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Conserved domains on  [gi|1468626397|ref|WP_117502506|]
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MULTISPECIES: sensor histidine kinase [Bifidobacterium]

Protein Classification

sensor histidine kinase( domain architecture ID 13394397)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 301-438 8.96e-45

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


:

Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 152.35  E-value: 8.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 301 VLDVILTTKERTCADRGITFTAVADGSLLSGMSSMDIASLFGNALDNAIEATSKLPKrEQRLIKLALYEQNRFIVIRVEN 380
Cdd:cd16935     1 ALDSLLSEKLELAREKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKIDK-ENRFIHLKIRQKKGFLIISIEN 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1468626397 381 YYDSRLKKDaEGNLRTTKRDDqhRHGFGVKSIRHIAQQYGGEVTIRTEDHWFVLTALI 438
Cdd:cd16935    80 SYEGELKKK-NGLFLSTKKDK--NHGIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
BaeS super family cl33988
Signal transduction histidine kinase [Signal transduction mechanisms];
139-429 2.54e-05

Signal transduction histidine kinase [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0642:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 46.05  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 139 ALCFGLAWMVERGNFSQATPTLPTASAAIATMAIMIVTFAMSNLSFVSTNTPFSGSVGQEIFYIRTLVDFCGFAILYAQQ 218
Cdd:COG0642     1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 219 EQARRIEANTELASINAQLESQHQEYLQSKENIesLGRLAHDLKHQLAA-------LRAEVDPKHAAAgFEQLEQSVQR- 290
Cdd:COG0642    81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRF--LANVSHELRTPLTAirgylelLLEELDEEQREY-LETILRSADRl 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 291 ---------YSAQQHTG----------NPVLDVILTTKERTCADRGITFTAVADGSLLSGMSSMD-IASLFGNALDNAIE 350
Cdd:COG0642   158 lrlindlldLSRLEAGKlelepepvdlAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDrLRQVLLNLLSNAIK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 351 ATsklpkREQRLIKLALYEQNRFIVIRVEnyyDS--RLKKDAEGNL----RTTKRDDQHR-HGFGVKSIRHIAQQYGGEV 423
Cdd:COG0642   238 YT-----PEGGTVTVSVRREGDRVRISVE---DTgpGIPPEDLERIfepfFRTDPSRRGGgTGLGLAIVKRIVELHGGTI 309


                  ....*.
gi 1468626397 424 TIRTED 429
Cdd:COG0642   310 EVESEP 315
 
Name Accession Description Interval E-value
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 301-438 8.96e-45

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 152.35  E-value: 8.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 301 VLDVILTTKERTCADRGITFTAVADGSLLSGMSSMDIASLFGNALDNAIEATSKLPKrEQRLIKLALYEQNRFIVIRVEN 380
Cdd:cd16935     1 ALDSLLSEKLELAREKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKIDK-ENRFIHLKIRQKKGFLIISIEN 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1468626397 381 YYDSRLKKDaEGNLRTTKRDDqhRHGFGVKSIRHIAQQYGGEVTIRTEDHWFVLTALI 438
Cdd:cd16935    80 SYEGELKKK-NGLFLSTKKDK--NHGIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 332-438 1.50e-37

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 132.34  E-value: 1.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 332 MSSMDIASLFGNALDNAIEATSKLPkrEQRLIKLALYEQNRFIVIRVENYYDSRLKKdaEGNLRTTKRDDQHrHGFGVKS 411
Cdd:pfam14501   1 ISDVDLCVIFGNLLDNAIEACSKID--DNRFIRLKIREKQNFLIIRIENTYEGELKF--EGKLPSTKTKGDG-HGIGLKS 75

                          90       100
                  ....*....|....*....|....*..
gi 1468626397 412 IRHIAQQYGGEVTIRTEDHWFVLTALI 438
Cdd:pfam14501  76 IRRIVKKYGGNLSTEIENGIFTLSILL 102
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 236-441 1.58e-32

