NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1462843226|emb|SXF32735|]
View 

iron compound permease protein of ABC transporter family [Klebsiella variicola]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 33-338 1.80e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 244.59  E-value: 1.80e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  33 HLGLGARWIAPQTVLQALLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 113 VATSALGLSLGAFpaGRPLTAACGAALLFGGVMALASAGrGGATPLRITLCGVALSAFASAVTAAILIL-DEQTLLAMRT 191
Cdd:COG0609    81 VLAIVLGGGLSAL--GLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:COG0609   158 WLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843226 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG0609   238 GLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 33-338 1.80e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 244.59  E-value: 1.80e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  33 HLGLGARWIAPQTVLQALLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 113 VATSALGLSLGAFpaGRPLTAACGAALLFGGVMALASAGrGGATPLRITLCGVALSAFASAVTAAILIL-DEQTLLAMRT 191
Cdd:COG0609    81 VLAIVLGGGLSAL--GLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:COG0609   158 WLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843226 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG0609   238 GLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 34-338 4.17e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 203.14  E-value: 4.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  34 LGLGARWIAPQTVLQALLEYNPrNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVV 113
Cdd:pfam01032  10 LFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 114 ATSALGLSLGAFpaGRPLTAACGAALLFGGVMALASaGRGGATPLRITLCGVALSAFASAVTAAILIL-DEQTLLAMRTW 192
Cdd:pfam01032  89 LAILLGGSLSLF--ALPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQSILFW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 193 LAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVG 272
Cdd:pfam01032 166 LMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVG 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1462843226 273 LVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:pfam01032 246 LIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
41-338 9.33e-52

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 174.11  E-value: 9.33e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  41 IAPQTVLQALLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGL 120
Cdd:PRK11228   25 ISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 121 SLgaFPAGR-PLTAACGAALLFGGVMALASAGRGGATPLRITLCGVALSAFASAVTAAILILDEQTLLAMRTWLAGDLAG 199
Cdd:PRK11228  105 TP--FAGYSlAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSH 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 200 LNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVV 279
Cdd:PRK11228  183 ARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLA 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1462843226 280 RRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK11228  263 RFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-335 3.01e-43

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 150.01  E-value: 3.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  83 VAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSLgaFPAGRPLTAACGAALLFGGVMALASagRGGATPLRITL 162
Cdd:cd06550    13 VSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGL--SNYALGAFAFAGALAIALLVLLLAS--RGGLSPSKLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 163 CGVALSAFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVN 242
Cdd:cd06550    89 IGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGIN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 243 LVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVaPQELATGA 322
Cdd:cd06550   169 VNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-PSELPVGP 247

                         250
                  ....*....|...
gi 1462843226 323 MTALVGAPLFIFI 335
Cdd:cd06550   248 VTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 33-338 1.80e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 244.59  E-value: 1.80e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  33 HLGLGARWIAPQTVLQALLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 113 VATSALGLSLGAFpaGRPLTAACGAALLFGGVMALASAGrGGATPLRITLCGVALSAFASAVTAAILIL-DEQTLLAMRT 191
Cdd:COG0609    81 VLAIVLGGGLSAL--GLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:COG0609   158 WLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843226 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG0609   238 GLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 34-338 4.17e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 203.14  E-value: 4.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  34 LGLGARWIAPQTVLQALLEYNPrNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVV 113
Cdd:pfam01032  10 LFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 114 ATSALGLSLGAFpaGRPLTAACGAALLFGGVMALASaGRGGATPLRITLCGVALSAFASAVTAAILIL-DEQTLLAMRTW 192
Cdd:pfam01032  89 LAILLGGSLSLF--ALPLAAFIGALLAALLVYFLSR-GRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQSILFW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 193 LAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVG 272
Cdd:pfam01032 166 LMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVG 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1462843226 273 LVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:pfam01032 246 LIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
41-338 9.33e-52

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 174.11  E-value: 9.33e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  41 IAPQTVLQALLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGL 120
Cdd:PRK11228   25 ISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 121 SLgaFPAGR-PLTAACGAALLFGGVMALASAGRGGATPLRITLCGVALSAFASAVTAAILILDEQTLLAMRTWLAGDLAG 199
Cdd:PRK11228  105 TP--FAGYSlAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSH 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 200 LNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVV 279
Cdd:PRK11228  183 ARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLA 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1462843226 280 RRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK11228  263 RFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 8-338 1.16e-48

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 166.45  E-value: 1.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226   8 AARRHARPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQALLEYNPRnFDQRIIVDLRLVRLAAALLTGAALGVAGLL 87
Cdd:COG4779    15 SLRLRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDP-GASFVVLELRLPRALAALLVGAALGLSGAI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  88 LQTVIRNPLGEPHILGLNAGASLAVVATSALglsLGAFPAGRPLTAACGAALLFGGVMALAsaGRGGATPLRITLCGVAL 167
Cdd:COG4779    94 FQSLTRNPLASPDIIGITAGASAGAVAAIVV---LGGSGLAVALGALAGGLATALLVYLLA--WRGGVSGYRLILVGIGV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 168 SAFASAVTAAILI-LDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQT 246
Cdd:COG4779   169 SAMLTAVNSYLLTrADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERT 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 247 RLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDiRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTAL 326
Cdd:COG4779   249 RLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSP-GPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGA 327

                         330
                  ....*....|..
gi 1462843226 327 VGAPLFIFIAAR 338
Cdd:COG4779   328 LGGPYLLWLLIR 339
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
8-338 1.75e-48

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 172.72  E-value: 1.75e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226   8 AARRHARPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQALLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLL 87
Cdd:PRK10577    3 RLMSRRRARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  88 LQTVIRNPLGEPHILGLNAGASLAVVATSALGLSLGAFpaGRPLTAACGAALLFGGVMALAsaGRGGATPLRITLCGVAL 167
Cdd:PRK10577   83 LQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALLAL--ASQLAAFAGGLLAAALVFALA--GGKRLSPLRLVLAGMVV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 168 SAFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTR 247
Cdd:PRK10577  159 SLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 248 LLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTL--VAPQELATGAMTA 325
Cdd:PRK10577  239 LAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTA 318

                         330
                  ....*....|...
gi 1462843226 326 LVGAPLFIFIAAR 338
Cdd:PRK10577  319 LIGAPLLLWLLPR 331
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
34-338 4.77e-44

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 154.09  E-value: 4.77e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  34 LGLGARWIAPQTVLQALLEYNpRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVV 113
Cdd:PRK10441   28 LLIGAKSLPASVVLEALSGTC-QSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 114 atsaLGLSLGAF--PAGRPLTAACGAALLFGGVMALASAGRGGATPLRITLCGVALSAFASAVTAAILILDEQTLLAMRT 191
Cdd:PRK10441  107 ----LGAALFGYssAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRF 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:PRK10441  183 WQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFI 262

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1462843226 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVaPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK10441  263 GLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRR 328
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 83-335 3.01e-43

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 150.01  E-value: 3.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  83 VAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSLgaFPAGRPLTAACGAALLFGGVMALASagRGGATPLRITL 162
Cdd:cd06550    13 VSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGL--SNYALGAFAFAGALAIALLVLLLAS--RGGLSPSKLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 163 CGVALSAFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVN 242
Cdd:cd06550    89 IGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGIN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 243 LVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVaPQELATGA 322
Cdd:cd06550   169 VNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-PSELPVGP 247

                         250
                  ....*....|...
gi 1462843226 323 MTALVGAPLFIFI 335
Cdd:cd06550   248 VTALLGAPYFLYL 260
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 32-338 1.14e-42

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 150.39  E-value: 1.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  32 VHLGLGARWIAPQTVLQALLEYnprnfdqrIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLA 111
Cdd:COG4139    28 LSLCAGEVWIPPTQWLSEAWQL--------FVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 112 VVATSALGLSLGAfPAGRPLTAACGAALLFGGVMALASAGRGGAtplRITLCGVALSAFASA-VTAAILILDEQTLLAMR 190
Cdd:COG4139   100 LVLVVLLGGGLLP-PWLLSLAAIAGALLVTLLLLAFARRRLSNA---RLLLIGVALGIICSAiMTWAVYFSSSLDLRQLM 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 191 TWLAGDLAGLNWSTLQTaLVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGF 270
Cdd:COG4139   176 YWMMGSFGGVDWRQLWL-LLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGF 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1462843226 271 VGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:COG4139   255 VGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLR 322
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
63-334 8.49e-42

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 154.23  E-value: 8.49e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  63 IVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVAtsALGLSLGAFPAGRPLTAACGAALLFG 142
Cdd:PRK10577  393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVL--ALFLVPGAGFGWLLAAALLGALAALA 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 143 GVMALAsaGRGGATPLRITLCGVALSAFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTALVPALIGLGVALLI 222
Cdd:PRK10577  471 LILLLA--RRGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLL 548

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 223 APRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVL 302
Cdd:PRK10577  549 RRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLM 628

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1462843226 303 VLADIAARTLVAPQELATGAMTALVGAPLFIF 334
Cdd:PRK10577  629 VLADWLGRTLLFPYQIPAGLLAALIGAPYFLW 660
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
50-338 4.40e-40

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 143.26  E-value: 4.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  50 LLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGLSLGAFpaGR 129
Cdd:PRK09777   34 LTDWQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPVM--WL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 130 PLTAACGAALLFGGVMALAsagrGGATPLRITLCGVALSAFASAVTAAILILDEQTLLAMRTWLAGDLAGLNWSTLQTAL 209
Cdd:PRK09777  112 PLLAFIGGMAGLILLKMLA----GTHQPMKLALTGVALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVAL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 210 VPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRL 289
Cdd:PRK09777  188 PWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRR 267

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1462843226 290 ALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVGAPLFIFIAAR 338
Cdd:PRK09777  268 LLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVR 316
btuC PRK09535
cobalamin ABC transporter permease BtuC;
33-335 3.96e-39

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 142.20  E-value: 3.96e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  33 HLGLGARWIAPQTVLQALLEYNPRNFDQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAV 112
Cdd:PRK09535   61 VLSVGLSLPAPDLEYASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 113 VATSALGLSLgafPAGRPLTAACGAALLFGGVMALASagRGGATPL-RITLCGVALSAFASAVTAAILILDEQTLLAMRT 191
Cdd:PRK09535  141 VAAIVLPLAV---PFGLQAAAFAGALVAAFGVYAIAT--ENGRTPVaTLLLAGVAVQTFLGAVISYLLLHSGESLRRAVY 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 192 WLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIGFV 271
Cdd:PRK09535  216 WLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFV 295

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1462843226 272 GLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTlvAPQELATGAMTALVGAPLFIFI 335
Cdd:PRK09535  296 GLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYL 357
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 7-338 2.26e-37

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 136.62  E-value: 2.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226   7 YAARRHARPRLALLLLTLLLIAASLVHLGLGARWIAPQTVLQAlleynprnFDQRIIVDLRLVRLAAALLTGAALGVAGL 86
Cdd:PRK03784    6 LARQQQRRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWLSP--------RGELFVWQLRLPRTLAVLLVGAALAVSGA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  87 LLQTVIRNPLGEPHILGLNAGASLAVVATSALGlsLGAFPAGRPLTAACGAALLFgGVMALASAGRGGATPLRITLCGVA 166
Cdd:PRK03784   78 VMQALFENPLAEPGLLGVSNGAGVALVAAVLLG--QGLLPPWALSLCAIAGALLI-TLILLRFARRHRLSTSRLLLAGVA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 167 LSAFASA-VTAAILILDEQTLLAMRTWLAGDLAGLNW--STLQTALVPALIGLGvalLIAPRLNVLALGDKVALGLGVNL 243
Cdd:PRK03784  155 LGIICSAlMTWAVYFSTSLDLRQLMYWMMGGFGGVDWrqSWLMLALLPVLIWLC---CQGRPLNMLALGEISARQLGLPL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 244 VQTRLLGLLAIALLCGAAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAM 323
Cdd:PRK03784  232 WFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVV 311

                         330
                  ....*....|....*
gi 1462843226 324 TALVGAPLFIFIAAR 338
Cdd:PRK03784  312 TATLGAPVFIWLLLR 326
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
34-328 7.11e-28

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 110.96  E-value: 7.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226  34 LGLGARWIAPQTVLQALLEYNPRNFdQRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVV 113
Cdd:PRK10440   27 LRSGAVTLETSQVFAALMGDAPRSM-TMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 114 ATSALglslgafpAGRPLTAACGAALLFGGVMALAS---AGRGGATPLRITLCGVALSAFASAVTAAILILDE-QTLLAM 189
Cdd:PRK10440  106 VAMVL--------FGQDLTAIALAAMAGGIVTSLLVwllAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASlETALTA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1462843226 190 RTWLAGDLAGLNWSTLQTALVPALIGLGVALLIAPRLNVLALGDKVALGLGVNLVQTRLLGLLAIALLCGAAVAVAGPIG 269
Cdd:PRK10440  178 GLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPIS 257

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1462843226 270 FVGLVVPHVVRRLvTEDIRLALPLAAPVGALVLVLADIAARTLVAPQELATGAMTALVG 328
Cdd:PRK10440  258 FIALVAPHIARRL-SGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLG 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH