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Conserved domains on  [gi|1464256134|gb|AXQ06328|]
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toll like receptor 3, partial [Pseudomys johnsoni]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 144-280 3.04e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 3.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 144 LAHSPLLT-LNLTKNHISKIASgtFSWLGQLRILDLGLNEIEqELTGREwkGLRNIFEIYLSY------NKFLQLTSNSF 216
Cdd:cd21340    42 LEFLTNLThLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1464256134 217 ALVPSLQRLMLRRvalKNVDiSPSPFRPLRNLTILDLSNNNIANINE--DLLEGLENLEILDFQHN 280
Cdd:cd21340   117 ALSNSLRVLNISG---NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
14-69 1.06e-09

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.06e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1464256134  14 TNLTWLDLSYNSFRDVGNDSFRWLPHLKYLSLDSNYIQCLSPRSFYGLSDLRYLSL 69
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR_8 super family cl38440
Leucine rich repeat;
97-159 7.20e-03

Leucine rich repeat;


The actual alignment was detected with superfamily member pfam13855:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 7.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1464256134  97 LEYLNMDDNNIMGIKCNTFTGLVSLKYLSLSKtfTSLQTLTNETFVSLAHspLLTLNLTKNHI 159
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSN--NLLTTLSPGAFSGLPS--LRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 144-280 3.04e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 3.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 144 LAHSPLLT-LNLTKNHISKIASgtFSWLGQLRILDLGLNEIEqELTGREwkGLRNIFEIYLSY------NKFLQLTSNSF 216
Cdd:cd21340    42 LEFLTNLThLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1464256134 217 ALVPSLQRLMLRRvalKNVDiSPSPFRPLRNLTILDLSNNNIANINE--DLLEGLENLEILDFQHN 280
Cdd:cd21340   117 ALSNSLRVLNISG---NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
14-69 1.06e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.06e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1464256134  14 TNLTWLDLSYNSFRDVGNDSFRWLPHLKYLSLDSNYIQCLSPRSFYGLSDLRYLSL 69
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-314 2.01e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  42 YLSLDSNYIQCLSPRSFYGLSDLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIMGIKCNTFTGLVSL 121
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 122 KYLSLSKTFTSLQTLTNETFVSLAHSPLL-------TLNLTKNHISKIASgTFSWLGQLRILDLGLNEIEQelTGREWKG 194
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELsnltnleSLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTD--LPEPLGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 195 LRNIFEIYLSYNKFLQLtSNSFALVPSLQRLMLRRVALKNVdisPSPFRPLRNLTILDLSNNNIANINEDlLEGLENLEI 274
Cdd:COG4886   158 LTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLET 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1464256134 275 LDFQHNNLARLwkranpggpvNFLKGLSHLHILNLESNGL 314
Cdd:COG4886   233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-314 2.58e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  37 LPHLKYLSLDSNYIQCLSPRS-FYGLSDLRYLSLKRAFTKQSVSLASHPNiddfsfqwlkyLEYLNMDDNNIMGIKCNTF 115
Cdd:PLN00113   92 LPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGSIPN-----------LETLDLSNNMLSGEIPNDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 116 TGLVSLKYLSLSKTftslqtltnetfVSLAHSPLLTLNLTKNHISKIASGTF-----SWLGQLRILD---LGLNEIEQEL 187
Cdd:PLN00113  161 GSFSSLKVLDLGGN------------VLVGKIPNSLTNLTSLEFLTLASNQLvgqipRELGQMKSLKwiyLGYNNLSGEI 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 188 TgREWKGLRNIFEIYLSYNKFLQLTSNSFALVPSLQRLMLRRVALKNvDISPSPFRpLRNLTILDLSNNNIANINEDLLE 267
Cdd:PLN00113  229 P-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLISLDLSDNSLSGEIPELVI 305

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1464256134 268 GLENLEILDFQHNNLARLWKRAnpggpvnfLKGLSHLHILNLESNGL 314
Cdd:PLN00113  306 QLQNLEILHLFSNNFTGKIPVA--------LTSLPRLQVLQLWSNKF 344
LRR_8 pfam13855
Leucine rich repeat;
220-282 5.38e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 5.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1464256134 220 PSLQRLMLRRVALknVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNL 282
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-159 7.20e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 7.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1464256134  97 LEYLNMDDNNIMGIKCNTFTGLVSLKYLSLSKtfTSLQTLTNETFVSLAHspLLTLNLTKNHI 159
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSN--NLLTTLSPGAFSGLPS--LRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 144-280 3.04e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 3.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 144 LAHSPLLT-LNLTKNHISKIASgtFSWLGQLRILDLGLNEIEqELTGREwkGLRNIFEIYLSY------NKFLQLTSNSF 216
Cdd:cd21340    42 LEFLTNLThLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS-VVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLA 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1464256134 217 ALVPSLQRLMLRRvalKNVDiSPSPFRPLRNLTILDLSNNNIANINE--DLLEGLENLEILDFQHN 280
Cdd:cd21340   117 ALSNSLRVLNISG---NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
14-69 1.06e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.06e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1464256134  14 TNLTWLDLSYNSFRDVGNDSFRWLPHLKYLSLDSNYIQCLSPRSFYGLSDLRYLSL 69
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-314 2.01e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  42 YLSLDSNYIQCLSPRSFYGLSDLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIMGIKCNTFTGLVSL 121
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 122 KYLSLSKTFTSLQTLTNETFVSLAHSPLL-------TLNLTKNHISKIASgTFSWLGQLRILDLGLNEIEQelTGREWKG 194
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELsnltnleSLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTD--LPEPLGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 195 LRNIFEIYLSYNKFLQLtSNSFALVPSLQRLMLRRVALKNVdisPSPFRPLRNLTILDLSNNNIANINEDlLEGLENLEI 274
Cdd:COG4886   158 LTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLET 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1464256134 275 LDFQHNNLARLwkranpggpvNFLKGLSHLHILNLESNGL 314
Cdd:COG4886   233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-314 2.58e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  37 LPHLKYLSLDSNYIQCLSPRS-FYGLSDLRYLSLKRAFTKQSVSLASHPNiddfsfqwlkyLEYLNMDDNNIMGIKCNTF 115
Cdd:PLN00113   92 LPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGSIPN-----------LETLDLSNNMLSGEIPNDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 116 TGLVSLKYLSLSKTftslqtltnetfVSLAHSPLLTLNLTKNHISKIASGTF-----SWLGQLRILD---LGLNEIEQEL 187
Cdd:PLN00113  161 GSFSSLKVLDLGGN------------VLVGKIPNSLTNLTSLEFLTLASNQLvgqipRELGQMKSLKwiyLGYNNLSGEI 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 188 TgREWKGLRNIFEIYLSYNKFLQLTSNSFALVPSLQRLMLRRVALKNvDISPSPFRpLRNLTILDLSNNNIANINEDLLE 267
Cdd:PLN00113  229 P-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG-PIPPSIFS-LQKLISLDLSDNSLSGEIPELVI 305

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1464256134 268 GLENLEILDFQHNNLARLWKRAnpggpvnfLKGLSHLHILNLESNGL 314
Cdd:PLN00113  306 QLQNLEILHLFSNNFTGKIPVA--------LTSLPRLQVLQLWSNKF 344
LRR_8 pfam13855
Leucine rich repeat;
220-282 5.38e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 5.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1464256134 220 PSLQRLMLRRVALknVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNL 282
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
14-285 7.40e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 7.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  14 TNLTWLDLSYNSFRDVGnDSFRWLPHLKYLSLDSNYIQCLsPRSFYGLSDLRYLSLKRAftkqsvslashpNIDDF--SF 91
Cdd:COG4886   113 TNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN------------QLTDLpeEL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  92 QWLKYLEYLNMDDNNIMGIKcNTFTGLVSLKYLSLSKTF-----TSLQTLTNetfvslahspLLTLNLTKNHISKIASgt 166
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQltdlpEPLANLTN----------LETLDLSNNQLTDLPE-- 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 167 FSWLGQLRILDLGLNEIEqelTGREWKGLRNIFEIYLSYNKFLQLTSNSFALVPSLQRLMLRRVALKNVDISPSPFRPLR 246
Cdd:COG4886   246 LGNLTNLEELDLSNNQLT---DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1464256134 247 NLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARL 285
Cdd:COG4886   323 LLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-227 3.36e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  12 KQTNLTWLDLSYNSFRDVGNDSFRWLPHLKYLSLDSNYIQCLSPRSFYGLSDLRYLSLkraftkQSVSLASHPNIDdfsF 91
Cdd:PLN00113  354 KHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRL------QDNSFSGELPSE---F 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  92 QWLKYLEYLNMDDNNIMGIKCNTFTGLVSLKYLSLSKtftslQTLTNETFVSLAHSPLLTLNLTKNHISKIASGTFSWLG 171
Cdd:PLN00113  425 TKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLAR-----NKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLS 499

