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Conserved domains on  [gi|146330970|sp|Q330B1|]
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RecName: Full=NADH-ubiquinone oxidoreductase chain 2; AltName: Full=NADH dehydrogenase subunit 2

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-347 0e+00

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 515.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*..
gi 146330970 321 KSTAHVSPLIILSTLALPLSPILMLLE 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-347 0e+00

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 515.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*..
gi 146330970 321 KSTAHVSPLIILSTLALPLSPILMLLE 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-296 9.81e-32

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 124.07  E-value: 9.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAV-IPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQW 84
Cdd:COG1007  104 FYALLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  85 SITK-----PLNQTASIIMTLAMAM-------KLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMS----ILYQIFPT 148
Cdd:COG1007  184 NLAGiaaalAAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLVEAFPG 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 149 INLNLMLLMSVLSVA---IGGWGGLNQTQLRKIMAYSSIAHMGWM-TAIMAYNPTM---TLLNLVIYILLTTTTFMMFML 221
Cdd:COG1007  264 LAADWQLLLAVLAVLsmtVGNLAALAQTNVKRMLAYSSIAHAGYLlLGLAAGTPLGvsaALFYLLAYLFMNLGAFAVILL 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 222 ----NSSTTTLS-LSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRL 296
Cdd:COG1007  344 lsrkGGEAEEIEdLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRV 423
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-268 7.92e-27

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 107.40  E-value: 7.92e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   23 SSHWLTVWIGFEMNMLAVIP-ILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQWSIT-----------KPL 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDelskaltgglnSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   91 NQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILL-TWQKLAP-----MSILYQIFPTINLNLMLLMSVLSVAI 164
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  165 GGWGGLNQTQLRKIMAYSSIAHMGWMTAIMA----YNPTMTLLNLVIYILLTTTTFMMFML-----NSSTTTLSLSHTWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGagtiYGIQAAIFHLLTHGLFSAGLFLCAGSviyrrVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 146330970  236 KAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQ 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILA 273
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-296 2.92e-26

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 108.50  E-value: 2.92e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970    6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAV-IPILMKNYNPRSMEASTKYFLTQATASMLLMLAI--------II 76
Cdd:TIGR01770 104 FYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgSL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   77 NL----LYSGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTI--- 149
Cdd:TIGR01770 184 NFedllLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  150 ----NLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGW----MTAIMAYNPTMTLLNLVIYILLTTTTFMMFML 221
Cdd:TIGR01770 264 fseaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSL 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  222 NSSTttlslSHTWNK-----------APLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNL 290
Cdd:TIGR01770 344 LRSY-----KDEWIEyisdfaglfktNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGA 418


                  ....*.
gi 146330970  291 YFYMRL 296
Cdd:TIGR01770 419 FYYLRV 424
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-347 0e+00

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 515.55  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*..
gi 146330970 321 KSTAHVSPLIILSTLALPLSPILMLLE 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-346 3.32e-132

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 380.69  E-value: 3.32e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTiNLNLMLLMSVL 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330       340
                 ....*....|....*....|....*.
gi 146330970 321 KSTAHVSPLIILSTLALPLSPILMLL 346
Cdd:MTH00135 320 QLTLPLAISTTATLMLLPLTPAILAL 345
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-344 2.10e-120

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 350.66  E-value: 2.10e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVL 160
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320

                        330       340
                 ....*....|....*....|....
gi 146330970 321 KSTaHVSPLIILSTLALPLSPILM 344
Cdd:MTH00112 321 KNT-LTATLTTLSTLLLPLSPMIL 343
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-346 1.97e-117

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 343.44  E-value: 1.97e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVL 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFKNK 320

                        330       340
                 ....*....|....*....|....*.
gi 146330970 321 KSTAhVSPLIILSTLALPLSPILMLL 346
Cdd:MTH00070 321 TNNL-LSLTIILSLMLLPITPTILNL 345
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-346 5.45e-97

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 291.45  E-value: 5.45e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVL 160
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGN 320

                        330       340
                 ....*....|....*....|....*...
gi 146330970 321 KS--TAHVSPLIILSTLALPLSPILMLL 346
Cdd:MTH00041 321 ITvyGVILSILSSISILGLLLIPLFLSF 348
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-346 2.53e-89

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 271.84  E-value: 2.53e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLY 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVL 160
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320

                        330       340
                 ....*....|....*....|....*.
gi 146330970 321 KSTaHVSPLIILSTLALPLSPILMLL 346
Cdd:MTH00200 321 SNL-LVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 13-315 5.84e-56

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 185.09  E-value: 5.84e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  13 IIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQWSItkplnq 92
Cdd:MTH00144  13 MVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS------ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  93 taSIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINL-NLMLLMSVLSVAIGGWGGLN 171
Cdd:MTH00144  87 --MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVISVLSALVGSIGGLN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 172 QTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTwNKAPLLTMTILTIMLSM 251
Cdd:MTH00144 165 QTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSL-KPSYKTGLSIISLLLSL 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146330970 252 GGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKW 315
Cdd:MTH00144 244 GGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-346 4.28e-55

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 183.10  E-value: 4.28e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLy 80
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 sgqwsITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFptiNLNLMLLMSVL 160
Cdd:MTH00160  81 -----NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLI---NNNFIIIIIIL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLL 240
Cdd:MTH00160 153 SAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 241 TMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYStslTMFPSTNNMKMKWQLNNT 320
Cdd:MTH00160 233 KFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYS---SLMLNYNKNKWNLKKKKN 309

                        330       340
                 ....*....|....*....|....*.
gi 146330970 321 KSTAHVSPLIILSTLALPLSPILMLL 346
Cdd:MTH00160 310 KFSLILNFLSFISLFGLILSSLLFLL 335
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 12-341 6.96e-50

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 169.58  E-value: 6.96e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  12 TIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQWSITKPLn 91
Cdd:MTH00011  14 TMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSLLKNITAL- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  92 qtasiIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVLSVAIGGWGGLN 171
Cdd:MTH00011  93 -----MLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGLGGMN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 172 QTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLLTMTILTIMLSM 251
Cdd:MTH00011 168 QTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 252 GGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLtystsltMFPSTNNMKMKWQLNNTKSTAHVSPLII 331
Cdd:MTH00011 248 GGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNL-------IFNFMYLSPTFSSLKSAPYEPKTKILIS 320

