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Conserved domains on  [gi|1446207975|gb|AXL96322|]
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two-component sensor protein [Providencia alcalifaciens]

Protein Classification

two-component system sensor histidine kinase CpxA( domain architecture ID 11484200)

two-component system sensor histidine kinase CpxA activates CpxR by phosphorylation and is part of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
1-409 0e+00

envelope stress sensor histidine kinase CpxA;


:

Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 755.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975   1 MLEQHIEAELAQAPMNDLLWWRRISNAIKKWAPPGQRLIIVTSEGRVIGAMPSEMQVIRNFIGQSDNADHPKKKKYGRAE 80
Cdd:PRK09470   52 MIEQHIEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRIIGAERSEMQAVRNFIGQSDNADHPQKKKYGRVE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  81 ILGPFSIRDGEDHYQLYLVRPASSPQSDFINLLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRP 160
Cdd:PRK09470  132 IVGPFSVRDGEDNYQLYLIRPANSPQSDFINLLFDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQ 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 161 HPELESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQLATALLRRRHGESKELERIETETHRLDSM 240
Cdd:PRK09470  212 HPELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSM 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 241 INDLLVLSRSQHKNEILREHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYSNT 320
Cdd:PRK09470  292 INDLLVLSRNQQKNHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 321 HIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRL 400
Cdd:PRK09470  372 KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRL 451


                  ....*....
gi 1446207975 401 QIWLPEHGR 409
Cdd:PRK09470  452 TIWLPLYKR 460
 
Name Accession Description Interval E-value
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
1-409 0e+00

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 755.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975   1 MLEQHIEAELAQAPMNDLLWWRRISNAIKKWAPPGQRLIIVTSEGRVIGAMPSEMQVIRNFIGQSDNADHPKKKKYGRAE 80
Cdd:PRK09470   52 MIEQHIEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRIIGAERSEMQAVRNFIGQSDNADHPQKKKYGRVE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  81 ILGPFSIRDGEDHYQLYLVRPASSPQSDFINLLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRP 160
Cdd:PRK09470  132 IVGPFSVRDGEDNYQLYLIRPANSPQSDFINLLFDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQ 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 161 HPELESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQLATALLRRRHGESKELERIETETHRLDSM 240
Cdd:PRK09470  212 HPELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSM 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 241 INDLLVLSRSQHKNEILREHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYSNT 320
Cdd:PRK09470  292 INDLLVLSRNQQKNHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 321 HIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRL 400
Cdd:PRK09470  372 KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRL 451


                  ....*....
gi 1446207975 401 QIWLPEHGR 409
Cdd:PRK09470  452 TIWLPLYKR 460
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
78-405 1.11e-67

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 219.81  E-value: 1.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  78 RAEILGPFSIRDGEDHYQLYLVRPASSPQSDFINLLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGN 157
Cdd:COG5002    51 LLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLL 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 158 LRPHPELESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQLATALLRRRHGESKE-----LERIET 232
Cdd:COG5002   131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEerreyLEIILE 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 233 ETHRLDSMINDLLVLSRSQHKNEIL-REHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIV 311
Cdd:COG5002   211 EAERLSRLVNDLLDLSRLESGELKLeKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLL 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 312 RNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVK 389
Cdd:COG5002   291 DNAIKYTpeGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIW 370

                         330
                  ....*....|....*.
gi 1446207975 390 ADDSPLGGLRLQIWLP 405
Cdd:COG5002   371 VESEPGKGTTFTITLP 386
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 303-405 7.88e-53

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 171.35  E-value: 7.88e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 303 IGSAFENIVRNALRYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAIS 382
Cdd:cd16949     1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80

                          90       100
                  ....*....|....*....|...
gi 1446207975 383 QHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16949    81 QHGGKIKASNRKPGGLRVRIWLP 103
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 185-386 7.01e-38

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 139.65  E-value: 7.01e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 185 LDGMvtaQQRLISDISHELRTPLTRLQ-----LATALLRRRHGESKELERIETETHRLDSMINDLLVLSRSQHKNEIL-R 258
Cdd:TIGR02966 110 LEQM---RRDFVANVSHELRTPLTVLRgyletLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLeD 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 259 EHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWpLYCNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILIT 336
Cdd:TIGR02966 187 EPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVD-VLGDEDELRSAFSNLVSNAIKYTpeGGTITVRWRRDGGGAEFS 265

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1446207975 337 VDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKG 386
Cdd:TIGR02966 266 VTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHA 315
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
93-407 8.82e-33

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 128.99  E-value: 8.82e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  93 HYQLYLVRPASSPQSdfiNLLFDRPFLLL--IATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRPHPElESGPQE 170
Cdd:NF040691  167 NYELYLLFPLEDEQS---TLALVRGTLLLggLALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERMP-VKGEDD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 171 FLSTGNSFNQM-------ISALDGMVTAQQRLISDISHELRTPLTRLQLATALLrrrHGESKEL--------ERIETETH 235
Cdd:NF040691  243 LARLARSFNQMadslqrqIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVI---HDSRDDFdpatarsaELLHTELD 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 236 RLDSMINDLLVLSRSQHKNEIL-REHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNA 314
Cdd:NF040691  320 RFESLLSDLLEISRFDAGAAELdVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNA 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 315 LRYSNtHIAVDFKEENNG--ILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADD 392
Cdd:NF040691  400 IEHGE-GKPVVVTVAQDDtaVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWG 478

                         330
                  ....*....|....*
gi 1446207975 393 SPLGGLRLQIWLPEH 407
Cdd:NF040691  479 RPGQGSQFRLTLPRV 493
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
118-405 1.61e-30

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 121.86  E-value: 1.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 118 FLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRPHPELESGpQEFLSTGNSFNQMISALDGMVTAQQRLIS 197
Cdd:NF012163  167 WLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSN-DELGKLAQDFNQLASTLEKNEQMRRDFMA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 198 DISHELRTPLTRLQLATALLRR--RHGESKELERIETETHRLDSMINDLLVLSRSQHKNeiLREHIKADELWGDILDDA- 274
Cdd:NF012163  246 DISHELRTPLAVLRAELEAIQDgiRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGA--LAYQKASVDLVPLLEVEGg 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 275 SFEAEQMNKTLDV-TSHPGPWPLYCNPSAIGSAFENIVRNALRYSNT--HIAVDFKEENNGILITVDDDGPGVSPADREH 351
Cdd:NF012163  324 AFRERFASAGLELeVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLAR 403

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1446207975 352 IFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:NF012163  404 LFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
 189-405 2.71e-28

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 116.78  E-value: 2.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 189 VTAQQRL-------ISDISHELRTPLTRL---------------QLAtallrrrhgeSKELERIETETHRLDSMINDLLV 246
Cdd:NF033092  362 VTEQEKIeqerrefVANVSHELRTPLTTMrsylealadgawkdpELA----------PRFLGVTQNETERMIRLVNDLLQ 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 247 LSRSQHKNEILR-EHIKADELWGDILDDASFEAEQMNKTL--DVTSHPgPWpLYCNPSAIGSAFENIVRNALRYS--NTH 321
Cdd:NF033092  432 LSRMDSKDYKLNkEWVNFNEFFNYIIDRFEMILKNKNITFkrEFPKRD-LW-VEIDTDKITQVLDNIISNAIKYSpeGGT 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 322 IAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKG--WVkadDSPLG-GL 398
Cdd:NF033092  510 ITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGriWA---ESEEGkGT 586


                  ....*..
gi 1446207975 399 RLQIWLP 405
Cdd:NF033092  587 TIYFTLP 593
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 299-405 5.89e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 106.19  E-value: 5.89e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  299 NPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEaRDRETGGTGLGLAI 376
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80

                           90       100
                   ....*....|....*....|....*....
gi 1446207975  377 VETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 299-406 4.21e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.20  E-value: 4.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 299 NPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNgILITVDDDGPGVSPADREHIFRPFYRTDearDRETGGTGLGLAI 376
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAakAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1446207975 377 VETAISQHKGWVKADDSPLGGLRLQIWLPE 406
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLPL 107
AdeS_HK NF012226
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ...
 142-386 7.56e-22

two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.


