148695531 263 -FTEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15413  243 sLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-295

1.01e-102

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 301.55 E-value: 1.01e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15420    4 FGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15420   84 AHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15420  164 ACADTWINEILIFAGCVFILLGPFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNS 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148695531 265 E--DKLVAVFYTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15420  244 AeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

24-295

2.21e-102

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 300.89 E-value: 2.21e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15228    2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15228  242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAA 274

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-296

9.96e-102

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 298.98 E-value: 9.96e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLL-AKVKTISLKGCLAQIFFFHF 104
Cdd:cd15916    4 FLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 105 LGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFK 184
Cdd:cd15916   84 LGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 185 LACTDTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:cd15916  164 LACADTTINELVIFASIGVVALGCFILILLSYGNIVrAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKE 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148695531 264 TEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15916  244 ALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

23-298

4.17e-101

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 297.77 E-value: 4.17e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSS 261
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 148695531 262 TFT--EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15412  241 EESveQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-298

4.81e-101

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 297.36 E-value: 4.81e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15416    4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15416   84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15416  164 SCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 ED--KLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15416  244 MDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

11-298

6.34e-101

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 297.81 E-value: 6.34e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  11 IITGLFQDPNVQKVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTI 90
Cdd:cd15945    2 ILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  91 SLKGCLAQIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPN 170
Cdd:cd15945   82 PFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 171 VIDHYFCDLQPLFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFF 249
Cdd:cd15945  162 TINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLFY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148695531 250 GPAIFLYMRPSSTFT--EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15945  242 GTLLFMYLRPSSSYSldTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-289

8.14e-100

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 294.17 E-value: 8.14e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15232    4 FWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15232   84 LGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15232  164 SCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15232  244 peKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

26-298

2.07e-99

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 293.17 E-value: 2.07e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15415    4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15415   84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15415  164 SCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15415  244 leQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

23-289

3.23e-99

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 292.60 E-value: 3.23e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15947    1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15947   81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDT-FVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSS 261
Cdd:cd15947  161 IKLACVDTtFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 148695531 262 TFTED--KLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15947  241 SYSQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-299

5.85e-98

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 290.04 E-value: 5.85e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  14 GLFQDPNVQKVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLK 93
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  94 GCLAQIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVID 173
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 174 HYFCDLQPLFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPA 252
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 253 IFLYMRPSS--TFTEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:cd15406  241 IFMYLKPSSssSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-289

1.05e-97

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 288.80 E-value: 1.05e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15224    4 FLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15224   84 ACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPS--ST 262
Cdd:cd15224  164 SCTDMSLAELVDFILALIILLVPLLVTVASYIcIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKaiSS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15224  244 FDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-303

3.58e-97

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 287.79 E-value: 3.58e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15414    4 FLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15414   84 VAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15414  164 SCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSS 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRKLWGKR 303
Cdd:cd15414  244 ldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

24-289

1.33e-95

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 283.11 E-value: 1.33e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15914    2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15914   82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15914  162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVkIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                        250       260
                 ....*....|....*....|....*....
gi 148695531 263 F--TEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15914  242 YslDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

11-299

3.26e-95

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 283.21 E-value: 3.26e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  11 IITGLFQDPNVQKVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTI 90
Cdd:cd15944    2 ILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  91 SLKGCLAQIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPN 170
Cdd:cd15944   82 SFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 171 VIDHYFCDLQPLFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFF 249
Cdd:cd15944  162 IINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLFY 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148695531 250 GPAIFLYMRPSSTFT--EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:cd15944  242 GTVIFMYLRPTSVYSldQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

26-296

4.63e-95

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 282.01 E-value: 4.63e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15942    4 FLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15942   84 GCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15942  164 ACADTAFNELVTFIDIGLVAMTCFLLILMSYVyIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDP 243

                        250       260       270
                 ....*....|....*....|....*....|..
gi 148695531 265 EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15942  244 LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-298

5.78e-93

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 276.99 E-value: 5.78e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15407    4 FIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15407   84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15407  164 SCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15407  244 mdTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-296

7.22e-93

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 276.62 E-value: 7.22e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15424    4 FVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15424   84 GSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15424  164 ACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGST 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148695531 265 E--DKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15424  244 PdrDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-289

1.61e-92

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 275.40 E-value: 1.61e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15430    1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSS 261
Cdd:cd15430  161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 148695531 262 --TFTEDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15430  241 knAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-296

1.43e-89

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 268.25 E-value: 1.43e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHS-PMYIFLSSLSLVEICYSSTVVPKFITDLLA-KVKTISLKGCLAQIFFFH 103
Cdd:cd15941    4 FLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYAFH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15941   84 FLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15941  164 KLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15941  244 QAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-289

1.62e-89

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 267.64 E-value: 1.62e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15913    4 FSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15913   84 GTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSY-VIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15913  164 SCVPAPGTELICYTLSSLIIFGTFLFILGSYtLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 ED--KLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15913  244 TGmqKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

22-299

3.69e-89

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 267.42 E-value: 3.69e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  22 QKVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFF 101
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 102 FHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQP 181
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 182 LFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPS 260
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 148695531 261 STFT--EDKLVAVFYTVITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:cd15418  241 SSHTpdRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-296

4.29e-89

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 267.04 E-value: 4.29e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15428    4 FILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15428   84 GITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFvESVIVMANSGLIALCS--FLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:cd15428  164 ASTDTH-QAEMAMFIMCVFTLVLpvLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 264 TE--DKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15428  243 SKeyDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-296

9.12e-89

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 265.98 E-value: 9.12e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15234    4 FGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15234   84 GGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMrpSSTFT 264
Cdd:cd15234  164 ACSDTLINNILIYLATVIFGGIPLSGIIFSYYkIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYI--SSAVT 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 265 ED---KLVA-VFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15234  242 HSsrkTAVAsVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

23-296

8.97e-88

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 263.47 E-value: 8.97e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15434    1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15434   81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDT-FVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRP-- 259
Cdd:cd15434  161 IKLACVDTtAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPkn 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 148695531 260 SSTFTEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15434  241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

24-295

2.26e-86

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 260.11 E-value: 2.26e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAvLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 263 FT--EDKLVAVFYTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15233  242 YSsdKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

24-296

4.76e-86

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 259.32 E-value: 4.76e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15236    2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLF 183
Cdd:cd15236   82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSST 262
Cdd:cd15236  162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 263 FTEDK--LVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15236  242 NSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-289

1.24e-84

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 255.48 E-value: 1.24e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15946    4 FAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15946   84 GITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTFT 264
Cdd:cd15946  164 ACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYS 243

                        250       260
                 ....*....|....*....|....*..
gi 148695531 265 --EDKLVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15946  244 peRDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

23-296

2.05e-84

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 255.10 E-value: 2.05e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDTFVESVIVMANSGLIALCSF-LVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSS 261
Cdd:cd15432  161 LKLSCVDTTANEAELFVISVLLLLIPLgLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 148695531 262 TFTED--KLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15432  241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-296

1.99e-83

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 252.72 E-value: 1.99e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15405    4 FFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15405   84 VISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSS--T 262
Cdd:cd15405  164 SCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNiLHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSvgS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15405  244 VNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

23-296

4.97e-79

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 241.23 E-value: 4.97e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15433    1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPL 182
Cdd:cd15433   81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 183 FKLACTDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSS 261
Cdd:cd15433  161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGhVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 148695531 262 TF--TEDKLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15433  241 RYsqAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-296

6.26e-65

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 205.22 E-value: 6.26e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15223    4 SLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15223   84 TAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFF--GPAIFLYMRPSST 262
Cdd:cd15223  164 ACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILrAVLRLASGEARSKALNTCGSHLIVILFFYtaVLVSSLTYRFGKT 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 263 FTED--KLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15223  244 IPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-292

4.45e-60

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 192.89 E-value: 4.45e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15917   87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVESVIVMANSGLIALCSFLVLVSSYVIILVN-LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYM-------RPS 260
Cdd:cd15917  167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthrfghhVPP 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 148695531 261 STFTedkLVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15917  247 HVHI---LLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-292

2.63e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 182.97 E-value: 2.63e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DtfvesVIVMANSGLIALCSF----LVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMrpSSTF 263
Cdd:cd15952  167 S-----IRINIIYGLFAISVLvldvILIALSYVLILrAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFL--THRF 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 264 TEDK------LVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15952  240 GHNIpryihiLLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

27-292

3.50e-56

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 182.61 E-value: 3.50e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15950    5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLA 186
Cdd:cd15950   85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 187 CTDTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIF-LYMRpssTFT 264
Cdd:cd15950  165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILrAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQ---RFG 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148695531 265 ED------KLVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15950  242 QGvpphtqVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-292

3.57e-56

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 182.88 E-value: 3.57e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFlymrpsSTFTE-- 265
Cdd:cd15221  167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILrAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFF------SFLTHrf 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 266 --------DKLVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15221  241 grhiprhvHILLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-292