                        330
                 ....*....|
gi 146330970 332 LSTLALPLSP 341
Cdd:MTH00011 321 MCTLSLGLIP 330
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 11-300 2.92e-39

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 141.35  E-value: 2.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  11 LTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLysgqwsiTKPL 90
Cdd:MTH00197   5 FIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFS-------NLYL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  91 NQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILyqIFPTINLNLMLLMSVLSVAIGGWGGL 170
Cdd:MTH00197  78 SLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLIL--AFNSSSFMGLLICSVLSSLIGGIGGM 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 171 NQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHTWNKAPLLTMTILTIMLS 250
Cdd:MTH00197 156 NQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLS 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 146330970 251 MGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYST 300
Cdd:MTH00197 236 LGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKS 285
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 6-296 9.81e-32

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 124.07  E-value: 9.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAV-IPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQW 84
Cdd:COG1007  104 FYALLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGISLLYGATGSL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  85 SITK-----PLNQTASIIMTLAMAM-------KLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMS----ILYQIFPT 148
Cdd:COG1007  184 NLAGiaaalAAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLVEAFPG 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 149 INLNLMLLMSVLSVA---IGGWGGLNQTQLRKIMAYSSIAHMGWM-TAIMAYNPTM---TLLNLVIYILLTTTTFMMFML 221
Cdd:COG1007  264 LAADWQLLLAVLAVLsmtVGNLAALAQTNVKRMLAYSSIAHAGYLlLGLAAGTPLGvsaALFYLLAYLFMNLGAFAVILL 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 222 ----NSSTTTLS-LSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRL 296
Cdd:COG1007  344 lsrkGGEAEEIEdLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRV 423
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 13-296 2.06e-29

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 115.90  E-value: 2.06e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  13 IIMGTMIVMTSSHWLTVWIGFEMNMLAV-IPILMKNYNPRSMEASTKYFLTQATASMLLMLAI-------------IINL 78
Cdd:MTH00196   2 VALGILCLISSSNWLSVYLAIELQTLSLfILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCallcgttgglhlsYINL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  79 LYSGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPtiNLNLMLLMS 158
Cdd:MTH00196  82 VLNSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL--NVNILLIGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 159 VLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNP----TMTLLNLVIYILLTTTTFMMFMLNSSTTTL--SLSH 232
Cdd:MTH00196 160 LFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSfesiQASLVYLFIYIIMSICVFSIILALNVYKNLiiEFSG 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146330970 233 TWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRL 296
Cdd:MTH00196 240 LSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 6-296 1.02e-28

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 115.50  E-value: 1.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAV-IPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQW 84
Cdd:MTH00199  99 SPILILIVALGSLLLVSSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGET 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  85 SI----TKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLnlMLLMSVL 160
Cdd:MTH00199 179 SIqginSILTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNV--VLICAVL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMG---WMTAIMAYNPTM-TLLNLVIYILLTTTTFMMFMLNSSTTTL--SLSHTW 234
Cdd:MTH00199 257 SIIYGAIGALNQTKIKRLLAYSGIGHMGfilFGVAIGSFESIQaSLIYMIIYVIMSICSFSIILSLKLTKGLivEVSGLS 336

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146330970 235 NKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRL 296
Cdd:MTH00199 337 RKNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-268 7.92e-27

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 107.40  E-value: 7.92e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   23 SSHWLTVWIGFEMNMLAVIP-ILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQWSIT-----------KPL 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDelskaltgglnSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   91 NQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILL-TWQKLAP-----MSILYQIFPTINLNLMLLMSVLSVAI 164
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  165 GGWGGLNQTQLRKIMAYSSIAHMGWMTAIMA----YNPTMTLLNLVIYILLTTTTFMMFML-----NSSTTTLSLSHTWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGagtiYGIQAAIFHLLTHGLFSAGLFLCAGSviyrrVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|...
gi 146330970  236 KAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQ 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILA 273
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-296 2.92e-26

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 108.50  E-value: 2.92e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970    6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAV-IPILMKNYNPRSMEASTKYFLTQATASMLLMLAI--------II 76
Cdd:TIGR01770 104 FYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgSL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   77 NL----LYSGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTI--- 149
Cdd:TIGR01770 184 NFedllLFLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  150 ----NLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGW----MTAIMAYNPTMTLLNLVIYILLTTTTFMMFML 221
Cdd:TIGR01770 264 fseaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYiligLLAGTLEGIKAVLFYIFIYALMSLGAFGVLSL 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  222 NSSTttlslSHTWNK-----------APLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNL 290
Cdd:TIGR01770 344 LRSY-----KDEWIEyisdfaglfktNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGA 418


                  ....*.
gi 146330970  291 YFYMRL 296
Cdd:TIGR01770 419 FYYLRV 424
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
6-296 3.05e-26

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 108.75  E-value: 3.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAV-IPILMKNYNPRSMEASTKYFLTQATAS-MLLM------------ 71
Cdd:PRK05777 105 FYLLVLFALLGMMVMVSANDLLTLFLGLELLSLPLyALAALRRDRRRSLEAAIKYFVLGALASgFLLYgmsllygatgsl 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  72 -LAIIINLLYSGQwsITKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIF---- 146
Cdd:PRK05777 185 sFAGIAKALADGS--GNSLLLLFGLVFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLLvvaf 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 147 ---PTINLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWM-TAIMAYNPTM---TLLNLVIYILLTTTTFMMF 219
Cdd:PRK05777 263 gglSEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLlVGLAAGTAEGysaVLFYLLAYLFMTLGAFGVI 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 220 MLNSS----TTTLS----LSHTwnkAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLY 291
Cdd:PRK05777 343 SLLRRkggeAESISdfagLSKR---SPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAF 419


                 ....*
gi 146330970 292 FYMRL 296
Cdd:PRK05777 420 YYLRV 424
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 5-296 2.25e-22

