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Conserved domains on  [gi|1471989743|gb|RHN61406|]
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putative methylecgonone reductase [Medicago truncatula]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 1-145 5.83e-85

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19124:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 281  Bit Score: 251.03  E-value: 5.83e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSFGSPAVM 80
Cdd:cd19124   137 MEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKWGSNAVM 216

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:cd19124   217 ESDVLKEIAAAKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEIPQ 281
 
Name Accession Description Interval E-value
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 1-145 5.83e-85

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 251.03  E-value: 5.83e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSFGSPAVM 80
Cdd:cd19124   137 MEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKWGSNAVM 216

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:cd19124   217 ESDVLKEIAAAKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEIPQ 281
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 1-145 1.76e-55

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 175.24  E-value: 1.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLggyklsfGSPAVM 80
Cdd:COG0656   113 LEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPL-------GRGKLL 185

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:COG0656   186 DDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDR 250
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 1-143 1.52e-28

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 107.01  E-value: 1.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMN--SSWHQGKLREFCKQKGIHVSAWSPLGG--------- 69
Cdd:pfam00248 123 LEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNllRRRQEEELLEYCKKNGIPLIAYSPLGGglltgkytr 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  70 ----------YKLSFGSPAVME-NSILREIAEARKKSVAQIALRWIYQQ--GAIPIVKSFNKERMKLNTEIFDWELNQEE 136
Cdd:pfam00248 203 dpdkgpgerrRLLKKGTPLNLEaLEALEEIAKEHGVSPAQVALRWALSKpgVTIPIPGASNPEQLEDNLGALEFPLSDEE 282


                  ....*..
gi 1471989743 137 FDKINQI 143
Cdd:pfam00248 283 VARIDEL 289
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
8-145 6.23e-25

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 97.07  E-value: 6.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPlggykLSFGSPAVMENSILRE 87
Cdd:PRK11565  130 GLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSP-----LAQGGKGVFDQKVIRD 204

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1471989743  88 IAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:PRK11565  205 LADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQ 262
 
Name Accession Description Interval E-value
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 1-145 5.83e-85

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 251.03  E-value: 5.83e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSFGSPAVM 80
Cdd:cd19124   137 MEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKWGSNAVM 216

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:cd19124   217 ESDVLKEIAAAKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEIPQ 281
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 1-141 2.68e-60

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 187.30  E-value: 2.68e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyklsfGSPAVM 80
Cdd:cd19071   116 LEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGR-----GRRPLL 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19071   191 DDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 1-148 1.10e-58

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 184.47  E-value: 1.10e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSFGSPAVM 80
Cdd:cd19125   138 MEKLVDSGKVRAIGVSNFSVKKLEDLLAVARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSPGTTWVKKNVL 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQCRL 148
Cdd:cd19125   218 KDPIVTKVAEKLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRR 285
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 1-145 1.76e-55

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 175.24  E-value: 1.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLggyklsfGSPAVM 80
Cdd:COG0656   113 LEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPL-------GRGKLL 185

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:COG0656   186 DDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDR 250
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 1-143 1.04e-52

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 169.39  E-value: 1.04e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSF--GSPA 78
Cdd:cd19116   141 MEDLVKLGLTRSIGVSNFNSEQINRLLSNCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRLVPRGqtNPPP 220

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  79 VMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19116   221 RLDDPTLVAIAKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSF 285
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 1-145 1.52e-45

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 150.23  E-value: 1.52e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLsfgspavM 80
Cdd:cd19157   119 LEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQL-------L 191

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:cd19157   192 DNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNE 256
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 1-143 2.21e-45

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 149.70  E-value: 2.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyklsfGSPAVM 80
Cdd:cd19136   125 LEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGS-----GDLRLL 199

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19136   200 EDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 1-140 1.71e-44

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 147.34  E-value: 1.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyklsfGSPAVM 80
Cdd:cd19133   117 MEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAE-----GRNNLF 191

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19133   192 ENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAI 251
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 1-143 6.10e-44

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 147.17  E-value: 6.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLG------GYKlSF 74
Cdd:cd19123   143 MEELVDKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGsgdrpaAMK-AE 221

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1471989743  75 GSPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19123   222 GEPVLLEDPVINKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAAL 290
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 8-145 1.97e-43

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 144.34  E-value: 1.97e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyklsfGSpAVMENSILRE 87
Cdd:cd19132   124 GLVRSIGVSNFLPEHLDRLIDETGVTPAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLGR-----GS-GLLDEPVIKA 197

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1471989743  88 IAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:cd19132   198 IAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALDR 255
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 1-143 3.19e-43

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 144.12  E-value: 3.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyklsfgsPAVM 80
Cdd:cd19126   118 LEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQ-------GGLL 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19126   191 SNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDAL 253
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 1-143 8.14e-42

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 140.83  E-value: 8.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNS--SWHQGKLREFCKQKGIHVSAWSPLGGYKLSFGSPA 78
Cdd:cd19120   122 LEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAVNQIEFHPylYPQQPALLEYCREHGIVVSAYSPLSPLTRDAGGPL 201

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  79 vmeNSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19120   202 ---DPVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEIDKA 263
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 1-143 1.04e-40

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 138.70  E-value: 1.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLG--GYKLSFGSPA 78
Cdd:cd19154   144 MEKVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGspGRANFTKSTG 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1471989743  79 V------MENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19154   224 VspapnlLQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEI 294
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 1-143 5.96e-40

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 135.72  E-value: 5.96e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLsfgspavM 80
Cdd:cd19156   118 FEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGKL-------L 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19156   191 SNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGL 253
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 1-140 2.66e-39

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 134.04  E-value: 2.66e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKlsfgspaVM 80
Cdd:cd19131   120 LIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGG-------LL 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19131   193 SDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAI 252
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 1-145 1.65e-36

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 127.61  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLF--ESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGgyklSFGSPA 78
Cdd:cd19117   142 MQKLPATGKVKAIGVSNFSIKNLEKLLasPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLG----STNAPL 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1471989743  79 VMENSILrEIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIfdWELNQEEFDKINQIPQ 145
Cdd:cd19117   218 LKEPVII-KIAKKHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKL--FTLSDEEFKEIDELHK 281
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 8-141 1.90e-36

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 126.23  E-value: 1.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKlsfgspaVMENSILRE 87
Cdd:cd19073   117 GKVKSIGVSNFTIELLEEALDISPLPIAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLARGE-------VLRDPVIQE 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1471989743  88 IAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19073   190 IAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 1-144 3.38e-35

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 123.59  E-value: 3.38e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLsFGSPAVM 80
Cdd:cd19135   129 LEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKA-LEEPTVT 207

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1471989743  81 ensilrEIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIP 144
Cdd:cd19135   208 ------ELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSLH 265
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 1-141 6.37e-35

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 124.03  E-value: 6.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSF---GSP 77
Cdd:cd19106   140 MEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSPDRPWakpDEP 219

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1471989743  78 AVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19106   220 VLLEEPKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLD 283
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 8-141 1.45e-34

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 122.13  E-value: 1.45e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKL-----SFGSPAVMEN 82
Cdd:cd19127   127 GRVRAIGVSNFTPEHLERLIDATTVVPAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGGVMRygasgPTGPGDVLQD 206

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1471989743  83 SILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19127   207 PTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAID 265
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 1-143 2.66e-34

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 122.21  E-value: 2.66e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLS---FGSP 77
Cdd:cd19112   145 MEKLVSAGLVRSIGISNYDIFLTRDCLAYSKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGGAAANaewFGSV 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1471989743  78 AVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19112   225 SPLDDPVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSL 290
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 1-140 3.07e-34

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 122.22  E-value: 3.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESA--KIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLG----GYKLSF 74
Cdd:cd19109   140 LEACKDAGLVKSIGVSNFNRRQLELILNKPglKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGtcrdPIWVNV 219

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1471989743  75 GSPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19109   220 SSPPLLEDPLLNSIGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDI 285
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 1-145 4.95e-34

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 121.48  E-value: 4.95e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKL-------- 72
Cdd:cd19155   146 MEAQVDQGLTRSIGLSNFNREQMARILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSPGAahfspgtg 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  73 --SFGSPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:cd19155   226 spSGSSPDLLQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDK 300
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 1-145 5.11e-33

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 118.37  E-value: 5.11e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGG-----YKLSFG 75
Cdd:cd19111   130 MEALVSEGKVKSIGLSNFNPRQINKILAYAKVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSpgranQSLWPD 209

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  76 SPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:cd19111   210 QPDLLEDPTVLAIAKELDKTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDR 279
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 1-136 7.47e-33

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 118.49  E-value: 7.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESA--KIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSF---- 74
Cdd:cd19108   146 MEKCKDAGLAKSIGVSNFNRRQLEMILNKPglKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEwvdq 225

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1471989743  75 GSPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEE 136
Cdd:cd19108   226 NSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSED 287
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 1-143 1.07e-31

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 115.29  E-value: 1.07e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyklsfGSPAVM 80
Cdd:cd19119   150 LEKIYLDGRAKAIGVSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGS-----HGAPNL 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFdwELNQEEFDKINQI 143
Cdd:cd19119   225 KNPLVKKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKIV--SLTKEDLQKLDDI 285
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 1-140 5.95e-31

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 113.67  E-value: 5.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGgyKLSF------ 74
Cdd:cd19115   150 MEKLVDKGLARSIGVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFG--PQSFleldlp 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1471989743  75 ---GSPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19115   228 gakDTPPLFEHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAI 296
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 8-143 9.35e-31

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 112.50  E-value: 9.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLsfGSPAVMENSILRE 87
Cdd:cd19118   152 GKVKSIGVSNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNLA--GLPLLVQHPEVKA 229

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1471989743  88 IAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFdwELNQEEFDKINQI 143
Cdd:cd19118   230 IAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFEQV--ELSDDEFNAVTAL 283
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 1-143 2.55e-30

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 111.47  E-value: 2.55e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGgyklSFGSPaVM 80
Cdd:cd19121   144 MEKVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLG----STGSP-LI 218

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDweLNQEEFDKINQI 143
Cdd:cd19121   219 SDEPVVEIAKKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIID--LDDEDMNKLNDI 279
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 6-141 1.30e-29

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 108.89  E-value: 1.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   6 RLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGgyklsfgSPAVMENSIL 85
Cdd:cd19140   122 EAGLARHIGVSNFTVALLREAVELSEAPLFTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLA-------RGEVLKDPVL 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1471989743  86 REIAEARKKSVAQIALRWIYQQ-GAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19140   195 QEIGRKHGKTPAQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIA 251
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 1-140 1.51e-29

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 109.84  E-value: 1.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLG-------GYKLS 73
Cdd:cd19113   149 LEKLVDAGKIKSIGVSNFPGALILDLLRGATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGpqsfvelNQGRA 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1471989743  74 FGSPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19113   229 LNTPTLFEHDTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEI 295
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 7-141 6.57e-29

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 107.25  E-value: 6.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   7 LGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLsfgspavMENSILR 86
Cdd:cd19134   127 EGLARSIGVSNFTAEHLENLIDLTFFTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGRL-------LDNPAVT 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  87 EIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19134   200 AIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALD 254
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 1-141 1.21e-28

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 106.54  E-value: 1.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYP-AVNQVEMN--SSWHQGKLREFCKQKGIHVSAWSPLGGYKLSFGSP 77
Cdd:cd19072   123 MEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGPiVANQVEYNlfDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAKG 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  78 avmeNSILREIAEARKKSVAQIALRW-IYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19072   203 ----SPLLDEIAKKYGKTPAQIALNWlISKPNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 1-143 1.52e-28

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 107.01  E-value: 1.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMN--SSWHQGKLREFCKQKGIHVSAWSPLGG--------- 69
Cdd:pfam00248 123 LEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNllRRRQEEELLEYCKKNGIPLIAYSPLGGglltgkytr 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  70 ----------YKLSFGSPAVME-NSILREIAEARKKSVAQIALRWIYQQ--GAIPIVKSFNKERMKLNTEIFDWELNQEE 136
Cdd:pfam00248 203 dpdkgpgerrRLLKKGTPLNLEaLEALEEIAKEHGVSPAQVALRWALSKpgVTIPIPGASNPEQLEDNLGALEFPLSDEE 282


                  ....*..
gi 1471989743 137 FDKINQI 143
Cdd:pfam00248 283 VARIDEL 289
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 8-141 3.94e-28

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 104.99  E-value: 3.94e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLsFGSPAVmensilRE 87
Cdd:cd19130   127 GRTRSIGVSNFLPPHLERIVAATGVVPAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGKL-LGDPPV------GA 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1471989743  88 IAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19130   200 IAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAID 253
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 1-143 6.43e-28

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 104.91  E-value: 6.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyKLSFGSPAVM 80
Cdd:cd19128   133 MEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLGG-SYGDGNLTFL 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1471989743  81 ENSILREIAEARKKSVAQIALRWIYQQ---GAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQI 143
Cdd:cd19128   212 NDSELKALATKYNTTPPQVIIAWHLQKwpkNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 1-140 1.50e-26

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 102.11  E-value: 1.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESA--KIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKLSF---G 75
Cdd:cd19107   136 MEELVDEGLVKAIGVSNFNHLQIERILNKPglKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWakpE 215

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  76 SPAVMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19107   216 DPSLLEDPKIKEIAAKHNKTTAQVLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATI 280
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 8-140 1.79e-26

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 101.57  E-value: 1.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESA--KIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGyklSFGSPAVMENSIL 85
Cdd:cd19110   143 GLVKNIGVSNFNHEQLERLLNKPglRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGG---SCEGVDLIDDPVI 219

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  86 REIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19110   220 QRIAKKHGKSPAQILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNL 274
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
8-145 6.23e-25

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 97.07  E-value: 6.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPlggykLSFGSPAVMENSILRE 87
Cdd:PRK11565  130 GLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSP-----LAQGGKGVFDQKVIRD 204

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1471989743  88 IAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKINQIPQ 145
Cdd:PRK11565  205 LADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQ 262
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 1-143 1.11e-23

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 94.23  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGY-KLSFGSPAV 79
Cdd:cd19122   148 MEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQnQVPSTGERV 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1471989743  80 MENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFdwELNQEEFDKINQI 143
Cdd:cd19122   228 SENPTLNEVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSI--ELSDEDFEAINQV 289
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 1-140 1.28e-23

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 94.16  E-value: 1.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSplggyklSFGSPA-- 78
Cdd:cd19114   142 MEKLVDAGLVRNIGIANFNVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYS-------SFGNAVyt 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  79 -----------VMENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19114   215 kvtkhlkhftnLLEHPVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEAL 287
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 1-136 8.75e-23

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 91.52  E-value: 8.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKL---SMLFESAKIYPAVNQVEMnSSWHQGKLR----EFCKQKGIHVSAWSPL------ 67
Cdd:cd19093   127 LADAVEEGLVRAVGVSNYSADQLrraHKALKERGVPLASNQVEY-SLLYRDPEQngllPACDELGITLIAYSPLaqgllt 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  68 GGYKLS---------FGSPAVMEN-----SILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELN 133
Cdd:cd19093   206 GKYSPEnpppggrrrLFGRKNLEKvqpllDALEEIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLS 285


                  ...
gi 1471989743 134 QEE 136
Cdd:cd19093   286 EEE 288
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 8-149 1.08e-22

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 91.36  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGgyklsFGS-PAVMENSILR 86
Cdd:cd19129   146 GRCKAIGLSDVSLEKLREIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLG-----HGMePKLLEDPVIT 220

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  87 EIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFdwELNQEEFDKINQIPQCRLQ 149
Cdd:cd19129   221 AIARRVNKTPAQVLLAWAIQRGTALLTTSKTPSRIRENFDIS--TLPEDAMREINEGIKTRYR 281
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 5-140 2.70e-22

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 89.72  E-value: 2.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   5 YRLGLAKSIGVSNFGIKklsmLFESAKIYP-----AVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKlsfgspaV 79
Cdd:cd19139   116 KEQGLTRHIGVSNFTIA----LLDEAIAVVgagaiATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGK-------V 184

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1471989743  80 MENSILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19139   185 LDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAI 245
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 1-136 2.24e-18