4.60e-53

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 174.76 E-value: 4.60e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSR-QVCHVLVAVSWLGGFLHSIIQVLISiQLPFCGPNVIDHYFCDLQPLFKLAC 187
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTNsRIAKLGLVGLIRGVLLILPLPLLLS-RLPFCANRIIPHTYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 188 TDTFVESVIVMANSGLIALCSFLVLVSSYV-IILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMrpSSTFTED 266
Cdd:cd15953  166 GDTTINRIYGLVVALLVVGLDLLLIALSYAlIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFL--THRFGQG 243

                        250       260       270
                 ....*....|....*....|....*....|..
gi 148695531 267 K------LVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15953  244 IaphihiILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

26-292

1.13e-52

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 173.84 E-value: 1.13e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15222    4 SIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIM-SRQVCHVLVAVSWLGGFLHSIIQVLISiQLPFCGPNVIDHYFCDLQPLFK 184
Cdd:cd15222   84 SFMESSVLLAMAFDRFVAICNPLRYASILtNSRIAKIGLAIVLRSVLLLLPLPFLLK-RLPFCHSNVLSHSYCLHQDVMK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 185 LACTDTFVESV----IVMANSGLIALCSFLvlvsSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYM-- 257
Cdd:cd15222  163 LACSDTRVNSIyglfVVLSTMGLDSLLILL----SYVLILkTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMvh 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 148695531 258 ---RPSSTFTEdKLVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15222  239 rfgKHASPLVH-VLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-289

1.98e-50

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 167.91 E-value: 1.98e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15951    7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15951   87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMrpSSTFTEDK 267
Cdd:cd15951  167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILrAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFL--THRFGHNV 244

                        250       260
                 ....*....|....*....|....*...
gi 148695531 268 ------LVAVFYTVITPMLNPIIYTLRN 289
Cdd:cd15951  245 pphvhiLIANVYLLVPPMLNPIIYGVRT 272

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-299

1.89e-45

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 154.97 E-value: 1.89e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531   29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  189 DTFVESVIVMansgLIALCSF----LVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMRPSSTF 263
Cdd:pfam13853 161 DIKVNNIYGL----FVVTSTFgidsLLIVLSYGLILrTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 148695531  264 TEDKLVAVF----YTVITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:pfam13853 237 NVPPLLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

29-292

3.75e-43

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 149.24 E-value: 3.75e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15956    7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15956   87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYM----RPSSTF 263
Cdd:cd15956  167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVkTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSVPS 246

                        250       260
                 ....*....|....*....|....*....
gi 148695531 264 TEDKLVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15956  247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

29-293

2.72e-41

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 144.53 E-value: 2.72e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15949   23 FCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15949  103 ESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACG 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAI-------FLYMRPS 260
Cdd:cd15949  183 DVSINNHYGLTIGFLVLIMDSLFIVLSYIMILrVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAvsslihrFGQNVPP 262

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148695531 261 STFTedkLVAVFYTVITPMLNPIIYTLRNAEVK 293
Cdd:cd15949  263 PTHI---LLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-293

3.18e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 141.58 E-value: 3.18e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFlymrpSSTFTEDK 267
Cdd:cd15948  168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILrAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVL-----SSTMHRFA 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 268 ---------LVAVFYTVITPMLNPIIYTLRNAEVK 293
Cdd:cd15948  243 rhvaphvhiLLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-292

5.69e-40

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 140.73 E-value: 5.69e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLACT 188
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVESVIVMANSGLIALCSFLVLVSSYVIIL-VNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMR-----PSST 262
Cdd:cd15954  167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILrAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfggHHIT 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 148695531 263 FTEDKLVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15954  247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-285

1.51e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 136.66 E-value: 1.51e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531   39 GNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVK-TISLKGCLAQIFFFHFLGVAEIFLLVVMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  118 YDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIdhyFCDLQPLFKLACtdtfvESVIV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT---VCFIDFPEDLSK-----PVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  198 MANSGLIALCSFLVLVSSYVIILVNLRKHSAEG--------RRKALSTCASHITVVVLFFGPAIFLYMRPSSTFTEDK-- 267
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsr 232

                         250       260
                  ....*....|....*....|....
gi 148695531  268 ------LVAVFYTVITPMLNPIIY 285
Cdd:pfam00001 233 lldkalSVTLWLAYVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

29-292

7.45e-35

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 127.58 E-value: 7.45e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  29 FLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVA 108
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVC-HVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPLFKLAC 187
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTPQVLlGIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 188 TDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNL-RKHSAEGRRKALSTCASHITVVVLFFGPAIFLYM--RPSSTFT 264
Cdd:cd15955  167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFGHHVA 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 148695531 265 E--DKLVAVFYTVITPMLNPIIYTLRNAEV 292
Cdd:cd15955  247 PyvHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

26-289

1.27e-25

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 102.75 E-value: 1.27e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCDLQPlfkl 185
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL---- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 actdtfvESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASH------------ITVVVLFF---G 250
Cdd:cd00637  158 -------SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLlcwL 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 148695531 251 PAIFLYMRPSSTFTEDKLVAVFYTVIT------PMLNPIIYTLRN 289
Cdd:cd00637  231 PYFILLLLDVFGPDPSPLPRILYFLALllaylnSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

27-295

8.16e-20

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 86.46 E-value: 8.16e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd14967    4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVlisIQLPFCGPNVIDHYFCDLQPlfkla 186
Cdd:cd14967   84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPL---VGWRDETQPSVVDCECEFTP----- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 187 ctdtfvESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHsaegrRKALSTcashITVVVLFFG----PAIFLYMRpSST 262
Cdd:cd14967  156 ------NKIYVLVSSVISFFIPLLIMIVLYARIFRVARRE-----LKAAKT----LAIIVGAFLlcwlPFFIIYLV-SAF 219

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 148695531 263 FTEDKLVAVFYTVIT------PMLNPIIYTLRNAEVKNA 295
Cdd:cd14967  220 CPPDCVPPILYAVFFwlgylnSALNPIIYALFNRDFRRA 258

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

27-296

2.40e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 65.78 E-value: 2.40e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEiCYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIqvlisiqlpfcgpnvidhyfcdlqPLFKLA 186
Cdd:cd14972   82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALL------------------------PVLGWN 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 187 CTDTFVESVIVMAN---SGLIALCSFLVLVSSYVIILVNLR------KHSAEGRRKALSTCASH--------ITVVVLF- 248
Cdd:cd14972  138 CVLCDQESCSPLGPglpKSYLVLILVFFFIALVIIVFLYVRifwclwRHANAIAARQEAAVPAQpstsrklaKTVVIVLg 217

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 148695531 249 -----FGPAIFLYMRPSSTFTEDKLVAVFYTVITPML-----NPIIYTLRNAEVKNAV 296
Cdd:cd14972  218 vflvcWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

34-296

1.22e-11

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 63.76 E-value: 1.22e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLL 113
Cdd:cd14969   12 VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 114 VVMAYDRYVAICKPLHYMNIMSRQVChVLVAVSWLGGFLHSIiqvlisiqLPFCGpnvIDHYfcDLQPLFKlACT-DTFV 192
Cdd:cd14969   92 AALAFERYLVIVRPLKAFRLSKRRAL-ILIAFIWLYGLFWAL--------PPLFG---WSSY--VPEGGGT-SCSvDWYS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 193 ESVIVMANSG-LIALCSFL---VLVSSYVIILVNLRKHSAEGRRKALSTCAS-----------HITVVVLFF----GP-A 252
Cdd:cd14969  157 KDPNSLSYIVsLFVFCFFLplaIIIFCYYKIYRTLRKMSKRAARRKNSAITKrtkkaekkvakMVLVMIVAFliawTPyA 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148695531 253 IF-LYmrpsSTFTEDKLVAVFYTVITPML-------NPIIYTLRNAEVKNAV 296
Cdd:cd14969  237 VVsLY----VSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

32-160

3.71e-10

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 59.17 E-value: 3.71e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYS-STVVPKFITDLlakvkTISLKGCLAQIFFFHFLGVAEI 110
Cdd:cd15196   10 ILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDI-----TYRFYGGDLLCRLVKYLQVVGM 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148695531 111 FL----LVVMAYDRYVAICKPLHYMNImSRQVCHVLVAVSWLGGFLHSIIQVLI 160
Cdd:cd15196   85 YAssyvLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLFI 137

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

27-147

7.56e-10

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 58.64 E-value: 7.56e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKG--------CLAQ 98
Cdd:cd15350    5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531  99 IFFFHFLGvaEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSW 147
Cdd:cd15350   85 LFCLSLLG--SIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIW 131

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

26-152

8.76e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 58.42 E-value: 8.76e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFItdLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAI--LISLGLPTNFHGCLFMACLVLVL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFL 152
Cdd:cd14968   82 TQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFL 128

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

34-295

9.76e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 58.11 E-value: 9.76e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIFFFHFLGV------ 107
Cdd:cd15064   12 LATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP------LSAVYELTGRWILGQVLCDIWISLdvtcct 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 108 AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLggflhsiIQVLISI--QLPFCGPNVIDHYFCDLQPLFKL 185
Cdd:cd15064   86 ASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWT-------LSICISLppLFGWRTPDSEDPSECLISQDIGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMAnsglialcsfLVLVSSYVIIlvnlrkHSAEGRRKALSTCASHITVVVL----FFGPAIFLYMRPSS 261
Cdd:cd15064  159 TIFSTFGAFYIPLL----------LMLILYWKIY------RAAARERKAAKTLGIILGAFIVcwlpFFLVALIVPLCSHC 222

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 262 TF-TEDKLVAVFYTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15064  223 WIpLALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

37-148

1.16e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 55.11 E-value: 1.16e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLLVVM 116
Cdd:cd15336   15 MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAI 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 148695531 117 AYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15336   95 SLDRYLVITKPLASIRWVSKKRAMIIILLVWL 126

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

27-151

5.62e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 53.01 E-value: 5.62e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKvkTISLKGCLAQIFFFHFLG 106
Cdd:cd15069    5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGF--CTDFHSCLFLACFVLVLT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGF 151
Cdd:cd15069   83 QSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAF 127

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

28-295

7.11e-08

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 52.70 E-value: 7.11e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP-KFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15052    6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLggflhsiIQVLISIQLPFCGpnVIDHyfcdlqplfkla 186
Cdd:cd15052   86 TASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWL-------ISIGISSPIPVLG--IIDT------------ 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 187 cTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVN--LRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYM-----RP 259
Cdd:cd15052  145 -TNVLNNGTCVLFNPNFVIYGSIVAFFIPLLIMVVTyaLTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNIltglcEE 223

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 148695531 260 SSTFTEDKLVAVFYTV--ITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15052  224 CNCRISPWLLSVFVWLgyVSSTINPIIYTIFNKTFRRA 261

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-156

7.24e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 52.56 E-value: 7.24e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIF--FFH 103
Cdd:cd15055    4 YIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSIETCWYFGDTFckLHS 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148695531 104 FLGV----AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSII 156
Cdd:cd15055   78 SLDYiltsASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV 134

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

32-160

8.07e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 52.76 E-value: 8.07e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYS-STVVPKFITDLLAKVKTISLkGCLAQIFFFHFLGVAEI 110
Cdd:cd14986   10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWVAGDV-LCRIVKYLQVVGLFAST 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 148695531 111 FLLVVMAYDRYVAICKPLHYMNimSRQVCHVLVAVSWLGGFLHSIIQVLI 160
Cdd:cd14986   89 YILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLVI 136

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

32-147

8.35e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 52.84 E-value: 8.35e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTI-SLKGCLAQIFFFHFLGVAEI 110
Cdd:cd15005   10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSA 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 148695531 111 FLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSW 147
Cdd:cd15005   90 FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

24-148

8.76e-08

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 52.45 E-value: 8.76e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIFF-F 102
Cdd:cd15317    2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP------FSMIRTVETCWYFGDLFCkF 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148695531 103 HF-----LGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15317   76 HTgldllLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

27-285

1.35e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 51.83 E-value: 1.35e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFfhfLG 106
Cdd:cd14993    5 VLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYL---QG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 V---AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPN--VIDHYFCD--- 178
Cdd:cd14993   82 VsvsASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEpgTITIYICTedw 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 179 ----LQPLFKLACTDT--FVESVIVMANSGLIA--LCSFLVLVSSYVIILVNLRKHSAEGRRKALSTcashITVVVLFFG 250
Cdd:cd14993  162 pspeLRKAYNVALFVVlyVLPLLIISVAYSLIGrrLWRRKPPGDRGSANSTSSRRILRSKKKVARML----IVVVVLFAL 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 148695531 251 P-------AIFLYMRPSSTFTEDKLVAVFYTVITPM------LNPIIY 285
Cdd:cd14993  238 SwlpyyvlSILLDFGPLSSEESDENFLLILPFAQLLgysnsaINPIIY 285

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

26-154

1.41e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 51.97 E-value: 1.41e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNglivAMVIVS----KSLHSPMYIFLSSLSLVEICYSSTVVPKFITDllakvktiSLKGC--LAQI 99
Cdd:cd15312    4 YLFMAGAILLTVFGN----LMVIISishfKQLHSPTNFLILSLAITDFLLGFLVMPYSMVR--------SVESCwyFGDL 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148695531 100 F------FFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHS 154
Cdd:cd15312   72 FckihssLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

24-152

1.68e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 51.34 E-value: 1.68e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15063    2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFL 152
Cdd:cd15063   82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV 130

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

32-159

2.34e-07

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 51.13 E-value: 2.34e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIFFFHFLGV---- 107
Cdd:cd15330   10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP------MAALYQVLNKWTLGQVTCDLFIALdvlc 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148695531 108 --AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVL 159
Cdd:cd15330   84 ctSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPML 137

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

28-295

2.86e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 50.82 E-value: 2.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGV 107
Cdd:cd15061    5 FLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 108 AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsiIQVLISIQLPFCGPNviDHYFCDLQplfklAC 187
Cdd:cd15061   85 ASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVW--------VISLLITSPPLVGPS--WHGRRGLG-----SC 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 188 TDTFVESVIVMAnsgliALCSFLVLVssYVIILVNLR-KHSAEGRRKALSTCASHITVVVLFFGPAIFLYMrpSSTFTED 266
Cdd:cd15061  150 YYTYDKGYRIYS-----SMGSFFLPL--LLMLFVYLRiFRVIAKERKTAKTLAIVVGCFIVCWLPFFIMYL--IEPFCDC 220

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 267 KLVAVFYTVIT------PMLNPIIYTLRNAEVKNA 295
Cdd:cd15061  221 QFSEALSTAFTwlgyfnSVINPFIYAFYNKDFRRA 255

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

28-161

3.07e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 50.57 E-value: 3.07e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIF------F 101
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsM 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 102 FHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLIS 161
Cdd:cd15103   86 ICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYS 145

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

27-159

3.15e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 50.71 E-value: 3.15e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVaMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQI-----FF 101
Cdd:cd14978    5 YVLPVICIFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 148695531 102 FHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVL 159
Cdd:cd14978   84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFF 141

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

34-295

7.27e-07

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 49.45 E-value: 7.27e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLH-SPMYIFLSSLSLVEICYSSTVVPKFIT-DLLAKVKTislkgclAQIFFFHFLGVAEIF 111
Cdd:cd15341   12 LLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFACSFVDfHVFHGVDS-------SAIFLLKLGGVTMSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 112 L-----LVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIqLPFCGPNVidhyfCDLQPlfklA 186
Cdd:cd15341   85 TaslgsLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMW-------VLTALIAY-LPLMGWNC-----CPLNS----P 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 187 CTDTF--VESVIVMANSGLIALCsFLVLVSSYVIILVNLRKHSA--------EGRRKA--------LSTCASHITVVVLF 248
Cdd:cd15341  148 CSELFplIPNDYLLSWLLLVAIL-LSGIIYTYGHVLWKAHKHVVymekhqdqQGPGNArmrldvrlAKTLGLVLAVLLIC 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148695531 249 FGPAIFLYMRPSSTFTEDKLVAVF-----YTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15341  227 WSPVLALMMHSLFTSLSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRSS 278

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

28-295

8.63e-07

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 49.27 E-value: 8.63e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVY-LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVK-TISLKGCLAQIFFFHFL 105
Cdd:cd15053    5 LFLLLLpLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILCDIYIAMDVMC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLggflhsiIQVLISIQLpFCGPNVidhyfcdlqplfkl 185
Cdd:cd15053   85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWV-------VSAAIACPL-LFGLNN-------------- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 acTDTFVESVIVMANSGLI---ALCSF----LVLVSSYVIILVNLRKhsaegRRKALSTCASHITVVVLFFGPAIFLYMR 258
Cdd:cd15053  143 --VPYRDPEECRFYNPDFIiysSISSFyipcIVMLLLYYRIFRALRR-----EKKATKTLAIVLGVFLFCWLPFFTLNIL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 148695531 259 PSSTFTEDK------LVAVFYTV----ITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15053  216 NAICPKLQNqschvgPALFSLTTwlgyVNSFLNPIIYTIFNIEFRKA 262

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

34-158

9.43e-07

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 49.35 E-value: 9.43e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMY-IFLSSLSLVEICYSSTVVPKFITDLLAKVKTISlKGCLAQIFFFHFLGVAEIFL 112
Cdd:cd15057   12 LLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIMCSTASILN 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 148695531 113 LVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQV 158
Cdd:cd15057   91 LCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPV 136

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

32-155

1.55e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 48.58 E-value: 1.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIF 111
Cdd:cd15050   10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIF 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 148695531 112 LLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd15050   90 SLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVI 133

