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Conserved domains on  [gi|14577917|ref|NP_005746|]
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interleukin-27 subunit beta precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10637190)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-27 subunit beta that associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 129-224 7.73e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 7.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917 129 PDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIfslKYWIRYKRQGAARFHRV--GPIEATSFILRAVRPRARYYVQVAAQ 206
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPIT---GYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                        90
                ....*....|....*...
gi 14577917 207 dlTDYGElSDWSLPATAT 224
Cdd:cd00063  78 --NGGGE-SPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 47-115 5.41e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 5.41e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14577917     47 SWTLPPAPNSTSpvsFIATYRLGMAARGHSWPCLQQTPTSTSCTITDvqLFSMAPYVLNVTAVHPWGSS 115
Cdd:smart00060  20 SWEPPPDDGITG---YIVGYRVEYREEGSEWKEVNVTPSSTSYTLTG--LKPGTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 129-224 7.73e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 7.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917 129 PDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIfslKYWIRYKRQGAARFHRV--GPIEATSFILRAVRPRARYYVQVAAQ 206
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPIT---GYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                        90
                ....*....|....*...
gi 14577917 207 dlTDYGElSDWSLPATAT 224
Cdd:cd00063  78 --NGGGE-SPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 129-207 7.02e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 7.02e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14577917    129 PDPPEGVRLSPLAERQLQVQWEPPGSwPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQD 207
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPD-DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
85-227 1.26e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.54  E-value: 1.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917  85 TSTSCTITDVQLFSMAPYVLNVTAVHPWGSSS-SFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPgswpfPEIFSL 163
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESApSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV-----TESDAT 262

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14577917 164 KYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTdyGELSDWSLPATATMSL 227
Cdd:COG3401 263 GYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA--GNESAPSNVVSVTTDL 324
fn3 pfam00041
Fibronectin type III domain;
130-215 1.50e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.02  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917   130 DPPEGVRLSPLAERQLQVQWEPPGSWPFP-EIFSLKYWIryKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDL 208
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPiTGYEVEYRP--KNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 14577917   209 TDYGELS 215
Cdd:pfam00041  79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 47-115 5.41e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 5.41e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14577917     47 SWTLPPAPNSTSpvsFIATYRLGMAARGHSWPCLQQTPTSTSCTITDvqLFSMAPYVLNVTAVHPWGSS 115
Cdd:smart00060  20 SWEPPPDDGITG---YIVGYRVEYREEGSEWKEVNVTPSSTSYTLTG--LKPGTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 129-224 7.73e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 7.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917 129 PDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIfslKYWIRYKRQGAARFHRV--GPIEATSFILRAVRPRARYYVQVAAQ 206
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPIT---GYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                        90
                ....*....|....*...
gi 14577917 207 dlTDYGElSDWSLPATAT 224
Cdd:cd00063  78 --NGGGE-SPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 129-207 7.02e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 7.02e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14577917    129 PDPPEGVRLSPLAERQLQVQWEPPGSwPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQD 207
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPD-DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
85-227 1.26e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.54  E-value: 1.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917  85 TSTSCTITDVQLFSMAPYVLNVTAVHPWGSSS-SFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPgswpfPEIFSL 163
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESApSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPV-----TESDAT 262

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14577917 164 KYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTdyGELSDWSLPATATMSL 227
Cdd:COG3401 263 GYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA--GNESAPSNVVSVTTDL 324
fn3 pfam00041
Fibronectin type III domain;
130-215 1.50e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.02  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917   130 DPPEGVRLSPLAERQLQVQWEPPGSWPFP-EIFSLKYWIryKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDL 208
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPiTGYEVEYRP--KNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 14577917   209 TDYGELS 215
Cdd:pfam00041  79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
85-224 3.12e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.53  E-value: 3.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14577917  85 TSTSCTITDVQLFSMAPYVLNVTAVHPWGSSS--SFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFpeifs 162
Cdd:COG3401 281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESapSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDADV----- 355

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14577917 163 LKYWIRYKRQGAARFHRVG-PIEATSFILRAVRPRARYYVQVAAQDltDYGELSDWSLPATAT 224
Cdd:COG3401 356 TGYNVYRSTSGGGTYTKIAeTVTTTSYTDTGLTPGTTYYYKVTAVD--AAGNESAPSEEVSAT 416
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 47-115 5.41e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 5.41e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14577917     47 SWTLPPAPNSTSpvsFIATYRLGMAARGHSWPCLQQTPTSTSCTITDvqLFSMAPYVLNVTAVHPWGSS 115
Cdd:smart00060  20 SWEPPPDDGITG---YIVGYRVEYREEGSEWKEVNVTPSSTSYTLTG--LKPGTEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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