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 79.91  E-value: 2.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLfESAKIYP-AVNQVEMN----SSWHQGKLrEFCKQKGIHVSAWSPLGGYKL--S 73
Cdd:cd19092   136 FDELVKSGKVRYFGVSNFTPSQIELL-QSYLDQPlVTNQIELSllhtEAIDDGTL-DYCQLLDITPMAWSPLGGGRLfgG 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  74 FGSPAVMENSILREIAEARKKSVAQIALRWIYQQGA--IPIVKSFNKERMKLNTEIFDWELNQEE 136
Cdd:cd19092   214 FDERFQRLRAALEELAEEYGVTIEAIALAWLLRHPAriQPILGTTNPERIRSAVKALDIELTREE 278
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 1-141 2.26e-18

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 79.60  E-value: 2.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYP-AVNQVEMNSSwHQG---KLREFCKQKGIHVSAWSPLG-GYKLSFG 75
Cdd:cd19138   124 MEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNcAANQVLYNLG-SRGieyDLLPWCREHGVPVMAYSPLAqGGLLRRG 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1471989743  76 SPavmENSILREIAEARKKSVAQIALRW-IYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19138   203 LL---ENPTLKEIAARHGATPAQVALAWvLRDGNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 1-141 6.84e-18

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 78.00  E-value: 6.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIYPAVNQVEMN---SSWHQGKLREFCKQKGIHVSAWSPlggyklsFGSP 77
Cdd:cd19137   123 MAEGVRQGLIRYIGVSNFNRRLLEEAISKSQTPIVCNQVKYNledRDPERDGLLEYCQKNGITVVAYSP-------LRRG 195

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1471989743  78 AVMENSILREIAEARKKSVAQIALRWIYQQ-GAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19137   196 LEKTNRTLEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 1-141 1.86e-17

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 77.18  E-value: 1.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIypAVNQVEMN--SSWHQGKLREFCKQKGIHVSAWSPLGG------YKL 72
Cdd:cd19084   130 LEKLKKEGKIRYIGVSNFSVEQLEEARKYGPI--VSLQPPYSmlEREIEEELLPYCRENGIGVLPYGPLAQglltgkYKK 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  73 S--------------FGSPAVMEN----SILREIAEARKKSVAQIALRWIYQQGAI--PIVKSFNKERMKLNTEIFDWEL 132
Cdd:cd19084   208 EptfppddrrsrfpfFRGENFEKNleivDKLKEIAEKYGKSLAQLAIAWTLAQPGVtsAIVGAKNPEQLEENAGALDWEL 287


                  ....*....
gi 1471989743 133 NQEEFDKIN 141
Cdd:cd19084   288 TEEELKEID 296
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
6-140 6.47e-17

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 75.45  E-value: 6.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   6 RLGLAKSIGVSNFGIKKLSMLFE---SAKIypAVNQVEMNSSWHQGKLREFCKQKGIHVSAWSPLGGYKlsfgspaVMEN 82
Cdd:PRK11172  119 KQGLTREIGISNFTIALMKQAIAavgAENI--ATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK-------VLKD 189

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1471989743  83 SILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:PRK11172  190 PVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAI 247
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 8-143 1.67e-16

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 74.83  E-value: 1.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAKIYP--AVNQVEMN--SSWHQGKLREFCKQKGIHVSAWSPLGG-------------- 69
Cdd:COG0667   145 GKIRYIGVSNYSAEQLRRALAIAEGLPpiVAVQNEYSllDRSAEEELLPAARELGVGVLAYSPLAGglltgkyrrgatfp 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  70 ----YKLSFGSPAVMENSI-----LREIAEARKKSVAQIALRWIYQQGAI--PIVKSFNKERMKLNTEIFDWELNQEEFD 138
Cdd:COG0667   225 egdrAATNFVQGYLTERNLalvdaLRAIAAEHGVTPAQLALAWLLAQPGVtsVIPGARSPEQLEENLAAADLELSAEDLA 304


                  ....*
gi 1471989743 139 KINQI 143
Cdd:COG0667   305 ALDAA 309
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 6-143 7.79e-16