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

27-249

2.72e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 48.06 E-value: 2.72e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAK-VKTISLKGCLAQIFFFHFL 105
Cdd:cd14997    5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWARePWLLGEFMCKLVPFVELTV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISI--QLPFCGPNVIdhYFCDLQplf 183
Cdd:cd14997   85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEfkEEDFNDGTPV--AVCRTP--- 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148695531 184 klacTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSA--EGRRKALSTCASH---------ITVVVLFF 249
Cdd:cd14997  160 ----ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPAleSRRADAANRHTLRsrrqvvymlITVVVLFF 232

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

27-148

3.23e-06

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 47.57 E-value: 3.23e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVvPKFITDLLAKVKTISLKGClaQIFFF--HF 104
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGC--QIYAFlgSL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 148695531 105 LGVAEIFLLVVMAYDRYVAICKPLHyMNIMSRQVCHVLVAVSWL 148
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWL 124

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

27-233

3.31e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 47.44 E-value: 3.31e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15012    4 ILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNvidhyfcdlqplfKLA 186
Cdd:cd15012   84 TASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQ-------------DGQ 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148695531 187 CTDTFVEsVIVMANSGLIALCSFLV--------LVSSYVIILVNLRKHSA-EGRRK 233
Cdd:cd15012  151 EEEICVL-DREMFNSKLYDTINFIVwyliplliMTVLYSKISIVLWKSSSiEARRK 205

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-155

4.00e-06

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 47.27 E-value: 4.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15329    4 GIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd15329   84 CTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISI 133

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

36-156

4.02e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 47.35 E-value: 4.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  36 TVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP-KFITDLLAKvktiSLKG---CLAQIFFFHFLGVAEIF 111
Cdd:cd15065   13 AIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTfAVVNDLLGY----WLFGetfCNIWISFDVMCSTASIL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 148695531 112 LLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSII 156
Cdd:cd15065   89 NLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFL 133

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

34-148

4.31e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 47.16 E-value: 4.31e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLL 113
Cdd:cd15318   12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 148695531 114 VVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15318   92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWL 126

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

24-152

4.86e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 47.24 E-value: 4.86e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITdlLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15068    2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFL 152
Cdd:cd15068   80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA 128

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

25-161

5.69e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 47.31 E-value: 5.69e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  25 CFVLFLpvYLATVLGNGLIVAMVIVSKSLHSPMY-IFLSSLSLVEICYSSTVVP-KFITDLLAKVKTISLkgCLAQIFFF 102
Cdd:cd15320    6 CFLSVL--ILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVAFD 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLIS 161
Cdd:cd15320   82 IMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLN 140

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

27-298

6.20e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 46.75 E-value: 6.20e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP-KFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPiALLTILFEAMWPLPLVLCPIWLFLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLggflhsiIQVLISIQLPFCG----PNVIDHYFCDLQP 181
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWL-------ISIGIAIPVPIKGietdVDNPNNITCVLTK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 182 lfklactDTFVESVIVmaNSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIFLYMR--- 258
Cdd:cd15306  158 -------ERFGDFILF--GSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITsvl 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 148695531 259 --PSSTFTEDKLVAVFYTV--ITPMLNPIIYTLRNAEVKNAVRK 298
Cdd:cd15306  229 cdSCNQTTLQMLMEIFVWIgyVSSGVNPLVYTLFNKTFRDAFGR 272

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

34-160

6.99e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 46.72 E-value: 6.99e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVL-----GN-GLIVAMVIVSKSLhSPMYIFLSSLSLVEICYSS-TVVPKFITDLLAKVKTISLKgCLAqIFFFHFLG 106
Cdd:cd15386    7 LAAILvvataGNlAVLLAMYRMRRKM-SRMHLFVLHLALTDLVVALfQVLPQLIWEITYRFQGPDLL-CRA-VKYLQVLS 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148695531 107 V-AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVChVLVAVSWLGGFLHSIIQVLI 160
Cdd:cd15386   84 MfASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLSCILSLPQVFI 137

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

27-165

9.49e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 46.33 E-value: 9.49e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15333    9 VLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP------ISIVYTVTGTWTLGQVVCDIWLS 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148695531 107 ------VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLggflhsiiqVLISIQLP 165
Cdd:cd15333   83 sditccTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWV---------ISISISLP 138

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

28-147

1.21e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 46.05 E-value: 1.21e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYS-----STVVPKFI--TDLLAKVKTISLKGCLAQIF 100
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvsngsETVVITLLngNDTDAQSFTVNIDNVIDSVI 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 148695531 101 FFHFLgvAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSW 147
Cdd:cd15353   86 CSSLL--ASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130

7tmA_D4_dopamine_R

cd15308

D4 dopamine receptor of the D2-like family, member of the class A family of ...

26-151

1.27e-05

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320434 [Multi-domain] Cd Length: 258 Bit Score: 45.60 E-value: 1.27e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFI-TDLLAKVKTISLKGCLAQIFFFHF 104
Cdd:cd15308    4 LVGGVLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVySEFQGGVWTLSPVLCDALMTMDVM 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 105 LGVAEIFLLVVMAYDRYVAICKPLHY--MNIMSRQVchVLVAVSWLGGF 151
Cdd:cd15308   84 LCTASIFNLCAISVDRFIAVSVPLNYnrRQGSVRQL--LLISATWILSF 130

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

32-237

1.54e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 45.54 E-value: 1.54e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYS-STVVPKFITDLlakvkTISLKG----CLAqIFFFHFLG 106
Cdd:cd15388   10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAfFQVLPQLVWDI-----TDRFRGpdvlCRL-VKYLQVVG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 V-AEIFLLVVMAYDRYVAICKPLHYMNiMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFcGPNVIDHYFCDLQPlFKL 185
Cdd:cd15388   84 MfASSYMIVAMTFDRHQAICRPMVTFQ-KGRARWNGPVCVAWAISLILSLPQVFIFSKVEV-APGVYECWACFIEP-WGL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALST 237
Cdd:cd15388  161 KAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIVAVVKKKQLLS 212

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

36-152

1.90e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 45.34 E-value: 1.90e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  36 TVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLLVV 115
Cdd:cd15074   14 STLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTA 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 148695531 116 MAYDRYVAICKPlHYMNIMSRQVCHVLVAVSWLGGFL 152
Cdd:cd15074   94 ISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALF 129

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

27-295

2.01e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 45.28 E-value: 2.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP-KFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIQLPFCGpnvidhyfcdLQPLFKL 185
Cdd:cd15305   85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------TISIGISMPIPVIG----------LQDDEKV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 actdtFVESVIVMANSGLIALCSFL-------VLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGPAIF---- 254
Cdd:cd15305  148 -----FVNGTCVLNDENFVLIGSFVaffipliIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFitni 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 148695531 255 LYMRPSSTFTED---KLVAVFYTV--ITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15305  223 LSVLCKEACDQKlmeELLNVFVWVgyVSSGINPLVYTLFNKTYRRA 268

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

28-147

2.15e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 45.31 E-value: 2.15e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG- 106
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDSl 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 148695531 107 -----VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSW 147
Cdd:cd15354   86 icisvVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

21-181

2.77e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 44.81 E-value: 2.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  21 VQKVCFVLFLpvylaTVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSS-TVVPKFITDLLAKVKTISLKGCLAQi 99
Cdd:cd15387    4 VTVLALILFL-----ALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDITFRFYGPDFLCRLVK- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 100 fFFHFLGV-AEIFLLVVMAYDRYVAICKPLHYMNimsRQVCHVLVAVSWLGGFLHSIIQVLIsIQLPFCGPNVIDHYFCD 178
Cdd:cd15387   78 -YLQVVGMfASTYMLLLMSIDRCLAICQPLRSLH---RRSDRVYVLFSWLLSLVFSIPQVHI-FSLREVGNGVYDCWADF 152


                 ...
gi 148695531 179 LQP 181
Cdd:cd15387  153 IQP 155

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

32-148

3.01e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 44.75 E-value: 3.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIF 111
Cdd:cd15058   10 IILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIE 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 148695531 112 LLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15058   90 TLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWI 126

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

32-160

3.35e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 44.81 E-value: 3.35e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSS-TVVPKFITDLlakvkTISLKG--CLAQIF-FFHFLGV 107
Cdd:cd15385   10 IFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDI-----TYRFYGpdFLCRIVkHLQVLGM 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148695531 108 -AEIFLLVVMAYDRYVAICKPLHYMNiMSRQVCHVLVAVSWLGGFLHSIIQVLI 160
Cdd:cd15385   85 fASTYMLVMMTADRYIAICHPLKTLQ-QPTKRSYLMIGSAWALSFILSTPQYFI 137

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

34-295

4.66e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 43.88 E-value: 4.66e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFIT-DLLAKVKTISLKGClaqiFFFHFLGV----A 108
Cdd:cd15067   11 LVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILhEMTGGYWLFGRDWC----DVWHSFDVlastA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 109 EIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIQLPFCGPNVIDHYFCDLQPLfklact 188
Cdd:cd15067   87 SILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVW-------ICSALISFPAIAWWRAVDPGPSPPNQCL------ 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 dtFVESVIVMANSGLIAL-CSFLVLVSSYVIILvnlrkHSAEGRRKALSTCASHITVVVL----FFGPAIFLYMRPSSTF 263
Cdd:cd15067  154 --FTDDSGYLIFSSCVSFyIPLVVMLFTYYRIY-----RAAAKEQKAAKTLGIVMGVFILcwlpFFVTNILIGFCPSNCV 226

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 264 TEDKLVAVFYT---VITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15067  227 SNPDILFPLVTwlgYINSGMNPIIYACSSRDFRRA 261

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

27-168

5.59e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 43.77 E-value: 5.59e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVK-TISLKGCLAQIFFFHFL 105
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLF 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIQLPFCG 168
Cdd:cd15304   85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFG 140

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

34-295

5.61e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 43.76 E-value: 5.61e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLL 113
Cdd:cd15321   18 LFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 114 VVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLggflhsiIQVLISIqlpfcgPNVIDHYFCDLQPLFKLACtDTFVE 193
Cdd:cd15321   98 CAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWL-------IAAVISL------PPLIYKGKQKDEQGGLPQC-KLNEE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 194 SVIVMANSgliaLCSFlvLVSSYVIILVNLRKHS-AEGRRKALS-TCASHITVVVLFFGPAIFLY----MRPSSTFTEDK 267
Cdd:cd15321  164 AWYILSSS----IGSF--FAPCLIMILVYLRIYLiAKNREKRFTfVLAVVIGVFVLCWFPFFFSYslgaICPELCKVPHS 237

                        250       260       270
                 ....*....|....*....|....*....|
gi 148695531 268 LVAVFYTV--ITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15321  238 LFQFFFWIgyCNSSLNPVIYTIFNQDFRRA 267

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

28-161

5.89e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 44.18 E-value: 5.89e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMY-IFLSSLSLVEICYSSTVVPkfiTDLLAKVKTISLKGCLAQIF--FFHF 104
Cdd:cd15319    6 LLSLLILWTLLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLFVALLVMP---WKAVAEVAGYWPFGAFCDVWvaFDIM 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148695531 105 LGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLIS 161
Cdd:cd15319   83 CSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLN 139

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

26-285

5.99e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 43.82 E-value: 5.99e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMniMSRQVCHVLVAVSWLGGFLHSIIQVLISiqlpfcgpNVIDHYFCDLQ--PLF 183
Cdd:cd15390   84 VAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQLLYS--------TTETYYYYTGSerTVC 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLIALCSFL---VLVSSYVIILVNLRKHSAEG---RRKALSTCASH------ITVVVLFfgp 251
Cdd:cd15390  154 FIAWPDGPNSLQDFVYNIVLFVVTYFLpliIMAVAYTRVGVELWGSKTIGentPRQLESVRAKRkvvkmmIVVVVIF--- 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 148695531 252 AI--------FLYMRPSSTFTEDKLVAVFYTVI------TPMLNPIIY 285
Cdd:cd15390  231 AIcwlpyhlyFILTYLYPDINSWKYIQQIYLAIywlamsNSMYNPIIY 278

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

24-155

6.88e-05

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 43.50 E-value: 6.88e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP-KFITDLLAKVKTISLKGCLAQIFFF 102
Cdd:cd15392    2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLILQYWPFGEFMCPVVNYLQ 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPLHYMniMSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd15392   82 AVSVFVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATAL 132

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

24-160

7.20e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 43.64 E-value: 7.20e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLpVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15054    3 VAAFLCL-IILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLI 160
Cdd:cd15054   82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIEL 138

7tmA_GPR135

cd15212

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...

28-148

7.43e-05

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320340 [Multi-domain] Cd Length: 285 Bit Score: 43.60 E-value: 7.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTI-SLKGCLAQIFFFHFLG 106
Cdd:cd15212    6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLfGDRLCLANGFFNACFG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMniMSRQVCHVLVAVSWL 148
Cdd:cd15212   86 IVSTLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWL 125

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

28-156

7.45e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 43.63 E-value: 7.45e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQifffHFLGV 107
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQ----HMDNV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148695531 108 AEIFL----------LVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSII 156
Cdd:cd15351   82 IDTMIcssvvsslsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTL 140

7tmA_GPR6

cd15962

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...

40-296

7.73e-05

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320628 [Multi-domain] Cd Length: 268 Bit Score: 43.38 E-value: 7.73e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  40 NGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISlkgcLAQIFFFHFLGVAEIFLLVVMAYD 119
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETIS----LITVGFLVASFTASVSSLLAITVD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 120 RYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVL----------ISIQLPFCGPNVI---DHYFCdlqpLFKLA 186
Cdd:cd15962   94 RYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLgwncleerasCSIVRPLTKSNVTllsASFFF----IFILM 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 187 CTDTFVESVIVMANSGLIALCSFLVLVSSYViilvnlrkhsaeGRRKALSTCAshitVVVLFFGPAIFLYMRPSSTFTED 266
Cdd:cd15962  170 LHLYIKICKIVCRHAHQIALQQHFLTASHYV------------ATKKGVSTLA----IILGTFGASWLPFAIYCVVGDHE 233

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 148695531 267 KLVAVFYTVITP-----MLNPIIYTLRNAEVKNAV 296
Cdd:cd15962  234 YPAVYTYATLLPatynsMINPIIYAYRNQEIQRSM 268

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-295

8.22e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 43.29 E-value: 8.22e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLH-SPMYIFLSSLSLVEICYSSTVVPKFIT-DLLAKVKTislkgclAQIFFFHF 104
Cdd:cd15099    5 VLCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDfHVFHQRDS-------RNLFLFKL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 105 LGVAEIFL-----LVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIqLPFCGPNVidhyfCDL 179
Cdd:cd15099   78 GGVTMAFTasvgsLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMW-------CVTIIISF-LPLMGWRC-----KTW 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 180 QPlfklACTDTF--VESVIVMANSGLIALCSFLVLVsSYVIILVNLRKHSAE------GRRKA-----------LSTCAS 240
Cdd:cd15099  145 DS----PCSRLFpyIDRHYLASWTGLQLVLLFLIIY-AYPYILWKAHRHEANmggpklGRQQVkgqarmrmdirLAKTLS 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148695531 241 HITVVVLF-FGPAIFLYMRPSSTFTEDKLVAVF-----YTVITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15099  220 LILLVLAIcWLPVLAFMLVDVRVTLTNKQKRMFafcsmLCLVNSCVNPIIYALRSRELRGA 280

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

27-234

8.44e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 43.48 E-value: 8.44e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggfLHSIIQVLisiqLPFCGPN--VIDHYFCDLQplFK 184
Cdd:cd15083   85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVW----LYSLLWVL----PPLFGWSryVLEGLLTSCS--FD 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148695531 185 LACTDTFVESVIvmansglIALCSF------LVLVSSYVIILVNLRKHSAEGRRKA 234
Cdd:cd15083  155 YLSRDDANRSYV-------ICLLIFgfvlplLIIIYCYSFIFRAVRRHEKAMKEMA 203

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

24-166

8.69e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 43.32 E-value: 8.69e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEI-----CYSSTVVPKFITDLLAKVKTislkgCLAQ 98
Cdd:cd15978    2 VRILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLmlclfCMPFTLIPNLLKDFIFGSAV-----CKTA 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148695531  99 IFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPF 166
Cdd:cd15978   77 TYFMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-176

8.79e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 43.38 E-value: 8.79e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKtiSLKGCL-AQIFF--F 102
Cdd:cd15314    4 YIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMP------PSMVR--SVETCWyFGDLFckI 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148695531 103 H-----FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIQLPFCGPNVIDHYF 176
Cdd:cd15314   76 HssfdiTLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISW-------SVSALVGFGIIFLELNIKGIYY 147

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

28-155

8.94e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 43.50 E-value: 8.94e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLL-AKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd14979    6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLFEACT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd14979   86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAI 134

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

27-155

1.28e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 42.84 E-value: 1.28e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

27-296

1.38e-04

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 42.42 E-value: 1.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15060    5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMS-RQVCHVLVAVsWlggflhsIIQVLISIQlPFCGPNVIDHYFCDLQPlfkl 185
Cdd:cd15060   85 TASILNLCAIALDRYWAIHDPINYAQKRTlKRVLLMIVVV-W-------ALSALISVP-PLIGWNDWPENFTETTP---- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 aCTDTFVESVIVMANSGLIaLCSFLVLVSSYVIILVNLRKHsaegrRKALSTCASHITVVVLFFGPAIFLYM-RP-SSTF 263
Cdd:cd15060  152 -CTLTEEKGYVIYSSSGSF-FIPLLIMTIVYVKIFIATSKE-----RRAARTLGIIMGVFVVCWLPFFLMYViLPfCETC 224

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148695531 264 TEDKLVAVFYT---VITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15060  225 SPSAKVVNFITwlgYVNSALNPVIYTIFNLDFRRAF 260

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

27-152

1.39e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 42.49 E-value: 1.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEI-----CYSSTVVPKFITDLLAKVKTislkgCLAQIFF 101
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlavfCMPFTLIPNLMGTFIFGEVI-----CKAVAYL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148695531 102 FHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFL 152
Cdd:cd15979   80 MGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGL 130