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 127.27  E-value: 1.58e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 236 QLESQHQEYLQSKENIESLGRLAHDLKHQLAALRA---EVDPKHAAAGFEQLEQSVQRYSAQ--QHTGNPVLDVILTTKE 310
Cdd:COG3290   175 ELERLEEELEGVKELAEALRAQRHDFRNHLHTISGllqLGEYDEALEYIDEISEELQELIDSllSRIGNPVLAALLLGKA 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 311 RTCADRGITFTAVADGSL-LSGMSSMDIASLFGNALDNAIEATSKLPKREqRLIKLALYEQNRFIVIRVENYYDSRLKKD 389
Cdd:COG3290   255 ARARERGIDLTIDIDSDLpDLPLSDTDLVTILGNLLDNAIEAVEKLPEEE-RRVELSIRDDGDELVIEVEDSGPGIPEEL 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1468626397 390 AEGNLR---TTKrdDQHRHGFGVKSIRHIAQQYGGEVTIRTEDHWF-VLTALIPRK 441
Cdd:COG3290   334 LEKIFErgfSTK--LGEGRGLGLALVKQIVEKYGGTIEVESEEGEGtVFTVRLPKE 387
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 229-440 9.36e-07

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 50.99  E-value: 9.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 229 ELASINAQLEsqhqeylQSKENIESLGRLAHDLKHQLAALRAEVDPKHaaagFEQLEQSVQRYS-AQQHT--------GN 299
Cdd:PRK15053  324 EISTLNAQLT-------QIKQYVESLRTLRHEHLNWMSTLNGLLQMKE----YDRVLEMVQGESqAQQQLidslreafAD 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 300 PVLDVILTTKERTCADRGITFTAVaDGSLLS----GMSSMDIASLFGNALDNAIEATSKLPKREqRLIKLALYEQNRFIV 375
Cdd:PRK15053  393 RQVAGLLFGKVQRARELGLKMVIV-PGSQLSqlppGLDSTEFAAIVGNLLDNAFEASLRSDEGN-KIVELFLSDEGDDVV 470

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468626397 376 IRVENY---YDSRLKKDAEGNLRTTKRDDQHRHGFGVKSIRHIAQQYGGEVTIRTEDHWFVL-TALIPR 440
Cdd:PRK15053  471 IEVADQgcgVPESLRDKIFEQGVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLfSIFIPK 539
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 340-428 1.20e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 44.18  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397  340 LFGNALDNAIEATSklpkrEQRLIKLALYEQNRFIVIRVENY---YDSRLKKDAEGNLRTTKRDDQHRHGFGV--KSIRH 414
Cdd:smart00387   9 VLSNLLDNAIKYTP-----EGGRITVTLERDGDHVEITVEDNgpgIPPEDLEKIFEPFFRTDKRSRKIGGTGLglSIVKK 83

                           90
                   ....*....|....
gi 1468626397  415 IAQQYGGEVTIRTE 428
Cdd:smart00387  84 LVELHGGEISVESE 97
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
139-429 2.54e-05

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 46.05  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 139 ALCFGLAWMVERGNFSQATPTLPTASAAIATMAIMIVTFAMSNLSFVSTNTPFSGSVGQEIFYIRTLVDFCGFAILYAQQ 218
Cdd:COG0642     1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 219 EQARRIEANTELASINAQLESQHQEYLQSKENIesLGRLAHDLKHQLAA-------LRAEVDPKHAAAgFEQLEQSVQR- 290
Cdd:COG0642    81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRF--LANVSHELRTPLTAirgylelLLEELDEEQREY-LETILRSADRl 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 291 ---------YSAQQHTG----------NPVLDVILTTKERTCADRGITFTAVADGSLLSGMSSMD-IASLFGNALDNAIE 350
Cdd:COG0642   158 lrlindlldLSRLEAGKlelepepvdlAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDrLRQVLLNLLSNAIK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 351 ATsklpkREQRLIKLALYEQNRFIVIRVEnyyDS--RLKKDAEGNL----RTTKRDDQHR-HGFGVKSIRHIAQQYGGEV 423
Cdd:COG0642   238 YT-----PEGGTVTVSVRREGDRVRISVE---DTgpGIPPEDLERIfepfFRTDPSRRGGgTGLGLAIVKRIVELHGGTI 309


