NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1440290856|emb|SUD95666|]
View 

Inner membrane amino-acid ABC transporter permease protein yecS [Pandoraea pulmonicola]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-215 3.23e-78

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 233.43  E-value: 3.23e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   2 FDLFMRALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGIT 81
Cdd:COG0765     5 FSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  82 IDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLAS 161
Cdd:COG0765    85 LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVS 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1440290856 162 TVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLARRY 215
Cdd:COG0765   165 VIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-215 3.23e-78

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 233.43  E-value: 3.23e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   2 FDLFMRALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGIT 81
Cdd:COG0765     5 FSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  82 IDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLAS 161
Cdd:COG0765    85 LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVS 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1440290856 162 TVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLARRY 215
Cdd:COG0765   165 VIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
2-216 1.83e-62

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 193.81  E-value: 1.83e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   2 FDLFMRALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGIT 81
Cdd:PRK15100    5 IQLVIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  82 IDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLAS 161
Cdd:PRK15100   85 LDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAA 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1440290856 162 TVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLARRYQ 216
Cdd:PRK15100  165 TIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQER 219
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 9-211 1.30e-41

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 140.37  E-value: 1.30e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   9 LPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGITIDPIPAA 88
Cdd:TIGR03003  10 LPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPALVAG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  89 LLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVTVVEL 168
Cdd:TIGR03003  90 VLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLEL 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1440290856 169 TRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKL 211
Cdd:TIGR03003 170 MNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 17-202 2.89e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 2.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  17 LVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYG---ITIDPIPAALLALT 93
Cdd:cd06261     2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  94 LFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVTVVELTRVAD 173
Cdd:cd06261    82 LLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGT 161

                         170       180
                  ....*....|....*....|....*....
gi 1440290856 174 QIGATTFRYMEMFLIVGSMYWLINQVLTL 202
Cdd:cd06261   162 GLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 30-213 1.68e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 57.69  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  30 GSVLGMLVALARIstiKPLRWLAFAYVSVFRGTPLLIQMLLIYFgLPNYGITIDPIPAALLALTLFAAAYLSENFRSGIT 109
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856 110 AVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVT----VVELTRVADQIGATTFRyMEM 185
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGswpgLGLLLIEAILGYDYPEI-QGP 155

                         170       180
                  ....*....|....*....|....*...
gi 1440290856 186 FLIVGSMYWLINQVLTLLQTWLEAKLAR 213
Cdd:pfam00528 156 VLAAALILLLLNLLVDILQRLLDPRVRK 183
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-215 3.23e-78

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 233.43  E-value: 3.23e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   2 FDLFMRALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGIT 81
Cdd:COG0765     5 FSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  82 IDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLAS 161
Cdd:COG0765    85 LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVS 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1440290856 162 TVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLARRY 215
Cdd:COG0765   165 VIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
2-216 1.83e-62

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 193.81  E-value: 1.83e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   2 FDLFMRALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGIT 81
Cdd:PRK15100    5 IQLVIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  82 IDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLAS 161
Cdd:PRK15100   85 LDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAA 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1440290856 162 TVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLARRYQ 216
Cdd:PRK15100  165 TIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQER 219
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 2-213 1.66e-54

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 173.74  E-value: 1.66e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   2 FDLFMRALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYG-- 79
Cdd:COG4160     3 LDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEwv 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  80 -------ITIDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIA 152
Cdd:COG4160    83 reswlwpLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVIL 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1440290856 153 LMKDTSLASTVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLAR 213
Cdd:COG4160   163 MLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLR 223
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
10-213 3.59e-47

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 155.28  E-value: 3.59e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  10 PLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGL------------PN 77
Cdd:COG4215    16 PALLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFGGqillnaladlfgYD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  78 YGITIDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDT 157
Cdd:COG4215    96 GFIEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKDT 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1440290856 158 SLASTVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLAR 213
Cdd:COG4215   176 ALVSVIGLVDLVRQAQEAAGSTREPFTFYLAAALIYLALTTVSELVLARLERRASR 231
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 9-211 1.30e-41

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 140.37  E-value: 1.30e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   9 LPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGITIDPIPAA 88
Cdd:TIGR03003  10 LPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPALVAG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  89 LLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVTVVEL 168
Cdd:TIGR03003  90 VLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLEL 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1440290856 169 TRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKL 211
Cdd:TIGR03003 170 MNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 8-211 1.35e-34

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 122.47  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   8 ALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPN--YGITIDPI 85
Cdd:PRK09494   11 AIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMafNDLRIDPF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  86 PAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVTV 165
Cdd:PRK09494   91 TAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGV 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1440290856 166 VELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKL 211
Cdd:PRK09494  171 AELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 9-213 2.15e-34

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 121.88  E-value: 2.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   9 LPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGITIDPIPAA 88
Cdd:TIGR03004   4 LPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVTTG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  89 LLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVTVVEL 168
Cdd:TIGR03004  84 VMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADL 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1440290856 169 TRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLAR 213
Cdd:TIGR03004 164 TFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRR 208
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
8-210 3.63e-26

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 100.67  E-value: 3.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   8 ALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNY---GITIDP 84
Cdd:PRK15107   12 SLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFlqnVLGLSP 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  85 -----IPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSL 159
Cdd:PRK15107   92 ktdirLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSL 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1440290856 160 ASTVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAK 210
Cdd:PRK15107  172 VYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
9-213 1.94e-25