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

28-161

1.75e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 42.18 E-value: 1.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG- 106
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSm 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 -----VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLIS 161
Cdd:cd15352   86 icislVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYS 145

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

26-285

1.91e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 42.25 E-value: 1.91e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd14982    4 PIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYIN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIiqVLISIQLPFCGPNVIDHYFCDLqplfkl 185
Cdd:cd14982   84 MYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV--PLLLLRSTIAKENNSTTCFEFL------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 actDTFVESVIVMANSGLIALC--SFLVLVSSYVIILVNLRKHSAEG-----RRKALSTCASHITVVVLFFGP---AIFL 255
Cdd:cd14982  156 ---SEWLASAAPIVLIALVVGFliPLLIILVCYSLIIRALRRRSKQSqksvrKRKALRMILIVLAVFLVCFLPyhvTRIL 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 148695531 256 YMRPSSTFTED----------KLVAVFYTVITPMLNPIIY 285
Cdd:cd14982  233 YLLVRLSFIADcsarnslykaYRITLCLASLNSCLDPLIY 272

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

27-250

2.64e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 42.02 E-value: 2.64e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSL--HSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHF 104
Cdd:cd15098    5 VVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 105 LGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLisIQLPFCGPNVIDHYFCDLQPLFK 184
Cdd:cd15098   85 SMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAV--HQDLVHHWTASNQTFCWENWPEK 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148695531 185 LAcTDTFVESVIVMAnsgliALCSFLVLVSSYVIILVNLRKHSAEGRRKALST---CASHITVVVLFFG 250
Cdd:cd15098  163 QQ-KPVYVVCTFVFG-----YLLPLLLITFCYAKVLNHLHKKLKNMSKKSERSkkkTAQTVLVVVVVFG 225

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

37-296

4.66e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 41.15 E-value: 4.66e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSstVVPKFitdllaKVKTIS--------------LKGCLAQIFff 102
Cdd:cd15337   15 VIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFS--AVNGF------PLKTISsfnkkwiwgkvaceLYGFAGGIF-- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 103 hflGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIiqvlisiqLPFCGpnvIDHYF------ 176
Cdd:cd15337   85 ---GFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFG---WGRYVpegfqt 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 177 -CDLQPLFKLACTDTFVESVIVMAnsgliALCSFLVLVSSYVIILVNLRKHSAE-----------GRRKALSTCASHITV 244
Cdd:cd15337  151 sCTFDYLSRDLNNRLFILGLFIFG-----FLCPLLIIIFCYVNIIRAVRNHEKEmtqtaksgmgkDTEKNDARKKAEIRI 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148695531 245 VVLFFGpAIFLYMRPSSTFTEDKLVAVF--YTVITPML--------------NPIIYTLRNAEVKNAV 296
Cdd:cd15337  226 AKVAII-LISLFLLSWTPYAVVALLGQFgpAYWITPYVselpvmfakasaiyNPIIYALSHPKFRAAL 292

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

34-147

4.73e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 41.05 E-value: 4.73e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLL 113
Cdd:cd15959   12 LVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETL 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 148695531 114 VVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSW 147
Cdd:cd15959   92 CAIAVDRYLAITNPLRYEALVTKRRARTAVCLVW 125

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

26-148

4.81e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 40.99 E-value: 4.81e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLaTVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15085    5 FLMFLNATF-SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVsWL 148
Cdd:cd15085   84 GIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFI-WL 125

7tmA_Histamine_H3R

cd15296

histamine receptor subtypes H3R and H3R-like, member of the class A family of ...

27-152

5.58e-04

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320423 [Multi-domain] Cd Length: 271 Bit Score: 40.93 E-value: 5.58e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15296    5 VLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHY--MNIMSRQVCHVLVAVsWLGGFL 152
Cdd:cd15296   85 TASVFNIVLISYDRFLSVTRAVSYraQKGMTRQAVLKMVLV-WVLAFL 131

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

24-156

5.65e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 40.78 E-value: 5.65e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15051    2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSII 156
Cdd:cd15051   82 MLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFL 134

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

37-151

6.25e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 40.88 E-value: 6.25e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP-KFITDLLAKVKtISLKGCLAQIFFFHFLGVAEIFLLVV 115
Cdd:cd15073   15 TISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPfSAASDLHGSWK-FGYAGCQWYAFLNIFFGMASIGLLTV 93

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 148695531 116 MAYDRYVAICKPLHYMNiMSRQVCHVLVAVSWLGGF 151
Cdd:cd15073   94 VAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAF 128

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

27-180

6.93e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 40.67 E-value: 6.93e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfITDLLAKVKTISLKGCLAQIFFFhFLG 106
Cdd:cd15203    5 LLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLP--FTLIYTLTKNWPFGSILCKLVPS-LQG 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148695531 107 VA---EIFLLVVMAYDRYVAICKPLHymNIMSRQVCHVLVAVSWLGGFLHSI--IQVLISIQLPFCGPNvIDHYFCDLQ 180
Cdd:cd15203   82 VSifvSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLplAIFQELSDVPIEILP-YCGYFCTES 157

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

26-155

7.76e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 40.49 E-value: 7.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICyssTVVPKFITDLLAKVkTISLKGCLAQIFFFHFL 105
Cdd:cd15197    4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC---VGLINVLTDIIWRI-TVEWRAGDFACKVIRYL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148695531 106 GV----AEIFLLVVMAYDRYVAICKPLHYMNimSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd15197   80 QVvvtyASTYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSI 131

7tmA_5-HT5

cd15328

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...

34-148

8.68e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320451 [Multi-domain] Cd Length: 259 Bit Score: 40.32 E-value: 8.68e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP-KFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFL 112
Cdd:cd15328   12 VATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPlSLVHELSGRRWQLGRSLCQVWISFDVLCCTASIWN 91

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 148695531 113 LVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15328   92 VTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWA 127

7tmA_D3_dopamine_R

cd15310

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

27-151

1.10e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320436 [Multi-domain] Cd Length: 259 Bit Score: 39.95 E-value: 1.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFI-TDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15310    5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMM 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCH---VLVAVSWLGGF 151
Cdd:cd15310   85 CTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRrvsLMITAVWVLAF 133

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

34-148

1.15e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 39.84 E-value: 1.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIFF-FHF-----LGV 107
Cdd:cd15316   12 VLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMP------FSTVRSVESCWYFGESFCtFHTccdvsFCY 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 148695531 108 AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15316   86 ASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWI 126

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

32-152

1.22e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 39.76 E-value: 1.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFItdLLAKVKTISLKGCLAQIFFFHFLGVAEIF 111
Cdd:cd15070   10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAI--VVSLGVTIHFYSCLFMSCLLVVFTHASIM 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 148695531 112 LLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFL 152
Cdd:cd15070   88 SLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFL 128

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

26-152

1.37e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 39.66 E-value: 1.37e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAmVIVSKSLH---SPMYIFLSSLSLVEICySSTVVPKFITDLL-----AKVKTIslkgCLA 97
Cdd:cd15104    2 AGVILAVLSPLIITGNLLVI-VALLKLIRkkdTKSNCFLLNLAIADFL-VGLAIPGLATDELlsdgeNTQKVL----CLL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148695531  98 QIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFL 152
Cdd:cd15104   76 RMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGL 130

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

27-249

1.39e-03

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 39.51 E-value: 1.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVvPKFITDLL-------AKVKTISLkgclaqI 99
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTL-PFWAVYAAdgwvfgsFLCKLVSA------L 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 100 FFFHFlgVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQlpfcgPNVIDHYFCDl 179
Cdd:cd14984   78 YTINF--YSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQV-----SEENGSSICS- 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 180 qpLFKLACTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCashITVVVLFF 249
Cdd:cd14984  150 --YDYPEDTATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVI---FAVVVVFF 214

7tmA_GPBAR1

cd15905

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...

26-159

1.54e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.

