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Conserved domains on  [gi|148686504|gb|EDL18451|]
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excision repaiross-complementing rodent repair deficiency, complementation group 8, isoform CRA_d [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-92 1.59e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319  137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                         90
                 ....*....|
gi 148686504  83 PRHDYiLATA 92
Cdd:COG2319  214 PDGKL-LASG 222
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-92 1.59e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319  137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                         90
                 ....*....|
gi 148686504  83 PRHDYiLATA 92
Cdd:COG2319  214 PDGKL-LASG 222
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-92 8.68e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 8.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   1 MFTSSSFDKTLKVWDTNTLQAADVFNF-EETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV 79
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV 183

                         90
                 ....*....|...
gi 148686504  80 SWSPRHDYILATA 92
Cdd:cd00200  184 AFSPDGEKLLSSS 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 62-89 9.81e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 31.13  E-value: 9.81e-03
                          10        20
                  ....*....|....*....|....*...
gi 148686504   62 SGSCSHILQGHRQEILAVSWSPRHDYIL 89
Cdd:smart00320  1 SGELLKTLKGHTGPVTSVAFSPDGKYLA 28
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-92 1.59e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319  137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                         90
                 ....*....|
gi 148686504  83 PRHDYiLATA 92
Cdd:COG2319  214 PDGKL-LASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
4-92 1.98e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFNFEE-TVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGR---LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                         90
                 ....*....|
gi 148686504  83 PRHDYiLATA 92
Cdd:COG2319  298 PDGKL-LASG 306
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-92 8.68e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 8.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   1 MFTSSSFDKTLKVWDTNTLQAADVFNF-EETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAV 79
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV 183

                         90
                 ....*....|...
gi 148686504  80 SWSPRHDYILATA 92
Cdd:cd00200  184 AFSPDGEKLLSSS 196
WD40 COG2319
WD40 repeat [General function prediction only];
4-92 1.17e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                         90
                 ....*....|
gi 148686504  83 PRHDYiLATA 92
Cdd:COG2319  340 PDGKT-LASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
4-92 5.51e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 5.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                         90
                 ....*....|
gi 148686504  83 PrHDYILATA 92
Cdd:COG2319  256 P-DGRLLASG 264
WD40 COG2319
WD40 repeat [General function prediction only];
4-92 6.44e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 6.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319  305 SGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                         90
                 ....*....|
gi 148686504  83 PRHDYiLATA 92
Cdd:COG2319  382 PDGRT-LASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-93 2.99e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   3 TSSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW 81
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                         90
                 ....*....|..
gi 148686504  82 SPRHDYILATAR 93
Cdd:cd00200  228 SPDGYLLASGSE 239
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-83 3.37e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 3.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   2 FTSSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVS 80
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGY---LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268


                 ...
gi 148686504  81 WSP 83
Cdd:cd00200  269 WSP 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-93 8.41e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 8.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQaadvfnFEETVYSHHMSPA-----ATKHCLVAVGTRGpKVQLCDLKSGSCSHILQGHRQEILA 78
Cdd:cd00200   26 TGSGDGTIKVWDLETGE------LLRTLKGHTGPVRdvaasADGTYLASGSSDK-TIRLWDLETGECVRTLTGHTSYVSS 98

                         90
                 ....*....|....*
gi 148686504  79 VSWSPRHDYILATAR 93
Cdd:cd00200   99 VAFSPDGRILSSSSR 113
WD40 COG2319
WD40 repeat [General function prediction only];
4-83 7.03e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 7.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319   95 SASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGK---TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171


                 .
gi 148686504  83 P 83
Cdd:COG2319  172 P 172
WD40 COG2319
WD40 repeat [General function prediction only];
4-93 1.12e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 36.04  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148686504   4 SSSFDKTLKVWDTNTLQAADVFNF-EETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319   53 AGAGDLTLLLLDAAAGALLATLLGhTAAVLSVAFSPDGR---LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS 129

                         90
                 ....*....|.
gi 148686504  83 PRHDYILATAR 93
Cdd:COG2319  130 PDGKTLASGSA 140
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-92 1.87e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 35.39  E-value: 1.87e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 148686504  45 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATA 92
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGS 70
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 62-89 9.81e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 31.13  E-value: 9.81e-03
                          10        20
                  ....*....|....*....|....*...
gi 148686504   62 SGSCSHILQGHRQEILAVSWSPRHDYIL 89
Cdd:smart00320  1 SGELLKTLKGHTGPVTSVAFSPDGKYLA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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