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 98.98  E-value: 1.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   9 LPLLEkAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGITIDPIPAA 88
Cdd:PRK11123    5 FPLAS-AAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGSSQLLLTLSDGFTL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  89 LLALTLFAAAYLSENF------------------------RSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIP 144
Cdd:PRK11123   84 NLGFVQIPVQMDIENFevspflcgvialsllyaayasqtlRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALP 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1440290856 145 PVGSRLIALMKDTSLASTVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLAR 213
Cdd:PRK11123  164 GLGNQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRATR 232
PRK15069 PRK15069
histidine ABC transporter permease HisM;
16-215 4.32e-25

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 98.20  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  16 VLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLpnYGITI------------D 83
Cdd:PRK15069   23 LAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGM--YSLEIvrgtdlldaffrS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  84 PIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTV 163
Cdd:PRK15069  101 GLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTA 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1440290856 164 TVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLtllqTWLEAKLARRY 215
Cdd:PRK15069  181 TVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVL----ISLFRRAERRW 228
artM PRK11122
arginine ABC transporter permease ArtM;
1-210 2.01e-24

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 95.80  E-value: 2.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   1 MFDLFMRALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALarisTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGlPNYGI 80
Cdd:PRK11122    1 MLEYLPELLKGLHTSLTLTVASLLVALVLALIFTIILTL----KTPVLVWLVRGYITLFTGTPLLVQIFLIYYG-PGQFP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  81 TIDPIPAA-----------LLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLsRVILPQALRIAIPPVGSR 149
Cdd:PRK11122   76 WLQEYPWLwhllsqpwlcaMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNE 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1440290856 150 LIALMKDTSLASTVTVVELTRVADQIGATTFRYMeMFLIVGSMYWLINQVLTLLQTWLEAK 210
Cdd:PRK11122  155 VVLVFKSTSLAYTITLMDVMGYSQLLYGRTYDVM-VFGAAGIIYLVVNGLLTLLMRLIERK 214
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 8-106 1.83e-21

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 84.89  E-value: 1.83e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856   8 ALPLLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYGITIDPIPA 87
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTA 80

                          90
                  ....*....|....*....
gi 1440290856  88 ALLALTLFAAAYLSENFRS 106
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIFRG 99
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 102-212 2.24e-19

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 85.20  E-value: 2.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856 102 ENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVTVVELTRVAdqIGAT--- 178
Cdd:COG4597   282 EIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIGYPDLVSVF--AGTTlnq 359

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1440290856 179 TFRYMEMFLIVGSMYWLINQVLTLLQTWLEAKLA 212
Cdd:COG4597   360 TGQAIEIIAITMAVYLTISLLISLLMNWYNRRVA 393
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
11-215 1.08e-17

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 78.30  E-value: 1.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  11 LLEKAVLVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNY-----------G 79
Cdd:PRK15135    8 VILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIAlnsvtealgvgQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  80 ITIDPIPAALLALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSL 159
Cdd:PRK15135   88 IDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATAL 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1440290856 160 ASTVTVVELTRVADQIGATTFRYMEMFLIVGSMYWLINQVLTLLQTWLEaklaRRY 215
Cdd:PRK15135  168 VSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLE----RRY 219
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 17-202 2.89e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 2.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  17 LVTLGLGFGAFVLGSVLGMLVALARISTIKPLRWLAFAYVSVFRGTPLLIQMLLIYFGLPNYG---ITIDPIPAALLALT 93
Cdd:cd06261     2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  94 LFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVTVVELTRVAD 173
Cdd:cd06261    82 LLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGT 161

                         170       180
                  ....*....|....*....|....*....
gi 1440290856 174 QIGATTFRYMEMFLIVGSMYWLINQVLTL 202
Cdd:cd06261   162 GLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 30-213 1.68e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 57.69  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  30 GSVLGMLVALARIstiKPLRWLAFAYVSVFRGTPLLIQMLLIYFgLPNYGITIDPIPAALLALTLFAAAYLSENFRSGIT 109
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856 110 AVDKGQWEAAWAMGMSYRKTLSRVILPQALRIAIPPVGSRLIALMKDTSLASTVT----VVELTRVADQIGATTFRyMEM 185
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGswpgLGLLLIEAILGYDYPEI-QGP 155

                         170       180
                  ....*....|....*....|....*...
gi 1440290856 186 FLIVGSMYWLINQVLTLLQTWLEAKLAR 213
Cdd:pfam00528 156 VLAAALILLLLNLLVDILQRLLDPRVRK 183
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 10-207 4.34e-06

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 45.91  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  10 PLLEKAVLVTLGLGFGAFVLGSVLGMLVALArISTIKPLRWLAFAYVSVFRGTPL--LIQMLLIYFGLPNYGITIdpipa 87
Cdd:COG0600    57 GELWEHLLASLLRVLLGFALAALLGVPLGLL-LGLSRLLRRLLDPLLVFLRPIPPlaLAPLLILWFGIGEASKIF----- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290856  88 allALTLFAAAYLSENFRSGITAVDKGQWEAAWAMGMSYRKTLSRVILPQA-------LRIAIPpvgsrlIALMkdtsla 160
Cdd:COG0600   131 ---VIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAAlpyiftgLRIALG------LAWI------ 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1440290856 161 sTVTVVELTRVADQIGATTFRYMEMF---------LIVGSMYWLINQVLTLLQTWL 207
Cdd:COG0600   196 -GLVVAELLGASSGLGYLILDARQLLdtdlvfaaiLVIGLLGLLLDLLLRLLERRL 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH