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Conserved domains on  [gi|1481066730|gb|AYB13208|]
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PTS sugar transporter subunit IIB [Salmonella enterica subsp. enterica serovar Dublin]

Protein Classification

PTS sugar transporter subunit IIB( domain architecture ID 10013543)

subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10499 PRK10499
PTS sugar transporter subunit IIB;
1-106 3.21e-66

PTS sugar transporter subunit IIB;


:

Pssm-ID: 182499  Cd Length: 106  Bit Score: 194.75  E-value: 3.21e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLLPGKPVEVID 80
Cdd:PRK10499    1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQNADVVLLGPQIAYMLPEIQRLLPNKPVEVID 80

                          90       100
                  ....*....|....*....|....*.
gi 1481066730  81 SMLYGKVDGLGVLKAAVAAIKKAAAN 106
Cdd:PRK10499   81 SLLYGKVDGLGVLKAAVAAIKKAAAN 106
 
Name Accession Description Interval E-value
PRK10499 PRK10499
PTS sugar transporter subunit IIB;
1-106 3.21e-66

PTS sugar transporter subunit IIB;


Pssm-ID: 182499  Cd Length: 106  Bit Score: 194.75  E-value: 3.21e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLLPGKPVEVID 80
Cdd:PRK10499    1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQNADVVLLGPQIAYMLPEIQRLLPNKPVEVID 80

                          90       100
                  ....*....|....*....|....*.
gi 1481066730  81 SMLYGKVDGLGVLKAAVAAIKKAAAN 106
Cdd:PRK10499   81 SLLYGKVDGLGVLKAAVAAIKKAAAN 106
pts-lac TIGR00853
PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and ...
 1-93 2.35e-42

PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as those in E. coli. While the Lac family usually consists of two polypeptide components IIA and IICB, the Chb permease of E. coli consists of three IIA, IIB and IIC. This family is specific for the IIB subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273300  Cd Length: 95  Bit Score: 134.06  E-value: 2.35e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLLPGK--PVEV 78
Cdd:TIGR00853   1 MNETNILLLCAAGMSTSLLVNKMNKAAEEYGVPVKIAAGSYGAAGEKLDDADVVLLAPQVAYMLPDLKKETDKKgiPVEV 80

                          90
                  ....*....|....*
gi 1481066730  79 IDSMLYGKVDGLGVL 93
Cdd:TIGR00853  81 INGAQYGKLTGAGVL 95
PTS_IIB_chitobiose_lichenan cd05564
PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N, ...
 5-93 3.36e-37

PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99906  Cd Length: 96  Bit Score: 120.69  E-value: 3.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   5 HIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLL--PGKPVEVIDSM 82
Cdd:cd05564     1 KILLVCSAGMSTSILVKKMKKAAEKRGIDAEIEAVPESELEEYIDDADVVLLGPQVRYMLDEVKKKAaeYGIPVAVIDMM 80

                          90
                  ....*....|.
gi 1481066730  83 LYGKVDGLGVL 93
Cdd:cd05564    81 DYGMMNGEKVL 91
CelA COG1440
Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and ...
 4-93 5.26e-36

Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism];


Pssm-ID: 441049  Cd Length: 100  Bit Score: 117.94  E-value: 5.26e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   4 KHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLLP--GKPVEVIDS 81
Cdd:COG1440     1 KKILLVCAAGMSTSLLVKKMKKAAKERGIDVEIEAVSAGELEDVIDDYDVVLLGPQVRYMLDEIKKIADekGIPVAVIDM 80

                          90
                  ....*....|..
gi 1481066730  82 MLYGKVDGLGVL 93
Cdd:COG1440    81 QDYGMMDGEKVL 92
PTS_IIB pfam02302
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar ...
 6-93 1.02e-11

PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.


Pssm-ID: 396744  Cd Length: 92  Bit Score: 56.19  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   6 IYLFCSAGMSTSLLV-SKMRAQAEKY-EVPVIIEAFPETLAGEKGPA-ADVVLLGPQIAYMlpEIQRlLPGKPVEVIDSM 82
Cdd:pfam02302   2 ILTACGAGMATSLMAaEALEKAAKELgIVEAQGAAGVNELTAEDIADdADVVILAPDVAVE--DLAR-FAGKPVYVIPVK 78

                          90
                  ....*....|..
gi 1481066730  83 -LYGKVDGLGVL 93
Cdd:pfam02302  79 dALGMKDAEEVL 90
 