Pssm-ID: 411090 [Multi-domain]  Cd Length: 353  Bit Score: 95.83  E-value: 7.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 142 PARKLKMAADDVAKGNL--RPHPElESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQlatallRR 219
Cdd:NF012226   87 PINFLADAAKKISQGDLsaRAEDS-QIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQ------GR 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 220 RHG------ESKE------LERIETETHrldsMINDLLVLSRSQhkNEILREHIKadelWGDILD---------DASFEA 278
Cdd:NF012226  160 LQGildgvfEPDPalfkslLNQVEGLSH----LVEDLRTLSLVE--NQQLRLNYE----SVDLKDsiekvlkmfEDRLEQ 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 279 EQMNKTLDVTSHpgpwPLYCNPSAIGSAFENIVRNALRYSNT-HIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFY 357
Cdd:NF012226  230 AQLTIVLNLTAT----PVFCDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFF 305

                         250       260
                  ....*....|....*....|....*....
gi 1446207975 358 RTDEARDRETGGTGLGLAIVETAISQHKG 386
Cdd:NF012226  306 RLEQSRNKEFGGTGLGLAVVHAIVIAHKG 334
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 180-374 1.51e-12

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 68.70  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 180 QMISALDGMVTAQqrlisdiSHELRTPLTRLQLAtallrrrhgeSKELERIETETHRLdsmINDL-LVLSRSQHKNEILR 258
Cdd:NF033792  197 QHLSALDGLAAAA-------AHELGTPLATIALV----------AKELERELPDDPPL---REDAeLLRSQAERCRDILR 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 259 EHIKADELWGDILDDASFEA---EQMNK--------TLDVTSHPGPWP-LYCNPsAIGSAFENIVRNALRYSNTHIAVDF 326
Cdd:NF033792  257 RLTSLGEEGDAHLDRLPLSAlieEAAAPhrgfgkeiEVVVAGDPGEEPvIRRNP-EILYGLGNLIENAVDFARSTVTVTA 335

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1446207975 327 KEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGL 374
Cdd:NF033792  336 SWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEERRPGGGGLGL 383
 
Name Accession Description Interval E-value
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
1-409 0e+00

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 755.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975   1 MLEQHIEAELAQAPMNDLLWWRRISNAIKKWAPPGQRLIIVTSEGRVIGAMPSEMQVIRNFIGQSDNADHPKKKKYGRAE 80
Cdd:PRK09470   52 MIEQHIEAELANDPPNDLMWWRRLFRAIDKWAPPGQRLLLVTSEGRIIGAERSEMQAVRNFIGQSDNADHPQKKKYGRVE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  81 ILGPFSIRDGEDHYQLYLVRPASSPQSDFINLLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRP 160
Cdd:PRK09470  132 IVGPFSVRDGEDNYQLYLIRPANSPQSDFINLLFDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQ 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 161 HPELESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQLATALLRRRHGESKELERIETETHRLDSM 240
Cdd:PRK09470  212 HPELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSM 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 241 INDLLVLSRSQHKNEILREHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYSNT 320
Cdd:PRK09470  292 INDLLVLSRNQQKNHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT 371

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 321 HIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRL 400
Cdd:PRK09470  372 KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRL 451


                  ....*....
gi 1446207975 401 QIWLPEHGR 409
Cdd:PRK09470  452 TIWLPLYKR 460
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
78-405 1.11e-67

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 219.81  E-value: 1.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  78 RAEILGPFSIRDGEDHYQLYLVRPASSPQSDFINLLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGN 157
Cdd:COG5002    51 LLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLL 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 158 LRPHPELESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQLATALLRRRHGESKE-----LERIET 232
Cdd:COG5002   131 LGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEerreyLEIILE 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 233 ETHRLDSMINDLLVLSRSQHKNEIL-REHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIV 311
Cdd:COG5002   211 EAERLSRLVNDLLDLSRLESGELKLeKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLL 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 312 RNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVK 389
Cdd:COG5002   291 DNAIKYTpeGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIW 370

                         330
                  ....*....|....*.
gi 1446207975 390 ADDSPLGGLRLQIWLP 405
Cdd:COG5002   371 VESEPGKGTTFTITLP 386
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
112-405 2.47e-59

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 195.90  E-value: 2.47e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 112 LLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRPHPELESGPQEFLSTGNSFNQMISALDGMVTA 191
Cdd:COG0642    30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 192 QQRLISDISHELRTPLTRLQLATALLRRRHGE--SKELERIETETHRLDSMINDLLVLSRSQH-KNEILREHIKADELWG 268
Cdd:COG0642   110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEeqREYLETILRSADRLLRLINDLLDLSRLEAgKLELEPEPVDLAELLE 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 269 DILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSP 346
Cdd:COG0642   190 EVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTpeGGTVTVSVRREGDRVRISVEDTGPGIPP 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1446207975 347 ADREHIFRPFYRTDEArdRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:COG0642   270 EDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
191-405 4.59e-58

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 189.73  E-value: 4.59e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 191 AQQRLISDISHELRTPLTRLQLATALLRRRHGESKE-----LERIETETHRLDSMINDLLVLSRSQHKNEIL-REHIKAD 264
Cdd:COG2205    15 LKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrelLEIIRESAERLLRLIEDLLDLSRLESGKLSLeLEPVDLA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 265 ELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGP 342
Cdd:COG2205    95 ELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTITISARREGDGVRISVSDNGP 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1446207975 343 GVSPADREHIFRPFYRTDeaRDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:COG2205   175 GIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 303-405 7.88e-53

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 171.35  E-value: 7.88e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 303 IGSAFENIVRNALRYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAIS 382
Cdd:cd16949     1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80

                          90       100
                  ....*....|....*....|...
gi 1446207975 383 QHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16949    81 QHGGKIKASNRKPGGLRVRIWLP 103
envZ PRK09467
osmolarity sensor protein; Provisional
 141-405 1.22e-47

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 168.17  E-value: 1.22e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 141 RPARKLKMAADDVAKGNLrPHPELESGPQEFLSTGNSFNQMISALDGMvtAQQR--LISDISHELRTPLTRLQLATALLr 218
Cdd:PRK09467  179 RPLVALEHAALQVGKGEI-PPPLREYGASEVRSVTRAFNQMAAGIKQL--EDDRtlLMAGVSHDLRTPLTRIRLATEMM- 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 219 rrhgeSKELERIEtethrlDSMINDLlvlsrsQHKNEILR---EHIKADElwgdildDASFEAEQMNKTL-DVTS----- 289
Cdd:PRK09467  255 -----SEEDGYLA------ESINKDI------EECNAIIEqfiDYLRTGQ-------EMPMEMADLNALLgEVIAaesgy 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 290 --------HPGPWPLYCNPSAIGSAFENIVRNALRYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDE 361
Cdd:PRK09467  311 ereietalQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDS 390

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1446207975 362 ARDREtgGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:PRK09467  391 ARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
PRK10604 PRK10604
sensor protein RstB; Provisional
 141-407 1.19e-45

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 162.85  E-value: 1.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 141 RPARKLKMAADDVAKGNLRPHPELESGpQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQLATALLRR- 219
Cdd:PRK10604  162 QDMLKLEAAAQRLGDGHLAERIHFDEG-SSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNl 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 220 RHGESKELERietETHRLDSMINDLLVLSR-SQHKNEILREHIKADELWGDILDDasFEAEQMNKTLDVTSHPGPWPLYC 298
Cdd:PRK10604  241 SAAESQALNR---DIGQLEALIEELLTYARlDRPQNELHLSEPDLPAWLSTHLAD--IQAVTPEKTVRLDTPHQGDYGAL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 299 NPSAIGSAFENIVRNALRYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVe 378
Cdd:PRK10604  316 DMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIV- 394

                         250       260       270
                  ....*....|....*....|....*....|
gi 1446207975 379 TAISQ-HKGWVKADDSPLGGLRLQIWLPEH 407
Cdd:PRK10604  395 HSIALaMGGSVNCDESELGGARFSFSWPVW 424
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 185-386 7.01e-38

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 139.65  E-value: 7.01e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 185 LDGMvtaQQRLISDISHELRTPLTRLQ-----LATALLRRRHGESKELERIETETHRLDSMINDLLVLSRSQHKNEIL-R 258
Cdd:TIGR02966 110 LEQM---RRDFVANVSHELRTPLTVLRgyletLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLeD 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 259 EHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWpLYCNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILIT 336
Cdd:TIGR02966 187 EPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVD-VLGDEDELRSAFSNLVSNAIKYTpeGGTITVRWRRDGGGAEFS 265

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1446207975 337 VDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKG 386
Cdd:TIGR02966 266 VTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHA 315
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 191-405 1.31e-35