                  ....*.
gi 1468626397 424 TIRTED 429
Cdd:COG0642   310 EVESEP 315
PRK11281 PRK11281
mechanosensitive channel MscK;
221-302 1.47e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397  221 ARRIEANTELASINAQLESQHQEyLQSKENIESLGRLAHDLK--------HQLAALRAEVDPKHAAAGFEQLEQSVQRYS 292
Cdd:PRK11281   192 SQRVLLQAEQALLNAQNDLQRKS-LEGNTQLQDLLQKQRDYLtariqrleHQLQLLQEAINSKRLTLSEKTVQEAQSQDE 270

                           90
                   ....*....|
gi 1468626397  293 AQQHTGNPVL 302
Cdd:PRK11281   271 AARIQANPLV 280
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 220-302 5.39e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 38.44  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 220 QARRIEANTELASINAQLESQHQEyLQSKENIESLGRLAHD--------LKHQLAALRAEVDPKHAAAGFEQLEQSVQRy 291
Cdd:pfam12795 148 EAQRWALQAELAALKAQIDMLEQE-LLSNNNRQDLLKARRDlltlriqrLEQQLQALQELLNEKRLQEAEQAVAQTEQL- 225

                          90
                  ....*....|..
gi 1468626397 292 sAQQHTG-NPVL 302
Cdd:pfam12795 226 -AEEAAGdHPLV 236
 
Name Accession Description Interval E-value
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 301-438 8.96e-45

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 152.35  E-value: 8.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 301 VLDVILTTKERTCADRGITFTAVADGSLLSGMSSMDIASLFGNALDNAIEATSKLPKrEQRLIKLALYEQNRFIVIRVEN 380
Cdd:cd16935     1 ALDSLLSEKLELAREKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKIDK-ENRFIHLKIRQKKGFLIISIEN 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1468626397 381 YYDSRLKKDaEGNLRTTKRDDqhRHGFGVKSIRHIAQQYGGEVTIRTEDHWFVLTALI 438
Cdd:cd16935    80 SYEGELKKK-NGLFLSTKKDK--NHGIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 332-438 1.50e-37

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 132.34  E-value: 1.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 332 MSSMDIASLFGNALDNAIEATSKLPkrEQRLIKLALYEQNRFIVIRVENYYDSRLKKdaEGNLRTTKRDDQHrHGFGVKS 411
Cdd:pfam14501   1 ISDVDLCVIFGNLLDNAIEACSKID--DNRFIRLKIREKQNFLIIRIENTYEGELKF--EGKLPSTKTKGDG-HGIGLKS 75

                          90       100
                  ....*....|....*....|....*..
gi 1468626397 412 IRHIAQQYGGEVTIRTEDHWFVLTALI 438
Cdd:pfam14501  76 IRRIVKKYGGNLSTEIENGIFTLSILL 102
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 236-441 1.58e-32

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 127.27  E-value: 1.58e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 236 QLESQHQEYLQSKENIESLGRLAHDLKHQLAALRA---EVDPKHAAAGFEQLEQSVQRYSAQ--QHTGNPVLDVILTTKE 310
Cdd:COG3290   175 ELERLEEELEGVKELAEALRAQRHDFRNHLHTISGllqLGEYDEALEYIDEISEELQELIDSllSRIGNPVLAALLLGKA 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 311 RTCADRGITFTAVADGSL-LSGMSSMDIASLFGNALDNAIEATSKLPKREqRLIKLALYEQNRFIVIRVENYYDSRLKKD 389
Cdd:COG3290   255 ARARERGIDLTIDIDSDLpDLPLSDTDLVTILGNLLDNAIEAVEKLPEEE-RRVELSIRDDGDELVIEVEDSGPGIPEEL 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1468626397 390 AEGNLR---TTKrdDQHRHGFGVKSIRHIAQQYGGEVTIRTEDHWF-VLTALIPRK 441
Cdd:COG3290   334 LEKIFErgfSTK--LGEGRGLGLALVKQIVEKYGGTIEVESEEGEGtVFTVRLPKE 387
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 229-440 9.36e-07

