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Conserved domains on  [gi|1468111116|gb|AXS80886|]
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phosphatase PAP2 family protein [Dechloromonas sp. HYN0024]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 68-200 8.19e-15

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03395:

Pssm-ID: 469784  Cd Length: 177  Bit Score: 70.76  E-value: 8.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  68 LQLALMLPFCLRYPRVFWALVLGALIAGMISRGFKIWL--PL---PRPAAVIDASQITIIGARLTAHSFPSGHTVSAFSF 142
Cdd:cd03395    38 IFLLLALFILFRKGPIGLLILLLVLLAVGFADQLASGFlkPLvarLRPCNALDGVRLVVLGDQGGSYSFASSHAANSFAL 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116 143 VVAWLALL--GWRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVGLRLSRYF 200
Cdd:cd03395   118 ALFIWLFFrrGLFSPVLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLFSWL 177
 
Name Accession Description Interval E-value
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 68-200 8.19e-15

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 70.76  E-value: 8.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  68 LQLALMLPFCLRYPRVFWALVLGALIAGMISRGFKIWL--PL---PRPAAVIDASQITIIGARLTAHSFPSGHTVSAFSF 142
Cdd:cd03395    38 IFLLLALFILFRKGPIGLLILLLVLLAVGFADQLASGFlkPLvarLRPCNALDGVRLVVLGDQGGSYSFASSHAANSFAL 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116 143 VVAWLALL--GWRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVGLRLSRYF 200
Cdd:cd03395   118 ALFIWLFFrrGLFSPVLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLFSWL 177
acidPPc smart00014
Acid phosphatase homologues;
88-192 6.67e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 63.90  E-value: 6.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116   88 VLGALIAGMISRGFKIWLPLPRPAAVIDASQITIIGARLT---AHSFPSGHTVSAFSFVVA---WLALLGWRALPIVLIA 161
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDACCTPNFLLTleaGYSFPSGHTAFAFAFALFlllYLPARAGRKLLIFLLL 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1468111116  162 LLA---AFSRIAVGAHWPVDVLAGAIIGLAGGWV 192
Cdd:smart00014  81 LLAlvvGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 86-199 6.24e-12

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 61.28  E-value: 6.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  86 ALVLGALIAGMISRGFKIWLPLPRPAAVIDASQITIIGARLTA--HSFPSGHTVSAFSFVVA--------WLALLGWRAL 155
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGlgYSFPSGHSATAFALALLlalllrrlRKIVRVLLAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1468111116 156 PIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVGLRLSRY 199
Cdd:pfam01569  81 LLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 16-198 1.12e-11

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 62.36  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  16 AAMLALFLLPALGLILLGQTGDWHGGFVPAQAASQVLPPWFWETLTTLGDGRLQLALMLPFCLRYPRVFWALVLGALIAG 95
Cdd:COG0671     2 LLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  96 M-----ISRGFKIWLPLPRPAAVIDasqITIIGARLTAHSFPSGHTVSAFSF--VVAWLALLGWRALPIVLIALLAAFSR 168
Cdd:COG0671    82 LlllllLLLLLKYLFGRPRPFVVPD---LELLLGTAGGYSFPSGHAAAAFALalVLALLLPRRWLAALLLALALLVGLSR 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 1468111116 169 IAVGAHWPVDVLAGAIIGLAGGWVGLRLSR 198
Cdd:COG0671   159 VYLGVHYPSDVLAGALLGLAIALLLLALLR 188
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 130-189 8.31e-06

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 45.39  E-value: 8.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468111116 130 SFPSGHTVSAFSFVVAWLALLG-WRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAG 189
Cdd:PRK11837  104 SFPSDHGTVIFTFALAFLFWHRlWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLVGMIG 164
 
Name Accession Description Interval E-value
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 68-200 8.19e-15

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 70.76  E-value: 8.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  68 LQLALMLPFCLRYPRVFWALVLGALIAGMISRGFKIWL--PL---PRPAAVIDASQITIIGARLTAHSFPSGHTVSAFSF 142
Cdd:cd03395    38 IFLLLALFILFRKGPIGLLILLLVLLAVGFADQLASGFlkPLvarLRPCNALDGVRLVVLGDQGGSYSFASSHAANSFAL 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116 143 VVAWLALL--GWRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVGLRLSRYF 200
Cdd:cd03395   118 ALFIWLFFrrGLFSPVLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLFSWL 177
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 82-192 8.44e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 66.33  E-value: 8.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  82 RVFWALVLGALIAGMISRGFKIWLPLPRPAAVIDASQITIIGARLTAH-SFPSGHTVSAFSFVVAWLALLG------WRA 154
Cdd:cd01610     3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLLLTEGGySFPSGHAAFAFALALFLALLLPrrllrlLLG 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1468111116 155 LPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWV 192
Cdd:cd01610    83 LLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALL 120
acidPPc smart00014
Acid phosphatase homologues;
88-192 6.67e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 63.90  E-value: 6.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116   88 VLGALIAGMISRGFKIWLPLPRPAAVIDASQITIIGARLT---AHSFPSGHTVSAFSFVVA---WLALLGWRALPIVLIA 161
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDACCTPNFLLTleaGYSFPSGHTAFAFAFALFlllYLPARAGRKLLIFLLL 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1468111116  162 LLA---AFSRIAVGAHWPVDVLAGAIIGLAGGWV 192
Cdd:smart00014  81 LLAlvvGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 86-199 6.24e-12