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1464256134 172 QLRILDLGLNEIEQELTgREWKGLRNIFEIYLSYNKFLQLTSNSFALVPSLQRLML 227
Cdd:PLN00113  500 ELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDL 554
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 14-282 3.54e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 3.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  14 TNLTWLDLSYNSFRDVGNDSFRWLPHLKYLSLDSNYIQCLSPRSFYGLSDLryLSLKraFTKQSVSlashPNIDDFSFQw 93
Cdd:PLN00113  236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKL--ISLD--LSDNSLS----GEIPELVIQ- 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  94 LKYLEYLNMDDNNIMGIKCNTFTGLVSLKYLSL-SKTFT------------------SLQTLTNETFVSLAHSPLLT-LN 153
Cdd:PLN00113  307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwSNKFSgeipknlgkhnnltvldlSTNNLTGEIPEGLCSSGNLFkLI 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 154 LTKNHISKIASGTFSWLGQLRILDLGLNEIEQELTgREWKGLRNIFEIYLSYNKFLQLTSNSFALVPSLQRLMLRRVA-- 231
Cdd:PLN00113  387 LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKff 465

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 232 -----------LKNVDIS--------PSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNL 282
Cdd:PLN00113  466 gglpdsfgskrLENLDLSrnqfsgavPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
246-314 9.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 9.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1464256134 246 RNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRAnpggpvnfLKGLSHLHILNLESNGL 314
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGA--------FSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-314 2.02e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  94 LKYLEYLNMDDNNIMGIKcNTFTGLVSLKYLSLSKTftSLQTLTNEtfvsLAHSPLLT-LNLTKNHISKIaSGTFSWLGQ 172
Cdd:COG4886   135 LTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNN--QLTDLPEE----LGNLTNLKeLDLSNNQITDL-PEPLGNLTN 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 173 LRILDLGLNEIEQEltGREWKGLRNIFEIYLSYNKFLQLTSnsFALVPSLQRLMLRRVALKNVdispSPFRPLRNLTILD 252
Cdd:COG4886   207 LEELDLSGNQLTDL--PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL----PPLANLTNLKTLD 278

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1464256134 253 LSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGL 314
Cdd:COG4886   279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
14-276 5.34e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  14 TNLTWLDLSYNSFRDVGnDSFRWLPHLKYLSLDSNYIQCLsPRSFYGLSDLRYLSLkraftkqsvslaSHPNIDDF--SF 91
Cdd:COG4886   159 TNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL------------SGNQLTDLpePL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134  92 QWLKYLEYLNMDDNNIMGIKCntFTGLVSLKYLSLS----KTFTSLQTLTNETFVSLAHSPLLTLNLTK---NHISKIAS 164
Cdd:COG4886   225 ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSnnqlTDLPPLANLTNLKTLDLSNNQLTDLKLKElelLLGLNSLL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1464256134 165 GTFSWLGQLRILDLGLNEIEQELTGREWKGLRNIFEIYLSYNKFLQLTSNSFALVPSLQRLMLRRVALKNVDISPSPFRP 244
Cdd:COG4886   303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1464256134 245 LRNLTILDLSNNNIANINEDLLEGLENLEILD 276
Cdd:COG4886   383 ALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
151-208 7.78e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 7.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1464256134 151 TLNLTKNHISKIASGTFSWLGQLRILDLGLNEIeQELTGREWKGLRNIFEIYLSYNKF 208
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
38-107 5.19e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 5.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1464256134  38 PHLKYLSLDSNYIQCLSPRSFYGLSDLRYLSLkraftkqsvslaSHPNIDDFS---FQWLKYLEYLNMDDNNI 107
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL------------SNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
4-50 5.35e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 5.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1464256134   4 SGSTFSGLKqtNLTWLDLSYNSFRDVGNDSFRWLPHLKYLSLDSNYI 50
Cdd:pfam13855  17 DDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 247-282 2.55e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1464256134 247 NLTILDLSNNNIANIneDLLEGLENLEILDFQHNNL 282
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNK 35
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 242-312 4.91e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 4.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1464256134 242 FRPLRNLTILDLSNNNIANIneDLLEGLENLEILDFQHNNLARLwkranpggpvNFLKGLSHLHILNLESN 312
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI----------ENLENLVNLKKLYLGGN 78
LRR_8 pfam13855
Leucine rich repeat;
97-159 7.20e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 7.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1464256134  97 LEYLNMDDNNIMGIKCNTFTGLVSLKYLSLSKtfTSLQTLTNETFVSLAHspLLTLNLTKNHI 159
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSN--NLLTTLSPGAFSGLPS--LRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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