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Conserved domains on  [gi|1471513202|gb|RHI97610|]
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lytic transglycosylase domain-containing protein [Phocaeicola vulgatus]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 13013999)

lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 111-236 6.89e-62

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


:

Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 193.12  E-value: 6.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 111 LKENGIPDDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNNVDERYHIEKATRAACRYLKDAYAKYKDWV 190
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLKDLYKRFGDWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1471513202 191 AVAASYNAGQARIASQLAKQDVDDSLD---LQLVEETARYVYRILAAKQ 236
Cdd:cd16894    81 LALAAYNAGEGRVRRAIKRAGTDKWEDyyrLYLPAETRRYVPKFLAAKI 129
 
Name Accession Description Interval E-value
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 111-236 6.89e-62

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 193.12  E-value: 6.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 111 LKENGIPDDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNNVDERYHIEKATRAACRYLKDAYAKYKDWV 190
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLKDLYKRFGDWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1471513202 191 AVAASYNAGQARIASQLAKQDVDDSLD---LQLVEETARYVYRILAAKQ 236
Cdd:cd16894    81 LALAAYNAGEGRVRRAIKRAGTDKWEDyyrLYLPAETRRYVPKFLAAKI 129
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 70-240 7.93e-40

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 140.52  E-value: 7.93e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202  70 LSRFDRHERMDRELLAftymhsTSLQMLKKANRYFPIVEPILKENGIPDD-FKYLMVIESNMNPTARSSAGAAGLWQFMQ 148
Cdd:COG0741    76 LAAFAAIAALAAELLA------LAALLLRRPLPYLPLIEEAAKKYGVDPAlVLALIRQESAFNPNAVSPAGARGLMQLMP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 149 GTGRDYGLEVN--NNVDERYHIEKATRAACRYLKDAYAKYK-DWVAVAASYNAGQARIASQLAKQDVDDsLDLQLVEETA 225
Cdd:COG0741   150 ATARRLGLKLGlgPSPDDLFDPETNIRAGAAYLRELLDRFDgDLVLALAAYNAGPGRVRRWLRRNGDRD-GEIIPYAETR 228

                         170
                  ....*....|....*
gi 1471513202 226 RYVYRILAAKQLFNA 240
Cdd:COG0741   229 NYVKKVLANYAIYRA 243
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 106-210 1.56e-23

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 93.14  E-value: 1.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 106 IVEPILKENGIPDDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNNVDERYHIEKATRAACRYLKDAYAK 185
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKELYKQ 80

                          90       100
                  ....*....|....*....|....*.
gi 1471513202 186 YK-DWVAVAASYNAGQARIASQLAKQ 210
Cdd:pfam01464  81 YGgDLWLALAAYNAGPGRVRKWIKNA 106
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 87-290 1.09e-22

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 97.88  E-value: 1.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202  87 TYMHSTSLqmlkKANRY-FPIVEPILKENgIPDDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNNVDER 165
Cdd:PRK10783   92 SYLHDVTL----RAEPYmYWIVGQIKKRN-MPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDAR 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 166 YHIEKATRAACRYLKDAYAKYK-DWVAVAASYNAGQAR----IASQLAKQDVDDSLDLQLVEETARYVYRILAAKQLFNA 240
Cdd:PRK10783  167 RDVVASTTAALDMMQRLNKMFDgDWLLTVAAYNSGEGRvmkaIKANKAKGKPTDFWSLSLPRETKIYVPKMLALSDILKN 246

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1471513202 241 PTTFGFRLRASDLYPPIpyTEVTVTKGIaDLARFARSKGINLAILKNMNP 290
Cdd:PRK10783  247 SKRYGVRLPTTDESRAL--ARVDLGQQI-ELAQAAEMAGMSLTKLKTFNA 293
 
Name Accession Description Interval E-value
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 111-236 6.89e-62

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 193.12  E-value: 6.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 111 LKENGIPDDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNNVDERYHIEKATRAACRYLKDAYAKYKDWV 190
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLKDLYKRFGDWL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1471513202 191 AVAASYNAGQARIASQLAKQDVDDSLD---LQLVEETARYVYRILAAKQ 236
Cdd:cd16894    81 LALAAYNAGEGRVRRAIKRAGTDKWEDyyrLYLPAETRRYVPKFLAAKI 129
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 70-240 7.93e-40

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 140.52  E-value: 7.93e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202  70 LSRFDRHERMDRELLAftymhsTSLQMLKKANRYFPIVEPILKENGIPDD-FKYLMVIESNMNPTARSSAGAAGLWQFMQ 148
Cdd:COG0741    76 LAAFAAIAALAAELLA------LAALLLRRPLPYLPLIEEAAKKYGVDPAlVLALIRQESAFNPNAVSPAGARGLMQLMP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 149 GTGRDYGLEVN--NNVDERYHIEKATRAACRYLKDAYAKYK-DWVAVAASYNAGQARIASQLAKQDVDDsLDLQLVEETA 225
Cdd:COG0741   150 ATARRLGLKLGlgPSPDDLFDPETNIRAGAAYLRELLDRFDgDLVLALAAYNAGPGRVRRWLRRNGDRD-GEIIPYAETR 228

                         170
                  ....*....|....*
gi 1471513202 226 RYVYRILAAKQLFNA 240
Cdd:COG0741   229 NYVKKVLANYAIYRA 243
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 95-233 3.10e-30

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 118.63  E-value: 3.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202  95 QMLKKANRYFPIVEPILKENGIP-DDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGlevnnnVDERYHIEKATR 173
Cdd:COG4623   256 RIEGRLPPYDPLFEKYAEEYGLDwRLLAALAYQESHWNPRARSPTGARGLMQLMPATAKELG------VDDRLDPEQSIR 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 174 AACRYLKDAYAKYKD--------WVAVAAsYNAGQARI--ASQLAKQ---------DVDDSLDLQLVE------ETARYV 228
Cdd:COG4623   330 AGAKYLRWLYDRFPEaidepdrwWFALAA-YNAGPGHVqdARRLAKKqgldpdrwfDVEKSQPKYYDTgyargrETVNYV 408


                  ....*
gi 1471513202 229 YRILA 233
Cdd:COG4623   409 PNIRA 413
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 106-210 1.56e-23

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 93.14  E-value: 1.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 106 IVEPILKENGIPDDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNNVDERYHIEKATRAACRYLKDAYAK 185
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKELYKQ 80

                          90       100
                  ....*....|....*....|....*.
gi 1471513202 186 YK-DWVAVAASYNAGQARIASQLAKQ 210
Cdd:pfam01464  81 YGgDLWLALAAYNAGPGRVRKWIKNA 106
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 87-290 1.09e-22

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 97.88  E-value: 1.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202  87 TYMHSTSLqmlkKANRY-FPIVEPILKENgIPDDFKYLMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNNVDER 165
Cdd:PRK10783   92 SYLHDVTL----RAEPYmYWIVGQIKKRN-MPMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDAR 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 166 YHIEKATRAACRYLKDAYAKYK-DWVAVAASYNAGQAR----IASQLAKQDVDDSLDLQLVEETARYVYRILAAKQLFNA 240
Cdd:PRK10783  167 RDVVASTTAALDMMQRLNKMFDgDWLLTVAAYNSGEGRvmkaIKANKAKGKPTDFWSLSLPRETKIYVPKMLALSDILKN 246

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1471513202 241 PTTFGFRLRASDLYPPIpyTEVTVTKGIaDLARFARSKGINLAILKNMNP 290
Cdd:PRK10783  247 SKRYGVRLPTTDESRAL--ARVDLGQQI-ELAQAAEMAGMSLTKLKTFNA 293
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 123-234 2.20e-21

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 87.27  E-value: 2.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 123 LMVIESNMNPTARSSAGAAGLWQFMQGTGRDYGLEvnnNVDERYHIEKATRAACRYLKDAYAKY-KDWVAVAASYNAGQA 201
Cdd:cd00254     7 VIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRR---GVDDLFDPEENIRAGARYLRELLDRFgGDLELALAAYNAGPG 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1471513202 202 RIASQLAKqdvddslDLQLVEETARYVYRILAA 234
Cdd:cd00254    84 AVDRWGGG-------EVPPYKETRNYVQRVLAY 109
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 103-240 5.18e-15

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 71.35  E-value: 5.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 103 YFPIVEPILKENGIPDDFKY-LMVIESNMNPTARSSAGAAGLWQFMQGTGRD----YGLEVNNNvDERYHIEKATRAACR 177
Cdd:cd13401     6 YRDLVERAAKKNGLDPALVYaIIRQESAFDPDAVSPAGALGLMQLMPATAKDvakkLGLPYYSP-RDLFDPEYNIRLGSA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1471513202 178 YLKDAYAKYK-DWVAVAASYNAGQARIASQLAKQDVDDSLDlqLVE-----ETARYVYRILAAKQLFNA 240
Cdd:cd13401    85 YLAELLDRFDgNPVLALAAYNAGPGRVRRWLKRRGDLDPDL--WIEtipfsETRNYVKRVLENYVVYRA 151
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 127-210 3.27e-13

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 66.40  E-value: 3.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 127 ESNMNPTARSSAGAAGLWQFMQGTGRDYGlevnnnVDERYHIEKATRAACRYLKDAYAKYKDWVAVA-------ASYNAG 199
Cdd:cd13403    22 ESRFNPNARSPAGARGLMQLMPSTARELG------VNDRLDPEQNIHAGAKYLRYLRDRFPPDIDEPdrlkfalAAYNAG 95

                          90
                  ....*....|...
gi 1471513202 200 QARI--ASQLAKQ 210
Cdd:cd13403    96 PGHVrdARRLAKK 108
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 125-237 2.79e-12

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 63.30  E-value: 2.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 125 VI--ESNMNPTARSSAGAAGLWQFMQGTGRD----YGLEvNNNVDERYHIEKATRAACRYLKDAYAKY-KDWVAVAASYN 197
Cdd:cd16896    25 VIkvESNFNPNAVSSKGAIGLMQIMPETAEWiaekLGLE-DFSEDDLYDPETNIRLGTWYLSYLLKEFdGNLVLALAAYN 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1471513202 198 AGQARIASQLAKQDVD---DSLDLQLVEETARYVYRILAAKQL 237
Cdd:cd16896   104 AGPGNVDKWLKDGGWSgdgKTLDQIPFPETRHYVKKVLKNYKI 146
PHA00368 PHA00368
internal virion protein D
 114-227 6.12e-12

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 66.73  E-value: 6.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202  114 NGIPDDFKYLMV-IESNMNPTARSSAGAAGLWQFMQGTGRDYGLEVNNnvDERYHIEKATRAACRYLKDAYAKYK-DWVA 191
Cdd:PHA00368    22 HGVSYDLLRKVGwDESRFNPTAKSPTGPKGLMQFTKATAKALGLIVDD--DDRLDPELAIDAGARYLADLVGKYDgDELK 99

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1471513202  192 VAASYNAGQARI-ASQLAKQDVDDSLDLQlvEETARY 227
Cdd:PHA00368   100 AALAYNQGEGRLgAPQLEAYDKGDFASIS--EEGRNY 134
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 126-201 3.91e-09

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 53.47  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 126 IESNMNPTA-RSSAGAAGLWQFMQGTGRDYGLEVNNN-VDERYHIEKATRAACRYLK-----DAYAKYKDWVAVAASYNA 198
Cdd:cd13399    14 VESGFGPNAgGSPAGAQGIAQFMPSTWKAYGVDGNGDgKADPFNPEDAIASAANYLCrhgwdLNAFLGEDNFLALAAYNA 93


                  ...
gi 1471513202 199 GQA 201
Cdd:cd13399    94 GPG 96
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 115-233 1.22e-06

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 50.06  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 115 GIPDDfkYLMVI---ESNMNPTARSSAGAAGLWQFMQGTGRD----YGLEVNNN----VDERYHIEKATraacRYLKDAY 183
Cdd:PRK11619  491 GIPQS--YAMAIarqESAWNPKARSPVGASGLMQIMPGTATHtvkmFSIPGYSSssqlLDPETNINIGT----SYLEYVY 564

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1471513202 184 AKY-KDWVAVAASYNAGQARIASQLAkqDVDDSLD-LQLVE-----ETARYVYRILA 233
Cdd:PRK11619  565 QQFgNNRILASAAYNAGPGRVRTWLG--NSAGRIDaVAFVEsipfsETRGYVKNVLA 619
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 127-178 9.78e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 42.40  E-value: 9.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1471513202 127 ESNMNPTAR--SSAGAAGLWQFMQGTGRDYGLevnNNVDERYHIEKATRAACRY 178
Cdd:cd00442     9 ESGGNKPANagSGSGAAGLFQFMPGTWKAYGK---NSSSDLNDPEASIEAAAKY 59
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 124-236 1.22e-05

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 44.86  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 124 MVIESNMNPTARSSAGAAGLWQFMQGT-GRD-----YGLEVNNNVDERYHIEKATRAACRYLKDAYAKY----KDWV--- 190
Cdd:cd16893    21 IETESSFNPYAVSHSPAYGLMQIVPSTaGRDvyrllGGKGGLPSKSYLFDPENNIDIGTAYLHILQNRYlkgiKNPKsre 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1471513202 191 -AVAASYNAG-------------QA-RIASQLAKQDVDDSLDLQL-VEETARYVYRILAAKQ 236
Cdd:cd16893   101 yCAIAAYNGGagnvlrtfssdrkKAiSKINRLSPDEVYQHLTKKLpAAETRNYLKKVLKAKK 162
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
91-153 2.05e-04

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 42.73  E-value: 2.05e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202  91 STSLQML-----KKANRYFPIVEPILKENGIPDDFKY-LMVIESNMNPTARSSAGAAGLWQFMQGT-GRD 153
Cdd:PRK11671  175 SVTINMVpnhldKRAHKYLPMVRKASRKYGVDESLILaIMQTESSFNPYAVSRSDALGLMQVVQHTaGKD 244
CwlT-like cd16891
CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall ...
 103-203 2.77e-03

CwlT-like N-terminal lysozyme domain and similar domains; CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain (gamma-d-D-glutamyl-L-diamino acid endopeptidase), and has been implicated in the spread of transposons. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381612 [Multi-domain]  Cd Length: 151  Bit Score: 37.58  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1471513202 103 YFPIVEPILKENGIPDDFKYLMVI---ESnmnptarssagaaglwqfmQGTGRD-------YGLEVNNNVDERYHIEkat 172
Cdd:cd16891     1 YRPLVEKEAKKYGIPEYVPLILAIimqES-------------------GGKGPDimqssesAGLPPNTITDPEESIE--- 58

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1471513202 173 rAACRYLKDAYAKYKD-----WVAVAAsYNAGQARI 203
Cdd:cd16891    59 -QGVKYFADVLKKAKGkgvdiWTAVQA-YNFGGGYI 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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