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 50.99  E-value: 9.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 229 ELASINAQLEsqhqeylQSKENIESLGRLAHDLKHQLAALRAEVDPKHaaagFEQLEQSVQRYS-AQQHT--------GN 299
Cdd:PRK15053  324 EISTLNAQLT-------QIKQYVESLRTLRHEHLNWMSTLNGLLQMKE----YDRVLEMVQGESqAQQQLidslreafAD 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 300 PVLDVILTTKERTCADRGITFTAVaDGSLLS----GMSSMDIASLFGNALDNAIEATSKLPKREqRLIKLALYEQNRFIV 375
Cdd:PRK15053  393 RQVAGLLFGKVQRARELGLKMVIV-PGSQLSqlppGLDSTEFAAIVGNLLDNAFEASLRSDEGN-KIVELFLSDEGDDVV 470

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468626397 376 IRVENY---YDSRLKKDAEGNLRTTKRDDQHRHGFGVKSIRHIAQQYGGEVTIRTEDHWFVL-TALIPR 440
Cdd:PRK15053  471 IEVADQgcgVPESLRDKIFEQGVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLfSIFIPK 539
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 340-428 1.20e-05

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 44.18  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397  340 LFGNALDNAIEATSklpkrEQRLIKLALYEQNRFIVIRVENY---YDSRLKKDAEGNLRTTKRDDQHRHGFGV--KSIRH 414
Cdd:smart00387   9 VLSNLLDNAIKYTP-----EGGRITVTLERDGDHVEITVEDNgpgIPPEDLEKIFEPFFRTDKRSRKIGGTGLglSIVKK 83

                           90
                   ....*....|....
gi 1468626397  415 IAQQYGGEVTIRTE 428
Cdd:smart00387  84 LVELHGGEISVESE 97
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
139-429 2.54e-05

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 46.05  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 139 ALCFGLAWMVERGNFSQATPTLPTASAAIATMAIMIVTFAMSNLSFVSTNTPFSGSVGQEIFYIRTLVDFCGFAILYAQQ 218
Cdd:COG0642     1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 219 EQARRIEANTELASINAQLESQHQEYLQSKENIesLGRLAHDLKHQLAA-------LRAEVDPKHAAAgFEQLEQSVQR- 290
Cdd:COG0642    81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRF--LANVSHELRTPLTAirgylelLLEELDEEQREY-LETILRSADRl 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 291 ---------YSAQQHTG----------NPVLDVILTTKERTCADRGITFTAVADGSLLSGMSSMD-IASLFGNALDNAIE 350
Cdd:COG0642   158 lrlindlldLSRLEAGKlelepepvdlAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDrLRQVLLNLLSNAIK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 351 ATsklpkREQRLIKLALYEQNRFIVIRVEnyyDS--RLKKDAEGNL----RTTKRDDQHR-HGFGVKSIRHIAQQYGGEV 423
Cdd:COG0642   238 YT-----PEGGTVTVSVRREGDRVRISVE---DTgpGIPPEDLERIfepfFRTDPSRRGGgTGLGLAIVKRIVELHGGTI 309


                  ....*.
gi 1468626397 424 TIRTED 429
Cdd:COG0642   310 EVESEP 315
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 334-429 7.16e-05

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 41.97  E-value: 7.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 334 SMDIASLFGNALDNAIEATSKLPKreqrlIKLALYEQNRfIVIRVENY---YDSRLKKDAEGNLRTTKRDDQHRHGFGVK 410
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGE-----ITVTLSEGGE-LTLTVEDNgigIPPEDLPRIFEPFSTADKRGGGGTGLGLS 76