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 97.14  E-value: 2.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   5 IFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQW 84
Cdd:COG0651  108 RFYPLFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  85 SIT----------KPLNQTASIIMTLAMAMKLGLSPFHFWVPE-----------VTQGIQLSSGLILLtwqklapMSILY 143
Cdd:COG0651  188 NMAdlaarlaeldPGLLLAAFALLLVGFGIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVYAI-------LRVLT 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 144 QIFPTINLN----LMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMT-AIMAYNPTMT---LLNLVIYILLTTTT 215
Cdd:COG0651  261 LLFGADPALflgtLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILlGLGLGTPLGLagaLFHLLNHALAKALL 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 216 FM---MFMLNSSTTTLS-LSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLY 291
Cdd:COG0651  341 FLaagAIERATGTRDLDkLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLA 420


                 ....*
gi 146330970 292 FYMRL 296
Cdd:COG0651  421 YFVRI 425
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
6-295 1.68e-15

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 77.40  E-value: 1.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMnmLAVIPILMKNY---NPRSMEASTKYFLTQATASMLLMLAIiiNLLY-- 80
Cdd:PRK02504 112 FAAILLTATLGGMFLSGATELVMIFISLET--LSIASYLLTGYmkrDPRSNEAALKYLLIGAASSAIFLYGS--SLLYgl 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 -SGQWS---ITKPLNQTASIIMTLAM-------AMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLA----PMSILYQI 145
Cdd:PRK02504 188 sGGSTQlsaIALALITSPSLGLALALvfviagiAFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTA 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 146 FPTINLNLMLL---MSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGW-MTAIMAYNPT---MTLLNLVIYILLTTTTFM- 217
Cdd:PRK02504 268 FPSFDEQWKLLftaLAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFvMIGLVAGTEAgyaSMVFYLLAYLFMNLGAFAc 347

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 218 --MFMLNSSTTTLS-LSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYM 294
Cdd:PRK02504 348 viLFSLRTGTDQISdYAGLYQKDPLLTLGLSLCLLSLGGIPPLAGFFGKIYLFWAGWQAGLYLLVLVGLVTSVISIYYYI 427


                 .
gi 146330970 295 R 295
Cdd:PRK02504 428 R 428
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 9-272 4.76e-15

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 76.05  E-value: 4.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   9 IVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSM---------EASTKYFLTQATASMLLMLAIIINLL 79
Cdd:MTH00198 193 LVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALYFG 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  80 YSGQ----WSITKPLNQTASI----------IMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQI 145
Cdd:MTH00198 273 FTGNegmlGTILSATLETTNIelrqgslgylFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSL 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 146 fpTINLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLN----LVIYILLTTTTFMMFML 221
Cdd:MTH00198 353 --VITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFILIGVSAGTYESLQAswtyAVTYLVSALASFTVICT 430

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146330970 222 NSSTTTLSLSHTWNKAP---------LLTMTILT------------IMLSMGGLPPLSGFLPKWMIIQEMVK 272
Cdd:MTH00198 431 LEEFGTRTPTSRQRDGSfgnynlvrrLVDLTILSrgqpyiafslaiVFLSLAGIPPLLGFLGKWFILVGSIK 502
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 50-287 6.68e-14

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 72.28  E-value: 6.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   50 PRSMEASTKYFLTQATASmLLMLAIIINLLYSGQWS------ITKPLNQTASIIMTL----AMAMKLGLSPFHFWVPEV- 118
Cdd:TIGR01972 152 PNRIYAAMKFFLYTLAGS-LLMLLAILGLYFLGGGTfdllelLNLPLPFGVQTWLFLaffiAFAVKVPLFPLHTWLPDAh 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  119 ----TQGIQLSSGLILltwqKLAP---MSILYQIFPTINLNLMLLMSVLSVA---IGGWGGLNQTQLRKIMAYSSIAHMG 188
Cdd:TIGR01972 231 veapTAGSVILAGVLL----KMGTygfLRFNLPLFPDASLYFAPVLAALGVIaiiYGALIALAQTDIKRLIAYSSISHMG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  189 WMT-AIMAYNPTMTLLNLVIYILLTTTTFMMF----MLNSSTTTLSLSH---TWNKAPLLTMTILTIMLSMGGLPPLSGF 260
Cdd:TIGR01972 307 FVLlGIFSFNELGISGAVFQMISHGLITAALFllvgVLYERAHTRDIAKyggLANKMPVLAAFFMLFAMASLGLPGTSGF 386

                         250       260
                  ....*....|....*....|....*..
gi 146330970  261 LPKWMIIQEMVKndniITPTIMAVTAL 287
Cdd:TIGR01972 387 VGEFLILLGSFK----VNPVVAFLAAL 409
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 50-267 3.29e-12

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 67.03  E-value: 3.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  50 PRSMEASTKYFLTQATASMLLMLAIIINLLYSGQWS------ITKPLNQTASII----MTLAMAMKLGLSPFHFWVPEV- 118
Cdd:COG1008  157 ERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTfdiaelAAAPLPLTAQLLlflaFFIAFAVKVPMFPFHTWLPDAh 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 119 ----TQGIQLSSGLILltwqKLAPMSIL---YQIFP---TINLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMG 188
Cdd:COG1008  237 veapTAGSVLLAGVLL----KMGGYGLLrfaLPLFPeasAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMG 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 189 WMT-AIMAYNPTM---TLLNLVIYILLTTTTFMM-FMLNSSTTTLSLSHT---WNKAPLLTMTILTIMLSMGGLPPLSGF 260
Cdd:COG1008  313 FVLlGIFALNPLGlqgAVLQMVSHGLITAALFLLvGVLYDRTHTRDIADLgglAKRMPVLAALFLLAALASLGLPGTSGF 392


                 ....*..
gi 146330970 261 LPKWMII 267
Cdd:COG1008  393 VGEFLVL 399
ndhB CHL00049
NADH dehydrogenase subunit 2
 6-263 1.33e-11

