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Conserved domains on  [gi|1472011185|ref|NP_001352564|]
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protein TASOR isoform d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3715 pfam12509
Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is ...
 166-319 2.16e-58

Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is approximately 170 amino acids in length.


:

Pssm-ID: 463613 [Multi-domain]  Cd Length: 150  Bit Score: 198.28  E-value: 2.16e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472011185  166 ELKFDGRLDKELSESYAFLMVDRYQVQTICEKGLHVGQSKITILGSPSMGVYLSRYADL-LQANPLDTGAMGDVVIFKIM 244
Cdd:pfam12509    1 EMRRDGRCSSELPENFAFLLSDENSVRGICDHGLHVGSSKGTLLGKPSSGVYLSRHSDLaLSQEEEKLGPCGPLIVFKVL 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1472011185  245 KGKIKSIYDPMGvkslesmlnKSALDPTPKHECHVSKNANRI--TSLLAYRAYELTQYYFYEYG--FDELRRRPRHVCP 319
Cdd:pfam12509   81 KGKTKEISDSSQ---------KSFLEPTPSYDCHVAEHSKKHlqQRGLPGPAFAKSQTYGYEYGtpVGKVFRRPRHVLP 150
TASOR_PBD cd22569
periphilin binding domain of protein TASOR and similar proteins; TASOR, also called CTCL tumor ...
 1014-1095 4.95e-29

periphilin binding domain of protein TASOR and similar proteins; TASOR, also called CTCL tumor antigen se89-1, retinoblastoma-associated protein RAP140, or transgene activation suppressor protein, is a component of the HUSH complex, a multiprotein complex that is at least composed of TASOR, PPHLN1 and MPHOSPH8, and mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. This model corresponds to a conserved region of TASOR, which is responsible for the binding of periphilin.


:

Pssm-ID: 439336 [Multi-domain]  Cd Length: 83  Bit Score: 111.50  E-value: 4.95e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472011185 1014 SETTERTVLGEYNLFSRKIEEILKQKNVSYVSTVSTPIFSTQE-KMKRLSEFIYSKTSKAGVQEFVDGLHEKLNTIIIKA 1092
Cdd:cd22569      1 SSSIDTIVDEEFSSFSSKIQELLKQENIYYVSQSSTPSFSAPEwPMSRFSEYVSSYTSPVPVQGYVSSLREKMNSVIDSA 80


                   ...
gi 1472011185 1093 SAK 1095
Cdd:cd22569     81 SAS 83
 
Name Accession Description Interval E-value
DUF3715 pfam12509
Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is ...
 166-319 2.16e-58

Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is approximately 170 amino acids in length.


Pssm-ID: 463613 [Multi-domain]  Cd Length: 150  Bit Score: 198.28  E-value: 2.16e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472011185  166 ELKFDGRLDKELSESYAFLMVDRYQVQTICEKGLHVGQSKITILGSPSMGVYLSRYADL-LQANPLDTGAMGDVVIFKIM 244
Cdd:pfam12509    1 EMRRDGRCSSELPENFAFLLSDENSVRGICDHGLHVGSSKGTLLGKPSSGVYLSRHSDLaLSQEEEKLGPCGPLIVFKVL 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1472011185  245 KGKIKSIYDPMGvkslesmlnKSALDPTPKHECHVSKNANRI--TSLLAYRAYELTQYYFYEYG--FDELRRRPRHVCP 319
Cdd:pfam12509   81 KGKTKEISDSSQ---------KSFLEPTPSYDCHVAEHSKKHlqQRGLPGPAFAKSQTYGYEYGtpVGKVFRRPRHVLP 150
TASOR_PBD cd22569
periphilin binding domain of protein TASOR and similar proteins; TASOR, also called CTCL tumor ...
 1014-1095 4.95e-29

periphilin binding domain of protein TASOR and similar proteins; TASOR, also called CTCL tumor antigen se89-1, retinoblastoma-associated protein RAP140, or transgene activation suppressor protein, is a component of the HUSH complex, a multiprotein complex that is at least composed of TASOR, PPHLN1 and MPHOSPH8, and mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. This model corresponds to a conserved region of TASOR, which is responsible for the binding of periphilin.


Pssm-ID: 439336 [Multi-domain]  Cd Length: 83  Bit Score: 111.50  E-value: 4.95e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472011185 1014 SETTERTVLGEYNLFSRKIEEILKQKNVSYVSTVSTPIFSTQE-KMKRLSEFIYSKTSKAGVQEFVDGLHEKLNTIIIKA 1092
Cdd:cd22569      1 SSSIDTIVDEEFSSFSSKIQELLKQENIYYVSQSSTPSFSAPEwPMSRFSEYVSSYTSPVPVQGYVSSLREKMNSVIDSA 80


                   ...
gi 1472011185 1093 SAK 1095
Cdd:cd22569     81 SAS 83
 
Name Accession Description Interval E-value
DUF3715 pfam12509
Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is ...
 166-319 2.16e-58

Protein of unknown function (DUF3715); This domain family is found in eukaryotes, and is approximately 170 amino acids in length.


Pssm-ID: 463613 [Multi-domain]  Cd Length: 150  Bit Score: 198.28  E-value: 2.16e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472011185  166 ELKFDGRLDKELSESYAFLMVDRYQVQTICEKGLHVGQSKITILGSPSMGVYLSRYADL-LQANPLDTGAMGDVVIFKIM 244
Cdd:pfam12509    1 EMRRDGRCSSELPENFAFLLSDENSVRGICDHGLHVGSSKGTLLGKPSSGVYLSRHSDLaLSQEEEKLGPCGPLIVFKVL 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1472011185  245 KGKIKSIYDPMGvkslesmlnKSALDPTPKHECHVSKNANRI--TSLLAYRAYELTQYYFYEYG--FDELRRRPRHVCP 319
Cdd:pfam12509   81 KGKTKEISDSSQ---------KSFLEPTPSYDCHVAEHSKKHlqQRGLPGPAFAKSQTYGYEYGtpVGKVFRRPRHVLP 150
TASOR_PBD cd22569
periphilin binding domain of protein TASOR and similar proteins; TASOR, also called CTCL tumor ...
 1014-1095 4.95e-29

periphilin binding domain of protein TASOR and similar proteins; TASOR, also called CTCL tumor antigen se89-1, retinoblastoma-associated protein RAP140, or transgene activation suppressor protein, is a component of the HUSH complex, a multiprotein complex that is at least composed of TASOR, PPHLN1 and MPHOSPH8, and mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. This model corresponds to a conserved region of TASOR, which is responsible for the binding of periphilin.


Pssm-ID: 439336 [Multi-domain]  Cd Length: 83  Bit Score: 111.50  E-value: 4.95e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1472011185 1014 SETTERTVLGEYNLFSRKIEEILKQKNVSYVSTVSTPIFSTQE-KMKRLSEFIYSKTSKAGVQEFVDGLHEKLNTIIIKA 1092
Cdd:cd22569      1 SSSIDTIVDEEFSSFSSKIQELLKQENIYYVSQSSTPSFSAPEwPMSRFSEYVSSYTSPVPVQGYVSSLREKMNSVIDSA 80


                   ...
gi 1472011185 1093 SAK 1095
Cdd:cd22569     81 SAS 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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