                          90
                  ....*....|....*....
gi 1468626397 411 SIRHIAQQYGGEVTIRTED 429
Cdd:pfam02518  77 IVRKLVELLGGTITVESEP 95
PRK11281 PRK11281
mechanosensitive channel MscK;
221-302 1.47e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397  221 ARRIEANTELASINAQLESQHQEyLQSKENIESLGRLAHDLK--------HQLAALRAEVDPKHAAAGFEQLEQSVQRYS 292
Cdd:PRK11281   192 SQRVLLQAEQALLNAQNDLQRKS-LEGNTQLQDLLQKQRDYLtariqrleHQLQLLQEAINSKRLTLSEKTVQEAQSQDE 270

                           90
                   ....*....|
gi 1468626397  293 AQQHTGNPVL 302
Cdd:PRK11281   271 AARIQANPLV 280
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
214-429 2.57e-04

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 42.20  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 214 LYAQQEQARRIEA-------------NTELASINAQLE----------SQHQEYLQS-KENIESLGRLAHDLkhqlaaLR 269
Cdd:COG2205     2 LEEALEELEELERlkseflanvshelRTPLTSILGAAEllldeedlspEERRELLEIiRESAERLLRLIEDL------LD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 270 aevdpkhaaagFEQLEQSVQRYSAQQHTGNPVLDVILTTKERTCADRGITFTAVADGSLLS-GMSSMDIASLFGNALDNA 348
Cdd:COG2205    76 -----------LSRLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLvYADPELLEQVLANLLDNA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 349 IEATSklpkrEQRLIKLALYEQNRFIVIRVENYY----DSRLKKDAEGNLRTTKRDDQHRHGFGVKSIRHIAQQYGGEVT 424
Cdd:COG2205   145 IKYSP-----PGGTITISARREGDGVRISVSDNGpgipEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIW 219


                  ....*
gi 1468626397 425 IRTED 429
Cdd:COG2205   220 VESEP 224
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
345-443 5.53e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 42.31  E-value: 5.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 345 LDNAIEAtSKLPKREQRLIKLALYEQNRFIVIRVENyyDSR-LKKDAEGNLRTTKRDDQHRHGFGVKSIRH-IAQQYGGE 422
Cdd:COG2972   345 VENAIEH-GIEPKEGGGTIRISIRKEGDRLVITVED--NGVgMPEEKLEKLLEELSSKGEGRGIGLRNVRErLKLYYGEE 421

                          90       100
                  ....*....|....*....|....
gi 1468626397 423 VTIRTE---DHWFVLTALIPRKTG 443
Cdd:COG2972   422 YGLEIEsepGEGTTVTIRIPLEEE 445
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
217-295 7.89e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.43  E-value: 7.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468626397 217 QQEQARRIEANTELASINAQLESQHQEYLQSKENIESLGRLAHDLKHQLAALRAEVdpkhaaagfEQLEQSVQRYSAQQ 295
Cdd:COG4372    69 EQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKER---------QDLEQQRKQLEAQI 138
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 217-309 7.99e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 7.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 217 QQEQARRIEANTELASINAQLESQHQEYLQSKENIESLGRLAHDLKHQLAALRAEVDpkhaaagfEQLEQSVQRYSAQQH 296
Cdd:COG3883    26 SELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE--------ERREELGERARALYR 97

                          90
                  ....*....|....*
gi 1468626397 297 TGNPV--LDVILTTK 309
Cdd:COG3883    98 SGGSVsyLDVLLGSE 112
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 338-439 1.14e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 38.42  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 338 ASLFGNALDNAIEATSKLPKREQRlIKLALYEQNRFIVIRVEnyyDSRLKKDAEgnLR--------TTKrdDQHRHGFGV 409
Cdd:cd16915     2 ITIVGNLIDNALDALAATGAPNKQ-VEVFLRDEGDDLVIEVR---DTGPGIAPE--LRdkvfergvSTK--GQGERGIGL 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1468626397 410 KSIRHIAQQYGGEVTIRTEDHWF-VLTALIP 439
Cdd:cd16915    74 ALVRQSVERLGGSITVESEPGGGtTFSIRIP 104
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 281-378 2.76e-03

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 39.90  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 281 FEQLE----QSVQRYSA-----QQHTGNPVLDVILTTKERTCADRGITFTaVADGSLL--SGMSSM--DIASLFGNALDN 347
Cdd:PRK11086  366 YDQLEdyilKTANNYQEeigslLGKIKSPVIAGFLLGKISRARELGITLI-ISEDSQLpdSGDEDQvhELITILGNLIEN 444

