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Conserved domains on  [gi|1463288400|emb|SVJ61019|]
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cobalamin synthase [Klebsiella pneumoniae]

Protein Classification

adenosylcobinamide-GDP ribazoletransferase( domain architecture ID 10011333)

adenosylcobinamide-GDP ribazoletransferase catalyzes the formation of adenosylcobalamin from Ado-cobamide-GDP and alpha-ribazole

EC:  2.7.8.26
Gene Ontology:  GO:0051073|GO:0008818|GO:0009236

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
cobS PRK00235
cobalamin synthase; Reviewed
1-235 2.93e-67

cobalamin synthase; Reviewed


:

Pssm-ID: 234697  Cd Length: 249  Bit Score: 208.15  E-value: 2.93e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   1 MIKSFFAALSFISRLPVPArlSQGLEIEQYQRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFH 80
Cdd:PRK00235    3 MLRLFLAALSFLTRLPVPG--SVGGDPEDLRRAARAFPLVGLLLGALAALVYWLLQLGLPPLLAALLAVAALLLLTGGLH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  81 LDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGEllLRDIHPIAALAAACAVGRGMAVLLMYRH 160
Cdd:PRK00235   81 LDGLADTADGLGGGRDRERRLEIMKDSRIGTFGVLALVLVLLLKILALAA--LRPAGALAALILAPAASRAAAVLLIARL 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1463288400 161 RYAREKGLGNLFIGKISLQQTLVTMAMAIALATALLGL-QGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:PRK00235  159 PYARPEGLGAPFAGKLSGRQLLLALALGLALLLPLLGGwAGLLALLVALVAAFLLGRLFVRRLGGQTGDTLGAAQE 234
 
Name Accession Description Interval E-value
cobS PRK00235
cobalamin synthase; Reviewed
1-235 2.93e-67

cobalamin synthase; Reviewed


Pssm-ID: 234697  Cd Length: 249  Bit Score: 208.15  E-value: 2.93e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   1 MIKSFFAALSFISRLPVPArlSQGLEIEQYQRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFH 80
Cdd:PRK00235    3 MLRLFLAALSFLTRLPVPG--SVGGDPEDLRRAARAFPLVGLLLGALAALVYWLLQLGLPPLLAALLAVAALLLLTGGLH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  81 LDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGEllLRDIHPIAALAAACAVGRGMAVLLMYRH 160
Cdd:PRK00235   81 LDGLADTADGLGGGRDRERRLEIMKDSRIGTFGVLALVLVLLLKILALAA--LRPAGALAALILAPAASRAAAVLLIARL 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1463288400 161 RYAREKGLGNLFIGKISLQQTLVTMAMAIALATALLGL-QGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:PRK00235  159 PYARPEGLGAPFAGKLSGRQLLLALALGLALLLPLLGGwAGLLALLVALVAAFLLGRLFVRRLGGQTGDTLGAAQE 234
CobS COG0368
Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) [Coenzyme transport and ...
1-235 1.55e-64

Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) [Coenzyme transport and metabolism]; Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440137  Cd Length: 246  Bit Score: 201.15  E-value: 1.55e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   1 MIKSFFAALSFISRLPVPARLsqGLEIEQYQRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFH 80
Cdd:COG0368     1 ELRGFLLALQFLTRLPVPAPV--DVDEEDLARAVRYFPLVGLLIGLLLALVLLLLSLLLPPLLAALLAVAALVLLTGGLH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  81 LDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGELLLRDIhpIAALAAACAVGRGMAVLLMYRH 160
Cdd:COG0368    79 LDGLADTADGLGGGRDRERRLEIMKDSRIGAFGVLALVLVLLLKVAALASLAAAAA--LLALLAAPVLSRLAMVLLIATL 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1463288400 161 RYAREKGLGNLFIGKISLQQTLVTMAMAIALATALLGLQGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:COG0368   157 PYARPEGLGAPFAGGVSRRALLLALLLALLLALLLLGWAGLLALLAALLAALLLRRWARRRLGGITGDVLGAAQE 231
CobS pfam02654
Cobalamin-5-phosphate synthase; This is family of Colbalmin-5-phosphate synthases, CobS, from ...
8-235 3.30e-50

Cobalamin-5-phosphate synthase; This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyzes the synthesis of AdoCbl-5'-p from AdoCbi-GDP and alpha-ribazole-5'-P. This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop assembly stage in conjunction with CobC, CobU and CobT.