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 61.28  E-value: 6.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  86 ALVLGALIAGMISRGFKIWLPLPRPAAVIDASQITIIGARLTA--HSFPSGHTVSAFSFVVA--------WLALLGWRAL 155
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGlgYSFPSGHSATAFALALLlalllrrlRKIVRVLLAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1468111116 156 PIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVGLRLSRY 199
Cdd:pfam01569  81 LLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 16-198 1.12e-11

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 62.36  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  16 AAMLALFLLPALGLILLGQTGDWHGGFVPAQAASQVLPPWFWETLTTLGDGRLQLALMLPFCLRYPRVFWALVLGALIAG 95
Cdd:COG0671     2 LLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  96 M-----ISRGFKIWLPLPRPAAVIDasqITIIGARLTAHSFPSGHTVSAFSF--VVAWLALLGWRALPIVLIALLAAFSR 168
Cdd:COG0671    82 LlllllLLLLLKYLFGRPRPFVVPD---LELLLGTAGGYSFPSGHAAAAFALalVLALLLPRRWLAALLLALALLVGLSR 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 1468111116 169 IAVGAHWPVDVLAGAIIGLAGGWVGLRLSR 198
Cdd:COG0671   159 VYLGVHYPSDVLAGALLGLAIALLLLALLR 188
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 81-191 1.24e-11

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 60.04  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  81 PRVFWALVLGALIAGMISRGFKIWLPLPRPaavidasqitiIGARLTAHSFPSGHTVSAFSFVVAWLALLGWRALPIVLI 160
Cdd:cd03394     2 REGLLILAEAAALTAAVTEGLKFAVGRARP-----------DGSNNGYRSFPSGHTASAFAAATFLQYRYGWRWYGIPAY 70

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1468111116 161 AL--LAAFSRIAVGAHWPVDVLAGAIIGLAGGW 191
Cdd:cd03394    71 ALasLVGASRVVANRHWLSDVLAGAAIGILVGY 103
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 55-202 2.49e-10

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 58.39  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  55 WFWETLTTLGDGRLQLALMLPFCL-----RYPRVFWALVLGALIAGMISRGFKIWLPLPRPAAVIDASqitiigarLTAH 129
Cdd:cd03392    30 AFMTAITFLGSPAVLLIIVLLLALllllkRRRRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVP--------EGGY 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116 130 SFPSGHTVSAFSFVvAWLALLGWRALP-----------IVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAggWVGLRLSR 198
Cdd:cd03392   102 SFPSGHAMGATVLY-GFLAYLLARRLPrrrvrilllilAAILILLVGLSRLYLGVHYPSDVLAGWLLGLA--WLALLILL 178


                  ....
gi 1468111116 199 YFRW 202
Cdd:cd03392   179 YRRL 182
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 130-188 1.52e-09

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 56.18  E-value: 1.52e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468111116 130 SFPSGHTVSAFSFVVAwLALL--GWRALPIVLiALLAAFSRIAVGAHWPVDVLAGAIIGLA 188
Cdd:cd03389   119 SFPSGHSATAGAAAAA-LALLfpRYRWAFILL-ALLIAFSRVIVGAHYPSDVIAGSLLGAV 177
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 130-195 2.42e-09

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 54.57  E-value: 2.42e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1468111116 130 SFPSGHTVSAFSFVVAWLAL-LGWRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVGLR 195
Cdd:cd03385    78 SFPSDHTTLFFSIAFSLLLRrRKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLVFQ 144
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 70-192 4.23e-08

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 52.22  E-value: 4.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  70 LALMLPFCLRYPRVFW-------ALVLGALIAGMISRGFKIWLPLPRP------AAVIDASQITIIGARLTAH------- 129
Cdd:cd03390    27 LLVIILISLFFRRSLWdlhtsllGLLLSVSLNGVITNVLKNYAGRPRPdflarcFPDGGTPSDTLVGIDICCTgdpgvlk 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116 130 ----SFPSGHTVSAFS-FVVAWLALLG-----------WRA----LPIvLIALLAAFSRIAVGAHWPVDVLAGAIIGLAG 189
Cdd:cd03390   107 egrkSFPSGHSSFAFAgLGFLSLYLAGklhifdprgssWRLllalLPL-LLAILVAVSRTRDYRHHFSDVIAGSLIGLII 185


