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Conserved domains on  [gi|145567185|gb|ABP81969|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Microcebus simmonsi]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.88e-36

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.11  E-value: 2.88e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  1 MPSISININLALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 145567185 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.88e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.11  E-value: 2.88e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  1 MPSISININLALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 145567185 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
10-98 1.03e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 50.64  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  10 LALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDY 89
Cdd:pfam00420  7 GLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDD 86


                 ....*....
gi 145567185  90 IQNLNLLQC 98
Cdd:pfam00420 87 VDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.88e-36

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 118.11  E-value: 2.88e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  1 MPSISININLALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 145567185 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.88e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 78.08  E-value: 1.88e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  1 MPSISININLALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 145567185 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 9.46e-19

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 73.73  E-value: 9.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  1 MPSISININLALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 145567185 81 VSNNYGLDYIQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 15-98 2.91e-15

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 65.01  E-value: 2.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185 15 ALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDYIQNLN 94
Cdd:MTH00067 15 GLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVATTRTHGTDHLKNLN 94


                ....
gi 145567185 95 LLQC 98
Cdd:MTH00067 95 LLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 15-96 8.02e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 50.71  E-value: 8.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185 15 ALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDYIQNLN 94
Cdd:MTH00181 12 LLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSDHLLKFN 91


                ..
gi 145567185 95 LL 96
Cdd:MTH00181 92 LL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
10-98 1.03e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 50.64  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  10 LALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDY 89
Cdd:pfam00420  7 GLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDD 86


                 ....*....
gi 145567185  90 IQNLNLLQC 98
Cdd:pfam00420 87 VDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 2.89e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 49.53  E-value: 2.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185  1 MPSISININLALATALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMPILLLVFAACEAAIGLALLVM 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 145567185 81 VSNNYGLDYIQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 15-98 4.32e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 43.81  E-value: 4.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185 15 ALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFtmSFTMPILLLVFAACEAAIGLALLVMVSNNYGLDYIQNLN 94
Cdd:MTH00188 16 GLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLIRSHGSDYVSSLN 93


                ....
gi 145567185 95 LLQC 98
Cdd:MTH00188 94 LIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 15-98 4.05e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 41.37  E-value: 4.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185 15 ALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFTMpiLLLVFAACEAAIGLALLVMVSNNYGLDYIQNLN 94
Cdd:MTH00149 16 GVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFL--IILTFGACEASLGLSLLVSLIRLHGNDYVSSLS 93


                ....
gi 145567185 95 LLQC 98
Cdd:MTH00149 94 SLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 16-92 1.51e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 39.75  E-value: 1.51e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145567185 16 LLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFtmPILLLVFAACEAAIGLALLVMVSNNYGLDYIQN 92
Cdd:MTH00162 15 LLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYF--LLFFLTFSVCEGALGLSILVSMIRSHGNDYFSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 15-98 9.93e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 37.81  E-value: 9.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145567185 15 ALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLTILNMQFTMSFtMPILLLVFAACEAAIGLALLVMVSNNYGLDYIQNLN 94
Cdd:MTH00013 15 SMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVLMTRSYGNDMLKSLT 93


                ....
gi 145567185 95 LLQC 98
Cdd:MTH00013 94 SNKC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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