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 135.47  E-value: 1.31e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 191 AQQRLISDISHELRTPLTRLQLATALLRRRHGESKE---------LERIETETHRLDSMINDLLVLSRSQhknEILREHI 261
Cdd:COG5000   200 AWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEedredleraLDTIIRQVDRLKRIVDEFLDFARLP---EPQLEPV 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 262 KADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALR--YSNTHIAVDFKEENNGILITVDD 339
Cdd:COG5000   277 DLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEaiEEGGEIEVSTRREDGRVRIEVSD 356

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1446207975 340 DGPGVSPADREHIFRPFYRTDEardretGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:COG5000   357 NGPGIPEEVLERIFEPFFTTKP------KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 34-405 1.50e-34

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 133.28  E-value: 1.50e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  34 PGQRLIIVTSEGRVIGAMPSEMQVIR-----NFIGQSDNADHPKKKKYGRAEILGPFSIRDGEDHYQlYLVRPASSPQSD 108
Cdd:TIGR01386  79 SDLALSILNPDGRLLFERAQGAALVPavaanDALLELDQADAKMTHYRSILRSVAALPGGKGRKPVQ-ITVALDINAHTH 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 109 FINLLFDRPFLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRPHPELESGPQEFLSTGNSFNQMISALDGM 188
Cdd:TIGR01386 158 LLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDA 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 189 VTAQQRLISDISHELRTPLTRL--QLATALLRRRHGESKE--LERIETETHRLDSMINDLLVLSRSQHKNEIL-REHIKA 263
Cdd:TIGR01386 238 FQRLSQFSADLAHELRTPLTNLlgQTQVALSQPRTGEEYRevLESNLEELERLSRMVSDMLFLARADNGQLALeRVRLDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 264 DELWGDILDDASFEAEQMNKTLDVTshpGPWPLYCNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDG 341
Cdd:TIGR01386 318 AAELAKVAEYFEPLAEERGVRIRVE---GEGLVRGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPG 394

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446207975 342 PGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKAdDSPLGGLRLQIWLP 405
Cdd:TIGR01386 395 PGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRFP 457
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 199-407 4.37e-34

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 132.60  E-value: 4.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 199 ISHELRTPLTRLQLATALLRRRHGES------KELERIETETHRLDSMINDLLVLSRSQhKNEILREHIKADELWGDILD 272
Cdd:COG4251   289 ASHDLREPLRKISGFSQLLEEDYGDKldeegrEYLERIRDAAERMQALIDDLLAYSRVG-RQELEFEPVDLNELLEEVLE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 273 DASFEAEQmnKTLDVTSHPGPwPLYCNPSAIGSAFENIVRNALRYSNT----HIAVDFKEENNGILITVDDDGPGVSPAD 348
Cdd:COG4251   368 DLEPRIEE--RGAEIEVGPLP-TVRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEY 444

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1446207975 349 REHIFRPFYRTDEARDREtgGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLPEH 407
Cdd:COG4251   445 AEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
93-407 8.82e-33

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 128.99  E-value: 8.82e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  93 HYQLYLVRPASSPQSdfiNLLFDRPFLLL--IATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRPHPElESGPQE 170
Cdd:NF040691  167 NYELYLLFPLEDEQS---TLALVRGTLLLggLALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERMP-VKGEDD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 171 FLSTGNSFNQM-------ISALDGMVTAQQRLISDISHELRTPLTRLQLATALLrrrHGESKEL--------ERIETETH 235
Cdd:NF040691  243 LARLARSFNQMadslqrqIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVI---HDSRDDFdpatarsaELLHTELD 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 236 RLDSMINDLLVLSRSQHKNEIL-REHIKADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNA 314
Cdd:NF040691  320 RFESLLSDLLEISRFDAGAAELdVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNA 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 315 LRYSNtHIAVDFKEENNG--ILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADD 392
Cdd:NF040691  400 IEHGE-GKPVVVTVAQDDtaVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWG 478

                         330
                  ....*....|....*
gi 1446207975 393 SPLGGLRLQIWLPEH 407
Cdd:NF040691  479 RPGQGSQFRLTLPRV 493
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 194-407 1.53e-32

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 125.68  E-value: 1.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 194 RLISDISHELRTPLTRLQLATALLRRRHGESKE-------LERIETETHRLDSMINDLLVLSRsqhKNEILREHIKADEL 266
Cdd:COG4191   144 ELAAGIAHEINNPLAAILGNAELLRRRLEDEPDpeelreaLERILEGAERAAEIVRSLRAFSR---RDEEEREPVDLNEL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 267 WGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNAL----RYSNTHIAVDFKEENNGILITVDDDGP 342
Cdd:COG4191   221 IDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameEGEGGRITISTRREGDYVVISVRDNGP 300

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1446207975 343 GVSPADREHIFRPFYRTDEardrETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLPEH 407
Cdd:COG4191   301 GIPPEVLERIFEPFFTTKP----VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
118-405 1.61e-30

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 121.86  E-value: 1.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 118 FLLLIATMLISAPLLLWLSWSLARPARKLKMAADDVAKGNLRPHPELESGpQEFLSTGNSFNQMISALDGMVTAQQRLIS 197
Cdd:NF012163  167 WLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSN-DELGKLAQDFNQLASTLEKNEQMRRDFMA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 198 DISHELRTPLTRLQLATALLRR--RHGESKELERIETETHRLDSMINDLLVLSRSQHKNeiLREHIKADELWGDILDDA- 274
Cdd:NF012163  246 DISHELRTPLAVLRAELEAIQDgiRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGA--LAYQKASVDLVPLLEVEGg 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 275 SFEAEQMNKTLDV-TSHPGPWPLYCNPSAIGSAFENIVRNALRYSNT--HIAVDFKEENNGILITVDDDGPGVSPADREH 351
Cdd:NF012163  324 AFRERFASAGLELeVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLAR 403

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1446207975 352 IFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:NF012163  404 LFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-405 1.21e-29

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 110.60  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 306 AFENIVRNALRYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHK 385
Cdd:cd16939     4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHG 83

                          90       100
                  ....*....|....*....|
gi 1446207975 386 GWVKADDSPLGGLRLQIWLP 405
Cdd:cd16939    84 GHVECDDSELGGACFRLTWP 103
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
178-407 1.22e-29

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 119.74  E-value: 1.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 178 FNQMISALDGMVTAQQRLISDISHELRTPLtrlqlatALLRrrhgesKELERIETETHRLDS---------------MIN 242
Cdd:PRK10549  226 FNQLASTLEKNEQMRRDFMADISHELRTPL-------AVLR------GELEAIQDGVRKFTPesvaslqaevgtltkLVD 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 243 DLLVLSRSQHKNEILR-EHIKADELWGdiLDDASFEAEQMNKTLDVTSH-PGPWPLYCNPSAIGSAFENIVRNALRYSNT 320
Cdd:PRK10549  293 DLHQLSLSDEGALAYRkTPVDLVPLLE--VAGGAFRERFASRGLTLQLSlPDSATVFGDPDRLMQLFNNLLENSLRYTDS 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 321 H--IAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGL 398
Cdd:PRK10549  371 GgsLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGV 450


                  ....*....
gi 1446207975 399 RLQIWLPEH 407
Cdd:PRK10549  451 SITVELPLE 459
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
194-405 2.70e-29

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 116.87  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 194 RLISDISHELRTPLTRLQLATALLRRRHGESKELE---RIETETHRLDSMINDLLVLSRSQhknEILREHIKADELWGDI 270
Cdd:COG3852   137 ELAAGLAHEIRNPLTGIRGAAQLLERELPDDELREytqLIIEEADRLNNLVDRLLSFSRPR---PPEREPVNLHEVLERV 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 271 LDDASFEAEQmNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNA-----------LR-YSNTHIAVDFKEENNGILITVD 338
Cdd:COG3852   214 LELLRAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAaeampeggtitIRtRVERQVTLGGLRPRLYVRIEVI 292

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1446207975 339 DDGPGVSPADREHIFRPFYRTDEardretGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:COG3852   293 DNGPGIPEEILDRIFEPFFTTKE------KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 303-404 1.04e-28

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 108.07  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 303 IGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEArdRETGGTGLGLAIVETA 380
Cdd:cd00075     1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKS--REGGGTGLGLAIVRRI 78

                          90       100
                  ....*....|....*....|....
gi 1446207975 381 ISQHKGWVKADDSPLGGLRLQIWL 404
Cdd:cd00075    79 VEAHGGRITVESEPGGGTTFTVTL 102
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
191-407 2.03e-28

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 115.49  E-value: 2.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 191 AQQRLISDISHELRTPLTRLQ----------LATALLRRRHGESKElerietETHRLDSMINDLLVLSRSQHKNEILREH 260
Cdd:PRK11006  203 ARRNFFANVSHELRTPLTVLQgylemmqdqpLEGALREKALHTMRE------QTQRMEGLVKQLLTLSKIEAAPTIDLNE 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 261 IKADELWGDIL--DDASFEAEQMNKTLDVTSHpgpWPLYCNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILIT 336
Cdd:PRK11006  277 KVDVPMMLRVLerEAQTLSQGKHTITFEVDNS---LKVFGNEDQLRSAISNLVYNAVNHTpeGTHITVRWQRVPQGAEFS 353

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446207975 337 VDDDGPGVSPadrEHIFR---PFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLPEH 407
Cdd:PRK11006  354 VEDNGPGIAP---EHIPRlteRFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPER 424
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
 189-405 2.71e-28

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 116.78  E-value: 2.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 189 VTAQQRL-------ISDISHELRTPLTRL---------------QLAtallrrrhgeSKELERIETETHRLDSMINDLLV 246
Cdd:NF033092  362 VTEQEKIeqerrefVANVSHELRTPLTTMrsylealadgawkdpELA----------PRFLGVTQNETERMIRLVNDLLQ 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 247 LSRSQHKNEILR-EHIKADELWGDILDDASFEAEQMNKTL--DVTSHPgPWpLYCNPSAIGSAFENIVRNALRYS--NTH 321
Cdd:NF033092  432 LSRMDSKDYKLNkEWVNFNEFFNYIIDRFEMILKNKNITFkrEFPKRD-LW-VEIDTDKITQVLDNIISNAIKYSpeGGT 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 322 IAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKG--WVkadDSPLG-GL 398
Cdd:NF033092  510 ITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGriWA---ESEEGkGT 586


                  ....*..
gi 1446207975 399 RLQIWLP 405
Cdd:NF033092  587 TIYFTLP 593
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 299-405 5.89e-28

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 106.19  E-value: 5.89e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  299 NPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEaRDRETGGTGLGLAI 376
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTpeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80

                           90       100
                   ....*....|....*....|....*....
gi 1446207975  377 VETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-405 7.28e-26

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 100.22  E-value: 7.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNALRYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDreTGGTGLGLAIVETAISQHKGWV 388
Cdd:cd16950     7 NLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISDAHGGSL 84

                          90
                  ....*....|....*..
gi 1446207975 389 KADDSPLGGLRLQIWLP 405
Cdd:cd16950    85 TLANRAGGGLCARIELP 101
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
141-408 2.72e-25

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 107.17  E-value: 2.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 141 RPARKLKMAADDVAKGNLRPHPELESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRL--QLATALLR 218
Cdd:PRK09835  211 APIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitQTEIALSQ 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 219 RRhgESKELERI----ETETHRLDSMINDLLVLSrsQHKNEILREHIKADELWGDILDDASF---EAEQMNKTLD-VTSH 290
Cdd:PRK09835  291 SR--SQKELEDVlysnLEELTRMAKMVSDMLFLA--QADNNQLIPEKKMLDLADEVGKVFDFfeaWAEERGVELRfVGDP 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 291 PGPWPlycNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETG 368
Cdd:PRK09835  367 CQVAG---DPLMLRRAISNLLSNALRYTpaGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGE 443

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1446207975 369 GTGLGLAIVETAISQHKG--WVKADdspLGGLRLQIWLPEHG 408
Cdd:PRK09835  444 GSGIGLAIVKSIVVAHKGtvAVTSD---ARGTRFVISLPRLE 482
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 307-405 4.64e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 95.61  E-value: 4.64e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 307 FENIVRNALRYSNT--HIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQH 384
Cdd:cd16946     9 FVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNIALAH 88

                          90       100
                  ....*....|....*....|.
gi 1446207975 385 KGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16946    89 GGTISAEHSPLGGLRLVLTLP 109
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
141-406 2.09e-23

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 100.43  E-value: 2.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 141 RPARKLKMAADDVAKGNLRPHPeLESGPQEFLSTGNSFNQMISALDGMVtAQQRLI-SDISHELRTPLTRLQLATALLRR 219
Cdd:PRK10755   87 RPLAELQKELEARTADNLTPIA-IHSSTLEIEAVTSALNQLVSRLTSTL-DQERLFtADVAHELRTPLAGIRLHLELLEK 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 220 RHG-ESKELerieteTHRLDSM---INDLLVLSRSqhKNEILREHIKADELWGDILDDASFEAEQM----NKTLDVTSHP 291
Cdd:PRK10755  165 QHHiDVAPL------IARLDQMmhtVEQLLQLARA--GQSFSSGHYQTVKLLEDVILPSQDELSEMleqrQQTLLLPESA 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 292 GPWPLYCNPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTdearDRETGG 369
Cdd:PRK10755  237 ADITVQGDATLLRLLLRNLVENAHRYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGG 312

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1446207975 370 TGLGLAIVeTAISQ-HKGWVKADD-SPLGGLRLQIWLPE 406
Cdd:PRK10755  313 IGLGLSIV-SRITQlHHGQFFLQNrQERSGTRAWVWLPK 350
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 299-406 4.21e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 93.20  E-value: 4.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 299 NPSAIGSAFENIVRNALRYS--NTHIAVDFKEENNgILITVDDDGPGVSPADREHIFRPFYRTDearDRETGGTGLGLAI 376
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAakAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1446207975 377 VETAISQHKGWVKADDSPLGGLRLQIWLPE 406
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLPL 107
AdeS_HK NF012226
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ...
 142-386 7.56e-22

two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.


Pssm-ID: 411090 [Multi-domain]  Cd Length: 353  Bit Score: 95.83  E-value: 7.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 142 PARKLKMAADDVAKGNL--RPHPElESGPQEFLSTGNSFNQMISALDGMVTAQQRLISDISHELRTPLTRLQlatallRR 219
Cdd:NF012226   87 PINFLADAAKKISQGDLsaRAEDS-QIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQ------GR 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 220 RHG------ESKE------LERIETETHrldsMINDLLVLSRSQhkNEILREHIKadelWGDILD---------DASFEA 278
Cdd:NF012226  160 LQGildgvfEPDPalfkslLNQVEGLSH----LVEDLRTLSLVE--NQQLRLNYE----SVDLKDsiekvlkmfEDRLEQ 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 279 EQMNKTLDVTSHpgpwPLYCNPSAIGSAFENIVRNALRYSNT-HIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFY 357
Cdd:NF012226  230 AQLTIVLNLTAT----PVFCDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFF 305

                         250       260
                  ....*....|....*....|....*....
gi 1446207975 358 RTDEARDRETGGTGLGLAIVETAISQHKG 386
Cdd:NF012226  306 RLEQSRNKEFGGTGLGLAVVHAIVIAHKG 334
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 141-408 1.40e-21

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 96.45  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 141 RPARKLKMAADDVAKGNLRPHPELESGpqEFLSTGNSFNQMISALDG--MVtaqQRLISDISHELRTPLTRLQLATALL- 217
Cdd:PRK11100  208 RSIRRLTRYADAVTEGKPVPLPKLGSS--ELRELAQALESMRVKLEGkaYV---EQYVQTLTHELKSPLAAIRGAAELLq 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 218 -------RRRHgeskeLERIETETHRLDSMINDLLVLSRSQHKNEIL-REHIKADELWGDILDDASFEAEQmnKTLDVTS 289
Cdd:PRK11100  283 edpppedRARF-----TGNILTQSARLQQLIDRLLELARLEQRQELEvLEPVALAALLEELVEAREAQAAA--KGITLRL 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 290 HPGPWPLYCNPSAIGSAFENIVRNALRYSNTH--IAVDFKEENNGILITVDDDGPGVSPADREHIFRPFY---RTDEARD 364
Cdd:PRK11100  356 RPDDARVLGDPFLLRQALGNLLDNAIDFSPEGgtITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK 435

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1446207975 365 retgGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLPEHG 408
Cdd:PRK11100  436 ----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 199-386 6.14e-20

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 91.57  E-value: 6.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 199 ISHELRTPLTRLQLATALLR-RRHGESKE-LERIETETHRLDSMINDLLVLSRSQHKNEilrEHIKADELWGDILDdaSF 276
Cdd:COG5809   277 IAHEIRNPLTSLKGFIQLLKdTIDEEQKTyLDIMLSELDRIESIISEFLVLAKPQAIKY---EPKDLNTLIEEVIP--LL 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 277 EAEQMNKTLDVTSHPG---PwPLYCNPSAIGSAFENIVRNALRY--SNTHIAVD-FKEENNGILITVDDDGPGVSPADRE 350
Cdd:COG5809   352 QPQALLKNVQIELELEddiP-DILGDENQLKQVFINLLKNAIEAmpEGGNITIEtKAEDDDKVVISVTDEGCGIPEERLK 430

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1446207975 351 HIFRPFYRTDEardretGGTGLGLAIVETAISQHKG 386
Cdd:COG5809   431 KLGEPFYTTKE------KGTGLGLMVSYKIIEEHGG 460
PRK10337 PRK10337
sensor protein QseC; Provisional
 113-398 1.83e-19

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 89.71  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 113 LFDRPFLLLIATMLIS---APLLlwlswslaRPARKLKMAADDVAKgnlrPHPElESGPQEFLSTGNSFNQMISALDGMV 189
Cdd:PRK10337  168 LVALPIMLIILMVLLGrelAPLK--------KLALALRMRDPDSET----PLNA-TGVPSEVRPLVEALNQLFARTHAMM 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 190 TAQQRLISDISHELRTPLTRLQLATALLRRRH----GESKELERIETETHRLDSMINDLLVLSR---SQHKNEIlrEHIK 262
Cdd:PRK10337  235 VRERRFTSDAAHELRSPLAALKVQTEVAQLSDddpqARKKALLQLHAGIDRATRLVDQLLTLSRldsLDNLQDV--AEIP 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 263 ADELWGDILDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYSNTHIAVDFKEENNGilITVDDDGP 342
Cdd:PRK10337  313 LEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN--FTVRDNGP 390

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1446207975 343 GVSPADREHIFRPFYRTDearDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGL 398
Cdd:PRK10337  391 GVTPEALARIGERFYRPP---GQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGF 443
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-406 3.73e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 82.25  E-value: 3.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 305 SAFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPadrEHIFR---PFYRTDEARDRETGGTGLGLAIVET 379
Cdd:cd16952     3 SAFSNLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPP---EHIPRlteRFYRVDIERCRNTGGTGLGLAIVKH 79

                          90       100
                  ....*....|....*....|....*..
gi 1446207975 380 AISQHKGWVKADDSPLGGLRLQIWLPE 406
Cdd:cd16952    80 VMSRHDARLLIASELGKGSRFTCLFPS 106
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-402 1.29e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 81.52  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNALRYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDretgGTGLGLAIVETAISQHKGWV 388
Cdd:cd16954    44 NLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGEL 119

                          90
                  ....*....|....
gi 1446207975 389 KADDSPLGGLRLQI 402
Cdd:cd16954   120 SLSDSPLGGARFEV 133
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
195-409 2.20e-18

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 86.76  E-value: 2.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 195 LISDISHELRTPLTRLQ-LATALLRR--RHGESKEL-ERIETETHRLDSMINDLLVLSRSQHKNeiLREHIKADeLWGDI 270
Cdd:PRK10364  240 LAAGVAHEIRNPLSSIKgLAKYFAERapAGGEAHQLaQVMAKEADRLNRVVSELLELVKPTHLA--LQAVDLND-LINHS 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 271 LDDASFEAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYSNTH--IAVDFKEENNGILITVDDDGPGVSPAD 348
Cdd:PRK10364  317 LQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHgvISVTASESGAGVKISVTDSGKGIAADQ 396

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1446207975 349 REHIFRPFYRTdeardrETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLPEHGR 409
Cdd:PRK10364  397 LEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 451
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-404 8.74e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 78.60  E-value: 8.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNALRYSNTHIAVDFK-EENNGILITVDDDGPGVSPADREHIFRPFYRTDEardRETGGTGLGLAIVETAISQHKGW 387
Cdd:cd16940    20 NLVDNAVRYSPQGSRVEIKlSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRIVELHGGQ 96

                          90
                  ....*....|....*..
gi 1446207975 388 VKADDSPLGGLRLQIWL 404
Cdd:cd16940    97 IFLGNAQGGGLEAWVRL 113
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 299-405 1.19e-17

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 77.92  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 299 NPSAIGSAFENIVRNALRYSNTHIAVDFKEE---NNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLA 375
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkfrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1446207975 376 IVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16925    81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 199-405 3.38e-17

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 83.24  E-value: 3.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 199 ISHELRTPLTR----LQLATALLRRRHgesKELERIETETHRLDSMINDLLVLSR--SQHK-----NEILREHI-----K 262
Cdd:COG5805   294 IAHEIRNPLTSikgfLQLLQPGIEDKE---EYFDIMLSELDRIESIISEFLALAKpqAVNKekeniNELIQDVVtlletE 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 263 AdelwgdILDDASFEAEQMNKTLDVtshpgpwplYCNPSAIGSAFENIVRNALRY--SNTHIAVDFKEENNGILITVDDD 340
Cdd:COG5805   371 A------ILHNIQIRLELLDEDPFI---------YCDENQIKQVFINLIKNAIEAmpNGGTITIHTEEEDNSVIIRVIDE 435

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1446207975 341 GPGVSPADREHIFRPFYRTDEArdretgGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:COG5805   436 GIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
PRK10490 PRK10490
sensor protein KdpD; Provisional
 195-405 4.91e-16

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 80.08  E-value: 4.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 195 LISDISHELRTPLTRL-------QLATALLRRRHGESKELERIET-ETHRLdsmINDLLVLSRSQHKNEILR-EHIKADE 265
Cdd:PRK10490  667 LLAALSHDLRTPLTVLfgqaeilTLDLASEGSPHARQASEIRQQVlNTTRL---VNNLLDMARIQSGGFNLRkEWLTLEE 743

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 266 LWGDILddASFEAEQMNKTLDVtSHPGPWPL-YCNPSAIGSAFENIVRNALRY--SNTHIAVDFKEENNGILITVDDDGP 342
Cdd:PRK10490  744 VVGSAL--QMLEPGLSGHPINL-SLPEPLTLiHVDGPLFERVLINLLENAVKYagAQAEIGIDAHVEGERLQLDVWDNGP 820

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1446207975 343 GVSPADREHIFRPFYRTDeaRDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:PRK10490  821 GIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 198-405 1.01e-15

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 78.35  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 198 DISHELRTPLTRLQLatallrrrhGESKELER-IETETHRLDSMINDLLVLSrsqhKNEILREhikadelwgdILDDASF 276
Cdd:COG3290   199 DFRNHLHTISGLLQL---------GEYDEALEyIDEISEELQELIDSLLSRI----GNPVLAA----------LLLGKAA 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 277 EAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRY------SNTHIAVDFKEENNGILITVDDDGPGVSPADRE 350
Cdd:COG3290   256 RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAveklpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLE 335

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1446207975 351 HIFRPFYRTdeardRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:COG3290   336 KIFERGFST-----KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-386 1.12e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 72.42  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 306 AFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDreTGGTGLGLAIVETAISQ 383
Cdd:cd16923     4 VFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAIIEL 81


                  ...
gi 1446207975 384 HKG 386
Cdd:cd16923    82 HGG 84
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
196-402 2.29e-15

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 77.75  E-value: 2.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 196 ISDISHELRTPLTRLQlaTALLRRRHG-----ESKE---LERIETET-------HRLdSMINDLLVLSRSQHKNEILREH 260
Cdd:PRK10815  270 LTDLTHSLKTPLAVLQ--STLRSLRSGkqmsvEQAEpimLEQISRISqqigyylHRA-SMRSEHNLLSRELHSVAPLLDN 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 261 I----------KADELWGDILDDASFEAEQmNKTLDVTShpgpwplycnpsaigsafeNIVRNALRYSNTHIAVDFKEEN 330
Cdd:PRK10815  347 LtsalnkvyqrKGVNITLDISPEITFVGEK-NDFMEVMG-------------------NVLDNACKYCLEFVEISARQTD 406

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1446207975 331 NGILITVDDDGPGVSPADREHIFRPFYRTDEARDretgGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQI 402
Cdd:PRK10815  407 EHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEV 474
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 191-249 1.94e-14

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 67.62  E-value: 1.94e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1446207975 191 AQQRLISDISHELRTPLTRLQLATALLRRRHGESKE----LERIETETHRLDSMINDLLVLSR 249
Cdd:cd00082     3 AKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqreyLERIREEAERLLRLINDLLDLSR 65
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
195-405 2.08e-14

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 75.10  E-value: 2.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 195 LISDISHE----LRTPLTRLQLATALLRRRHGESKELERIETETHRLDSMINDLLVLSRSQHKNeilREHIKADELWGDI 270
Cdd:PRK13837  453 LASGIAHNfnniLGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERN---TKPFDLSELVTEI 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 271 LDDASFeAEQMNKTLDVTSHPGPWPLYCNPSAIGSAFENIVRNALRYSNTHIAVDF----------KEENNG-------I 333
Cdd:PRK13837  530 APLLRV-SLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIslsraklrapKVLSHGvlppgryV 608

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1446207975 334 LITVDDDGPGVSPADREHIFRPFYRTdeardrETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:PRK13837  609 LLRVSDTGAGIDEAVLPHIFEPFFTT------RAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 191-252 2.11e-14

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 67.62  E-value: 2.11e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1446207975 191 AQQRLISDISHELRTPLTRLQLATALLRRRHGES---KELERIETETHRLDSMINDLLVLSRSQH 252
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEeqrEYLETILRSAERLLRLINDLLDLSRIEA 65
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 191-252 3.56e-14

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 66.82  E-value: 3.56e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1446207975  191 AQQRLISDISHELRTPLTRLQLATALLRRRHGESKE---LERIETETHRLDSMINDLLVLSRSQH 252
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQreyLETILREAERLLRLINDLLDLSRIEA 65
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
194-405 4.04e-14

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 73.85  E-value: 4.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 194 RLISDISHELRTPLTRLQLATALLRR---RHGESKELERIETETHRLDSMINDLLVLSR-SQHKNEilREHIKAdelwgd 269
Cdd:PRK11360  392 ELVAGVAHEIRNPLTAIRGYVQIWRQqtsDPPSQEYLSVVLREVDRLNKVIDQLLEFSRpRESQWQ--PVSLNA------ 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 270 ILDDASF---EAEQMNKTLDVTSHPGPWPL-YCNPSAIGSAFENIVRNALRYSNT--HIAVDFKEENNG-ILITVDDDGP 342
Cdd:PRK11360  464 LVEEVLQlfqTAGVQARVDFETELDNELPPiWADPELLKQVLLNILINAVQAISArgKIRIRTWQYSDGqVAVSIEDNGC 543

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1446207975 343 GVSPADREHIFRPFYRTDEArdretgGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:PRK11360  544 GIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
PRK15347 PRK15347
two component system sensor kinase;
196-376 1.16e-13

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 72.75  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 196 ISDISHELRTPLTRLQLATALLRRRHGESKELERIETE---THRLDSMINDLLVLSRSQHKNEILreHIKADELWgDILD 272
Cdd:PRK15347  402 LTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTArqcTLSLLAIINNLLDFSRIESGQMTL--SLEETALL-PLLD 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 273 DA--SFEAEQMNKTLD----VTSHPgPWPLYCNPSAIGSAFENIVRNALRYSNT-HIAVDFKEENNGILITVDDDGPGVS 345
Cdd:PRK15347  479 QAmlTIQGPAQSKSLTlrtfVGAHV-PLYLHLDSLRLRQILVNLLGNAVKFTETgGIRLRVKRHEQQLCFTVEDTGCGID 557

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1446207975 346 PADREHIFRPFYRTDEardrETGGTGLGLAI 376
Cdd:PRK15347  558 IQQQQQIFTPFYQADT----HSQGTGLGLTI 584
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-405 1.17e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 66.54  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNAL------RYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRetggtGLGLAIVETAIS 382
Cdd:cd16915     7 NLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQSVE 81

                          90       100
                  ....*....|....*....|...
gi 1446207975 383 QHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16915    82 RLGGSITVESEPGGGTTFSIRIP 104
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 300-405 2.99e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 65.52  E-value: 2.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 300 PSAIGSAFENIVRNALRYSNTH--IAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDretgGTGLGLAIV 377
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGRgrITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76

                          90       100
                  ....*....|....*....|....*...
gi 1446207975 378 ETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16943    77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 309-386 4.10e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 65.21  E-value: 4.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNALRYSNT-----HIAVDFKEENNGIL-ITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAIS 382
Cdd:cd16922     7 NLLGNAIKFTEEgevtlRVSLEEEEEDGVQLrFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLVE 86


                  ....
gi 1446207975 383 QHKG 386
Cdd:cd16922    87 LMGG 90
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-403 1.18e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 64.02  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 302 AIGSAFENIVRNALRY--SNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDREtGGTGLGLAIVET 379
Cdd:cd16975     4 LLSRALINIISNACQYapEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYIAKN 82

                          90       100
                  ....*....|....*....|....
gi 1446207975 380 AISQHKGWVKADDSPLGGLRLQIW 403
Cdd:cd16975    83 LVEKHGGSLIIENSQKGGAEVTVK 106
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 180-374 1.51e-12

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 68.70  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 180 QMISALDGMVTAQqrlisdiSHELRTPLTRLQLAtallrrrhgeSKELERIETETHRLdsmINDL-LVLSRSQHKNEILR 258
Cdd:NF033792  197 QHLSALDGLAAAA-------AHELGTPLATIALV----------AKELERELPDDPPL---REDAeLLRSQAERCRDILR 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 259 EHIKADELWGDILDDASFEA---EQMNK--------TLDVTSHPGPWP-LYCNPsAIGSAFENIVRNALRYSNTHIAVDF 326
Cdd:NF033792  257 RLTSLGEEGDAHLDRLPLSAlieEAAAPhrgfgkeiEVVVAGDPGEEPvIRRNP-EILYGLGNLIENAVDFARSTVTVTA 335

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1446207975 327 KEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGL 374
Cdd:NF033792  336 SWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEERRPGGGGLGL 383
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 303-405 2.12e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 63.11  E-value: 2.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 303 IGSAFENIVRNALRYSNTH----IAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEarDRETGGTGLGLAIVE 378
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78

                          90       100
                  ....*....|....*....|....*..
gi 1446207975 379 TAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16921    79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-405 5.27e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 62.03  E-value: 5.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 306 AFENIVRNA------------LRYSNTHiAVDFKEENNGILITVD--DDGPGVSPADREHIFRPFYRTDEardretGGTG 371
Cdd:cd16918     4 VFLNLVRNAaqalagsggeiiLRTRTQR-QVTLGHPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSGRE------NGTG 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1446207975 372 LGLAIVETAISQHKGWVKADDSPlGGLRLQIWLP 405
Cdd:cd16918    77 LGLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
marine_sort_HK TIGR03785
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ...
 176-405 8.17e-12

proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.


Pssm-ID: 163497 [Multi-domain]  Cd Length: 703  Bit Score: 67.08  E-value: 8.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 176 NSFNQMISALDGMVTAQQRLISDISHELRTP-------LTRLQLATAllrrrHGESKE-LERIETETHRLDSMINDLLVL 247
Cdd:TIGR03785 469 RSFAQMVARLRQYTHYLENMSSRLSHELRTPvavvrssLENLELQAL-----EQEKQKyLERAREGTERLSMILNNMSEA 543

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 248 SR------SQHK-----NEILREHIKADELwgdilddaSFEAEQMNKTLDVTshpgPWPLYCNPSAIGSAFENIVRNALR 316
Cdd:TIGR03785 544 TRleqaiqSAEVedfdlSEVLSGCMQGYQM--------TYPPQRFELNIPET----PLVMRGSPELIAQMLDKLVDNARE 611

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 317 YS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSP 394
Cdd:TIGR03785 612 FSpeDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQ 691

                         250
                  ....*....|..
gi 1446207975 395 LG-GLRLQIWLP 405
Cdd:TIGR03785 692 QNdGVVFRISLP 703
PRK09303 PRK09303
histidine kinase;
191-396 3.45e-11

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 64.20  E-value: 3.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 191 AQQRLISDISHELRTPLTRLQLATALLR-RRHGESKELERIETE---------THRLDSMINDLLVLSRsqHKNEILReh 260
Cdd:PRK09303  150 FKDRVLAMLAHDLRTPLTAASLALETLElGQIDEDTELKPALIEqlqdqarrqLEEIERLITDLLEVGR--TRWEALR-- 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 261 IKADEL-WGDILDDA------SFEAEQMNKTLDVtshPGPWPL-YCNPSAIGSAFENIVRNALRYSNT--HIAVD-FKEE 329
Cdd:PRK09303  226 FNPQKLdLGSLCQEVilelekRWLAKSLEIQTDI---PSDLPSvYADQERIRQVLLNLLDNAIKYTPEggTITLSmLHRT 302

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1446207975 330 NNGILITVDDDGPGVSPADREHIFRPFYRTDeaRDRETGGTGLGLAIVETAISQHKG--WVkadDSPLG 396
Cdd:PRK09303  303 TQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGqiWV---DSEPG 366
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 295-394 1.39e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 58.68  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 295 PLYC--NPSAIGSAFENIVRNALRYSNT--HIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGT 370
Cdd:cd16947    11 PIYAnaNTEALQRILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGN 90

                          90       100
                  ....*....|....*....|....
gi 1446207975 371 GLGLAIVETAISQHKGWVKADDSP 394
Cdd:cd16947    91 GLGLTITKRLAESMGGSIYVNSKP 114
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 303-405 1.81e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 57.97  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 303 IGSAFENIVRNALRYS---NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVET 379
Cdd:cd16953     1 LGQVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1446207975 380 AISQHKGWVKA----DDSPLGGLRLQIWLP 405
Cdd:cd16953    81 IIEAHGGISVAenhnQPGQVIGARFTVQLP 110
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 309-405 2.82e-10

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 57.39  E-value: 2.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNA-----------LRYSNTHIAVDFKE------ENNGILITVDDDGPGVSPADREHIFRPFYRTDEardrETGGTG 371
Cdd:cd16919     7 NLAVNArdampeggrltIETSNQRVDADYALnyrdliPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE----VGKGTG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1446207975 372 LGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16919    83 LGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
TMAO_torS TIGR02956
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ...
 191-376 3.63e-10

TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]


Pssm-ID: 274362 [Multi-domain]  Cd Length: 968  Bit Score: 62.10  E-value: 3.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 191 AQQRLISDISHELRTPLTRLqLATALLRRRHG----ESKELERIETETHRLDSMINDLLVLSRSQHKN-EILREHIKADE 265
Cdd:TIGR02956 463 AKSAFLATMSHEIRTPLNGI-LGTLELLGDTGltsqQQQYLQVINRSGESLLDILNDILDYSKIEAGHlSISPRPFDLNA 541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 266 LWGDILddASFEAEQMNKTLDVTSH-PGPWPLYCN--PSAIGSAFENIVRNALRYSNT---HIAVDFKEENNgILITVDD 339
Cdd:TIGR02956 542 LLDDVH--HLMVSRAQLKGIQLRLNiPEQLPNWWQgdGPRIRQVLINLVGNAIKFTDRgsvVLRVSLNDDSS-LLFEVED 618

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1446207975 340 DGPGVSPADREHIFRPFYRTDEArdRETGGTGLGLAI 376
Cdd:TIGR02956 619 TGCGIAEEEQATLFDAFTQADGR--RRSGGTGLGLAI 653
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
179-405 3.03e-09

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 58.98  E-value: 3.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  179 NQMISAldgmVTAQQRLISDISHELRTPLTRLQLATALLRRRhGESKElERIETET------HRLDSMINDLLVLSRSQH 252
Cdd:PRK09959   703 NKAINA----TVAKSQFLATMSHEIRTPISSIMGFLELLSGS-GLSKE-QRVEAISlayatgQSLLGLIGEILDVDKIES 776

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  253 KNEILREHikadelWGDILDDA-----SFEAEQMNKTLDVT---SHPGPWPLYCNPSAIGSAFENIVRNALRYSN----- 319
Cdd:PRK09959   777 GNYQLQPQ------WVDIPTLVqntchSFGAIAASKSIALScssTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTegavk 850

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  320 -THIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDREtgGTGLGLAIVETAISQHKGWVKADDSPLGGL 398
Cdd:PRK09959   851 iTTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGT 928


                   ....*..
gi 1446207975  399 RLQIWLP 405
Cdd:PRK09959   929 TFTITIP 935
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-405 6.12e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 53.31  E-value: 6.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 302 AIGSAFENIVRNA------LRYSNTHIAVDFKEENNG-ILITVDDDGPGVSPADREHIFRPFYRTDEArdretgGTGLGL 374
Cdd:cd16944     4 QISQVLTNILKNAaeaiegRPSDVGEVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEPYVTTRPK------GTGLGL 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1446207975 375 AIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16944    78 AIVKKIMEEHGGRISLSNREAGGACIRIILP 108
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 293-405 6.28e-09

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 57.61  E-value: 6.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 293 PWpLYCNPSAIGSAFENIVRNALRySNTHIAVDFKE-------ENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDR 365
Cdd:TIGR02938 379 PA-ILGRELQLRSLFKALVDNAIE-AMNIKGWKRRElsittalNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSRK 456

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1446207975 366 etgGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:TIGR02938 457 ---HIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFR 493
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 191-405 1.07e-08

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 57.22  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 191 AQQRLISDISHELRTPLTRLqLATALLRRRHGESK----ELERIETETHRLDSMINDLLVLSRSQ---HKNEILREHIKA 263
Cdd:PRK11466  443 AKSAFLAAMSHEIRTPLYGI-LGTAQLLADNPALNaqrdDLRAITDSGESLLTILNDILDYSAIEaggKNVSVSDEPFEP 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 264 DELWGDILDDASFEAEQMNKTLDVT-SHPGPWPLYCNPSAIGSAFENIVRNALRYSNT-HIAVDFKEENNGILITVDDDG 341
Cdd:PRK11466  522 RPLLESTLQLMSGRVKGRPIRLATDiADDLPTALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVEDSG 601

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446207975 342 PGVSPADREHIFRPFYRTDEARdretGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:PRK11466  602 CGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-405 3.21e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 51.24  E-value: 3.21e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1446207975 335 ITVDDDGPGVSPADREHIFRPFYRTdeardrETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16920    40 ISVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
213-409 4.04e-08

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 53.85  E-value: 4.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 213 ATALLRRRHGESKELERIETETHrlDSMINDLLVLS--------RSQHKNEILREHIKA----------------DELWG 268
Cdd:COG4585    40 RELAARAEEAREEERRRIARELH--DGVGQSLSAIKlqleaarrLLDADPEAAREELEEirelarealaelrrlvRGLRP 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 269 DILDDASFEA----------EQMNKTLDVTSHPGPWPLycnPSAIGSAFENIVR----NALRYSN-THIAVDFKEENNGI 333
Cdd:COG4585   118 PALDDLGLAAaleelaerllRAAGIRVELDVDGDPDRL---PPEVELALYRIVQealtNALKHAGaTRVTVTLEVDDGEL 194

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1446207975 334 LITVDDDGPGVSPAdrehifrpfyrtdeardrETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLPEHGR 409
Cdd:COG4585   195 TLTVRDDGVGFDPE------------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-399 4.97e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 50.53  E-value: 4.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNAL----RYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTdeardRETG-GTGLGLAIVETAISQ 383
Cdd:cd16976     7 NLLQNALdamgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGLSISYGIVEE 81

                          90
                  ....*....|....*.
gi 1446207975 384 HKGWVKADDSPLGGLR 399
Cdd:cd16976    82 HGGRLSVANEEGAGAR 97
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-385 1.10e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 49.59  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 306 AFENIVRNALRYS--NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYrTDEARDRETGGTGLGLAIVETAISQ 383
Cdd:cd16948     9 IIGQIVSNALKYSkqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF-TGENGRNFQESTGMGLYLVKKLCDK 87


                  ....
gi 1446207975 384 --HK 385
Cdd:cd16948    88 lgHK 91
CpxA_peri pfam16527
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic ...
 34-113 3.09e-07

Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic domain-family of the Gram-negative Gammaproteobacteria two-component signalling system, Cpx. It represents the recognition-site for sensing specific envelope stress signals. The fold that the domain-core of CpxA_peri conforms to is a PAS fold. The domain senses the environmental change and triggers a signal transduction to the cytoplasmic domain. As well as the PAS-core, there is a C-terminal tail that is necessary for ligand-sensing and binding to CpxP, a CpxA-associated and a regulatory protein. This domain recognizes KCl and RbCl (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435400 [Multi-domain]  Cd Length: 134  Bit Score: 49.34  E-value: 3.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975  34 PGQRLIIVTSEGRVIGAMPS---EMQVIRNFIGQSDNADHPKKKKYGRAEILGPFSIRDGEDHYQLYLVRPASSPQSDFI 110
Cdd:pfam16527  51 GRPRFFFTDYEGEILTTKRRsdfRLKALRNFVTSIEDPQKPQQKLYGRYMMAGPVPITLADQTLLMYVGRKWNEPPPFLL 130


                  ...
gi 1446207975 111 NLL 113
Cdd:pfam16527 131 RLF 133
glnL PRK11073
nitrogen regulation protein NR(II);
296-405 2.27e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 49.31  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 296 LYCNPSAIGSAFENIVRNALRYsnthiavdFKEENNGIL---------------------ITVDDDGPGVSPADREHIFR 354
Cdd:PRK11073  231 LAHDPDQIEQVLLNIVRNALQA--------LGPEGGTITlrtrtafqltlhgeryrlaarIDIEDNGPGIPPHLQDTLFY 302

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1446207975 355 PFYRTDEardretGGTGLGLAIVETAISQHKGWVKADDSPlGGLRLQIWLP 405
Cdd:PRK11073  303 PMVSGRE------GGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLP 346
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-398 7.55e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 44.37  E-value: 7.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 306 AFENIVRNALRYSNTH--IAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEARDRETGgTGLGLAIVETAISQ 383
Cdd:cd16945     8 AINNLLDNAIDFSPEGglIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAFVQEVAQL 86

                          90
                  ....*....|....*
gi 1446207975 384 HKGWVKADDSPLGGL 398
Cdd:cd16945    87 HGGRITLRNRPDGVL 101
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 200-383 1.15e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 47.54  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 200 SHELRTPL------TRLQLATALlrrrHGESKE-LERIETETHRLDSMINDLLVLSRSQHKNEILrEHIKADelWGDILD 272
Cdd:PRK11107  301 SHELRTPLngvigfTRQTLKTPL----TPTQRDyLQTIERSANNLLAIINDILDFSKLEAGKLVL-ENIPFS--LRETLD 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 273 DA------SFEAEQMNKTLDVtSHPGPWPLYCNPSAIGSAFENIVRNALRYS---NTHIAVDFKEENNG---ILITVDDD 340
Cdd:PRK11107  374 EVvtllahSAHEKGLELTLNI-DPDVPDNVIGDPLRLQQIITNLVGNAIKFTesgNIDILVELRALSNTkvqLEVQIRDT 452

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1446207975 341 GPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQ 383
Cdd:PRK11107  453 GIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNE 495
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
199-405 9.70e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 44.58  E-value: 9.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 199 ISHELRTPLTRLQLATALLRrrhgeSKELERietETHRLDSMINDllvlSRSqhkneILREHIKadelwgDILDDASFEA 278
Cdd:PRK10841  454 VSHELRTPLYGIIGNLDLLQ-----TKELPK---GVDRLVTAMNN----SSS-----LLLKIIS------DILDFSKIES 510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 279 EQMN------KTLDVTSH----------PGPWPLYC------------NPSAIGSAFENIVRNALRYSNT-----HIAVD 325
Cdd:PRK10841  511 EQLKieprefSPREVINHitanylplvvKKRLGLYCfiepdvpvalngDPMRLQQVISNLLSNAIKFTDTgcivlHVRVD 590

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 326 fkeenNGIL-ITVDDDGPGVSPADREHIFRPFYRTDEARDRETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWL 404
Cdd:PRK10841  591 -----GDYLsFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRI 665


                  .
gi 1446207975 405 P 405
Cdd:PRK10841  666 P 666
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
310-377 1.08e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 44.24  E-value: 1.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1446207975 310 IVRNALRYS------NTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTDEardretgGTGLGLAIV 377
Cdd:COG2972   344 LVENAIEHGiepkegGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGE-------GRGIGLRNV 410
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 210-409 1.66e-04

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 43.74  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 210 LQLATALLR--RRHGESKELERIETET-HRLDSM--INDLLVLSRSqhkneilREHIKADELWGDILDD--ASFEAEQMN 282
Cdd:COG3920   310 LQVVSSLLRlqARRADDPEAREALEESqNRIQALalVHELLYQSED-------WEGVDLRDYLRELLEPlrDSYGGRGIR 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 283 KTLDVTshpgpwPLYCNPSA---IGSAFENIVRNALRY-----SNTHIAVDFKEENNGILITVDDDGPGVsPADREhifr 354
Cdd:COG3920   383 IELDGP------DVELPADAavpLGLILNELVTNALKHaflsgEGGRIRVSWRREDGRLRLTVSDNGVGL-PEDVD---- 451

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1446207975 355 pfyrtdeardrETGGTGLGLAIVETAISQHKGWVKADDSPlgGLRLQIWLPEHGR 409
Cdd:COG3920   452 -----------PPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLAEL 493
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
140-190 1.77e-04

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 39.15  E-value: 1.77e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1446207975  140 ARPARKLKMAADDVAKGNLRPHPElESGPQEFLSTGNSFNQMISALDGMVT 190
Cdd:smart00304   4 LRPLRRLAEAAQRIADGDLTVRLP-VDGRDEIGELARAFNEMADRLEETIA 53
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
310-379 3.60e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 40.28  E-value: 3.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1446207975 310 IVRNALRYSN-----THIAVDFKEENNGILITVDDDGPGVSPADREHifrpfyrtdeaRDRETGGTGLGLAIVET 379
Cdd:COG2172    42 AVTNAVRHAYggdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLPD-----------PYSTLAEGGRGLFLIRR 105
HAMP pfam00672
HAMP domain;
141-185 3.73e-04

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 37.99  E-value: 3.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1446207975 141 RPARKLKMAADDVAKGNLRPHPElESGPQEFLSTGNSFNQMISAL 185
Cdd:pfam00672   8 RPLRRLAEAARRIASGDLDVRLP-VSGRDEIGELARAFNQMAERL 51
PRK13557 PRK13557
histidine kinase; Provisional
 335-405 7.40e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 41.58  E-value: 7.40e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1446207975 335 ITVDDDGPGVSPADREHIFRPFYRTDEardrETGGTGLGLAIVETAISQHKGWVKADDSPLGGLRLQIWLP 405
Cdd:PRK13557  327 IAVTDTGSGMPPEILARVMDPFFTTKE----EGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 141-185 9.11e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 36.65  E-value: 9.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1446207975 141 RPARKLKMAADDVAKGNLRPHPELESGPqEFLSTGNSFNQMISAL 185
Cdd:cd06225     2 RPLRRLTEAARRIAEGDLDVRVPVRSKD-EIGELARAFNQMAERL 45
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
140-243 1.94e-03

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 40.39  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 140 ARPARKLKMAADDVAKGNLRPHPELESGPqEFLSTGNSFNQMISALDGMVTAqqrlISDISHELRTPLTRLQLATALLRR 219
Cdd:COG0840   207 TRPLRELLEVLERIAEGDLTVRIDVDSKD-EIGQLADAFNRMIENLRELVGQ----VRESAEQVASASEELAASAEELAA 281

                          90       100
                  ....*....|....*....|....*
gi 1446207975 220 RHGE-SKELERIETETHRLDSMIND 243
Cdd:COG0840   282 GAEEqAASLEETAAAMEELSATVQE 306
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 302-379 3.77e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 36.48  E-value: 3.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1446207975 302 AIGSAFENIVRNALRYS-NTHIAVDFKEENNGILITVDDDGPGVSPADRehifrpfyRTDEARDREtggTGLGLAIVET 379
Cdd:cd16936     4 AVSEAVTNAVRHAYRHDgPGPVRLELDLDPDRLRVEVTDSGPGFDPLRP--------ADPDAGLRE---GGRGLALIRA 71
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 309-386 4.17e-03

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 39.13  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 309 NIVRNAL----RYSNTHIAVDFKEENNGILITVDDDGPGVSPADREHIFRPFYRTdEARDRetggtGLGLAIVETAISQH 384
Cdd:PRK11086  440 NLIENALeavgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYST-KGSNR-----GVGLYLVKQSVENL 513


                  ..
gi 1446207975 385 KG 386
Cdd:PRK11086  514 GG 515
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 310-405 6.28e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 35.61  E-value: 6.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1446207975 310 IVR----NALRYSN-THIAVDFKEENNGILITVDDDGPGVSPADREhifrpfyrtdeardretGGTGLGLAIVETAISQH 384
Cdd:cd16917     4 IVQealtNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELL 66

                          90       100
                  ....*....|....*....|.
gi 1446207975 385 KGWVKADDSPLGGLRLQIWLP 405
Cdd:cd16917    67 GGTLTIGSRPGGGTRVTARLP 87
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
302-379 6.76e-03

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 36.50  E-value: 6.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1446207975 302 AIGSAFENIVRNALRY-SNTHIAVDFKEENNGILITVDDDGPGVSPADREHifrpfyRTDEARDRETGGTGLGLAIVET 379
Cdd:pfam13581  35 AVGEACTNAVEHAYREgPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP------PDLEEPDEDRKEGGRGLALIRG 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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