Pssm-ID: 460640  Cd Length: 215  Bit Score: 163.51  E-value: 3.30e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   8 ALSFISRLPVPARlsqgleieqyqRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFHLDGLADT 87
Cdd:pfam02654   1 ALSFLTRLPVPPG-----------RAARFFPLVGLLIGAILALAALLLLLLLPPLLAAALAVAALVLLTGGLHLDGLADT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  88 CDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGELLLRDIHPIaalAAACAVGRGMAVLLMYRHRYAREKG 167
Cdd:pfam02654  70 ADGLGSGRDRERKLEIMKDSRIGAFGVIALVLVLLLKVAALAALPAASLPAL---LAAPVLSRLAMLLLIARLPYARPEG 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1463288400 168 LGNLFIGKislqqtlVTMAMAIALATALLGLQGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:pfam02654 147 LGALFAGA-------SKRAVAALLALLLAALLLLAALLLAALLAALLLRRLARRLGGITGDVLGAAVE 207
cobS TIGR00317
cobalamin 5'-phosphate synthase/cobalamin synthase; cobS is involved with cobalamin ...
1-235 6.61e-50

cobalamin 5'-phosphate synthase/cobalamin synthase; cobS is involved with cobalamin biosynthesis in part III of colbalmin biosynthesis. The enzyme catyalzes the reactions adenosylcobinamide-GDP + alpha-ribazole-5'-P = adenosylcobalamin-5'-phosphate + GMP and adenosylcobinamide-GDP + alpha-ribazole = adenosylcobalamin + GMP. The protein product is associated with a large complex of proteins and is induced by cobinamide. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213524  Cd Length: 241  Bit Score: 163.38  E-value: 6.61e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   1 MIKSFFAALSFISRLPVPARlsqGLEIEQYQRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFH 80
Cdd:TIGR00317   1 MGKLLRAAISFLTRLPVPGS---WVDFERIARNIWLFPLVGILIGLASGIPGHILSAVLDNLLLAVVLYLFIEGLTGGHH 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  81 LDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGELLLRDIHPIAALAAACAVGRGMAVLLMYRH 160
Cdd:TIGR00317  78 LDGLADFGDGLFAPGSKERKLEAMKDSYTGTGGVVALIVVVLLKILALSSLSQRGLASYALIGAVCAKRSMLLLATASRP 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1463288400 161 ryaREKGLGNLFIGKISLQQTLVT--MAMAIALATALLGLQGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:TIGR00317 158 ---REEGTGRYFIEKARSRFTMIGviLGLPAVLALAGVPWLGLAALASAILIGLLVGRYAKRHFGGVTGDVLGASNE 231
 
Name Accession Description Interval E-value
cobS PRK00235
cobalamin synthase; Reviewed
1-235 2.93e-67

cobalamin synthase; Reviewed


Pssm-ID: 234697  Cd Length: 249  Bit Score: 208.15  E-value: 2.93e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   1 MIKSFFAALSFISRLPVPArlSQGLEIEQYQRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFH 80
Cdd:PRK00235    3 MLRLFLAALSFLTRLPVPG--SVGGDPEDLRRAARAFPLVGLLLGALAALVYWLLQLGLPPLLAALLAVAALLLLTGGLH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  81 LDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGEllLRDIHPIAALAAACAVGRGMAVLLMYRH 160
Cdd:PRK00235   81 LDGLADTADGLGGGRDRERRLEIMKDSRIGTFGVLALVLVLLLKILALAA--LRPAGALAALILAPAASRAAAVLLIARL 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1463288400 161 RYAREKGLGNLFIGKISLQQTLVTMAMAIALATALLGL-QGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:PRK00235  159 PYARPEGLGAPFAGKLSGRQLLLALALGLALLLPLLGGwAGLLALLVALVAAFLLGRLFVRRLGGQTGDTLGAAQE 234
CobS COG0368
Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) [Coenzyme transport and ...
1-235 1.55e-64

Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) [Coenzyme transport and metabolism]; Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440137  Cd Length: 246  Bit Score: 201.15  E-value: 1.55e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   1 MIKSFFAALSFISRLPVPARLsqGLEIEQYQRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFH 80
Cdd:COG0368     1 ELRGFLLALQFLTRLPVPAPV--DVDEEDLARAVRYFPLVGLLIGLLLALVLLLLSLLLPPLLAALLAVAALVLLTGGLH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  81 LDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGELLLRDIhpIAALAAACAVGRGMAVLLMYRH 160
Cdd:COG0368    79 LDGLADTADGLGGGRDRERRLEIMKDSRIGAFGVLALVLVLLLKVAALASLAAAAA--LLALLAAPVLSRLAMVLLIATL 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1463288400 161 RYAREKGLGNLFIGKISLQQTLVTMAMAIALATALLGLQGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:COG0368   157 PYARPEGLGAPFAGGVSRRALLLALLLALLLALLLLGWAGLLALLAALLAALLLRRWARRRLGGITGDVLGAAQE 231
CobS pfam02654
Cobalamin-5-phosphate synthase; This is family of Colbalmin-5-phosphate synthases, CobS, from ...
8-235 3.30e-50

Cobalamin-5-phosphate synthase; This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyzes the synthesis of AdoCbl-5'-p from AdoCbi-GDP and alpha-ribazole-5'-P. This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop assembly stage in conjunction with CobC, CobU and CobT.


Pssm-ID: 460640  Cd Length: 215  Bit Score: 163.51  E-value: 3.30e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   8 ALSFISRLPVPARlsqgleieqyqRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFHLDGLADT 87
Cdd:pfam02654   1 ALSFLTRLPVPPG-----------RAARFFPLVGLLIGAILALAALLLLLLLPPLLAAALAVAALVLLTGGLHLDGLADT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  88 CDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGELLLRDIHPIaalAAACAVGRGMAVLLMYRHRYAREKG 167
Cdd:pfam02654  70 ADGLGSGRDRERKLEIMKDSRIGAFGVIALVLVLLLKVAALAALPAASLPAL---LAAPVLSRLAMLLLIARLPYARPEG 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1463288400 168 LGNLFIGKislqqtlVTMAMAIALATALLGLQGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:pfam02654 147 LGALFAGA-------SKRAVAALLALLLAALLLLAALLLAALLAALLLRRLARRLGGITGDVLGAAVE 207
cobS TIGR00317
cobalamin 5'-phosphate synthase/cobalamin synthase; cobS is involved with cobalamin ...
1-235 6.61e-50

cobalamin 5'-phosphate synthase/cobalamin synthase; cobS is involved with cobalamin biosynthesis in part III of colbalmin biosynthesis. The enzyme catyalzes the reactions adenosylcobinamide-GDP + alpha-ribazole-5'-P = adenosylcobalamin-5'-phosphate + GMP and adenosylcobinamide-GDP + alpha-ribazole = adenosylcobalamin + GMP. The protein product is associated with a large complex of proteins and is induced by cobinamide. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213524  Cd Length: 241  Bit Score: 163.38  E-value: 6.61e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400   1 MIKSFFAALSFISRLPVPARlsqGLEIEQYQRSIVTFPLVGLLLGAIAGAVVLLLQPWCGVPLAALFGVLALALLTGGFH 80
Cdd:TIGR00317   1 MGKLLRAAISFLTRLPVPGS---WVDFERIARNIWLFPLVGILIGLASGIPGHILSAVLDNLLLAVVLYLFIEGLTGGHH 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1463288400  81 LDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGELLLRDIHPIAALAAACAVGRGMAVLLMYRH 160
Cdd:TIGR00317  78 LDGLADFGDGLFAPGSKERKLEAMKDSYTGTGGVVALIVVVLLKILALSSLSQRGLASYALIGAVCAKRSMLLLATASRP 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1463288400 161 ryaREKGLGNLFIGKISLQQTLVT--MAMAIALATALLGLQGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIE 235
Cdd:TIGR00317 158 ---REEGTGRYFIEKARSRFTMIGviLGLPAVLALAGVPWLGLAALASAILIGLLVGRYAKRHFGGVTGDVLGASNE 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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