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 65.41  E-value: 1.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMnmLAVIPILMKNY---NPRSMEASTKYFLTQATASMLLMLAIiiNLLY-- 80
Cdd:CHL00049 113 FLLFVLTATLGGMFLCGANDLITIFVALEC--LSLCSYLLSGYtkkDVRSNEATMKYLLMGGASSSILVYGF--SWLYgl 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  81 SGQ----WSITKPLNQT----------ASIIMTLAMAMKLGLSPFHFWVPEVTQG-----------IQLSSGLILLTwqk 135
Cdd:CHL00049 189 SGGeielQEIVNGLINTqmynspgisiALIFITVGIGFKLSLAPFHQWTPDVYEGsptpvvaflsvTSKVAASALAT--- 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 136 lAPMSILYQIFPTINLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGW-MTAIMAYNP----TMTLLNLVIYIL 210
Cdd:CHL00049 266 -RIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYvIIGIIVGDSndgyASMITYMLFYIF 344

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 146330970 211 LTTTTF---MMFMLNSSTTTL-SLSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPK 263
Cdd:CHL00049 345 MNLGTFaciVLFGLRTGTDNIrDYAGLYTKDPFLALSLALCLLSLGGIPPLAGFFGK 401
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 6-299 6.69e-11

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 63.19  E-value: 6.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPIL-MKNYNPRSMEASTKYFLTQATASMLLMLAIiiNLLYsGQW 84
Cdd:PRK08376 123 YYTLILLLELGMLGMAITGDLFNFFVFLEIMSIASYALVaFRNDTWEAIEAGIKYMFVGSLASSMVLLGI--ALLY-GQY 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  85 SI-------------TKPLNQTASIIMTLAMAMKLGLSPFHFWVP----EVTQGIqlSSGLILLTWQKL-APMSILYQIF 146
Cdd:PRK08376 200 GTlnmaylavkmsenPTVVAKIALALFIAGLAMKSGAVPVHMWLPdaypAAPSSI--SAMLLVIKQAGLyALARVLFSIY 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 147 -PTINLN----LMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWM-----TAIMAYNPT------MTLLNLVIYIL 210
Cdd:PRK08376 278 gPAINLAtvgwVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYMllglgVGLAALGDPamasygEIALAGGIYHI 357

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 211 LTTTTFMMFMLNSSTTTLSLSHTWNKAPL----LTMTILTIMLSMG-----GLPPLSGFLPKWMIIqEMVKNDNIITPTI 281
Cdd:PRK08376 358 VNHALYKALLFLTAGAVIYETGTRNLNELgglaRTMPKTTIAFLIGaaaivGLPPFNGFASKWLIY-ESSALFNPILGVI 436

                        330
                 ....*....|....*...
gi 146330970 282 MAVTALLNLYFYMRLTYS 299
Cdd:PRK08376 437 AMIGSVLTLASFVKVFHT 454
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-341 2.01e-10

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 55.73  E-value: 2.01e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 146330970  291 YFYMRLTYSTSLTMFPSTNNMKMKWQLNNTKSTAHVSPLIILSTLALPLSP 341
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 49-298 3.30e-10

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 61.05  E-value: 3.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  49 NPRSMEASTKYFLTQATASMLLMLAIIinLLYSgqwsITKPLN--------------QTASIIMTLAMAMKLGLSPFHFW 114
Cdd:PRK08375 151 DRRALAAARKYLIVGLIGSTFLLIGVG--LLYG----VTGTLNmadlagalaenptvVTAFGFVLLALALKAAVFPLHTW 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 115 VPEV-TQGIQLSSGLILLTWQKLAP---MSILYQIFP------TINLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSI 184
Cdd:PRK08375 225 LPRAyPAAPPVVTALLSGLVTKVAVyalIRIYFTVFGgdfrfaLGLGWLLAVLALLSMLVGSLAALGQDDVKRVLAYSTV 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 185 AHMGWMTAIMAYN----PTMTLLNLVIYILLTTTTFM---MFMLNSSTTTLS-LSHTWNKAPLLTMTILTIMLSMGGLPP 256
Cdd:PRK08375 305 SQMGYILLGLALLtplaLAAGLLHLLHHALMKGALFLaagAIEVTYGTRRLSeLSGLGRRMPLTAAAFAVASLSLIGVPP 384

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 146330970 257 LSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTY 298
Cdd:PRK08375 385 TSGFVSKWYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWY 426
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 2-282 1.23e-09

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 59.62  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   2 NPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNyNPRSMEASTKYFLTQATASMLLMLAIIINLLYS 81
Cdd:PRK08668  96 NDAYFNMFALMSLAGVLGVFLANDLLTLYIFWEIMTFSSFMMVPMG-KKESRKASLKYFVLSAIGAYAMLYAIFLIYAKT 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  82 GQWSIT--------KPLNQTASIIMTLAMAM---KLGLSPFHFWVPEV--------------------TQGIQLSSGLIL 130
Cdd:PRK08668 175 GTFDFAdisqglinDTSTGFALIVFLFLLAFgvaKAGIFPLHVWAPDAyseapqsfsavlsgqlsklgAYGFLLVLYVLP 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 131 LTwqKLAPMSILYQIFPTINLNLMLLmSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGW-------MTAIMAYNPTMTLL 203
Cdd:PRK08668 255 GT--KLFSEFGTYRGVPLFNYILAWL-GNISIIVGTLMAILQEDIKKLIAYSSVANGGYilvglglGTSLGFAGGLFHVF 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 204 NLVIYILLTTTTFMMFMLNSSTTTLS----LSHtwnKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITP 279
Cdd:PRK08668 332 NHALFKGLFFLIFAAVIYRTGTTKISemggLIE---KMPFTFAMYLVAIISLAGIPPMSGFASKWLIFEALISKGMPITA 408


                 ...
gi 146330970 280 TIM 282
Cdd:PRK08668 409 FMA 411
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
27-296 4.61e-09