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 73.00  E-value: 7.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   6 RLGLAKSIGVSNFGIKKLSMLFESAKIypAVNQVEMNSSWHQ--GKLREFCKQKGIHVSAWSPLGGYKLS--FGSPAVME 81
Cdd:cd19085   124 EEGKIRAIGVSNFGPAQLEEALDAGRI--DSNQLPYNLLWRAieYEILPFCREHGIGVLAYSPLAQGLLTgkFSSAEDFP 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  82 N-----------------------SILREIAEARKKSVAQIALRWIYQQGAI--PIVKSFNKERMKLNTEIFDWELNQEE 136
Cdd:cd19085   202 PgdartrlfrhfepgaeeetfealEKLKEIADELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSV 281


                  ....*..
gi 1471989743 137 FDKINQI 143
Cdd:cd19085   282 LERLDEI 288
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
 8-141 1.50e-11

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 61.10  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFG---IKKlsmlfeSAKIYP-AVNQVEMnSSWHQGKLR----EFCKQKGIHVSAWSPL------GGYKLS 73
Cdd:cd19077   141 GKIRGIGLSEVSaetIRR------AHAVHPiAAVEVEY-SLFSREIEEngvlETCAELGIPIIAYSPLgrglltGRIKSL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  74 --------------FGSPAVMEN----SILREIAEARKKSVAQIALRWIYQQGA---IPIVKSFNKERMKLNTEIFDWEL 132
Cdd:cd19077   214 adipegdfrrhldrFNGENFEKNlklvDALQELAEKKGCTPAQLALAWILAQSGpkiIPIPGSTTLERVEENLKAANVEL 293


                  ....*....
gi 1471989743 133 NQEEFDKIN 141
Cdd:cd19077   294 TDEELKEIN 302
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 6-143 5.40e-10

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 56.85  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   6 RLGLAKSIGVSNFG----IKKLSML-------FESAKIY--PAVNQVEmnsswHQgkLREFCKQKGIHVSAWSPLGGYKL 72
Cdd:cd19091   148 RQGKVRYIGVSNFSawqiMKALGISerrglarFVALQAYysLLGRDLE-----HE--LMPLALDQGVGLLVWSPLAGGLL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  73 S-------------------FGSPAVMENSI------LREIAEARKKSVAQIALRWIYQQGAIP--IVKSFNKERMKLNT 125
Cdd:cd19091   221 SgkyrrgqpapegsrlrrtgFDFPPVDRERGydvvdaLREIAKETGATPAQVALAWLLSRPTVSsvIIGARNEEQLEDNL 300

                         170
                  ....*....|....*...
gi 1471989743 126 EIFDWELNQEEFDKINQI 143
Cdd:cd19091   301 GAAGLSLTPEEIARLDKV 318
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 1-143 9.36e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 53.06  E-value: 9.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSmlfESAKIYP-AVNQVeMNSSWHQGKLRE---FCKQKGIHVSAWSPLGGYKLS--- 73
Cdd:cd19102   131 LAELKEEGKVRAIGVSNFSVDQMK---RCQAIHPiASLQP-PYSLLRRGIEAEilpFCAEHGIGVIVYSPMQSGLLTgkm 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  74 -------------------FGSPAVMEN----SILREIAEARKKSVAQIALRWIYQQGAI--PIVKSFNKERMKLNTEIF 128
Cdd:cd19102   207 tpervaslpaddwrrrspfFQEPNLARNlalvDALRPIAERHGRTVAQLAIAWVLRRPEVtsAIVGARRPDQIDETVGAA 286

                         170
                  ....*....|....*
gi 1471989743 129 DWELNQEEFDKINQI 143
Cdd:cd19102   287 DLRLTPEELAEIEAL 301
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 8-111 1.65e-08

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 52.22  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLsmlfESAKIYPAVNQVE-MNSSWHQG--KLREFCKQKGIHVSAWSPLGGYKLSFGSpavmenSI 84
Cdd:cd19088   136 GLIRHIGLSNVTVAQI----EEARAIVRIVSVQnRYNLANRDdeGVLDYCEAAGIAFIPWFPLGGGDLAQPG------GL 205

