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Conserved domains on  [gi|1447241974|gb|REI76138|]
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hypothetical protein DYZ99_01315 [Klebsiella variicola]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pilot_rel_YacC NF037975
YacC family pilotin-like protein; Members of this, including YacC from Escherichia coli K-12, ...
 1-115 4.69e-74

YacC family pilotin-like protein; Members of this, including YacC from Escherichia coli K-12, resemble the lipoprotein GspS of type II secretion systems (T2SS), but in general are not lipoproteins. In E. coli K-12, where the T2SS is cryptic (not expressed, but able to function after manipulation to force its express), YacC is encoded far from the locus where the main set of T2SS genes are found, and it is not clear that YacC is a true GspS.


:

Pssm-ID: 411579  Cd Length: 115  Bit Score: 214.92  E-value: 4.69e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447241974   1 MKTLFRTMVLGSLLALSANSYALSESEAEDMADLTAVFVFLKNDCGYQNLPNTQIRRALVFFAQQNQWDLSNYDSYNMKA 80
Cdd:NF037975    1 MKKFILALLLLSLLGFSSASKALTESEAEDLADLTAVFVYLKNDCGYQDLPNRQIRRAIVFFAQQNRWDLSNYNSFDMKK 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1447241974  81 LGEDSYRDLSGINIPTAKKCKALARDSLSLLAYVK 115
Cdd:NF037975   81 LGEDSYRDLSGIALPNDKKCKSLARDSLSLLAYVK 115
 
Name Accession Description Interval E-value
pilot_rel_YacC NF037975
YacC family pilotin-like protein; Members of this, including YacC from Escherichia coli K-12, ...
 1-115 4.69e-74

YacC family pilotin-like protein; Members of this, including YacC from Escherichia coli K-12, resemble the lipoprotein GspS of type II secretion systems (T2SS), but in general are not lipoproteins. In E. coli K-12, where the T2SS is cryptic (not expressed, but able to function after manipulation to force its express), YacC is encoded far from the locus where the main set of T2SS genes are found, and it is not clear that YacC is a true GspS.


Pssm-ID: 411579  Cd Length: 115  Bit Score: 214.92  E-value: 4.69e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447241974   1 MKTLFRTMVLGSLLALSANSYALSESEAEDMADLTAVFVFLKNDCGYQNLPNTQIRRALVFFAQQNQWDLSNYDSYNMKA 80
Cdd:NF037975    1 MKKFILALLLLSLLGFSSASKALTESEAEDLADLTAVFVYLKNDCGYQDLPNRQIRRAIVFFAQQNRWDLSNYNSFDMKK 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1447241974  81 LGEDSYRDLSGINIPTAKKCKALARDSLSLLAYVK 115
Cdd:NF037975   81 LGEDSYRDLSGIALPNDKKCKSLARDSLSLLAYVK 115
T2SS_PulS_OutS pfam09691
Type II secretion system pilotin lipoprotein (PulS_OutS); This family comprises lipoproteins ...
 29-105 1.13e-07

Type II secretion system pilotin lipoprotein (PulS_OutS); This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. In the pilotin from this four-helix protein from enterohemorrhagic Escherichia coli, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. These helices create a prominent groove, mainly formed by side chains of helices 1,2 and 3 suggesting this groove is important as a binding site.


Pssm-ID: 401580  Cd Length: 96  Bit Score: 46.07  E-value: 1.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1447241974  29 EDMADLTAVFVFLKNDCGYQNLPN--TQIRRALVfFAQQNQWDLSNYDSynMKALGEDSYRDLSGINIPTAKKCKALAR 105
Cdd:pfam09691  14 EQLSSLVAGIKYLKQQCNRSDLPDdaTIINVAMI-VAKQRGWDTDNYQS--LPQRSERLYQGLLKDSTPKGTQCSSFNR 89
PulS_OutS TIGR01004
lipoprotein, PulS/OutS family; This family comprises lipoproteins from four gamma ...
 1-105 9.73e-05

lipoprotein, PulS/OutS family; This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae, the OutS protein of Erwinia chrysanthemi and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273390  Cd Length: 128  Bit Score: 38.76  E-value: 9.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447241974   1 MKTLFRTMVLGSLLALSAN-----SYALSESEA-EDMADLTAVFVFLKNDCGYQNLPNTQ-IRRALVFFAQQNQWDLSNY 73
Cdd:TIGR01004   6 LKVVLFGVCCVSLSGCQQNtasrsAASVPANEQlEQLASLVAASRYLKVQCNRSDLPDDGtILKTAVNVAVQKGWDTGRY 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1447241974  74 DSynMKALGEDSYRDLSGINIPTAKKCKALAR 105
Cdd:TIGR01004  86 QS--LPQLSENLYQGLLKDSTPEATKCSSFNR 115
 
Name Accession Description Interval E-value
pilot_rel_YacC NF037975
YacC family pilotin-like protein; Members of this, including YacC from Escherichia coli K-12, ...
 1-115 4.69e-74

YacC family pilotin-like protein; Members of this, including YacC from Escherichia coli K-12, resemble the lipoprotein GspS of type II secretion systems (T2SS), but in general are not lipoproteins. In E. coli K-12, where the T2SS is cryptic (not expressed, but able to function after manipulation to force its express), YacC is encoded far from the locus where the main set of T2SS genes are found, and it is not clear that YacC is a true GspS.


Pssm-ID: 411579  Cd Length: 115  Bit Score: 214.92  E-value: 4.69e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447241974   1 MKTLFRTMVLGSLLALSANSYALSESEAEDMADLTAVFVFLKNDCGYQNLPNTQIRRALVFFAQQNQWDLSNYDSYNMKA 80
Cdd:NF037975    1 MKKFILALLLLSLLGFSSASKALTESEAEDLADLTAVFVYLKNDCGYQDLPNRQIRRAIVFFAQQNRWDLSNYNSFDMKK 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1447241974  81 LGEDSYRDLSGINIPTAKKCKALARDSLSLLAYVK 115
Cdd:NF037975   81 LGEDSYRDLSGIALPNDKKCKSLARDSLSLLAYVK 115
T2SS_PulS_OutS pfam09691
Type II secretion system pilotin lipoprotein (PulS_OutS); This family comprises lipoproteins ...
 29-105 1.13e-07

Type II secretion system pilotin lipoprotein (PulS_OutS); This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. In the pilotin from this four-helix protein from enterohemorrhagic Escherichia coli, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. These helices create a prominent groove, mainly formed by side chains of helices 1,2 and 3 suggesting this groove is important as a binding site.


Pssm-ID: 401580  Cd Length: 96  Bit Score: 46.07  E-value: 1.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1447241974  29 EDMADLTAVFVFLKNDCGYQNLPN--TQIRRALVfFAQQNQWDLSNYDSynMKALGEDSYRDLSGINIPTAKKCKALAR 105
Cdd:pfam09691  14 EQLSSLVAGIKYLKQQCNRSDLPDdaTIINVAMI-VAKQRGWDTDNYQS--LPQRSERLYQGLLKDSTPKGTQCSSFNR 89
PulS_OutS TIGR01004
lipoprotein, PulS/OutS family; This family comprises lipoproteins from four gamma ...
 1-105 9.73e-05

lipoprotein, PulS/OutS family; This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae, the OutS protein of Erwinia chrysanthemi and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273390  Cd Length: 128  Bit Score: 38.76  E-value: 9.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1447241974   1 MKTLFRTMVLGSLLALSAN-----SYALSESEA-EDMADLTAVFVFLKNDCGYQNLPNTQ-IRRALVFFAQQNQWDLSNY 73
Cdd:TIGR01004   6 LKVVLFGVCCVSLSGCQQNtasrsAASVPANEQlEQLASLVAASRYLKVQCNRSDLPDDGtILKTAVNVAVQKGWDTGRY 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1447241974  74 DSynMKALGEDSYRDLSGINIPTAKKCKALAR 105
Cdd:TIGR01004  86 QS--LPQLSENLYQGLLKDSTPEATKCSSFNR 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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