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Conserved domains on  [gi|1463310239|emb|SVK39167|]
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iron-sulfur cluster insertion protein ErpA [Acinetobacter baumannii]

Protein Classification

iron-sulfur cluster insertion protein ErpA( domain architecture ID 10014301)

iron-sulfur cluster insertion protein ErpA is essential for growth and may play a role in isoprenoid biosynthesis

CATH:  2.60.300.12
Gene Ontology:  GO:0005506|GO:0016226|GO:0051537
SCOP:  4003950

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13623 PRK13623
iron-sulfur cluster insertion protein ErpA; Provisional
 7-116 3.09e-80

iron-sulfur cluster insertion protein ErpA; Provisional


:

Pssm-ID: 184186  Cd Length: 115  Bit Score: 230.58  E-value: 3.09e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239   7 TPTPLLFTPGAANKVKTLIDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEV 86
Cdd:PRK13623    6 VPLPLVFTDAAAAKVKELIEEEGNPDLKLRVYITGGGCSGFQYGFTFDEQVNEDDTTIEKQGVTLVVDPMSLQYLVGAEV 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 1463310239  87 DYQEGLEGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:PRK13623   86 DYTEGLEGSRFVIKNPNAKTTCGCGSSFSI 115
 
Name Accession Description Interval E-value
PRK13623 PRK13623
iron-sulfur cluster insertion protein ErpA; Provisional
 7-116 3.09e-80

iron-sulfur cluster insertion protein ErpA; Provisional


Pssm-ID: 184186  Cd Length: 115  Bit Score: 230.58  E-value: 3.09e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239   7 TPTPLLFTPGAANKVKTLIDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEV 86
Cdd:PRK13623    6 VPLPLVFTDAAAAKVKELIEEEGNPDLKLRVYITGGGCSGFQYGFTFDEQVNEDDTTIEKQGVTLVVDPMSLQYLVGAEV 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 1463310239  87 DYQEGLEGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:PRK13623   86 DYTEGLEGSRFVIKNPNAKTTCGCGSSFSI 115
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 10-116 6.84e-60

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 178.81  E-value: 6.84e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  10 PLLFTPGAANKVKTLIDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQ 89
Cdd:COG0316     1 PITLTDAAAKRIKRLLAKEGNPGLGLRVGVKGGGCSGFSYGLDFDDEPNEDDLVFEQDGVKVVVDPKSLPYLDGTEIDYV 80

                          90       100
                  ....*....|....*....|....*..
gi 1463310239  90 EGLEGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:COG0316    81 EELLGSGFKFNNPNAKSSCGCGESFSV 107
TIGR00049 TIGR00049
Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be ...
 13-116 1.98e-51

Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272875 [Multi-domain]  Cd Length: 105  Bit Score: 157.74  E-value: 1.98e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  13 FTPGAANKVKTLIDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQEGL 92
Cdd:TIGR00049   2 LTDSAAKRIKALLAGEGEPNLGLRVGVKGGGCSGLQYGLEFDDEPNEDDEVFEQDGVKVVVDPKSLPYLDGSEIDYVEEL 81

                          90       100
                  ....*....|....*....|....
gi 1463310239  93 EGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:TIGR00049  82 LGSGFTFTNPNAKGTCGCGKSFSV 105
Fe-S_biosyn pfam01521
Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster ...
 13-111 3.44e-17

Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.


Pssm-ID: 426304  Cd Length: 111  Bit Score: 70.75  E-value: 3.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  13 FTPGAANKVKTLIDEEGNPrlkLRVFVTGGG-------CS-GFQYGFTF-DEDIADDDTVIERDGVGLVVDPMSFQYL-A 82
Cdd:pfam01521   5 ITDAAAERLKKLLAGDKKE---LRLDVDDGGgpyskggCSiGGKFSLVLvDEPDPDYDEVIESNGGPIYVDSYSLPFLdE 81

                          90       100
                  ....*....|....*....|....*....
gi 1463310239  83 GSEVDYQEGLEGSRFVIKNPNAATTCGCG 111
Cdd:pfam01521  82 GLTLDFVEDLGTLGLKSDNGNLDGNVGCG 110
IscA_HesB_Se NF038090
IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, ...
 35-111 2.27e-04

IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, are homologous to proteins of iron-sulfur cluster biosynthesis such as IscA, and belong to the broader set of HesB-related proteins.