Name Accession Description Interval E-value
PRK10499 PRK10499
PTS sugar transporter subunit IIB;
1-106 3.21e-66

PTS sugar transporter subunit IIB;


Pssm-ID: 182499  Cd Length: 106  Bit Score: 194.75  E-value: 3.21e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLLPGKPVEVID 80
Cdd:PRK10499    1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQNADVVLLGPQIAYMLPEIQRLLPNKPVEVID 80

                          90       100
                  ....*....|....*....|....*.
gi 1481066730  81 SMLYGKVDGLGVLKAAVAAIKKAAAN 106
Cdd:PRK10499   81 SLLYGKVDGLGVLKAAVAAIKKAAAN 106
pts-lac TIGR00853
PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and ...
 1-93 2.35e-42

PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as those in E. coli. While the Lac family usually consists of two polypeptide components IIA and IICB, the Chb permease of E. coli consists of three IIA, IIB and IIC. This family is specific for the IIB subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273300  Cd Length: 95  Bit Score: 134.06  E-value: 2.35e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   1 MEKKHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLLPGK--PVEV 78
Cdd:TIGR00853   1 MNETNILLLCAAGMSTSLLVNKMNKAAEEYGVPVKIAAGSYGAAGEKLDDADVVLLAPQVAYMLPDLKKETDKKgiPVEV 80

                          90
                  ....*....|....*
gi 1481066730  79 IDSMLYGKVDGLGVL 93
Cdd:TIGR00853  81 INGAQYGKLTGAGVL 95
PTS_IIB_chitobiose_lichenan cd05564
PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N, ...
 5-93 3.36e-37

PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99906  Cd Length: 96  Bit Score: 120.69  E-value: 3.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   5 HIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLL--PGKPVEVIDSM 82
Cdd:cd05564     1 KILLVCSAGMSTSILVKKMKKAAEKRGIDAEIEAVPESELEEYIDDADVVLLGPQVRYMLDEVKKKAaeYGIPVAVIDMM 80

                          90
                  ....*....|.
gi 1481066730  83 LYGKVDGLGVL 93
Cdd:cd05564    81 DYGMMNGEKVL 91
CelA COG1440
Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and ...
 4-93 5.26e-36

Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism];


Pssm-ID: 441049  Cd Length: 100  Bit Score: 117.94  E-value: 5.26e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   4 KHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGPAADVVLLGPQIAYMLPEIQRLLP--GKPVEVIDS 81
Cdd:COG1440     1 KKILLVCAAGMSTSLLVKKMKKAAKERGIDVEIEAVSAGELEDVIDDYDVVLLGPQVRYMLDEIKKIADekGIPVAVIDM 80

                          90
                  ....*....|..
gi 1481066730  82 MLYGKVDGLGVL 93
Cdd:COG1440    81 QDYGMMDGEKVL 92
PTS_IIB pfam02302
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar ...
 6-93 1.02e-11

PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.


Pssm-ID: 396744  Cd Length: 92  Bit Score: 56.19  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   6 IYLFCSAGMSTSLLV-SKMRAQAEKY-EVPVIIEAFPETLAGEKGPA-ADVVLLGPQIAYMlpEIQRlLPGKPVEVIDSM 82
Cdd:pfam02302   2 ILTACGAGMATSLMAaEALEKAAKELgIVEAQGAAGVNELTAEDIADdADVVILAPDVAVE--DLAR-FAGKPVYVIPVK 78

                          90
                  ....*....|..
gi 1481066730  83 -LYGKVDGLGVL 93
Cdd:pfam02302  79 dALGMKDAEEVL 90
PTS_IIB cd00133
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the ...
 5-83 5.55e-07

PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system. The PTS is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, polyols, amino sugars, and other sugar derivatives. The four proteins (domains) forming the PTS phosphorylation cascade (EI, HPr, EIIA, and EIIB), can phosphorylate or interact with numerous non-PTS proteins thereby regulating their activity.


Pssm-ID: 99904  Cd Length: 84  Bit Score: 43.78  E-value: 5.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481066730   5 HIYLFCSAGMSTS-LLVSKMRAQAEKYEVPVIIEAFPETlAGEKGPAADVVLLGPQIAymlpeiqRLLPGKPVEVIDSML 83
Cdd:cd00133     1 KILVVCGSGIGSSsMLAEKLEKAAKELGIEVKVEAQGLS-EVIDLADADLIISTVPLA-------ARFLGKPVIVVSPLL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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