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1468626397 348 AIEATSKLPKREqrlIKLALYEQNRFIVIRV 378
Cdd:PRK11086  445 ALEAVGGEEGGE---ISVSLHYRNGWLHCEV 472
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 217-297 3.48e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 39.94  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397  217 QQEQARRIEANTELASINAQLESQHQEYLQSKENIESLGRLAH--------DLKHQLAALRAEVDPKHAAA--------- 279
Cdd:COG3096    839 AALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPqanlladeTLADRLEELREELDAAQEAQafiqqhgka 918

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1468626397  280 ----------------GFEQLEQSVQRYSAQQHT 297
Cdd:COG3096    919 laqleplvavlqsdpeQFEQLQADYLQAKEQQRR 952
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 220-302 5.39e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 38.44  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 220 QARRIEANTELASINAQLESQHQEyLQSKENIESLGRLAHD--------LKHQLAALRAEVDPKHAAAGFEQLEQSVQRy 291
Cdd:pfam12795 148 EAQRWALQAELAALKAQIDMLEQE-LLSNNNRQDLLKARRDlltlriqrLEQQLQALQELLNEKRLQEAEQAVAQTEQL- 225

                          90
                  ....*....|..
gi 1468626397 292 sAQQHTG-NPVL 302
Cdd:pfam12795 226 -AEEAAGdHPLV 236
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
218-391 5.83e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.73  E-value: 5.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 218 QEQARRIEAntELASINAQLESQHQEYLQSKENIESLGRLAHDLKHQLAALRAEVdpKHAAAGFEQLEQSVQRYSAQQHt 297
Cdd:COG4372   107 QEEAEELQE--ELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQL--ESLQEELAALEQELQALSEAEA- 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 298 gNPVLDVILTTkertcADRGITFTAVADGSLLSGMSSMDIASLFGNALDNAIEATSKLPKREQRLIKLALYEQNRFIVIR 377
Cdd:COG4372   182 -EQALDELLKE-----ANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEV 255

                         170
                  ....*....|....
gi 1468626397 378 VENYYDSRLKKDAE 391
Cdd:COG4372   256 ILKEIEELELAILV 269
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
211-440 6.55e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 38.06  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 211 FAILYAQQEQARRIEANTELASiNAQLESQHQEylqskeniesLGRLAHDL-----------KHQLAALRAEV--DPKHA 277
Cdd:COG4585    22 LALVLLRARRAERAAELERELA-ARAEEAREEE----------RRRIARELhdgvgqslsaiKLQLEAARRLLdaDPEAA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 278 AAGFEQLEQSVQR-----------YSAQQHTGNPVLDVILTTKERTCADRGITFTAVADGSL--LSGMSSMDIASLFGNA 344
Cdd:COG4585    91 REELEEIRELAREalaelrrlvrgLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPdrLPPEVELALYRIVQEA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 345 LDNAI---EATSklpkreqrlIKLALYEQNRFIVIRVENyydsrlkkdaegNLRTTKRDDQHRHGFGVKSIRHIAQQYGG 421
Cdd:COG4585   171 LTNALkhaGATR---------VTVTLEVDDGELTLTVRD------------DGVGFDPEAAPGGGLGLRGMRERAEALGG 229

                         250       260
                  ....*....|....*....|
gi 1468626397 422 EVTIR-TEDHWFVLTALIPR 440
Cdd:COG4585   230 TLTIGsAPGGGTRVRATLPL 249
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
218-295 8.72e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.34  E-value: 8.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626397 218 QEQARRI-----EANTELASINAQLESQHQEYLQSKENIESLGRLAHDLKHQLAALRAEVDPKHAAAgfEQLEQSVQRYS 292
Cdd:COG4372    44 QEELEQLreeleQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEA--EELQEELEELQ 121


                  ...
gi 1468626397 293 AQQ 295
Cdd:COG4372   122 KER 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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