                  ...
gi 1468111116 190 GWV 192
Cdd:cd03390   186 AYL 188
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 108-186 3.66e-07

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 49.74  E-value: 3.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116 108 PRPAAVIDASQITIIGAR--LTAH-SFPSGHTVSAFSFVVAWLALLGWRALPIVLIALLAAFSRIAVGAHWPVDVLAGAI 184
Cdd:cd03380   119 PRPFVAIRLQWLPICTPEegTPKHpSYPSGHATFGGAAALVLAELFPERAAELLARAAEAGNSRVVAGVHWPSDVEAGRI 198


                  ..
gi 1468111116 185 IG 186
Cdd:cd03380   199 LG 200
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 81-193 1.36e-06

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 46.60  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  81 PRVFWALVLGALIAGMISRGFKIWLPLPRPaaviDASQITIIGARLTA--HSFPSGHTVSAFSFVVAWLALLGWRALPI- 157
Cdd:cd03393    12 KRLGRYLGLALCASGYLNAALKEVFKIPRP----FTYDGIQAIYEESAggYGFPSGHAQTSATFWGSLMLHVRKKWFTLi 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1468111116 158 -VLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVG 193
Cdd:cd03393    88 gVVLVVLISFSRLYLGVHWPSDVIGGVLIGLLVLVLG 124
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 130-189 8.31e-06

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 45.39  E-value: 8.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468111116 130 SFPSGHTVSAFSFVVAWLALLG-WRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAG 189
Cdd:PRK11837  104 SFPSDHGTVIFTFALAFLFWHRlWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLVGMIG 164
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 130-194 8.84e-06

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 45.00  E-value: 8.84e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1468111116 130 SFPSGHTVSAF---SFVVAWLALLGWRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLAGGWVGL 194
Cdd:cd03391    92 SFPSGHASRAAfvaRFLLNHLVLAVPLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLVE 159
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 121-192 2.63e-05

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 43.39  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116 121 IIGARLtahSFPSGH-TVSAFS--FVVAWL-ALLGWRALPI---------VLIALLAAFSRIAVGAHWPVDVLAGAIIGL 187
Cdd:cd03384    67 IREARL---SFPSGHaSLSMYAavFLALYLqARLKLRGSRLlrpllqfllLALALYVGLSRISDYKHHWSDVLAGALLGS 143


                  ....*
gi 1468111116 188 AGGWV 192
Cdd:cd03384   144 VIALF 148
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 51-186 1.31e-04

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 41.45  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  51 VLPPWFWetlttLGDGRLQLALMlpfclryprVFWALVLGaliagmISRGFKIWLPLPRPAAVIdasqITIIGARLTA-- 128
Cdd:cd03388    22 FLPFLFW-----NGDPYVGRDLV---------VVLALGMY------IGQFIKDLFCLPRPSSPP----VVRLTMSSAAle 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1468111116 129 HSFPSGHTVSAFSFVVAWLALLgWRALPIVLIALLAA---------FSRIAVGAHWPVDVLAGAIIG 186
Cdd:cd03388    78 YGFPSTHAMNATAISFYLLIYL-YDRYQYPFVLGLILalfystlvcLSRIYMGMHSVLDVIAGSLIG 143
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 130-188 2.72e-04

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 41.17  E-value: 2.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468111116 130 SFPSGHTVSAFSFVVAWLALLGWRALPIVLIALLAAFSRIAVGAHWPVDVLAGAIIGLA 188
Cdd:cd03397   151 SYPSGHTAAGYAWALILAELVPERADEILARGSEYGQSRIVCGVHWPSDVMGGRIMAAA 209
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 55-185 4.64e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 37.28  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468111116  55 WFWETLTTLGDGRLQLALMLPFCLRYP--RVFWALVLGALIAGMIS---RGFKIWLPLPRPAAVIDAS--------QITI 121
Cdd:cd03396    35 HLGGRLLSIALAVLLLALALLFFRRKRlrRRRRALLLLILVIGLGLlvvAILKSHWGRPRPWDLTEFGgdapytplFSGP 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468111116 122 IGARLTAHSFPSGHTVSAFSFVVAWLAL------LGWRALPIVLIA-LLAAFSRIAVGAHWPVDVLAGAII 185
Cdd:cd03396   115 SNGCGKGCSFPSGHASAGFALLALYFLFrrrrprLARLVLAAGLALgALMGLARMARGAHFLSDVLWSLLL 185
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 127-185 4.67e-03

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 37.70  E-value: 4.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1468111116 127 TAHSFPSGHTVSAFSFVVAWLALLGWR--ALPIVLIALLAA---FSRIAVGAHWPVDVLAGAII 185
Cdd:PRK10699  155 TGFAFPSGHTMFAASWALLAVGLLWPRrrYKTVALLMLWATgvmGSRLLLGMHWPRDLVVATLI 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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