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1471989743  85 LREIAEARKKSVAQIALRWIYQQG----AIP 111
Cdd:cd19088   206 LAEVAARLGATPAQVALAWLLARSpvmlPIP 236
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 8-143 1.89e-08

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 52.21  E-value: 1.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFEsAKIYPAVNQVemnsswhQ---------GKLREFCKQKGIHVSAWSPLGG--------- 69
Cdd:cd19101   135 GKIRHLGLTNFDTERLREILD-AGVPIVSNQV-------QyslldrrpeNGMAALCEDHGIKLLAYGTLAGgllsekylg 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  70 ----------------YKLS---FGSPAVMEN--SILREIAEARKKSVAQIALRWIYQQGAI--PIVKSFNKERMKLNTE 126
Cdd:cd19101   207 vpeptgpaletrslqkYKLMideWGGWDLFQEllRTLKAIADKHGVSIANVAVRWVLDQPGVagVIVGARNSEHIDDNVR 286

                         170
                  ....*....|....*..
gi 1471989743 127 IFDWELNQEEFDKINQI 143
Cdd:cd19101   287 AFSFRLDDEDRAAIDAV 303
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 8-113 5.28e-08

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 50.60  E-value: 5.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFGIKKLSMLFESAK----IYPAVNQVEMN---SSWHQGKLREFCKQKGIHVSAWSPLGGyklsfGspavm 80
Cdd:cd06660   130 GKIRYIGVSNWSAERLAEALAYAKahglPGFAAVQPQYSlldRSPMEEELLDWAEENGLPLLAYSPLAR-----G----- 199

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1471989743  81 ensilreiaearkksVAQIALRWIYQQ--GAIPIV 113
Cdd:cd06660   200 ---------------PAQLALAWLLSQpfVTVPIV 219
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 6-141 6.96e-08

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 50.68  E-value: 6.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   6 RLGLAKSIGVSNFGIKKLSMLFESAK---------IYPAVNQVEMNSSwhQGKLREFCKQKGIHVSAWSPLGG------Y 70
Cdd:cd19081   142 RQGKVRYIGASNYSAWRLQEALELSRqhglpryvsLQPEYNLVDRESF--EGELLPLCREEGIGVIPYSPLAGgfltgkY 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  71 ----KLSfGSPAVMEN-------------SILREIAEARKKSVAQIALRWIYQQGAI--PIVKSFNKERMKLNTEIFDWE 131
Cdd:cd19081   220 rseaDLP-GSTRRGEAakrylnerglrilDALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLEDLLAAAGLR 298

                         170
                  ....*....|
gi 1471989743 132 LNQEEFDKIN 141
Cdd:cd19081   299 LTDEEVARLD 308
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 51-136 2.11e-07

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 49.12  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  51 RE---FCKQKGIHVSAWSPL-----------------------GGYKLSFGSP--AVMENsiLREIAEARKKSVAQIALR 102
Cdd:cd19079   194 REmipLCEEEGIGVIPWSPLargrlarpwgdtterrrsttdtaKLKYDYFTEAdkEIVDR--VEEVAKERGVSMAQVALA 271

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1471989743 103 WIYQQGAI--PIVKSFNKERMKLNTEIFDWELNQEE 136
Cdd:cd19079   272 WLLSKPGVtaPIVGATKLEHLEDAVAALDIKLSEEE 307
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 1-143 3.43e-07

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 48.46  E-value: 3.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   1 MEYCYRLGLAKSIGVSNFGIKKLSMLFESAKIypAVNQVEMNsswhqgkLRE---------FCKQKGIHVSAWSPLGGYK 71
Cdd:cd19148   132 LKELLDEGKIRAIGVSNFSPEQMETFRKVAPL--HTVQPPYN-------LFEreiekdvlpYARKHNIVTLAYGALCRGL 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  72 LS--------------------FGSP-------AVMEnsiLREIAEAR-KKSVAQIALRWIYQQGAIPIVKSFNKERMKL 123
Cdd:cd19148   203 LSgkmtkdtkfegddlrrtdpkFQEPrfsqylaAVEE---LDKLAQERyGKSVIHLAVRWLLDQPGVSIALWGARKPEQL 279