Pssm-ID: 320571 [Multi-domain] Cd Length: 272 Bit Score: 39.35 E-value: 1.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLsLVEICYSSTVVPKFitDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15905    2 FWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSL-LLADLLTGVALPFI--PGMSNESRRGYHSCLFVYVAPNFL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVL 159
Cdd:cd15905   79 FLSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPAL 132

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

34-155

1.54e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 39.39 E-value: 1.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLL 113
Cdd:cd15062   12 LFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148695531 114 VVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd15062   92 CVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISI 133

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

37-148

1.65e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 39.38 E-value: 1.65e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLLVVM 116
Cdd:cd15209   15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAI 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 148695531 117 AYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15209   95 AINRYCYICHSLQYDRLYSLRNTCCYLCLTWL 126

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

23-299

1.99e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 39.16 E-value: 1.99e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  23 KVCFVLFLPVYLA--TVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIF 100
Cdd:cd15299    2 QVVLIAFLTGILAlvTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 101 FFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISiqlpfcgpnvidHYFCDLQ 180
Cdd:cd15299   82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFW------------QYFVGKR 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 181 PLFKLACTDTFVESVIVMANSgliALCSFLVLVSSYVIILVNLRKHSAEgRRKALSTCASHITVVVLFFGPaiFLYMRPS 260
Cdd:cd15299  150 TVPPDECFIQFLSEPIITFGT---AIAAFYLPVTIMTILYWRIYKETIK-EKKAAQTLSAILLAFIITWTP--YNIMVLV 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 148695531 261 STFTEDKLVAVFYTV------ITPMLNPIIYTLRNAEVKNAVRKL 299
Cdd:cd15299  224 NTFCDSCIPKTYWNLgywlcyINSTVNPVCYALCNKTFRTTFKML 268

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

27-128

2.15e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 39.08 E-value: 2.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLS----LVEICYSSTVVPKFITDLLAKVKTIslkgCLAQIFFF 102
Cdd:cd15084   15 VLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAvadlLVTLFGSSVSFSNNIVGFFVFGKTM----CEFEGFMV 90

                         90       100
                 ....*....|....*....|....*.
gi 148695531 103 HFLGVAEIFLLVVMAYDRYVAICKPL 128
Cdd:cd15084   91 SLTGIVGLWSLAILAFERYLVICKPM 116

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

26-285

2.18e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 38.80 E-value: 2.18e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVIDHYFCdlqplfKL 185
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHC------QK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 ACTDTFVESVIVMANSGLIALCSFLVLVSSYViilvnlrkhsAEGRRKALSTCASHITVVVLFFGPAI-------FLYMR 258
Cdd:cd15001  157 AWPSTLYSRLYVVYLAIVIFFIPLIVMTFAYA----------RDTRKQVIKMLISVVVLFAVCWGPLLidnllvsFDVIS 226

                        250       260
                 ....*....|....*....|....*....
gi 148695531 259 PSSTFTEDKLVAVFY--TVITPMLNPIIY 285
Cdd:cd15001  227 TLHTQALKYMRIAFHllSYANSCINPIIY 255

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

37-156

2.37e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 38.79 E-value: 2.37e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLLVVM 116
Cdd:cd15210   15 VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLI 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 148695531 117 AYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSII 156
Cdd:cd15210   95 TLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLP 134

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

32-226

3.15e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 38.62 E-value: 3.15e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIF 111
Cdd:cd15056   10 VILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 112 LLVVMAYDRYVAIC-KPLHYMniMSRQVCHVLVAVSWLggflhsiIQVLISIQLPFCGPNVIdhyfcDLQPLFKLACTDT 190
Cdd:cd15056   90 HLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWV-------IPTFISFLPIMQGWNHI-----GIEDLIAFNCASG 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 148695531 191 fVESVIVMANSGLIALCS-------FLVLVSSYVIILVNLRKH 226
Cdd:cd15056  156 -STSCVFMVNKPFAIICStvafyipALLMVLAYYRIYVAAREQ 197

7tmA_TRH-R

cd14995

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...

27-128

3.18e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.

Pssm-ID: 320126 [Multi-domain] Cd Length: 269 Bit Score: 38.52 E-value: 3.18e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVE-ICYSSTVVPKFITDLLAKVKTI-SLKGCLAqIFFFHF 104
Cdd:cd14995    5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADlMVLVAAGLPNEIESLLGPDSWIyGYAGCLL-ITYLQY 83

                         90       100
                 ....*....|....*....|....*
gi 148695531 105 LGV-AEIFLLVVMAYDRYVAICKPL 128
Cdd:cd14995   84 LGInASSLSITAFTIERYIAICHPM 108

7tmA_Beta2_AR

cd15957

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...

32-158

3.26e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.

Pssm-ID: 341355 [Multi-domain] Cd Length: 301 Bit Score: 38.69 E-value: 3.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIF 111
Cdd:cd15957   10 IVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIE 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 148695531 112 LLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQV 158
Cdd:cd15957   90 TLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPI 136

7tmA_Bombesin_R-like

cd15927

bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...

27-177

3.42e-03

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.

Pssm-ID: 320593 [Multi-domain] Cd Length: 294 Bit Score: 38.40 E-value: 3.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVP--------------KFITDLLAKVKTISl 92
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPftstiytldswpfgEFLCKLSEFLKDTS- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  93 kgclaqifffhfLGVAeIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNVI 172
Cdd:cd15927   84 ------------IGVS-VFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQ 150


                 ....*
gi 148695531 173 DHYFC 177
Cdd:cd15927  151 TIQIC 155

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

34-294

4.00e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 38.03 E-value: 4.00e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLL 113
Cdd:cd17790   12 LVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 114 VVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFlhsiiqVLISIQLPFCgpnvidHYFCDLQPLFKLACTDTFVE 193
Cdd:cd17790   92 LIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISF------VLWAPAILFW------QYLVGERTVLAGQCYIQFLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 194 SVIVMANSgliALCSFLVLVSSYVIILVNLRKHSAEgRRKALSTCASHITVVVLFFGPaiFLYMRPSSTFTEDKLVAVFY 273
Cdd:cd17790  160 QPIITFGT---AIAAFYLPVTIMIILYWRIYRETIK-EKKAARTLSAILLAFILTWTP--YNIMVLVSTFCKDCVPKTLW 233

                        250       260
                 ....*....|....*....|....*..
gi 148695531 274 TV------ITPMLNPIIYTLRNAEVKN 294
Cdd:cd17790  234 ELgywlcyVNSTVNPMCYALCNKSFRD 260

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

28-148

4.17e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 38.18 E-value: 4.17e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVYLATVL----GNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15394    2 LIIPLYSLVVLvgvvGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVP------LTLAYAFEPRGWVFGRFMCY 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148695531 104 FLGV-------AEIFLLVVMAYDRYVAICKPLHYMniMSRQVCHVLVAVSWL 148
Cdd:cd15394   76 FVFLmqpvtvyVSVFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWL 125

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

27-285

4.30e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 38.04 E-value: 4.30e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVvPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDAYNM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPFCGPNV--IDHYFCDLQPLFK 184
Cdd:cd14970   84 FTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTIscNLQWPDPPDYWGR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 185 LACTDTFVESVIVmansglialcSFLVLVSSYVIILVNLR----------KHSAEGRRKALSTCASHITVVVLFFGP-AI 253
Cdd:cd14970  164 VFTIYTFVLGFAV----------PLLVITVCYSLIIRRLRssrnlstsgaREKRRARRKVTRLVLVVVAVFVVCWLPfHV 233

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 148695531 254 FLYMRPSSTFTEDKLVAVFYTVITPM------LNPIIY 285
Cdd:cd14970  234 FQIVRLLIDPPETLTVVGVFLFCIALsyanscLNPILY 271

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

26-147

4.38e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 38.39 E-value: 4.38e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  26 FVLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLL-AKVKTISLKGC-----LAQI 99
Cdd:cd15217    4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRnGSAWTYSVLSCkivafMAVL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 148695531 100 FFFHflgvaEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSW 147
Cdd:cd15217   84 FCFH-----AAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVW 126

7tmA_UII-R

cd14999

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...

27-164

4.82e-03

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.

Pssm-ID: 320130 [Multi-domain] Cd Length: 282 Bit Score: 37.81 E-value: 4.82e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVvPKFITDLLAKVKTISLKGCLAqIFFFHFLG 106
Cdd:cd14999    4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTI-PFYVSTYFLKKWYFGDVGCRL-LFSLDFLT 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148695531 107 V-AEIFLLVVMAYDRYVAICKPLHYMNiMSRQVCHVLVAVSWLGGFLHSiIQVLISIQL 164
Cdd:cd14999   82 MhASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLT-LPMAIMIRL 138

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

28-295

4.92e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 37.97 E-value: 4.92e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  28 LFLPVY-LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKfitdllakVKTISLKGCLA--QIFFFHF 104
Cdd:cd15327    5 VFLAIFiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPF--------SATLEVLGFWAfgRVFCDIW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 105 LGV------AEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVlisiqLPFCGPNVIDHYFCD 178
Cdd:cd15327   77 AAVdvlcctASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPL-----LGWKEPPPPDESICS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 179 L--QPLFKLactdtfvesvivmansgLIALCSF----LVLVSSYVIILVNLRKHSAEgrRKALSTCASHITVVVLFFGPa 252
Cdd:cd15327  152 IteEPGYAL-----------------FSSLFSFylplMVILVMYFRVYVVALKFSRE--KKAAKTLAIVVGVFILCWFP- 211

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 148695531 253 IFLYMRPSSTFTEDKLVAVFYTVI------TPMLNPIIYTLRNAEVKNA 295
Cdd:cd15327  212 FFFVLPLGSFFPALKPSEMVFKVIfwlgyfNSCVNPIIYPCSSKEFKRA 260

7tmA_BRS-3

cd15123

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...

37-128

5.13e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.

Pssm-ID: 320251 [Multi-domain] Cd Length: 294 Bit Score: 37.98 E-value: 5.13e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGClAQIFFFHFLGVA-EIFLLVV 115
Cdd:cd15123   15 ILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGC-KLLSFIQLTSVGvSVFTLTV 93

                         90
                 ....*....|...
gi 148695531 116 MAYDRYVAICKPL 128
Cdd:cd15123   94 LSADRYRAIVKPL 106

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

37-160

5.43e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 37.88 E-value: 5.43e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLLVVM 116
Cdd:cd15391   15 VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAI 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 148695531 117 AYDRYVAICKPLHYMNIMSRQVChvLVAVSWLGGFLHSIIQVLI 160
Cdd:cd15391   95 GIDRFFAVIFPLRSRHTKSRTKC--IIASIWAISFSLSSVQLFA 136

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

32-295

6.42e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 37.70 E-value: 6.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  32 VYLATVLGNgLIVAMVIV-SKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVK-TISLKGCLAQIFFFHFLGVAE 109
Cdd:cd15134   10 IFVTGVVGN-LCTCIVIArNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPwVFGEVFCKLRAFLSEMSSYAS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 110 IFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSI-IQVLISIQ----LPFCGPNVIDHYFC------- 177
Cdd:cd15134   89 VLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpFAIQTRIVyleyPPTSGEALEESAFCamlneip 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 178 DLQPLFKLACTDTFVesvivmansglIALCSFLVLvssYVIILVNLRkHSAEGRRKALSTCASH-------------ITV 244
Cdd:cd15134  169 PITPVFQLSTFLFFI-----------IPMIAIIVL---YVLIGLQLR-RSTLLRRGQRSVSGGRrssqsrrtvlrmlVAV 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148695531 245 VVLFF---GP-----AIFLYMRPSSTFTEDKLVAVFYT-----VITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15134  234 VVAFFicwAPfhaqrLLTVYAKNMTPPYLFINRILFYIsgvlyYVSSTVNPILYNVMSAKYRQA 297

7tmA_Histamine_H4R

cd15295

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...

34-132

6.44e-03

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320422 [Multi-domain] Cd Length: 267 Bit Score: 37.50 E-value: 6.44e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  34 LATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLL 113
Cdd:cd15295   12 LVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNI 91

                         90
                 ....*....|....*....
gi 148695531 114 VVMAYDRYVAICKPLHYMN 132
Cdd:cd15295   92 VLISYDRYQSVSNAVSYRN 110

7tmA_5-HT1A_invertebrates

cd15331

serotonin receptor subtype 1A from invertebrates, member of the class A family of ...

27-296

6.46e-03

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320454 [Multi-domain] Cd Length: 261 Bit Score: 37.33 E-value: 6.46e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQ------IF 100
Cdd:cd15331    5 IILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMP------LSAVYEVSQHWFLGPevcdmwIS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 101 FFHFLGVAEIFLLVVMAYDRYVAICKpLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIQlPFCGPNVIDHYfcdLQ 180
Cdd:cd15331   79 MDVLCCTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVW-------FVSLIISIA-PLFGWKDEDDL---DR 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 181 PLFKLACTDTFVESVIVMAnsgliALCSFLVLVSsyVIILVNLRKHSAEGR-RKALSTCASHITVVVL----FFGPAIFL 255
Cdd:cd15331  147 VLKTGVCLISQDYGYTIFS-----TVGAFYVPLL--LMIIIYWKIYQAAKReRKAARTLAIITGAFVVcwlpFFLVALVM 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 148695531 256 YMRPS---STFTEDKLVAVFYtvITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15331  220 PFCGAwqiSRFLESFFLWLGY--FNSLLNPIIYTIFSPDFRGAF 261

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

37-155

7.22e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 37.18 E-value: 7.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  37 VLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPkfitdlLAKVKTISLKGCLAQIFFFHFLGV------AEI 110
Cdd:cd15325   15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP------FSAIFEILGYWAFGRVFCNIWAAVdvlcctASI 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 148695531 111 FLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSI 155
Cdd:cd15325   89 MSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI 133

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

27-289

7.36e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 37.41 E-value: 7.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd14992    5 VALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLIS---IQLPFCGPNVIDhyFCDLQPLf 183
Cdd:cd14992   85 YASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYAtteVLFSVKNQEKIF--CCQIPPV- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 klacTDTFVESVIVMANSGLIALCSFLVLVSSYVIILVNLRKHSAEG-------------RRKALSTCASHITVVVLFFG 250
Cdd:cd14992  162 ----DNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGfsikeverkrlkcKRRVIKMLVCVVVLFVICWL 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 148695531 251 PA-IFLYMRPSST--FTEDKLVAVFYTVI-----TPMLNPIIYTLRN 289
Cdd:cd14992  238 PFhLFFLLRDFFPliMKEKHTLQVYYFLHwiamsNSMYNPIIYVTLN 284

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

27-148

7.43e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 37.50 E-value: 7.43e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVS-KSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFL 105
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 148695531 106 GVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWL 148
Cdd:cd15097   85 MYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWG 127

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

27-148

7.46e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 37.22 E-value: 7.46e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYlaTVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15323    7 VGFLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHY-MNIMSRQVCHVLVAVsWL 148
Cdd:cd15323   85 TSSIVHLCAISLDRYWSVTQAVEYnLKRTPRRVKAIIVTV-WL 126

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

27-299

7.93e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 37.24 E-value: 7.93e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  27 VLFLPVYLATVLGNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLG 106
Cdd:cd15307    5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 107 VAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWLGGFLHSIIQVLISIQLPfcgPNVIDHYFCDL-QPLFKL 185
Cdd:cd15307   85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQIpDPVYKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 186 actdtfVESVIVMansgLIALCSFLVLVSSYVIILVnlRKHSAEGRRKALSTCASHITVVVLF-----FGPAIFLYMRPS 260
Cdd:cd15307  162 ------VGSIVCF----YIPLGVMLLTYCLTVRLLA--RQRSRHGRIIRLEQKATKVLGVVFFtfvilWSPFFVLNLLPT 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 148695531 261 -STFTEDKLVAVFYTVIT------PMLNPIIYTLRNAEVKNAVRKL 299
Cdd:cd15307  230 vCAECEERISHWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKV 275

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

24-295

8.30e-03

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 37.21 E-value: 8.30e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  24 VCFVLFLPVYLATVLgNGLIVAMVIVSKSLHSPMYIFLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFH 103
Cdd:cd15335    3 IVLTLALITILTTVL-NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 104 FLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVCHVLVAVSWlggflhsIIQVLISIQlpfcgpnvidhyfcdlqPLF 183
Cdd:cd15335   82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVW-------TISIFISIP-----------------PLF 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 184 KLACTDTFVESVIVMANSGLI----ALCSFLVLVSSYVIILVNLRKHSAEGRRKALSTCASHITVVVLFFGP------AI 253
Cdd:cd15335  138 WRNHHDANIPSQCIIQHDHVIytiySTFGAFYIPLTLILILYYRIYHAASRERKAARILGLILGAFILSWLPffikelIV 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 148695531 254 FLYMRPSSTFTEDKLVAVFYtvITPMLNPIIYTLRNAEVKNA 295
Cdd:cd15335  218 GLSVMTVSPEVADFLTWLGY--VNSLVNPLLYTSFNEDFKLA 257

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

60-154

8.47e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 37.13 E-value: 8.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531  60 FLSSLSLVEICYSSTVVPKFITDLLAKVKTISLKGCLAQIFFFHFLGVAEIFLLVVMAYDRYVAICKPLHYMNIMSRQVC 139
Cdd:cd15215   37 FIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRG 116

                         90
                 ....*....|....*
gi 148695531 140 HVLVAVSWLGGFLHS 154
Cdd:cd15215  117 YLLIYGTWIVSVLQS 131

7tmA_Relaxin_R

cd15137

relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...

110-296

8.81e-03

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.

Pssm-ID: 320265 [Multi-domain] Cd Length: 284 Bit Score: 37.18 E-value: 8.81e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 110 IFLLVVMAYDRYVAICKPLHYMNIMSRQVcHVLVAVSWLGGFLHSIIQVLISIQLP-FCGPNVIdhyfCdlqplFKLACT 188
Cdd:cd15137   95 VLILTLITLDRFICIVFPFSGRRLGLRRA-IIVLACIWLIGLLLAVLPLLPWDYFGnFYGRSGV----C-----LPLHIT 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148695531 189 DTFVE----SVIVMAnsgLIALCSFLVLVSSYVIILVNLRK-HSAEGRRKALSTC--ASHITVVVL----------FFGP 251
Cdd:cd15137  165 DERPAgweySVFVFL---GLNFLAFVFILLSYIAMFISIRRtRKAAASRKSKRDMavAKRFFLIVLtdflcwipiiVIGI 241

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 148695531 252 AIFLYMRPSSTFTEdkLVAVFYTVITPMLNPIIYTLRNAEVKNAV 296
Cdd:cd15137  242 LALSGVPIPGEVYA--WVAVFVLPINSALNPILYTLSTPKFRKKL 284

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01