cyclic nucleotide-binding domain-containing protein 2 isoform 4 [Homo sapiens]
cyclic nucleotide-binding domain-containing protein( domain architecture ID 10034975)
cyclic nucleotide-binding domain-containing protein binds cyclic nucleotides (cAMP or cGMP) where binding of the effector leads to conformational changes; may be involved in regulating transcription, be present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK), or be part of vertebrate cyclic nucleotide-gated ion-channels.
List of domain hits
Name | Accession | Description | Interval | E-value | |||
CAP_ED | cd00038 | effector domain of the CAP family of transcription factors; members include CAP (or cAMP ... |
122-218 | 2.08e-16 | |||
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels : Pssm-ID: 237999 [Multi-domain] Cd Length: 115 Bit Score: 75.44 E-value: 2.08e-16
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Name | Accession | Description | Interval | E-value | |||
CAP_ED | cd00038 | effector domain of the CAP family of transcription factors; members include CAP (or cAMP ... |
122-218 | 2.08e-16 | |||
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels Pssm-ID: 237999 [Multi-domain] Cd Length: 115 Bit Score: 75.44 E-value: 2.08e-16
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cNMP_binding | pfam00027 | Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ... |
134-218 | 5.77e-15 | |||
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 459637 [Multi-domain] Cd Length: 89 Bit Score: 70.33 E-value: 5.77e-15
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Crp | COG0664 | cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ... |
127-263 | 1.40e-12 | |||
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Pssm-ID: 440428 [Multi-domain] Cd Length: 207 Bit Score: 66.93 E-value: 1.40e-12
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cNMP | smart00100 | Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ... |
118-241 | 1.27e-09 | |||
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases. Pssm-ID: 197516 [Multi-domain] Cd Length: 120 Bit Score: 56.26 E-value: 1.27e-09
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PLN02868 | PLN02868 | acyl-CoA thioesterase family protein |
128-216 | 4.99e-04 | |||
acyl-CoA thioesterase family protein Pssm-ID: 178459 [Multi-domain] Cd Length: 413 Bit Score: 42.79 E-value: 4.99e-04
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Name | Accession | Description | Interval | E-value | |||
CAP_ED | cd00038 | effector domain of the CAP family of transcription factors; members include CAP (or cAMP ... |
122-218 | 2.08e-16 | |||
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels Pssm-ID: 237999 [Multi-domain] Cd Length: 115 Bit Score: 75.44 E-value: 2.08e-16
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cNMP_binding | pfam00027 | Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ... |
134-218 | 5.77e-15 | |||
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 459637 [Multi-domain] Cd Length: 89 Bit Score: 70.33 E-value: 5.77e-15
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Crp | COG0664 | cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ... |
127-263 | 1.40e-12 | |||
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Pssm-ID: 440428 [Multi-domain] Cd Length: 207 Bit Score: 66.93 E-value: 1.40e-12
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cNMP | smart00100 | Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ... |
118-241 | 1.27e-09 | |||
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases. Pssm-ID: 197516 [Multi-domain] Cd Length: 120 Bit Score: 56.26 E-value: 1.27e-09
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PLN02868 | PLN02868 | acyl-CoA thioesterase family protein |
128-216 | 4.99e-04 | |||
acyl-CoA thioesterase family protein Pssm-ID: 178459 [Multi-domain] Cd Length: 413 Bit Score: 42.79 E-value: 4.99e-04
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PRK11753 | PRK11753 | cAMP-activated global transcriptional regulator CRP; |
124-203 | 1.02e-03 | |||
cAMP-activated global transcriptional regulator CRP; Pssm-ID: 236969 [Multi-domain] Cd Length: 211 Bit Score: 40.74 E-value: 1.02e-03
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Blast search parameters | ||||
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