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 57.65  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  27 LTVWigFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIiiNLLYS--------------GQWSITKPLnQ 92
Cdd:PRK12663 133 LYVW--FEVMLIASFVLITLGQEREQLRGAIKYVVLNLIGSWLFLLGI--GLLYGtfgtlnmahiamrlNDMGDTATL-T 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  93 TASIIMTLAMAMKLGLSPFhFWVPEV--TQGIQLSSGLI-LLT----WQKLAPMSILYQIFPTINLNLMLLMSVLSVAIG 165
Cdd:PRK12663 208 TIALLFLLAFGMKAALFPF-MWLPAAyhTPNTEVAALFAaLLTkvgiYALIRVFTLLFPQERELLHPLLATMAAITMVIG 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 166 GWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIY----ILLTTTTFM----MFMLNSSTTTLSLSHTWNKA 237
Cdd:PRK12663 287 ALGALAYKDIRRIAGYQVISSIGFILLGLALGTPAGINGAIFYlvhdMVVKTALFLiagsLVRLTGYRSLQYLGGLYRKE 366

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 146330970 238 PLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRL 296
Cdd:PRK12663 367 PLFGALFLILIFAIGGLPPFSGFWGKVLLVQGALDNGAYILLALMLITSLITMYSLFRI 425
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 49-300 1.15e-08

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 56.31  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  49 NPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQWSITKPLNQTASII----MTLAMAM-------KLGLSPFHFWVPE 117
Cdd:COG1009  157 KPSARRAARKAFLVTRVGDLGLLLGILLLGAIAGTLNFSELLAAAPTILssplLTLILLLlllgafgKSAQFPLHFWLPD 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 118 -----------------VTQGIQLssglilltwqkLAPMSILYQIFPTInLNLMLLMSVLSVAIGGWGGLNQTQLRKIMA 180
Cdd:COG1009  237 amegptpvsallhaatmVKAGVYL-----------LARLSPLFALSPVW-LTVVAIIGAITALFAALIALAQTDIKRVLA 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 181 YSSIAHMGWMTAIMAynptMTLLNLVIYILLTTTTFM--MFMlnsstTTLSLSHT------------WNKAPLLTMTILT 246
Cdd:COG1009  305 YSTVSQLGYMFLALG----VGAYVAALFHLLTHAFFKalLFL-----GAGSVIHAtgtrdirkmgglRKKMPITAITFLI 375

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 146330970 247 IMLSMGGLPPLSGFLPKWMIIQEMVKND--NIITPTIMAVTALLNLYFYMRLTYST 300
Cdd:COG1009  376 GALSLAGIPPFAGFFSKEAILEAALEAGglGPLLLAVALLGAFLTAFYSFRLFFLV 431
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 50-299 6.04e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 54.21  E-value: 6.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  50 PRSMEASTKYFLTQATASMLLMLAIIInlLYSG--------------QWSITKPLNQTASIIMTLAMAM---------KL 106
Cdd:PRK12667 160 GDAVEAAIKYALIGAVGTTLYFLALAF--LYATfgtlnmadlsakirGLSFPLTGGLAGNPPLALGVALalalwaftiKA 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 107 GLSPFHFWVPEV-----TQGIQLSSGLILLTwQKLAPMSILYQIFP---------TINLNLMLLMSVLSVAIGGWGGLNQ 172
Cdd:PRK12667 238 AIFPNHFWLPDAhpaapSPVSAMLSGLVVNV-GAYAIIRFLYTIFGispslidfrAALSPILIILGAVSAIIGALMMVVQ 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 173 TQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNS--------STTTLSLSHTWNKAPLLTMTI 244
Cdd:PRK12667 317 KDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASgvfihaagTRDIDELAGLGRKMPIASFAF 396

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 146330970 245 LTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYS 299
Cdd:PRK12667 397 LIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYS 451
PRK12665 PRK12665
putative monovalent cation/H+ antiporter subunit D; Reviewed
 145-291 2.83e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237165 [Multi-domain]  Cd Length: 521  Bit Score: 48.81  E-value: 2.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 145 IFPTINLN-LMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIY----ILLTTTTFMMF 219
Cdd:PRK12665 266 LFPGGGLDtLLMVVALLTMVVGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTVAGLSGAIYYvahhITVQTTLFLVV 345

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146330970 220 ML---NSSTTTLS-LSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMA---VTALLNLY 291
Cdd:PRK12665 346 GLierQAGSSSLRrLGGLAKASPLLAVLFFVPALNLGGIPPFSGFIGKVALLEAGAEDGTWLAWALVAggvVTSLLTLY 424
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 50-267 2.43e-05

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 45.96  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  50 PRSMEASTKYFLTQATASMLLMLAII----INLLYSGQWSITK----PLNQTASIIMTLAM----AMKLGLSPFHFWVPE 117
Cdd:PRK05846 157 KNRIYAATKFFLYTLLGSLLMLVAIIylvvVYYNATGTFDIADllnlPLPPGVQYWLFLAFfiafAVKMPMFPLHTWLPD 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 118 V-----TQGIQLSSGLILltwqKLAP---MSILYQIFPTINLNLMLLMSVLSV-AI--GGWGGLNQTQLRKIMAYSSIAH 186
Cdd:PRK05846 237 AhvqapTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEFAPIIITLGViAIiyGALVALAQTDIKKLIAYSSISH 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 187 MGWMT-AIMAYNpTMTLLNLVIYI----LLTTTTFMM-FMLNSSTTTLSLSH---TWNKAPLLTMTILTIMLSMGGLPPL 257
Cdd:PRK05846 313 MGFVTlGIFAGN-QLGIQGAIFQMishgLSSAALFLLvGVLYDRLHTRDIADyggLAKVMPVLAAFFLFFAMASLGLPGT 391

                        250
                 ....*....|
gi 146330970 258 SGFLPKWMII 267
Cdd:PRK05846 392 SGFVGEFLIL 401
PRK12650 PRK12650
DUF4040 family protein;
93-263 2.80e-05

