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Conserved domains on  [gi|145533787|ref|XP_001452638|]
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uncharacterized protein GSPATT00002641001 [Paramecium tetraurelia]

Protein Classification

succinate--CoA ligase [ADP/GDP-forming] subunit alpha( domain architecture ID 11488210)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 1-310 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


:

Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 583.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   1 MIGKQIFRAFSSTTAPYVWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHL--GLPVFKDCQEAKSA 78
Cdd:PTZ00187   7 MILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  79 TGCDASVIYVPPPTAASAIIEAIEAQIGLVVVITDGIPQHDMIKVKHALRSQSVTRVIGPNCPGIIKPNECKIGIMPGYI 158
Cdd:PTZ00187  87 TGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 159 HQNGKIGIVSRSGTLTYEAVDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWI 238
Cdd:PTZ00187 167 HKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWI 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145533787 239 kKNNPKNKPVVGFIAGITAPPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVMKEKG 310
Cdd:PTZ00187 247 -KNNPIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 1-310 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 583.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   1 MIGKQIFRAFSSTTAPYVWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHL--GLPVFKDCQEAKSA 78
Cdd:PTZ00187   7 MILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  79 TGCDASVIYVPPPTAASAIIEAIEAQIGLVVVITDGIPQHDMIKVKHALRSQSVTRVIGPNCPGIIKPNECKIGIMPGYI 158
Cdd:PTZ00187  87 TGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 159 HQNGKIGIVSRSGTLTYEAVDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWI 238
Cdd:PTZ00187 167 HKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWI 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145533787 239 kKNNPKNKPVVGFIAGITAPPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVMKEKG 310
Cdd:PTZ00187 247 -KNNPIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 18-307 7.76e-178

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 492.65  E-value: 7.76e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  18 VWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASAI 97
Cdd:COG0074    2 ILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  98 IEAIEAQIGLVVVITDGIPQHDMIKVKHALRSQSvTRVIGPNCPGIIKPNECKIGIMPGYIHQNGKIGIVSRSGTLTYEA 177
Cdd:COG0074   82 LEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKG-TRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 178 VDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWIKKNNpkNKPVVGFIAGITA 257
Cdd:COG0074  161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENM--TKPVVAYIAGRTA 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 145533787 258 PPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVMK 307
Cdd:COG0074  239 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 18-306 2.59e-159

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 445.71  E-value: 2.59e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   18 VWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASAI 97
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   98 IEAIEAQIGLVVVITDGIPQHDMIKVKHALrSQSVTRVIGPNCPGIIKPNECKIGIMPGYIHQNGKIGIVSRSGTLTYEA 177
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYM-EESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  178 VDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWIKKNnpKNKPVVGFIAGITA 257
Cdd:TIGR01019 160 VHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQN--MSKPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 145533787  258 PPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVM 306
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 167-289 2.08e-33

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 119.29  E-value: 2.08e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  167 VSRSGTLTYEAVDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIG-GENEEMAADWIKKNN--- 242
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGyGACEDPAGGLLKAIKear 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 145533787  243 PKNKPVVGFIAGITAPPERRMGHAGAIVSKGKGSAPEKIRALEQAGI 289
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGA 127
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 20-115 4.01e-26

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 99.12  E-value: 4.01e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787    20 VNKHTKVICQGITGNQGTFQTEQALN---YFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASA 96
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMRNlleYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 145533787    97 IIEAIEAQIGLVVVITDGI 115
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 1-310 0e+00

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 583.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   1 MIGKQIFRAFSSTTAPYVWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHL--GLPVFKDCQEAKSA 78
Cdd:PTZ00187   7 MILKVSFRARSSTSAPRVWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  79 TGCDASVIYVPPPTAASAIIEAIEAQIGLVVVITDGIPQHDMIKVKHALRSQSVTRVIGPNCPGIIKPNECKIGIMPGYI 158
Cdd:PTZ00187  87 TGADASVIYVPPPHAASAIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKTRLIGPNCPGIIKPGECKIGIMPGHI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 159 HQNGKIGIVSRSGTLTYEAVDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWI 238
Cdd:PTZ00187 167 HKKGKIGIVSRSGTLTYEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWI 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145533787 239 kKNNPKNKPVVGFIAGITAPPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVMKEKG 310
Cdd:PTZ00187 247 -KNNPIKKPVVSFIAGITAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMKKKG 317
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 18-307 7.76e-178

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 492.65  E-value: 7.76e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  18 VWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASAI 97
Cdd:COG0074    2 ILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  98 IEAIEAQIGLVVVITDGIPQHDMIKVKHALRSQSvTRVIGPNCPGIIKPNECKIGIMPGYIHQNGKIGIVSRSGTLTYEA 177
Cdd:COG0074   82 LEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKG-TRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 178 VDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWIKKNNpkNKPVVGFIAGITA 257
Cdd:COG0074  161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENM--TKPVVAYIAGRTA 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 145533787 258 PPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVMK 307
Cdd:COG0074  239 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 18-309 1.68e-175

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 486.99  E-value: 1.68e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  18 VWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASAI 97
Cdd:PRK05678   3 ILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAADAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  98 IEAIEAQIGLVVVITDGIPQHDMIKVKHALRsQSVTRVIGPNCPGIIKPNECKIGIMPGYIHQNGKIGIVSRSGTLTYEA 177
Cdd:PRK05678  83 LEAIDAGIDLIVCITEGIPVLDMLEVKAYLE-RKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYEA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 178 VDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWIKKNnpKNKPVVGFIAGITA 257
Cdd:PRK05678 162 VAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKAN--VTKPVVGYIAGVTA 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145533787 258 PPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVMKEK 309
Cdd:PRK05678 240 PPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLKGL 291
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 16-312 1.42e-170

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 474.84  E-value: 1.42e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  16 PYVWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAAS 95
Cdd:PLN00125   5 PAVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPFAAA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  96 AIIEAIEAQIGLVVVITDGIPQHDMIKVKHALRSQSVTRVIGPNCPGIIKPNECKIGIMPGYIHQNGKIGIVSRSGTLTY 175
Cdd:PLN00125  85 AILEAMEAELDLVVCITEGIPQHDMVRVKAALNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 176 EAVDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWIKKNNpKNKPVVGFIAGI 255
Cdd:PLN00125 165 EAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESG-TEKPVVAFIAGL 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145533787 256 TAPPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVMKEKGLA 312
Cdd:PLN00125 244 TAPPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFKERGLL 300
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 18-306 2.59e-159

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 445.71  E-value: 2.59e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   18 VWVNKHTKVICQGITGNQGTFQTEQALNYFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASAI 97
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   98 IEAIEAQIGLVVVITDGIPQHDMIKVKHALrSQSVTRVIGPNCPGIIKPNECKIGIMPGYIHQNGKIGIVSRSGTLTYEA 177
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYM-EESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  178 VDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIGGENEEMAADWIKKNnpKNKPVVGFIAGITA 257
Cdd:TIGR01019 160 VHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQN--MSKPVVGFIAGATA 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 145533787  258 PPERRMGHAGAIVSKGKGSAPEKIRALEQAGIRVVKSPAQIGKTMLEVM 306
Cdd:TIGR01019 238 PPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 167-289 2.08e-33

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 119.29  E-value: 2.08e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  167 VSRSGTLTYEAVDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLERFMVDPETEGIVMIGEIG-GENEEMAADWIKKNN--- 242
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGyGACEDPAGGLLKAIKear 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 145533787  243 PKNKPVVGFIAGITAPPERRMGHAGAIVSKGKGSAPEKIRALEQAGI 289
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGA 127
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 21-114 5.56e-27

