carbohydrate kinase family protein that accepts a wide variety of substrates, including carbohydrates and aromatic small molecules, all being phosphorylated at a hydroxyl group; belongs to the ribokinase/pfkB sugar kinase superfamily
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including ...
1-253
2.52e-117
ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-dehydro-3-deoxygluconokinase, 1-phosphofructokinase, the minor 6-phosphofructokinase (PfkB), inosine-guanosine kinase, and adenosine kinase. Even though there is a high degree of structural conservation within this superfamily, their multimerization level varies widely, monomeric (e.g. adenosine kinase), dimeric (e.g. ribokinase), and trimeric (e.g THZ kinase).
The actual alignment was detected with superfamily member cd01938:
Pssm-ID: 469648 Cd Length: 445 Bit Score: 342.84 E-value: 2.52e-117
ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are ...
1-253
2.52e-117
ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ADPGK has been characterized in mouse and is assumed to be desirable during ischemia/hypoxia. ADPGK and ADPPFK contain a large and a small domain with the binding site located in a groove between the domains. Partial domain closing is seen when ADP is bound, and further domain closing is observed when glucose is also bound. The oligomerization state apparently varies depending on the species, with some existing as monomers, some as dimers, and some as tetramers.
Pssm-ID: 238913 Cd Length: 445 Bit Score: 342.84 E-value: 2.52e-117
ADP-specific Phosphofructokinase/Glucokinase conserved region; In archaea a novel type of ...
1-251
4.91e-91
ADP-specific Phosphofructokinase/Glucokinase conserved region; In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilizes two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase. This conserved region is present at the C-terminal of both these proteins. Interestingly this family contains sequences from higher eukaryotes..
Pssm-ID: 461360 Cd Length: 427 Bit Score: 275.26 E-value: 4.91e-91
Archaeal ADP-dependent glucokinase/phosphofructokinase [Carbohydrate transport and metabolism]; ...
17-254
2.23e-16
Archaeal ADP-dependent glucokinase/phosphofructokinase [Carbohydrate transport and metabolism]; Archaeal ADP-dependent glucokinase/phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 443837 Cd Length: 456 Bit Score: 78.04 E-value: 2.23e-16
ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are ...
1-253
2.52e-117
ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ADPGK has been characterized in mouse and is assumed to be desirable during ischemia/hypoxia. ADPGK and ADPPFK contain a large and a small domain with the binding site located in a groove between the domains. Partial domain closing is seen when ADP is bound, and further domain closing is observed when glucose is also bound. The oligomerization state apparently varies depending on the species, with some existing as monomers, some as dimers, and some as tetramers.
Pssm-ID: 238913 Cd Length: 445 Bit Score: 342.84 E-value: 2.52e-117
ADP-specific Phosphofructokinase/Glucokinase conserved region; In archaea a novel type of ...
1-251
4.91e-91
ADP-specific Phosphofructokinase/Glucokinase conserved region; In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilizes two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase. This conserved region is present at the C-terminal of both these proteins. Interestingly this family contains sequences from higher eukaryotes..
Pssm-ID: 461360 Cd Length: 427 Bit Score: 275.26 E-value: 4.91e-91
Archaeal ADP-dependent glucokinase/phosphofructokinase [Carbohydrate transport and metabolism]; ...
17-254
2.23e-16
Archaeal ADP-dependent glucokinase/phosphofructokinase [Carbohydrate transport and metabolism]; Archaeal ADP-dependent glucokinase/phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 443837 Cd Length: 456 Bit Score: 78.04 E-value: 2.23e-16
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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