Pssm-ID: 411672  Cd Length: 99  Bit Score: 37.31  E-value: 2.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1463310239  35 LRVFVTGGGCSGFQYGFTFDEDiADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQEGLEGsrFVIKNPNAATTCGCG 111
Cdd:NF038090   25 IRVFLNQGGUAGPSLGLALDEP-KENDEVFEQDGLTFVIDKELLEQCGPIKVDFIDCRSG--FSITSSMPLGGGGCG 98
 
Name Accession Description Interval E-value
PRK13623 PRK13623
iron-sulfur cluster insertion protein ErpA; Provisional
 7-116 3.09e-80

iron-sulfur cluster insertion protein ErpA; Provisional


Pssm-ID: 184186  Cd Length: 115  Bit Score: 230.58  E-value: 3.09e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239   7 TPTPLLFTPGAANKVKTLIDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEV 86
Cdd:PRK13623    6 VPLPLVFTDAAAAKVKELIEEEGNPDLKLRVYITGGGCSGFQYGFTFDEQVNEDDTTIEKQGVTLVVDPMSLQYLVGAEV 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 1463310239  87 DYQEGLEGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:PRK13623   86 DYTEGLEGSRFVIKNPNAKTTCGCGSSFSI 115
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 10-116 6.84e-60

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 178.81  E-value: 6.84e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  10 PLLFTPGAANKVKTLIDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQ 89
Cdd:COG0316     1 PITLTDAAAKRIKRLLAKEGNPGLGLRVGVKGGGCSGFSYGLDFDDEPNEDDLVFEQDGVKVVVDPKSLPYLDGTEIDYV 80

                          90       100
                  ....*....|....*....|....*..
gi 1463310239  90 EGLEGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:COG0316    81 EELLGSGFKFNNPNAKSSCGCGESFSV 107
TIGR00049 TIGR00049
Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be ...
 13-116 1.98e-51

Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272875 [Multi-domain]  Cd Length: 105  Bit Score: 157.74  E-value: 1.98e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  13 FTPGAANKVKTLIDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQEGL 92
Cdd:TIGR00049   2 LTDSAAKRIKALLAGEGEPNLGLRVGVKGGGCSGLQYGLEFDDEPNEDDEVFEQDGVKVVVDPKSLPYLDGSEIDYVEEL 81

                          90       100
                  ....*....|....*....|....
gi 1463310239  93 EGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:TIGR00049  82 LGSGFTFTNPNAKGTCGCGKSFSV 105
PLN03082 PLN03082
Iron-sulfur cluster assembly; Provisional
 14-116 1.93e-25

Iron-sulfur cluster assembly; Provisional


Pssm-ID: 215564  Cd Length: 163  Bit Score: 93.45  E-value: 1.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  14 TPGAANKVKTLIDEEGNPRLK-LRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQEGL 92
Cdd:PLN03082   58 TDNCIRRLKELQTSEPSAEDKmLRLSVETGGCSGFQYVFELDDKTNSDDRVFEKDGVKLVVDNISYDFVKGATVDYVEEL 137

                          90       100
                  ....*....|....*....|....*
gi 1463310239  93 EGSRFVIK-NPNAATTCGCGQSFSI 116
Cdd:PLN03082  138 IRSAFVVStNPSAVGGCSCKSSFMV 162
sufA_proteo TIGR01997
FeS assembly scaffold SufA; This model represents the SufA protein of the SUF system of ...
 11-116 1.81e-21

FeS assembly scaffold SufA; This model represents the SufA protein of the SUF system of iron-sulfur cluster biosynthesis. This system performs FeS biosynthesis even during oxidative stress and tends to be absent in obligate anaerobic and microaerophilic bacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131052  Cd Length: 107  Bit Score: 81.80  E-value: 1.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  11 LLFTPGAANKVKTLIDEEGNpRLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQE 90
Cdd:TIGR01997   3 ITLTDAAAIHIRELVAKRPE-AVGIRLGVKKTGCAGMEYVLDLVSEPKKDDDLIEHDGAKVFVAPEAVLFILGTQVDFVR 81

                          90       100
                  ....*....|....*....|....*.
gi 1463310239  91 GLEGSRFVIKNPNAATTCGCGQSFSI 116
Cdd:TIGR01997  82 TTLRQGFKFNNPNATSACGCGESFEL 107
IscA TIGR02011
iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC ...
 14-116 4.25e-21

iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin. IscA previously was believed to act as a scaffold and now is seen as an iron donor protein. This clade is limited to the proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 213674  Cd Length: 105  Bit Score: 80.64  E-value: 4.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  14 TPGAANKVKTLIDEEGNPrLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDY-QEGL 92
Cdd:TIGR02011   4 TDSAAARVNTFLANRGKG-FGLRLGVKTSGCSGMAYVLEFVDEPTPDDIVFEDKGVKIVIDGKSLQYLDGTQLDFvKEGL 82

                          90       100
                  ....*....|....*....|....*
gi 1463310239  93 -EGSRFviKNPNAATTCGCGQSFSI 116
Cdd:TIGR02011  83 nEGFKF--TNPNVKDECGCGESFHV 105
iscA PRK09502
iron-sulfur cluster assembly protein IscA;
17-116 1.41e-20

iron-sulfur cluster assembly protein IscA;


Pssm-ID: 181914 [Multi-domain]  Cd Length: 107  Bit Score: 79.53  E-value: 1.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  17 AANKVKTLIDEEGNPrLKLRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDY-QEGL-EG 94
Cdd:PRK09502    9 AAARVNTFLANRGKG-FGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFvKEGLnEG 87

                          90       100
                  ....*....|....*....|..
gi 1463310239  95 SRFviKNPNAATTCGCGQSFSI 116
Cdd:PRK09502   88 FKF--TNPNVKDECGCGESFHV 107
sufA PRK09504
iron-sulfur cluster assembly scaffold protein; Provisional
 1-116 4.22e-19

iron-sulfur cluster assembly scaffold protein; Provisional


Pssm-ID: 181915  Cd Length: 122  Bit Score: 76.31  E-value: 4.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239   1 MSIETFTPTP-----LLFTPGAANKVKTLIDEegNPRLK-LRVFVTGGGCSGFQYGFTFDEDIADDDTVIERDGVGLVVD 74
Cdd:PRK09504    3 MHSGTFNPDDfawqgLTLTPAAAAHIRELMAK--QPGMKgVRLGVKQTGCAGFGYVLDSVSEPDKDDLVFEHDGAKLFVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1463310239  75 PMSFQYLAGSEVDY-QEGLEgSRFVIKNPNAATTCGCGQSFSI 116
Cdd:PRK09504   81 LQAMPFIDGTEVDYvREGLN-QIFKFHNPKAQNECGCGESFGV 122
Fe-S_biosyn pfam01521
Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster ...
 13-111 3.44e-17

Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.


Pssm-ID: 426304  Cd Length: 111  Bit Score: 70.75  E-value: 3.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  13 FTPGAANKVKTLIDEEGNPrlkLRVFVTGGG-------CS-GFQYGFTF-DEDIADDDTVIERDGVGLVVDPMSFQYL-A 82
Cdd:pfam01521   5 ITDAAAERLKKLLAGDKKE---LRLDVDDGGgpyskggCSiGGKFSLVLvDEPDPDYDEVIESNGGPIYVDSYSLPFLdE 81

                          90       100
                  ....*....|....*....|....*....
gi 1463310239  83 GSEVDYQEGLEGSRFVIKNPNAATTCGCG 111
Cdd:pfam01521  82 GLTLDFVEDLGTLGLKSDNGNLDGNVGCG 110
PRK11190 PRK11190
iron-sulfur cluster biogenesis protein NfuA;
21-104 2.40e-05

iron-sulfur cluster biogenesis protein NfuA;


Pssm-ID: 183027 [Multi-domain]  Cd Length: 192  Bit Score: 41.15  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463310239  21 VKTLIDEEgnPRLKLRVFVTGGGCSGFQYGFTF--DEDIADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQEGLEGSRFV 98
Cdd:PRK11190   13 AKLLANQE--EGTQIRVFVINPGTPNAECGVSYcpPDAVEATDTELKFDGFSAYVDELSAPFLEDAEIDFVTDQLGSQLT 90


                  ....*.
gi 1463310239  99 IKNPNA 104
Cdd:PRK11190   91 LKAPNA 96
IscA_HesB_Se NF038090
IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, ...
 35-111 2.27e-04

IscA/HesB family protein; Members of this family, a large fraction of which are selenoproteins, are homologous to proteins of iron-sulfur cluster biosynthesis such as IscA, and belong to the broader set of HesB-related proteins.


Pssm-ID: 411672  Cd Length: 99  Bit Score: 37.31  E-value: 2.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1463310239  35 LRVFVTGGGCSGFQYGFTFDEDiADDDTVIERDGVGLVVDPMSFQYLAGSEVDYQEGLEGsrFVIKNPNAATTCGCG 111
Cdd:NF038090   25 IRVFLNQGGUAGPSLGLALDEP-KENDEVFEQDGLTFVIDKELLEQCGPIKVDFIDCRSG--FSITSSMPLGGGGCG 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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