                         170       180
                  ....*....|....*....|..
gi 1471989743 124 N--TEIFDWELNQEEFDKINQI 143
Cdd:cd19148   280 DavDEVFGWSLNDEDMKEIDAI 301
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 6-110 1.47e-06

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 46.87  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   6 RLGLAKSIGVSNFG---IKKLSMLFESAKIYPAVNQVEMN--SSWHQGKLREFCKQKGIHVSAWSPLGGYKLS----FGS 76
Cdd:cd19089   144 RSGKALYVGISNYPgakARRAIALLRELGVPLIIHQPRYSllDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTdkylNGI 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1471989743  77 PA---VMENSI-----------------LREIAEARKKSVAQIALRWIYQQGAI 110
Cdd:cd19089   224 PPdsrRAAESKflteealtpekleqlrkLNKIAAKRGQSLAQLALSWVLRDPRV 277
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 45-141 2.25e-06

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 46.07  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  45 WHQGKLREFCKQKGIHVSAWSPLG-GYkLS--------------------FGSPAVMEN----SILREIAEARKKSVAQI 99
Cdd:cd19078   176 EPEKEVLPTLEELGIGFVPFSPLGkGF-LTgkidentkfdegddraslprFTPEALEANqalvDLLKEFAEEKGATPAQI 254

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1471989743 100 ALRWIYQQGA--IPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19078   255 ALAWLLAKKPwiVPIPGTTKLSRLEENIGAADIELTPEELREIE 298
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 51-141 3.65e-06

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 45.67  E-value: 3.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  51 REF---CKQKGIHVSAWSPLGGYKLS------------------FGSPAVMENSI-----LREIAEARKKSVAQIALRWI 104
Cdd:cd19080   189 RELlpmARALGLGVTPWSPLGGGLLTgkyqrgeegrageakgvtVGFGKLTERNWaivdvVAAVAEELGRSAAQVALAWV 268

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1471989743 105 YQQ--GAIPIVKSFNKERMKLNTEIFDWELNQEEFDKIN 141
Cdd:cd19080   269 RQKpgVVIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 8-143 6.30e-06

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 45.10  E-value: 6.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFgikKLSMLFESAKI-YPAVNQVEMN--SSWHQGKLREFCKQKGIHVSAWSPL------GGY----KLS- 73
Cdd:cd19083   145 GKIRAIGVSNF---SLEQLKEANKDgYVDVLQGEYNllQREAEEDILPYCVENNISFIPYFPLasgllaGKYtkdtKFPd 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  74 ---------FGSPAVMEN----SILREIAEARKKSVAQIALRWIYQQGAIPIVKSFNK--ERMKLNTEIFDWELNQEEFD 138
Cdd:cd19083   222 ndlrndkplFKGERFSENldkvDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKraEQVIDNLKALDVTLTEEEIA 301


                  ....*
gi 1471989743 139 KINQI 143
Cdd:cd19083   302 FIDAL 306
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 8-113 1.72e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 43.48  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743   8 GLAKSIGVSNFG---IKKLSMLFESA--KIYPAVNQVEM-NSSWHQGKLREFCKQKGIHVSAWSPL------GGY----K 71
Cdd:cd19103   135 GKVKHVGVSNHNlaeIKRANEILAKAgvSLSAVQNHYSLlYRSSEEAGILDYCKENGITFFAYMVLeqgalsGKYdtkhP 214

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1471989743  72 LSFGSP-AVMENSIL----------REIAEARKKSVAQIALRWIYQQGAIPIV 113
Cdd:cd19103   215 LPEGSGrAETYNPLLpqleeltavmAEIGAKHGASIAQVAIAWAIAKGTTPII 267
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 54-140 6.03e-04

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 39.12  E-value: 6.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471989743  54 CKQKGIHVSAWSPLGGYKLS--FGSPAVMENSI----------------------LREIAEARKKSVAQIALRWIYQQGA 109
Cdd:cd19076   191 CRELGIGFVAYSPLGRGFLTgaIKSPEDLPEDDfrrnnprfqgenfdknlklvekLEAIAAEKGCTPAQLALAWVLAQGD 270

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1471989743 110 --IPIVKSFNKERMKLNTEIFDWELNQEEFDKI 140
Cdd:cd19076   271 diVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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