NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|146324898|ref|XP_748790|]
View 

C6 finger domain protein, putative [Aspergillus fumigatus Af293]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10637801)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0008270|GO:0003700
PubMed:  9290251|16959962

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 178-220 5.63e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 5.63e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 146324898    178 HRAQQACDRCRARKAKCDKGRPSCGHCKENNLICVYKEVLPHK 220
Cdd:smart00066    1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 642-914 3.90e-11

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 66.31  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  642 GLSYYAYATQILGELQGANG-LPHVQAALLAGLYAGQLAHPFQSHGWIYQAARACQV--LVRSKRYDQMKDGPLKELYDF 718
Cdd:cd12148    76 AERYYEAARQLLDLALFLPPsLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSlgLHRDPSSLPGLSPFERELRRR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  719 AYWTCLQLESDILAELDLPaSGISRAESRISLP----KGRFTLPLQIEISAPSTMMMFFYSAQIYLRKFLNRVHTDLYKV 794
Cdd:cd12148   156 LWWSLYILDRLLSLSLGRP-PSISDEDIDVPLPsnedDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLLYSP 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  795 DRNRgpnkatnaagsasavkaaiaaitanpssntttttsssNNRWTSDVQEIFSMnLELWRNSLPEIMKWKDADPPSNDI 874
Cdd:cd12148   235 RASS-------------------------------------PEDSLETILELDAE-LEEWRASLPPELRLDSSSLESPSL 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 146324898  875 NVAR--MRAKYYGARYIIHRPLLYQALHFAGLPYPNPTSALV 914
Cdd:cd12148   277 LPQRllLHLLYHLLLILLHRPFLLRSLSSLSPSSSSAESRRA 318
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 4-150 1.57e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898    4 TDDKLNPLPPYSTPLPPSQAHHGVPPEAAHGLPNAPGAYNQSwcpYQPSLPPLkypaiPNRqlPQLPhEGPYDRPNNLPG 83
Cdd:PHA03247 2545 SDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRA---RRPDAPPQ-----SAR--PRAP-VDDRGDPRGPAP 2613

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146324898   84 PSHILTESHPPTFPHINRAPHYSIPPSAPPHPAPHPLPQLTAPEfrPQTIYPSQDHSSNGNPPSPPA 150
Cdd:PHA03247 2614 PSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA--PGRVSRPRRARRLGRAAQASS 2678
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 178-220 5.63e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 5.63e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 146324898    178 HRAQQACDRCRARKAKCDKGRPSCGHCKENNLICVYKEVLPHK 220
Cdd:smart00066    1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 179-214 2.23e-13

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 64.99  E-value: 2.23e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 146324898  179 RAQQACDRCRARKAKCDKGRPSCGHCKENNLICVYK 214
Cdd:cd00067     1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
182-215 1.02e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 63.09  E-value: 1.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....
gi 146324898   182 QACDRCRARKAKCDKGRPSCGHCKENNLICVYKE 215
Cdd:pfam00172    1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSR 34
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 642-914 3.90e-11

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 66.31  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  642 GLSYYAYATQILGELQGANG-LPHVQAALLAGLYAGQLAHPFQSHGWIYQAARACQV--LVRSKRYDQMKDGPLKELYDF 718
Cdd:cd12148    76 AERYYEAARQLLDLALFLPPsLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSlgLHRDPSSLPGLSPFERELRRR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  719 AYWTCLQLESDILAELDLPaSGISRAESRISLP----KGRFTLPLQIEISAPSTMMMFFYSAQIYLRKFLNRVHTDLYKV 794
Cdd:cd12148   156 LWWSLYILDRLLSLSLGRP-PSISDEDIDVPLPsnedDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLLYSP 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  795 DRNRgpnkatnaagsasavkaaiaaitanpssntttttsssNNRWTSDVQEIFSMnLELWRNSLPEIMKWKDADPPSNDI 874
Cdd:cd12148   235 RASS-------------------------------------PEDSLETILELDAE-LEEWRASLPPELRLDSSSLESPSL 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 146324898  875 NVAR--MRAKYYGARYIIHRPLLYQALHFAGLPYPNPTSALV 914
Cdd:cd12148   277 LPQRllLHLLYHLLLILLHRPFLLRSLSSLSPSSSSAESRRA 318
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-150 1.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898    4 TDDKLNPLPPYSTPLPPSQAHHGVPPEAAHGLPNAPGAYNQSwcpYQPSLPPLkypaiPNRqlPQLPhEGPYDRPNNLPG 83
Cdd:PHA03247 2545 SDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRA---RRPDAPPQ-----SAR--PRAP-VDDRGDPRGPAP 2613