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 45.80  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  93 TASIIMTLAMA--MKLGLSPFHFWVPE-----------------VTQGIQLssglilltwqkLAPMSILYQIFPTINLnL 153
Cdd:PRK12650 207 TTVVAVLIAVAafTKSAQFPFHFWLPEamaaitpvsaflhaaavVKAGIYL-----------LLRFSPVFHDVAVWNW-L 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 154 MLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYI----LLTTTTFMMF-MLNSSTTTL 228
Cdd:PRK12650 275 LIIVGMITALMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTlahaLFKSSLFMLIgVVDHQAGTR 354

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 146330970 229 S---LSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPK 263
Cdd:PRK12650 355 DirrLGSLWRRMPFTFVSVTIAALSMAAVPPLFGFVSK 392
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 100-301 3.95e-05

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 45.30  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 100 LAMAMKLGLSPFHFWVPEV-----TQGIQLSSGlILLTWQKLAPMSILYQIFPTINLNL---MLLMSVLSVAIGGWGGLN 171
Cdd:MTH00226 238 LAMAVKIPIFPFHIWLPKAhveapVAGSVLLAG-ILLKLGGYGLVRLSWPILPLGAQNLapaVIAMGIVGIVYGSFATCR 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 172 QTQLRKIMAYSSIAHMGwMTAIMAYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLSHT----WNKAPLLTMTILTI 247
Cdd:MTH00226 317 QIDVKRLVAYSSVAHMG-LVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTrlikYYRGLSITMPIWGT 395

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146330970 248 MLSMGGL-----PPLSGFLPKWMIIQEMVKNDNIITPTIMA---VTALLNLYFYMRLTYSTS 301
Cdd:MTH00226 396 IMIVTSLanvavPPSGNFIGEYLSILSSFNWNPIIGVFVCSgviLSAVYSFYFANRVTFGAP 457
ND5 MTH00207
NADH dehydrogenase subunit 5; Provisional
 6-341 7.32e-05

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 164753 [Multi-domain]  Cd Length: 572  Bit Score: 44.37  E-value: 7.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   6 FTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLlYSGQWS 85
Cdd:MTH00207  90 FISLVLLFVLSMNMLIFFPHLMILLLGWDGLGLVSFILVIYYQNPKSLGAGMITALTNRIGDVMLLLSIGWTL-NQGHWS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  86 ITK----PLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTIN-----LNLMLL 156
Cdd:MTH00207 169 ITNmwqtDMNNYIALSIMIAAMTKSAQMPFSSWLPAAMAAPTPVSALVHSSTLVTAGVFLLIRFYPFLSstywfNPALLL 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 157 MSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYN-PTMTLLNLVIYILLTTTTFMMF--MLNSSTTTLSLSH- 232
Cdd:MTH00207 249 TASLTMLMAGLSAMTECDMKKIIALSTLSQLGVMMASLGLGmPKLALFHLITHALFKALLFVCAgsLIHSHHHSQDLRTm 328

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 233 --TWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIM-----AVTALLNLYFYMRLTYSTSLT-- 303
Cdd:MTH00207 329 gnLTNQMPLTTSCLLIANLALCGSPFLSGFYSKDLILESSLFYPHNSLMILMiflatALTAAYSTRFTLAVLWSPNSSsp 408

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 146330970 304 -MFPSTNNMKMKWQLNNTKSTAHVSPLIILSTLALPLSP 341
Cdd:MTH00207 409 yHHLEDEDKSLTTPMLLLTLGAITSGSALNWWLPTPQEE 447
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 96-315 1.30e-04

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 42.94  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  96 IIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVLSVaiggWGGLNQTQL 175
Cdd:MTH00091  61 YFQFLILMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLLFGLLICF----FQMFLLKSY 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 176 RKIMAYSSIAHMGWMTAIMAYNptmtlLNLVIYILLTTTTFMMFMLNSstttlslshtWNKAPLLTMTILTIMLSMGGLP 255
Cdd:MTH00091 137 KNLLILSSTESFNWLILSFFFS-----FFNVFFLFFYYFLLMLFLIPK----------FNNVNKLNFVSWETLLVFMNLP 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 256 PLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLTYSTSLTMFPSTNNMKMKW 315
Cdd:MTH00091 202 FSVTFFVKIFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFF 261
ND5 MTH00209
NADH dehydrogenase subunit 5; Provisional
 2-298 1.81e-04

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 177252 [Multi-domain]  Cd Length: 564  Bit Score: 43.10  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   2 NPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIiNLLYS 81
Cdd:MTH00209  81 FKKRFILLVLLFILSMNFLIFVPNLITLLLGWDGLGLVSYLLVIYYQNSKSLSAGMLTALTNRVGDALLILSIA-WMLMH 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  82 GQWSI-----TKPLNQTASIIMTLAMAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLM-- 154
Cdd:MTH00209 160 GNWNIfylnfNSNLGSVISVLIVLAAMTKSAQIPFSAWLPAAMAAPTPVSALVHSSTLVTAGVYLLIRFFPSLFSSPFfs 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 155 ---LLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYN-PTMTLLNLVIYILLTTTTF-----MMFMLNSST 225
Cdd:MTH00209 240 mslLLLGSLTTLMASMSANVESDLKKIIALSTLSQLGLMMCSLGLNqPELAFFHLITHALFKALLFicagnIIHSHGHSQ 319

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146330970 226 TTLSLSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKND-NIITPTIMAVTALLNLYFYMRLTY 298
Cdd:MTH00209 320 DIRMVGNLWYQMPITSICLNIANLSLCGIPFLAGFYSKDLILESMLESNmPIMTLILMFLSTSLTAAYSMRLSY 393
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 152-296 2.40e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 42.80  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 152 NLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTMTLLNLVIYI----LLTTTTFMMFMLNS---- 223
Cdd:PRK12662 280 NVFMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIvnhsIVKSALFMVSGSISyhfg 359

