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Conserved domains on  [gi|1475686141|gb|AXY63946|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Ornebius fuscicerci]

Protein Classification

NADH dehydrogenase subunit 4L( domain architecture ID 10009597)

NADH dehydrogenase subunit 4L is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 5.51e-22

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177218  Cd Length: 89  Bit Score: 81.74  E-value: 5.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  3 LWMMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 1475686141 83 SHGNDFFQS 91
Cdd:MTH00162  81 SHGNDYFSS 89
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 5.51e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 81.74  E-value: 5.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  3 LWMMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 1475686141 83 SHGNDFFQS 91
Cdd:MTH00162  81 SHGNDYFSS 89
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-97 3.20e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 41.78  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  4 WMMIFVMYMYMSGLLVfMMKRKHLIMTLLSLEYMMLMMyFILYFYLFQYEGDLYYLMM---FLVFSVCEGVLGLSILVLM 80
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAV-NLALVLFGRLTADPLPQALiltAIVIAAAEAAVGLALLVRI 78

                         90
                 ....*....|....*..
gi 1475686141 81 IRSHGNDFFQSFVILRC 97
Cdd:pfam00420 79 YRTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-91 5.51e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 81.74  E-value: 5.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  3 LWMMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLMIR 82
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 1475686141 83 SHGNDFFQS 91
Cdd:MTH00162  81 SHGNDYFSS 89
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 1-97 3.11e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 57.29  E-value: 3.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  1 MDLWMMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLM 80
Cdd:MTH00188   1 MFFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSL 80

                         90
                 ....*....|....*..
gi 1475686141 81 IRSHGNDFFQSFVILRC 97
Cdd:MTH00188  81 IRSHGSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 4-97 4.51e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 54.08  E-value: 4.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  4 WMMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLMIRS 83
Cdd:MTH00149   4 MLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRL 83

                         90
                 ....*....|....
gi 1475686141 84 HGNDFFQSFVILRC 97
Cdd:MTH00149  84 HGNDYVSSLSSLKF 97
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 13-97 1.79e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 52.66  E-value: 1.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141 13 YMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYL--MMFLVFSVCEGVLGLSILVLMIRSHGNDFFQ 90
Cdd:MTH00126  12 FILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAapMLLLAFSACEASAGLALLVATARTHGTDRLQ 91


                 ....*..
gi 1475686141 91 SFVILRC 97
Cdd:MTH00126  92 NLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 5-97 9.28e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 50.61  E-value: 9.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  5 MMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYLM--MFLVFSVCEGVLGLSILVLMIR 82
Cdd:MTH00125   4 THFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMpiILLTFSACEAGTGLALLVATTR 83

                         90
                 ....*....|....*
gi 1475686141 83 SHGNDFFQSFVILRC 97
Cdd:MTH00125  84 THGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 5-97 3.34e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 49.22  E-value: 3.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  5 MMIFVMYM-YMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYL--MMFLVFSVCEGVLGLSILVLMI 81
Cdd:MTH00067   3 PTYFTFYSaFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSlpMFMLTFSACEASTGLALMVATT 82

                         90
                 ....*....|....*.
gi 1475686141 82 RSHGNDFFQSFVILRC 97
Cdd:MTH00067  83 RTHGTDHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 5-95 1.49e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 44.93  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  5 MMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFIL--YFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLMIR 82
Cdd:MTH00181   1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLalFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                         90
                 ....*....|...
gi 1475686141 83 SHGNDFFQSFVIL 95
Cdd:MTH00181  81 THGSDHLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-97 3.20e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 41.78  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  4 WMMIFVMYMYMSGLLVfMMKRKHLIMTLLSLEYMMLMMyFILYFYLFQYEGDLYYLMM---FLVFSVCEGVLGLSILVLM 80
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAV-NLALVLFGRLTADPLPQALiltAIVIAAAEAAVGLALLVRI 78

                         90
                 ....*....|....*..
gi 1475686141 81 IRSHGNDFFQSFVILRC 97
Cdd:pfam00420 79 YRTHGTDDVDSLNLLKG 95
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 14-97 7.54e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 40.89  E-value: 7.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141 14 MSGLLVFMMKRKHLIMTLLSLEYMML-MMYFILYFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLMIRSHGNDFFQSF 92
Cdd:MTH00013  13 FISMFNLSLQRKHLLMSLLSLEAMILsLALFIPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVLMTRSYGNDMLKSL 92


                 ....*
gi 1475686141 93 VILRC 97
Cdd:MTH00013  93 TSNKC 97
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 7-96 1.78e-04

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 37.21  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  7 IFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMM--LMMYFILYFYLFQYEGDLYYLMMFLVFSVCEGVLGLSILVLMIRSH 84
Cdd:MTH00043   6 IIILSSFFLGLLGILINRLHLLSILLCLELLLisLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVLLSRNH 85

                         90
                 ....*....|..
gi 1475686141 85 GNDFFQSFVILR 96
Cdd:MTH00043  86 NSDLVASLNLLQ 97
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 5-97 3.37e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 36.45  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475686141  5 MMIFVMYMYMSGLLVFMMKRKHLIMTLLSLEYMMLMMYFILYFYLFQYEGDLYYLM--MFLVFSVCEGVLGLSILVLMIR 82
Cdd:MTH00107   4 IYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMpiILLVFAACEAAVGLALLVMVSN 83

                         90
                 ....*....|....*
gi 1475686141 83 SHGNDFFQSFVILRC 97
Cdd:MTH00107  84 TYGTDYVQNLNLLQC 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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