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Conserved domains on  [gi|145345019|ref|XP_001417021|]
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predicted protein [Ostreococcus lucimarinus CCE9901]

Protein Classification

steroid 5-alpha reductase family protein( domain architecture ID 11476951)

steroid 5-alpha reductase family protein similar to Arabidopsis thaliana very-long-chain enoyl-CoA reductase that catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle.

EC:  1.3.1.-
Gene Ontology:  GO:0016491|GO:0042761

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 1-310 0e+00

enoyl-CoA reductase


:

Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 548.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019   1 MKLQIVTRSGRAVVAGGLVVPNDAKVSDLKRSFHALKRKFYPSRQRFTTVPARGETRGTALRDDTLLSEYGLNDGDTIVF 80
Cdd:PLN02560   1 MKVTVVSRSGREIIKGGLEVPDSATVADLKKAIHKRKKKYYPSRQRLTLPLPPGKTRPTVLDDSKSLKDYGLGDGGTVVF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019  81 KDLGPQVSYKAVFFFEYLGPLLAYLPFYFMRKeIYGgIFGIKnAGKPVLEAQTLAMYFHTAHYAKRILETFFVHKFSHAT 160
Cdd:PLN02560  81 KDLGPQVSYRTLFFFEYLGPLLIYPLFYFFPQ-VYK-YFGYP-ARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHAT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019 161 MPIFNLMRNCGYYWTFGAFMSYFINHPAYTPVGRTQMMAGFAFSAVMQLSNLRCHIILANLRK-DGAKGYVIPTGFLFNY 239
Cdd:PLN02560 158 SPLFNVFRNCAYYWTFGAYIAYFVNHPLYTPVSETQMKVGFGFGLVCQLANFYCHIILRNLRKpDGKGGYQIPRGFLFNY 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145345019 240 VTCANYATEIYQWLGFNIATQSVMGYTFMCCGAAQMMQWAIAKHKRLRQLFDGKDGKPKFRRPFILLPPFF 310
Cdd:PLN02560 238 VTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFDGKDGRPKYPRRWVILPPFL 308
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 1-310 0e+00

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 548.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019   1 MKLQIVTRSGRAVVAGGLVVPNDAKVSDLKRSFHALKRKFYPSRQRFTTVPARGETRGTALRDDTLLSEYGLNDGDTIVF 80
Cdd:PLN02560   1 MKVTVVSRSGREIIKGGLEVPDSATVADLKKAIHKRKKKYYPSRQRLTLPLPPGKTRPTVLDDSKSLKDYGLGDGGTVVF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019  81 KDLGPQVSYKAVFFFEYLGPLLAYLPFYFMRKeIYGgIFGIKnAGKPVLEAQTLAMYFHTAHYAKRILETFFVHKFSHAT 160
Cdd:PLN02560  81 KDLGPQVSYRTLFFFEYLGPLLIYPLFYFFPQ-VYK-YFGYP-ARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHAT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019 161 MPIFNLMRNCGYYWTFGAFMSYFINHPAYTPVGRTQMMAGFAFSAVMQLSNLRCHIILANLRK-DGAKGYVIPTGFLFNY 239
Cdd:PLN02560 158 SPLFNVFRNCAYYWTFGAYIAYFVNHPLYTPVSETQMKVGFGFGLVCQLANFYCHIILRNLRKpDGKGGYQIPRGFLFNY 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145345019 240 VTCANYATEIYQWLGFNIATQSVMGYTFMCCGAAQMMQWAIAKHKRLRQLFDGKDGKPKFRRPFILLPPFF 310
Cdd:PLN02560 238 VTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFDGKDGRPKYPRRWVILPPFL 308
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 159-310 1.41e-26

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 102.10  E-value: 1.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019  159 ATMPIFNLMRNCGYyWTFGAFMS--YFINH--PAYTPVGRTQMMAGFAFSAVMQLSNLRCHIILANLRKDGAKGYVIPTG 234
Cdd:pfam02544   1 ATMPLTIVAKAFAF-CTLNGLIQgrYNSYYqpYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145345019  235 FLFNYVTCANYATEIYQWLGFNIATQSVMGYTFMCCGAAQMMQWAIAKHKRLRQLFdgkDGKPKFRRpfILLPPFF 310
Cdd:pfam02544  80 GLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKF---EKYPKSRK--ALIPFVF 150
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 2-83 2.44e-21

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 85.80  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019   2 KLQIVTRSGRAVVAGGLVVPnDAKVSDLKRSFHALKRKFYPSRQRFTTVPArgetRGTALRDDTLLSEYGLNDGDTIVFK 81
Cdd:cd01801    1 KIEVVSRKGGKQIITLEVSS-SATVADLKKAIHKKKKKLYPERQRLRLEVP----KGKVLKDDKTLSSYGVKDGSTLYFK 75


                 ..
gi 145345019  82 DL 83
Cdd:cd01801   76 DL 77
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 1-310 0e+00

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 548.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019   1 MKLQIVTRSGRAVVAGGLVVPNDAKVSDLKRSFHALKRKFYPSRQRFTTVPARGETRGTALRDDTLLSEYGLNDGDTIVF 80
Cdd:PLN02560   1 MKVTVVSRSGREIIKGGLEVPDSATVADLKKAIHKRKKKYYPSRQRLTLPLPPGKTRPTVLDDSKSLKDYGLGDGGTVVF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019  81 KDLGPQVSYKAVFFFEYLGPLLAYLPFYFMRKeIYGgIFGIKnAGKPVLEAQTLAMYFHTAHYAKRILETFFVHKFSHAT 160
Cdd:PLN02560  81 KDLGPQVSYRTLFFFEYLGPLLIYPLFYFFPQ-VYK-YFGYP-ARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHAT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019 161 MPIFNLMRNCGYYWTFGAFMSYFINHPAYTPVGRTQMMAGFAFSAVMQLSNLRCHIILANLRK-DGAKGYVIPTGFLFNY 239
Cdd:PLN02560 158 SPLFNVFRNCAYYWTFGAYIAYFVNHPLYTPVSETQMKVGFGFGLVCQLANFYCHIILRNLRKpDGKGGYQIPRGFLFNY 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145345019 240 VTCANYATEIYQWLGFNIATQSVMGYTFMCCGAAQMMQWAIAKHKRLRQLFDGKDGKPKFRRPFILLPPFF 310
Cdd:PLN02560 238 VTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFDGKDGRPKYPRRWVILPPFL 308
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 159-310 1.41e-26

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 102.10  E-value: 1.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019  159 ATMPIFNLMRNCGYyWTFGAFMS--YFINH--PAYTPVGRTQMMAGFAFSAVMQLSNLRCHIILANLRKDGAKGYVIPTG 234
Cdd:pfam02544   1 ATMPLTIVAKAFAF-CTLNGLIQgrYNSYYqpYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145345019  235 FLFNYVTCANYATEIYQWLGFNIATQSVMGYTFMCCGAAQMMQWAIAKHKRLRQLFdgkDGKPKFRRpfILLPPFF 310
Cdd:pfam02544  80 GLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKF---EKYPKSRK--ALIPFVF 150
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 2-83 2.44e-21

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 85.80  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019   2 KLQIVTRSGRAVVAGGLVVPnDAKVSDLKRSFHALKRKFYPSRQRFTTVPArgetRGTALRDDTLLSEYGLNDGDTIVFK 81
Cdd:cd01801    1 KIEVVSRKGGKQIITLEVSS-SATVADLKKAIHKKKKKLYPERQRLRLEVP----KGKVLKDDKTLSSYGVKDGSTLYFK 75


                 ..
gi 145345019  82 DL 83
Cdd:cd01801   76 DL 77
PLN02392 PLN02392
probable steroid reductase DET2
 211-310 1.75e-09

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 57.51  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019 211 NLRCHIILANLRKDGAkGYVIPTGFLFNYVTCANYATEIYQWLGFNIATQSVMGYTFMCCGAAQMMQWAIAKHKRLRQLF 290
Cdd:PLN02392 166 NVWSDRVLVGLKREGG-GYKVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKF 244

                         90       100
                 ....*....|....*....|
gi 145345019 291 dgKDGKPKFRRPFIllpPFF 310
Cdd:PLN02392 245 --GEDYPKGRKAVI---PFL 259
PLN03164 PLN03164
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional
 142-259 1.57e-05

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional


Pssm-ID: 215610 [Multi-domain]  Cd Length: 323  Bit Score: 45.96  E-value: 1.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145345019 142 HYAKRILETFFVHKFS-HATMPIFNLMRNCGYYWT---------FGAFMSYFINHPAYTPVGRTQMMAGFAF------SA 205
Cdd:PLN03164 124 HVLRRLYESLYVFKYSpSARMHILGYLTGLFFYVAaplslccncAPEVAKFVGNQVAEFIVKGKSAMSAIEFdwwdfvSP 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145345019 206 VMQLSNL----------------RCHIILANLRKDGAKG--YVIPTGFLFNYVTCANYATEIYQWLGFNIAT 259
Cdd:PLN03164 204 LMKLGWFqwigaaiflwgwihqyRCHAILGSLREHKKQAdeYVIPYGDWFEMVSCPHYLAEIVIYAGLLIAS 275
Ubl_ubiquitin_like cd17039
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ...
 18-79 3.92e-05

ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340559 [Multi-domain]  Cd Length: 68  Bit Score: 41.04  E-value: 3.92e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145345019  18 LVVPNDAKVSDLKRSFHAlKRKFYPSRQRFTTvpargetRGTALRDDTLLSEYGLNDGDTIV 79
Cdd:cd17039   13 VEVDPDDTVADLKEKIEE-KTGIPVEQQRLIY-------NGKELKDDKTLSDYGIKDGSTIH 66
Ubl_TECR cd17124
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed ...
 19-83 1.92e-04

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR homolog (TSC13p) is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340644 [Multi-domain]  Cd Length: 79  Bit Score: 39.55  E-value: 1.92e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145345019  19 VVPNdAKVSDLKRSFHALKRKFYPSRQRFttvpaRGETRGTALRDDTLLSEYGLNDGDTIVFKDL 83
Cdd:cd17124   21 VEPN-ATIGEIKNLFHKSHPQWYPARQSL-----RLDPKGKSLKDEDILQNLPVGTTATFYFRDL 79
Ubl_SNRNP25 cd17058
ubiquitin-like (Ubl) domain found in small nuclear ribonucleoprotein U11/U12 subunit 25 ...
 19-80 6.90e-04

ubiquitin-like (Ubl) domain found in small nuclear ribonucleoprotein U11/U12 subunit 25 (SNRNP25) and similar proteins; SNRNP25, also termed U11/U12 small nuclear ribonucleoprotein 25 kDa protein, U11/U12 snRNP 25 kDa protein (U11/U12-25K), or minus-99 protein, is a component of the U11/U12 snRNPs that are part of the U12-type spliceosome. It contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340578  Cd Length: 89  Bit Score: 37.88  E-value: 6.90e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145345019  19 VVPNDAKVSDLKRsfhALKRKFYPSRQRfttvpaRGETR----------------GTALRDD-TLLSEYGLNDGDTIVF 80
Cdd:cd17058   17 VVPQNATVLDLKK---AIERYFTLKLKR------EGGTKkiswkyvwktyclcfdGQKLTDDkAKLKDYGIRNGDELTF 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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