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Conserved domains on  [gi|1440640862|emb|SUD35232|]
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transcriptional regulator GlmR [Pseudomonas fluorescens]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-252 6.29e-92

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 271.24  E-value: 6.29e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   5 NTPQRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQELVGDPAQPVSVH----KRA 80
Cdd:COG1349     2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLnaeeKRA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  81 IARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVlLMTGGTWDPHSDSFQGQVAEQV 160
Cdd:COG1349    82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEV-ILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 161 LRSYDFDQLFIGADGIDLQRGTTTFNELLG-LSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRLPLEAR 239
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAeVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 1440640862 240 DQIQARGITLICA 252
Cdd:COG1349   241 EALEEAGVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-252 6.29e-92

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 271.24  E-value: 6.29e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   5 NTPQRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQELVGDPAQPVSVH----KRA 80
Cdd:COG1349     2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLnaeeKRA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  81 IARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVlLMTGGTWDPHSDSFQGQVAEQV 160
Cdd:COG1349    82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEV-ILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 161 LRSYDFDQLFIGADGIDLQRGTTTFNELLG-LSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRLPLEAR 239
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAeVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 1440640862 240 DQIQARGITLICA 252
Cdd:COG1349   241 EALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
8-250 8.97e-86

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 255.77  E-value: 8.97e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   8 QRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQElvGDPAQPVSVH-----KRAIA 82
Cdd:PRK10434    5 QRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEE--SDPPIDHKTLinthkKELIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  83 RAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVLLMTGGTWDPHSDSFQGQVAEQVLR 162
Cdd:PRK10434   83 EAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 163 SYDFDQLFIGADGIDLQRGTTTFNELLGLSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRLPLEARDQI 242
Cdd:PRK10434  163 HFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQAL 242


                  ....*...
gi 1440640862 243 QARGITLI 250
Cdd:PRK10434  243 EEKGIEVI 250
AgaR NF040755
transcriptional repressor AgaR;
5-250 1.28e-67

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 209.43  E-value: 1.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   5 NTPQRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAitMPQELVGDPAQPvSVH------- 77
Cdd:NF040755    3 GTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGA--LINDGFIPGAEP-SVEdksrlnt 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  78 --KRAIARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVlLMTGGTWDPHSDSFQGQ 155
Cdd:NF040755   80 avKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEV-LMTGGHLRRQSLSFYGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 156 VAEQVLRSYDFDQLFIGADGIDLQRGTTTFNE-LLGLSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRL 234
Cdd:NF040755  159 QAEQSLQNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGI 238

                         250
                  ....*....|....*.
gi 1440640862 235 PLEARDQIQARGITLI 250
Cdd:NF040755  239 PEEYLQGLRKLGVEVI 254
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 77-231 1.74e-59

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 185.41  E-value: 1.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  77 HKRAIARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVlLMTGGTWDPHSDSFQGQV 156
Cdd:pfam00455   5 EKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEV-ILLGGEVRPKTGAFVGPL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1440640862 157 AEQVLRSYDFDQLFIGADGIDLQRGTTTFNELLG-LSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITD 231
Cdd:pfam00455  84 AEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAeVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 2.04e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 57.62  E-value: 2.04e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1440640862    9 RRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAI 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-58 6.11e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.66  E-value: 6.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1440640862   7 PQRRhNILTLLTEqGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGG 58
Cdd:cd00090     7 PTRL-RILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 12-52 1.23e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 38.88  E-value: 1.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1440640862  12 NILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLL 52
Cdd:TIGR01884 147 KILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV 187
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 7-55 5.23e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 5.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1440640862   7 PQRRhNILTLLTEqGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRR 55
Cdd:NF033788   11 PTRL-RILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 5-252 6.29e-92

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 271.24  E-value: 6.29e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   5 NTPQRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQELVGDPAQPVSVH----KRA 80
Cdd:COG1349     2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLnaeeKRA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  81 IARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVlLMTGGTWDPHSDSFQGQVAEQV 160
Cdd:COG1349    82 IARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEV-ILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 161 LRSYDFDQLFIGADGIDLQRGTTTFNELLG-LSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRLPLEAR 239
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAeVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 1440640862 240 DQIQARGITLICA 252
Cdd:COG1349   241 EALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
8-250 8.97e-86

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 255.77  E-value: 8.97e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   8 QRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQElvGDPAQPVSVH-----KRAIA 82
Cdd:PRK10434    5 QRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEE--SDPPIDHKTLinthkKELIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  83 RAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVLLMTGGTWDPHSDSFQGQVAEQVLR 162
Cdd:PRK10434   83 EAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 163 SYDFDQLFIGADGIDLQRGTTTFNELLGLSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRLPLEARDQI 242
Cdd:PRK10434  163 HFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQAL 242


                  ....*...
gi 1440640862 243 QARGITLI 250
Cdd:PRK10434  243 EEKGIEVI 250
AgaR NF040755
transcriptional repressor AgaR;
5-250 1.28e-67

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 209.43  E-value: 1.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   5 NTPQRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAitMPQELVGDPAQPvSVH------- 77
Cdd:NF040755    3 GTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGA--LINDGFIPGAEP-SVEdksrlnt 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  78 --KRAIARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVlLMTGGTWDPHSDSFQGQ 155
Cdd:NF040755   80 avKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEV-LMTGGHLRRQSLSFYGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 156 VAEQVLRSYDFDQLFIGADGIDLQRGTTTFNE-LLGLSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRL 234
Cdd:NF040755  159 QAEQSLQNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGI 238

                         250
                  ....*....|....*.
gi 1440640862 235 PLEARDQIQARGITLI 250
Cdd:NF040755  239 PEEYLQGLRKLGVEVI 254
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 77-231 1.74e-59

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 185.41  E-value: 1.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  77 HKRAIARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEHEPVlLMTGGTWDPHSDSFQGQV 156
Cdd:pfam00455   5 EKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEV-ILLGGEVRPKTGAFVGPL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1440640862 157 AEQVLRSYDFDQLFIGADGIDLQRGTTTFNELLG-LSRVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITD 231
Cdd:pfam00455  84 AEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAeVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
PRK09802 PRK09802
DeoR family transcriptional regulator;
4-253 4.66e-58

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 185.83  E-value: 4.66e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   4 RNTPQRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQelvGDPAQPVSVH------ 77
Cdd:PRK09802   13 TGTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDS---TTPSVEPSVEdksaln 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  78 ---KRAIARAAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALseLEHEPV-LLMTGGTWDPHSDSFQ 153
Cdd:PRK09802   90 tamKRSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANAL--LEAEGVeLLMTGGHLRRQSQSFY 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 154 GQVAEQVLRSYDFDQLFIGADGIDLQRGTTTFNELLG-LSRVMAEVAREVVVMVESDKIGR----KIPNLElpwsSVHTL 228
Cdd:PRK09802  168 GDQAEQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEArLNRRMCEVAERIIVVTDSSKFNRsslhKIIDTQ----RIDMI 243

                         250       260
                  ....*....|....*....|....*
gi 1440640862 229 ITDDRLPLEARDQIQARGITLICAA 253
Cdd:PRK09802  244 IVDEGIPADSLEGLRKAGVEVILVG 268
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
6-252 6.63e-22

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 91.22  E-value: 6.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   6 TPQRRHN-ILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQELVGdpAQPVSVH------- 77
Cdd:PRK13509    2 TEAQRHQiLLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPR--WTPMNIHqaqnhde 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  78 KRAIARAAVKRLREHARIIIDSGSTTAAMIPELGHQPgLVVMTNSLHVASALSELEHEPVLLMtGGTWDPhSDSFQGQVA 157
Cdd:PRK13509   80 KVRIAKAASQLCNPGESVVINCGSTAFLLGRELCGKP-VQIITNYLPLANYLIDQEHDSVIIM-GGQYNK-SQSITLSPQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 158 EQVLRSYDFDQLFIGADGIDLQrGTTTFNELLGLS-RVMAEVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRLPL 236
Cdd:PRK13509  157 GSENSLYAGHWMFTSGKGLTAD-GLYKTDMLTAMAeQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNADP 235

                         250
                  ....*....|....*.
gi 1440640862 237 EARDQIQARGITLICA 252
Cdd:PRK13509  236 EVLQQLEAQGVSILLV 251
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 35-251 1.14e-16

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 77.04  E-value: 1.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  35 SEVTIRKDLAALESNGLLLrryGGAITM-PQE----LVGDPAQPVSVHKRAIARAAVKRLREHARIIIDSGSTTAAMIPE 109
Cdd:PRK10681   34 SEMTIRRDLNAHSAPVVLL---GGYIVLePRSashyLLSDQKSRLVEEKRRAAQLAATLVEPNQTLFFDCGTTTPWIIEA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 110 LGHQPGLVVMTNSLHVASALSELEHEPVLLmTGGTWDPHSDSFQGQVAEQVLRSYDFDQLFIGADGIDLQRGTTTFN--E 187
Cdd:PRK10681  111 IDNELPFTAVCYSLNTFLALQEKPHCRAIL-CGGEFHASNAIFKPLDFQQTLDNICPDIAFYSAAGVHVSKGATCFNleE 189

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1440640862 188 LLGLSRVMAeVAREVVVMVESDKIGRKIPNLELPWSSVHTLITDDRLPLEARDQIQARGITLIC 251
Cdd:PRK10681  190 LPVKHWAMA-MAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCPDDEFVKYAQAQRIKLMY 252
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
8-237 5.51e-16

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 74.89  E-value: 5.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   8 QRRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAiTMPQELVGDPAQPV----SVHKRAIAR 83
Cdd:PRK10906    5 QRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGA-ALPSSSVNTPWHDRkatqTEEKERIAR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  84 AAVKRLREHARIIIDSGSTTAAMIPELGHQPGLVVMTNSLHVASALSELEhEPVLLMTGGTWDPHSDSFQGQVAEQVLRS 163
Cdd:PRK10906   84 KVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKE-DFRIILAGGELRSRDGGIIGEATLDFISQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862 164 YDFDQLFIGADGIDLQRGTTTFN-ELLGLSRVMAEVAREVVVMVESDKIGRK-IPNL------------ELPWSSVHTLI 229
Cdd:PRK10906  163 FRLDFGILGISGIDSDGSLLEFDyHEVRTKRAIIENSRHVMLVVDHSKFGRNaMVNMgsismvdavytdQLPPASVMQVI 242


                  ....*...
gi 1440640862 230 TDDRLPLE 237
Cdd:PRK10906  243 EDHHVQLE 250
PRK10411 PRK10411
L-fucose operon activator;
9-177 2.61e-12

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 64.44  E-value: 2.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862   9 RRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAITMPQElVGDPAQPVSV-------HKRAI 81
Cdd:PRK10411    5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQ-NQDSGDPFHIrlkshyaHKADI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440640862  82 ARAAVKRLREHARIIIDSGSTTAAMIPELGHQPgLVVMTNSLHVASALSELEHePVLLMTGGTWDPHSDSFQGQVAEQVL 161
Cdd:PRK10411   84 AREALAWIEEGMVIALDASSTCWYLARQLPDIN-IQVFTNSHPICQELGKRER-IQLISSGGTLERKYGCYVNPSLISQL 161

                         170
                  ....*....|....*.
gi 1440640862 162 RSYDFDQLFIGADGID 177
Cdd:PRK10411  162 KSLEIDLFIFSCEGID 177
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
9-60 2.04e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 57.62  E-value: 2.04e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1440640862    9 RRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAI 60
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
9-60 1.61e-10

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 55.34  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1440640862   9 RRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAI 60
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAV 52
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
9-56 2.36e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 47.23  E-value: 2.36e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1440640862   9 RRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRY 56
Cdd:COG2345    14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 13-51 1.04e-05

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 41.65  E-value: 1.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1440640862  13 ILTLLTE-QGEVSVDELAKRFETSEVTIRKDLAALESNGL 51
Cdd:pfam08279   3 ILQLLLEaRGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
HTH_Mga pfam08280
M protein trans-acting positive regulator (MGA) HTH domain; Mga is a DNA-binding protein that ...
 13-46 9.89e-05

M protein trans-acting positive regulator (MGA) HTH domain; Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions.


Pssm-ID: 311953 [Multi-domain]  Cd Length: 59  Bit Score: 39.13  E-value: 9.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1440640862  13 ILTLLTEQGEVSVDELAKRFETSEVTIRKDLAAL 46
Cdd:pfam08280  10 LLELLTENKWITLDELAEELGLSELTLKSDISEL 43
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 9-50 1.52e-04

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 42.37  E-value: 1.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1440640862   9 RRHNILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNG 50
Cdd:COG2378     6 RLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELG 47
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-58 6.11e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.66  E-value: 6.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1440640862   7 PQRRhNILTLLTEqGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGG 58
Cdd:cd00090     7 PTRL-RILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG 56
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 12-52 1.23e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 38.88  E-value: 1.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1440640862  12 NILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLL 52
Cdd:TIGR01884 147 KILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLV 187
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
4-58 1.74e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.94  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1440640862   4 RNTPQRRhnILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGG 58
Cdd:COG3398    95 RRETPRR--ILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDG 147
BglG COG3711
Transcriptional antiterminator [Transcription];
5-57 1.80e-03

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 39.46  E-value: 1.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1440640862   5 NTPQRRHNIL--TLLTEQGEVSVDELAKRFETSEVTIRKDLAALESnglLLRRYG 57
Cdd:COG3711    77 LSPKERVAYIllRLLLAGDPISLDDLAEELFVSRSTILNDLKKIEK---ILKKYG 128
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
27-58 2.38e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 38.46  E-value: 2.38e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1440640862  27 ELAKRFETSEVTIRKDLAALESNGLLLRRYGG 58
Cdd:PRK09464   39 ELAKQFDVSRPSLREAIQRLEAKGLLLRRQGG 70
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
10-61 2.57e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 35.24  E-value: 2.57e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1440640862   10 RHNILTLLTEQGEV--SVDELAKRFETSEVTIRKDLAALESNGLLLRRYGGAIT 61
Cdd:smart00345   6 REDIVSGELRPGDKlpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTF 59
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 12-52 3.41e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 37.74  E-value: 3.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1440640862  12 NILTLLTEQGEVSVDELAKRFETSEVTIRKDLAALESNGLL 52
Cdd:cd09655   143 KILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLV 183
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 7-55 5.23e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 5.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1440640862   7 PQRRhNILTLLTEqGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRR 55
Cdd:NF033788   11 PTRL-RILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR 57
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
13-58 5.56e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 5.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1440640862   13 ILTLLtEQGEVSVDELAKRFETSEVTIRKDLAALESNGLLLRRYGG 58
Cdd:smart00418   2 ILKLL-AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREG 46
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
27-55 7.16e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 36.76  E-value: 7.16e-03
                          10        20
                  ....*....|....*....|....*....
gi 1440640862  27 ELAKRFETSEVTIRKDLAALESNGLLLRR 55
Cdd:COG2188    34 ELAEEFGVSRMTVRKALDELVEEGLLERR 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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