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 101.52  E-value: 5.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787   21 NKHTKVICQGITGN--QGT-FQTEQALNYFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASAI 97
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 145533787   98 IEAIEAQIGLVVVITDG 114
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 20-115 4.01e-26

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 99.12  E-value: 4.01e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787    20 VNKHTKVICQGITGNQGTFQTEQALN---YFTKMVGGVSPKKAGSTHLGLPVFKDCQEAKSATGCDASVIYVPPPTAASA 96
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMRNlleYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 145533787    97 IIEAIEAQIGLVVVITDGI 115
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 60-294 1.08e-24

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 104.13  E-value: 1.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  60 GSTHLGLPVFKDCQEA-KSATGCDASVIYVPPPTAASAIIEAI-EAQIGLVVVITDGIPQHDMIKVKHALRSQSVTrVIG 137
Cdd:PLN02522  57 GQEEIAIPVHGSIEAAcKAHPTADVFINFASFRSAAASSMEALkQPTIRVVAIIAEGVPESDTKQLIAYARANNKV-VIG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 138 PNCPGIIKPNECKIGIMPGYI--------HQNGKIGIVSRSGTLTYEAVDQTTRAGLGQSTVVGIGGDPFNGTNFIDVLE 209
Cdd:PLN02522 136 PATVGGIQAGAFKIGDTAGTLdniiqcklYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYEGIAIGGDVFPGSTLSDHVL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 210 RFMVDPETEGIVMIGEIGGENEEMAADWIKKNNpKNKPVVGFIAGITA---PPERRMGHAGAIVSKGKGSAPEKIRALEQ 286
Cdd:PLN02522 216 RFNNIPQIKMIVVLGELGGRDEYSLVEALKQGK-VSKPVVAWVSGTCArlfKSEVQFGHAGAKSGGDMESAQAKNKALKD 294


                 ....*...
gi 145533787 287 AGIRVVKS 294
Cdd:PLN02522 295 AGAIVPTS 302
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 162-307 1.39e-09

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 55.55  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  162 GKIGIVSRSGTLTYEAVDQTTRAGLGQSTVVGIGgdpfNGT--NFIDVLERFMVDPETEGIVM-IGEIGGENEEMAAdwI 238
Cdd:pfam13607   2 GNIALVSQSGALGAALLDWARSRGIGFSKFVSLG----NEAdvDFADLLEYLADDPETRVILLyLEGIRDGRRFLRA--A 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145533787  239 KKNNpKNKPVVGFIAGITAPPER-RMGHAGAIVSkgkgsaPEKIR--ALEQAGIRVVKSPAQigktMLEVMK 307
Cdd:pfam13607  76 RRAA-RRKPVVVLKAGRSEAGARaAASHTGALAG------SDAVYdaAFRQAGVIRVDDLEE----LFDAAE 136
PRK06091 PRK06091
membrane protein FdrA; Validated
 86-261 2.02e-06

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 48.89  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787  86 IYVPPPTAASAIIEAIEAqiGL-VVVITDGIPQHDMIKVKHALRSQSVTrVIGPNC-PGIIK------PNeckigIMPgy 157
Cdd:PRK06091 123 ISVAGEYAAELAEQALDR--NLnVMMFSDNVTLEDEIRLKTRAREKGLL-VMGPDCgTAMIAgtplafAN-----VMP-- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145533787 158 ihqNGKIGIVSRSGTLTYEAVDQTTRAGLGQSTVVGIGGDPFN----GTNFIDVLERFMVDPETEGIVMIGEigGENEEM 233
Cdd:PRK06091 193 ---EGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSaevgGISALTALEMLSADEKSEVIAFVSK--PPAEAV 267

                        170       180
                 ....*....|....*....|....*...
gi 145533787 234 AADWIKKNNPKNKPVVGFIAGITAPPER 261
Cdd:PRK06091 268 RLKIINAMKATGKPVVALFLGYTPAVAR 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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