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146330970 224 STTTLSLSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRL 296
Cdd:PRK12662 360 TTKLEDCLNLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKWYILDAFIKSNAWIGLVVLLVGSGLSVIYVWKI 432
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 10-299 2.49e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 42.88  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  10 VLTIIMGTMIVMtSSHWLTVWIGFEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIInLLYSG------- 82
Cdd:PRK06589 123 NLTILIGVLIAL-SSDLFTMFVCYELLTISTAFLIGHTRNNISLSGGYKYLKILMISALLLFLPAVI-LIYTKtgnldfv 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  83 QWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPE-----------------VTQGIQLSSGLILLTWqKLAPMSILYQI 145
Cdd:PRK06589 201 SGGLFSKNQSIILLLMFIYGIAKTAIFPVHSWLPAamvahypvsallhavivVKTGLFCIYKILLYIF-GLSYLQRIFAE 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 146 FptinlNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGW--MTAIMAYNPTM--TLLNLVIYILLTTTTFM---- 217
Cdd:PRK06589 280 F-----NWLIFIPIVSIFYSSLKALKTDNIKKILAYSTISQLSLalLSAFILTPKALgaAILHLVSHSFAKICLFYsmgs 354

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 218 MFMLNSSTTTLSLSHTWNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMA----VTALLNLYFY 293
Cdd:PRK06589 355 IYSLKKEDQVDKLHGTSKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQPWLSIIVMlvviASSILSALYL 434


                 ....*.
gi 146330970 294 MRLTYS 299
Cdd:PRK06589 435 LKILSS 440
PRK07691 PRK07691
putative monovalent cation/H+ antiporter subunit D; Reviewed
 56-296 3.71e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 181085 [Multi-domain]  Cd Length: 496  Bit Score: 42.24  E-value: 3.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  56 STKYFLTQATASMLLMLAIIInlLYSgqwsITKPLN-------------------QTASIIMTLAMAMKLGLSPFHFWVP 116
Cdd:PRK07691 160 SIKYVLINVVSSAFFVVAVAI--LYS----VVGTLNmadisvkiaelsagqtgliTVVAILFLFVFATKAGLFPLYFWLP 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 117 EVTQG----IQLSSGLILLTWQKLAPMSILYQIF---PTINLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGW 189
Cdd:PRK07691 234 GSYYAppiaIAALFGALLTKVGVYAIARTFTLFFshdTSFTHYLILILALLTIIFGVIGAVAYFDIKKIIIYNIMIAVGV 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 190 MTAIMAYNPTMTLLNLVIY----ILLTTTTFM----MFMLNSSTTTLSLSHTWNKAPLLTMTILTIMLSMGGLPPLSGFL 261
Cdd:PRK07691 314 ILVGVAMMTESGMIGAIYYlihdMIVKAALFLligiMIKITGTTDLKKMGGLIKRYPVLGWMFFIAALSLAGIPPLSGFY 393

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 146330970 262 PKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRL 296
Cdd:PRK07691 394 GKFFIVEGTFEAGFYVSGIIVLLSSLLVLYSVIKI 428
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-332 4.65e-04

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 41.65  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970   1 MNPLIFTTIVLTIIMGTMIVMTSSHWLTVWIGFEMNML-AVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIII--- 76
Cdd:MTH00014  87 KAPKTFMTNILILNLILLLTFSASNLLMFYIFFEASLIpTLFLILGWGYQPERLQASFYLMIYTVTASLPLLMSILLify 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  77 -----NLLYSGQWSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPE------VTQGIQLSSGLILLTWQKLAPMSILYQI 145
Cdd:MTH00014 167 tnnslSMLMSSMEPPSIYLMNLWWLITILAFMVKMPLYTVHLWLPKahveapVAGSMILAGILLKLGGYGLLRMSSLFMH 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 146 FPTINLNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMAYNPTM----TLLNLVIYILLTTTTFMMFML 221
Cdd:MTH00014 247 INKSLSAPFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNTSWgwqgALAMMIAHGLCSSALFALANM 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 222 NSSTT-TLSLSHT---WNKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVKNDNIITPTIMAVTALLNLYFYMRLT 297
Cdd:MTH00014 327 TYETThTRSLFLTkglLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYT 406

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 146330970 298 YSTSLTMFPSTNNMKMKWQLNNTKSTAHVSPLIIL 332
Cdd:MTH00014 407 STQHGSPPSFMNPLNLFTPRNHTLMTLHLVPLFIL 441
PRK06277 PRK06277
energy conserving hydrogenase EhbF;
33-268 5.46e-04

energy conserving hydrogenase EhbF;


Pssm-ID: 235767 [Multi-domain]  Cd Length: 478  Bit Score: 41.56  E-value: 5.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  33 FEMNMLAVIPILMKNYNPRSMEASTKYFLTQATASMLLMLAIIINLLYSGQWSIT-----------KPLNQTASIIMTLA 101
Cdd:PRK06277 129 FEIAAIVQVGLVIASGTEEAYKAALKYMILGNVAGSILLLGIGFLLASTGTLNITdihnallvnptSPVIYGGLLLLIFG 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 102 MAMKLGLSPFHFWVPEVTQGIQLSSGLILLTWQKL---APMSILYQIF------PTINLnLMLLMSVLSVAIGGWGGLNQ 172
Cdd:PRK06277 209 LLYGSGLPPFHTIKSDIYAKAKPFGSALLQTFSKFvlvALMLVIFKLFgglsyfPSAQG-VLIALSVLAMVFGVVMALLQ 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 173 TQLRKIMAYSSIAHMGWMTAIMAYNPTMTL-------LNLVIYI-LLTTTTFMMFMLNSSTTTLSLSHTWNKAPLLTMTI 244
Cdd:PRK06277 288 TDYKRLLAYHAISQGGYVAAGLALGTPLGIvagifhaINHVIYKsALFLGAGIVSYRTKTSNLRKLGGLLPVMPVVAFMV 367

                        250       260
                 ....*....|....*....|....
gi 146330970 245 LTIMLSMGGLPPLSGFLPKWMIIQ 268
Cdd:PRK06277 368 LCAKLAISGVPPFNGFQSKLMLAQ 391
PRK12647 PRK12647
putative monovalent cation/H+ antiporter subunit A; Reviewed
 153-263 1.16e-03

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237156 [Multi-domain]  Cd Length: 761  Bit Score: 40.67  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 153 LMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMT---------AIMAYnptmtLLNLVIYILLTTTTFMMF-MLN 222
Cdd:PRK12647 261 ILPLFGGLTMLTGALLAVRQTDLKLILAYSTVSALGTLVmllglgselAIKAA-----VLFLVAHSLYKGALFMVAgIID 335

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 146330970 223 SSTTTLSLSHT---WNKAPLLTMTILTIMLSMGGLPPLSGFLPK 263
Cdd:PRK12647 336 HETGTRDITKLgglRRAMPITAAAALLAALSMAGLPPLFGFLAK 379
PRK06459 PRK06459
hydrogenase 4 subunit B; Validated
 14-277 2.00e-03

hydrogenase 4 subunit B; Validated


Pssm-ID: 235806 [Multi-domain]  Cd Length: 585  Bit Score: 39.77  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  14 IMGTMIVMTSSHWLTVWIGFEMNMLA---VIPILMKNYNPRSMeastkyFLTQATASMLLMLAIIINLLY-SGQWSITKP 89
Cdd:PRK06459  82 ILGMAIVLTSDNYLLFLAGWEIMTIPsyvAIALTKKNKRPAFV------FMAFGELSTVLILAGFAWAFIiSGTTNFSYL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  90 LNQTASIIMTLAMAMKLGLSPFHF--WVPEV------TQGIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLL-MSVL 160
Cdd:PRK06459 156 PSPVPLILASFGFIIKMGMMPFLVseWLPIAhgnapsNFSAILSATMTLMGVYGILKMTILTQTIPIGYFGLTILaIGAF 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 161 SVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIM-AYNPTMTLLNLVIYILLTTTTFMMFMLNSSTTTLSLS-------- 231
Cdd:PRK06459 236 SILFGALYAYVSENVKGLLAFSTIENNGAILVALgLYMVTKQLITSIEHFSLITVILYSFAHSVAKTGLFLSsglqekqs 315

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 146330970 232 HTWNKAPLLTMTILTIML---SMGGLPPLSGFLPKWMIIQEMVKNDNII 277
Cdd:PRK06459 316 ITYSKKIRNRWIELGLTLlasSLSGLLPNIGGVASWLLLESLFMFAYVL 364
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 52-190 3.74e-03

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 38.97  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  52 SMEASTKYFLTQATASMLLMLAIIINLLYSGQWSITKPLNQT----------------ASIIMTLAMAMKLGLSPFHFWV 115
Cdd:PRK08676 150 NIDAALKYIFIASTAMIFAFIGLIFLFSLTRQALGTGTLNWTelaahasllspsvlgaSFLFIFIGFLAKSGLVPFHTWL 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 116 PEV-TQGIQLSSGLILLTWQKLAPMSILY--------QIFPTINlNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAH 186
Cdd:PRK08676 230 PAAyAKAPSVVSALLSGTVLNIGIYGILRlsallrqsGAAEQFS-NVLIGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEH 308


                 ....
gi 146330970 187 MGWM 190
Cdd:PRK08676 309 MGLM 312
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 54-191 4.18e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 38.88  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  54 EASTKYFLTQATASMLLMLAIIINLLYSGQ--------WSITKPLNQTASIIMTLAMAMKLGLSPFHFWVPE-------- 117
Cdd:MTH00217 160 QASYYFFFYTFIGSVFMLLGIFTLYSYAGTtdyqalccLKIEKELQYFIFLGFFLSLAIKIPKIPFHIWLPQahveapva 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 118 ---VTQGIQLS---SGLILLTWQKLAPMSILYQifptinlNLMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMT 191
Cdd:MTH00217 240 gsvILAGVLLKlggYGFIRFSWPLLPEASEYFS-------PLIQTLSLLAIIYGSLTTCRQVDLKRIIAYSSVAHMGLVT 312
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 100-191 4.42e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 38.89  E-value: 4.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 100 LAMAMKLGLSPFHFWVPEVTQGIQLSSGLILL-TWQKLAPMSIL---YQIFPTINL---NLMLLMSVLSVAIGGWGGLNQ 172
Cdd:MTH00204 217 LSLAVKIPQIPFHIWLPQAHVEAPVAGSVILAgILLKLGGYGFLrfsWPLFPAASEyfaPLIVMLSVIAVIYGSLTTCRQ 296

                         90
                 ....*....|....*....
gi 146330970 173 TQLRKIMAYSSIAHMGWMT 191
Cdd:MTH00204 297 VDFKRLIAYSSVAHMGLVP 315
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 55-188 4.50e-03

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 38.86  E-value: 4.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970  55 ASTKYFLTQATASMLLMLAIIINLLYSGQW----------SITKPLNQTASIIMTLAMAMKLGLSPFHFWVP----EVTQ 120
Cdd:PRK12561 138 AATKFILYTALASIFILVAGLALALSGDTFtfdlaelgakSYPLALELLLYAGFLIAFGVKLPIFPLHTWLPdahgEASA 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146330970 121 GIQLSSGLILLTWQKLAPMSILYQIFPTINLNLMLLMSVLSVAIGGWGGLN---QTQLRKIMAYSSIAHMG 188
Cdd:PRK12561 218 PVSMILAGVLLKMGGYALIRFNVQMLPDAHVYFAPALAILGVVNIIYGALNafaQDNVKRRLAYSSVSHMG 288
PRK08042 PRK08042
formate hydrogenlyase subunit 3; Reviewed
 153-272 8.49e-03

formate hydrogenlyase subunit 3; Reviewed


Pssm-ID: 181206 [Multi-domain]  Cd Length: 593  Bit Score: 37.88  E-value: 8.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146330970 153 LMLLMSVLSVAIGGWGGLNQTQLRKIMAYSSIAHMG--------WMTAIMAYNPTMTLLNLV--IYILLTTTTFmmfmln 222
Cdd:PRK08042 247 ALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGiillglgaGVTGIALEQPALIALGLVggLYHLLNHSLF------ 320

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146330970 223 SSTTTLSLSHTW---------------NKAPLLTMTILTIMLSMGGLPPLSGFLPKWMIIQEMVK 272
Cdd:PRK08042 321 KSVLFLGAGSVWfrtghrdieklggigKKMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFK 385
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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