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Conserved domains on  [gi|1468626276|ref|WP_117502385|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacillota]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-71 7.93e-13

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 62.32  E-value: 7.93e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468626276   1 MELSIQERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNfKDISHYALIELAKFYEVTVDYLLGRSQTR 71
Cdd:COG1396     4 LKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGR-RNPSLETLLKLAKALGVSLDELLGGADEE 73
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-71 7.93e-13

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 62.32  E-value: 7.93e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468626276   1 MELSIQERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNfKDISHYALIELAKFYEVTVDYLLGRSQTR 71
Cdd:COG1396     4 LKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGR-RNPSLETLLKLAKALGVSLDELLGGADEE 73
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 7-64 3.45e-10

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.48  E-value: 3.45e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1468626276   7 ERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNfKDISHYALIELAKFYEVTVDYL 64
Cdd:cd00093     2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGK-RNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-64 1.21e-09

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 52.91  E-value: 1.21e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1468626276    8 RLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNfKDISHYALIELAKFYEVTVDYL 64
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGK-RKPSLETLKKLAKALGVSLDEL 56
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 7-65 1.75e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 49.98  E-value: 1.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468626276   7 ERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNFkDISHYALIELAKFYEVTVDYLL 65
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKS-VPPAETLYKIAELLGVPANWLL 59
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-71 7.93e-13

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 62.32  E-value: 7.93e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468626276   1 MELSIQERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNfKDISHYALIELAKFYEVTVDYLLGRSQTR 71
Cdd:COG1396     4 LKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGR-RNPSLETLLKLAKALGVSLDELLGGADEE 73
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-69 1.52e-10

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 55.62  E-value: 1.52e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468626276   1 MELSIQERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNFkDISHYALIELAKFYEVTVDYLLGRSQ 69
Cdd:COG1476     1 MKKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKY-NPSLELALKIARALGVSLEELFSLEE 68
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 7-64 3.45e-10

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 54.48  E-value: 3.45e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1468626276   7 ERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNfKDISHYALIELAKFYEVTVDYL 64
Cdd:cd00093     2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGK-RNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-64 1.21e-09

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 52.91  E-value: 1.21e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1468626276    8 RLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNfKDISHYALIELAKFYEVTVDYL 64
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGK-RKPSLETLKKLAKALGVSLDEL 56
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 7-65 1.75e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 49.98  E-value: 1.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468626276   7 ERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNFkDISHYALIELAKFYEVTVDYLL 65
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKS-VPPAETLYKIAELLGVPANWLL 59
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 1-65 2.44e-08

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 49.80  E-value: 2.44e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468626276   1 MELSIQERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNFKDISHYA-----LIELAKFYEVTVDYLL 65
Cdd:COG1426     2 ALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGDFDALPGPVyvrgfLRSYARALGLDPEELL 71
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 9-64 2.18e-07

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 46.76  E-value: 2.18e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1468626276   9 LKDLRVERGLTLEQLAEKTHLSKSALGSYE-GDNFKDISHyaLIELAKFYEVTVDYL 64
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIEnGKREPSLET--LKKLAEALGVSLDEL 55
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 7-62 3.20e-05

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 40.97  E-value: 3.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1468626276   7 ERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNFKDISHYALIELAKFYEVTVD 62
Cdd:pfam13560   4 ARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRRGRPSPAVVERLARALGVDGA 59
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 7-63 1.24e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 39.54  E-value: 1.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1468626276   7 ERLKDLRVERGLTLEQLAEKTHLSKSALGSYE-GDNFKDISHyaLIELAKFYEVTVDY 63
Cdd:COG1813    15 ERIREAREARGLSQEELAEKLGVSESTIRRIErGEATPSLDT--LRKLEKALGISLAE 70
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 8-51 1.33e-04

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 39.02  E-value: 1.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1468626276   8 RLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNFKDISHYALI 51
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFDALPEPVYA 44
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
4-65 2.38e-03

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 35.89  E-value: 2.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1468626276   4 SIQERLKDLRVERGLTLEQLAEKTHLSKSALGSYEGDNFKDISHYALIELAKFYEVTVDYLL 65
Cdd:COG3655     1 MIYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAKAVRLDTLEKICKALDCQPGDLL 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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