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146324898   84 PSHILTESHPPTFPHINRAPHYSIPPSAPPHPAPHPLPQLTAPEfrPQTIYPSQDHSSNGNPPSPPA 150
Cdd:PHA03247 2614 PSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA--PGRVSRPRRARRLGRAAQASS 2678
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 8-167 7.80e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 7.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898     8 LNPLPPYSTPLPPSQAHHGVPPEA--AHGLPNAPGAYNQSWCPYQPSLPPLKYPAIPNRQLPQLPHEGPYD-RPNNL-PG 83
Cdd:pfam03154  206 VPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPpMPHSLqTG 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898    84 PSHILTESHPPTFPHINRAPHYSIPPSAPPHPAPHPLPQLTAPefrpqtiyPSQDHSSNGNPPS----PPAQSS------ 153
Cdd:pfam03154  286 PSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP--------PSQSQLQSQQPPReqplPPAPLSmphikp 357

                          170
                   ....*....|....*..
gi 146324898   154 ---TTISHISRTPAHQH 167
Cdd:pfam03154  358 pptTPIPQLPNPQSHKH 374
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 178-220 5.63e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 5.63e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 146324898    178 HRAQQACDRCRARKAKCDKGRPSCGHCKENNLICVYKEVLPHK 220
Cdd:smart00066    1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 179-214 2.23e-13

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 64.99  E-value: 2.23e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 146324898  179 RAQQACDRCRARKAKCDKGRPSCGHCKENNLICVYK 214
Cdd:cd00067     1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
182-215 1.02e-12

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 63.09  E-value: 1.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....
gi 146324898   182 QACDRCRARKAKCDKGRPSCGHCKENNLICVYKE 215
Cdd:pfam00172    1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSR 34
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 642-914 3.90e-11

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 66.31  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  642 GLSYYAYATQILGELQGANG-LPHVQAALLAGLYAGQLAHPFQSHGWIYQAARACQV--LVRSKRYDQMKDGPLKELYDF 718
Cdd:cd12148    76 AERYYEAARQLLDLALFLPPsLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSlgLHRDPSSLPGLSPFERELRRR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  719 AYWTCLQLESDILAELDLPaSGISRAESRISLP----KGRFTLPLQIEISAPSTMMMFFYSAQIYLRKFLNRVHTDLYKV 794
Cdd:cd12148   156 LWWSLYILDRLLSLSLGRP-PSISDEDIDVPLPsnedDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLLYSP 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898  795 DRNRgpnkatnaagsasavkaaiaaitanpssntttttsssNNRWTSDVQEIFSMnLELWRNSLPEIMKWKDADPPSNDI 874
Cdd:cd12148   235 RASS-------------------------------------PEDSLETILELDAE-LEEWRASLPPELRLDSSSLESPSL 276

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 146324898  875 NVAR--MRAKYYGARYIIHRPLLYQALHFAGLPYPNPTSALV 914
Cdd:cd12148   277 LPQRllLHLLYHLLLILLHRPFLLRSLSSLSPSSSSAESRRA 318
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-150 1.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898    4 TDDKLNPLPPYSTPLPPSQAHHGVPPEAAHGLPNAPGAYNQSwcpYQPSLPPLkypaiPNRqlPQLPhEGPYDRPNNLPG 83
Cdd:PHA03247 2545 SDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRA---RRPDAPPQ-----SAR--PRAP-VDDRGDPRGPAP 2613

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146324898   84 PSHILTESHPPTFPHINRAPHYSIPPSAPPHPAPHPLPQLTAPEfrPQTIYPSQDHSSNGNPPSPPA 150
Cdd:PHA03247 2614 PSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA--PGRVSRPRRARRLGRAAQASS 2678
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 8-167 7.80e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 7.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898     8 LNPLPPYSTPLPPSQAHHGVPPEA--AHGLPNAPGAYNQSWCPYQPSLPPLKYPAIPNRQLPQLPHEGPYD-RPNNL-PG 83
Cdd:pfam03154  206 VPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPpMPHSLqTG 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146324898    84 PSHILTESHPPTFPHINRAPHYSIPPSAPPHPAPHPLPQLTAPefrpqtiyPSQDHSSNGNPPS----PPAQSS------ 153
Cdd:pfam03154  286 PSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP--------PSQSQLQSQQPPReqplPPAPLSmphikp 357

                          170
                   ....*....|....*..
gi 146324898   154 ---TTISHISRTPAHQH 167
Cdd:pfam03154  358 pptTPIPQLPNPQSHKH 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH