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Conserved domains on  [gi|1440290845|emb|SUD95655|]
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Heme:hemopexin utilization protein A [Pandoraea pulmonicola]

Protein Classification

adhes_NPXG and DUF3739 domain-containing protein( domain architecture ID 10020069)

adhes_NPXG and DUF3739 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3739 pfam12545
Filamentous haemagglutinin family outer membrane protein; This domain family is found in ...
 3893-4003 1.75e-43

Filamentous haemagglutinin family outer membrane protein; This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam05860.


:

Pssm-ID: 432625  Cd Length: 111  Bit Score: 155.19  E-value: 1.75e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845 3893 GGSILAWSAQGDINAGRGAKTTVLYTPPKLTYDDKGNVTLASQVPSTGAGIATLAPIAEVPAGDVDLIAPLGTIDAGEAG 3972
Cdd:pfam12545    1 GGDILVWSSEGDIDAGRGAKTALSAPPPRIVYDQDGNVTLEFTGPVSGSGIRTLTASPGGPPGDVDLIAPRGTIDAGEAG 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1440290845 3973 IRVSGNANVAALHVVNAENIQVQGKSTGMPT 4003
Cdd:pfam12545   81 IRSGGNVNIAAPVVVNADNIQVGGSTTGVPT 111
adhes_NPXG TIGR01901
filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain ...
 176-253 1.74e-17

filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain found near the N-terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. Members generally have a signal sequence, then an intervening region, then the region described by this model. Following this region, proteins typically have regions rich in repeats but may show no homology between the repeats of one member and the repeats of another. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, heme/hemopexin-binding protein, etc.


:

Pssm-ID: 273865  Cd Length: 79  Bit Score: 79.63  E-value: 1.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  176 ILNWETFNVGKNTTLNFAQQKD-WAALNRVNDPQarPSQIQGRIQGDGT--VMIVNRNGIVFTGTSQVDTRNLVAAAANI 252
Cdd:TIGR01901    1 FNNWQQFNVGQGGTVTFNQPPAaSNILNRVTGGS--ASQIQGLLQVNGKanVFLINPNGIIFGGGAQINVGGLVASTTAI 78


                   .
gi 1440290845  253 S 253
Cdd:TIGR01901   79 S 79
TPS super family cl47936
TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the ...
 151-401 1.07e-15

TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.


The actual alignment was detected with superfamily member pfam05860:

Pssm-ID: 461762 [Multi-domain]  Cd Length: 249  Bit Score: 80.06  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  151 NANAPTQTVADGRTTVNVRQTAD-----KAILNWETFNVGKNTTLNFAQQKDWA-ALNRVNDPQarPSQIQGRIQGDGT- 223
Cdd:pfam05860    8 TLPTNGPTVLQTGNGVPIVNIATpnaggNLFNSFSQFNVGPGGAVLFNSPTDAQnILNRVTGGN--PSQIQGYIEANGTr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  224 --VMIVNRNGIVFTGTSQVDTRNLVAAAANISNDQfqkqgiyGVNAATPSFTDALGKVEVRAGARIATreptsvtqGGGY 301
Cdd:pfam05860   86 anLFLANPNGIIFGGNAFINIGGSFLTTTAPSIKF-------GDGTEFNPSSVPLGTVSVPGGGQFGS--------NGGY 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  302 VLLMGSTVENAGEIVTHRgQTQLAAGDAFIIRRGVGTDGNAESTTRGNEIA--PQFAVSSTAGAVINrglivaregDVTL 379
Cdd:pfam05860  151 IDLIARAVDNNGQVPAGK-TLALVAGNNDVDGGAPGGRVEIGSVTAAGTVAidAASLGSMYAGNIRL---------IGTD 220

                          250       260
                   ....*....|....*....|..
gi 1440290845  380 GGRDVRQLGVALSSTTVNNRGT 401
Cdd:pfam05860  221 KGAGVRLANGSLVASGGDLNGT 242
 
Name Accession Description Interval E-value
DUF3739 pfam12545
Filamentous haemagglutinin family outer membrane protein; This domain family is found in ...
 3893-4003 1.75e-43

Filamentous haemagglutinin family outer membrane protein; This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam05860.


Pssm-ID: 432625  Cd Length: 111  Bit Score: 155.19  E-value: 1.75e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845 3893 GGSILAWSAQGDINAGRGAKTTVLYTPPKLTYDDKGNVTLASQVPSTGAGIATLAPIAEVPAGDVDLIAPLGTIDAGEAG 3972
Cdd:pfam12545    1 GGDILVWSSEGDIDAGRGAKTALSAPPPRIVYDQDGNVTLEFTGPVSGSGIRTLTASPGGPPGDVDLIAPRGTIDAGEAG 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1440290845 3973 IRVSGNANVAALHVVNAENIQVQGKSTGMPT 4003
Cdd:pfam12545   81 IRSGGNVNIAAPVVVNADNIQVGGSTTGVPT 111
adhes_NPXG TIGR01901
filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain ...
 176-253 1.74e-17

filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain found near the N-terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. Members generally have a signal sequence, then an intervening region, then the region described by this model. Following this region, proteins typically have regions rich in repeats but may show no homology between the repeats of one member and the repeats of another. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, heme/hemopexin-binding protein, etc.


Pssm-ID: 273865  Cd Length: 79  Bit Score: 79.63  E-value: 1.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  176 ILNWETFNVGKNTTLNFAQQKD-WAALNRVNDPQarPSQIQGRIQGDGT--VMIVNRNGIVFTGTSQVDTRNLVAAAANI 252
Cdd:TIGR01901    1 FNNWQQFNVGQGGTVTFNQPPAaSNILNRVTGGS--ASQIQGLLQVNGKanVFLINPNGIIFGGGAQINVGGLVASTTAI 78


                   .
gi 1440290845  253 S 253
Cdd:TIGR01901   79 S 79
TPS pfam05860
TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the ...
 151-401 1.07e-15

TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.


Pssm-ID: 461762 [Multi-domain]  Cd Length: 249  Bit Score: 80.06  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  151 NANAPTQTVADGRTTVNVRQTAD-----KAILNWETFNVGKNTTLNFAQQKDWA-ALNRVNDPQarPSQIQGRIQGDGT- 223
Cdd:pfam05860    8 TLPTNGPTVLQTGNGVPIVNIATpnaggNLFNSFSQFNVGPGGAVLFNSPTDAQnILNRVTGGN--PSQIQGYIEANGTr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  224 --VMIVNRNGIVFTGTSQVDTRNLVAAAANISNDQfqkqgiyGVNAATPSFTDALGKVEVRAGARIATreptsvtqGGGY 301
Cdd:pfam05860   86 anLFLANPNGIIFGGNAFINIGGSFLTTTAPSIKF-------GDGTEFNPSSVPLGTVSVPGGGQFGS--------NGGY 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  302 VLLMGSTVENAGEIVTHRgQTQLAAGDAFIIRRGVGTDGNAESTTRGNEIA--PQFAVSSTAGAVINrglivaregDVTL 379
Cdd:pfam05860  151 IDLIARAVDNNGQVPAGK-TLALVAGNNDVDGGAPGGRVEIGSVTAAGTVAidAASLGSMYAGNIRL---------IGTD 220

                          250       260
                   ....*....|....*....|..
gi 1440290845  380 GGRDVRQLGVALSSTTVNNRGT 401
Cdd:pfam05860  221 KGAGVRLANGSLVASGGDLNGT 242
Haemagg_act smart00912
haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent ...
 143-256 2.38e-15

haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.


Pssm-ID: 214908 [Multi-domain]  Cd Length: 119  Bit Score: 75.01  E-value: 2.38e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845   143 NSLTQGWINANA---PTQTVADGRTTVNvrQTADKAIlNWETFNVGKNTTLNFAQQKD-WAALNRVNDPQarPSQIQGRI 218
Cdd:smart00912    2 NGLPVVNIVTPNshnQYSSFNVGTRGVN--QILNNAI-NWQSFSVGAGETVNFNQPGSaSVILNRVTGGN--PSQINGAL 76

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 1440290845   219 Q----GDGTVMIVNRNGIVFTGTSQVDT-RNLVAAAANISNDQ 256
Cdd:smart00912   77 EvagkAAGVVFLNNPGGIVFGCGAIVNVgGVTVATTLPIIDDG 119
 
Name Accession Description Interval E-value
DUF3739 pfam12545
Filamentous haemagglutinin family outer membrane protein; This domain family is found in ...
 3893-4003 1.75e-43

Filamentous haemagglutinin family outer membrane protein; This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with pfam05860.


Pssm-ID: 432625  Cd Length: 111  Bit Score: 155.19  E-value: 1.75e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845 3893 GGSILAWSAQGDINAGRGAKTTVLYTPPKLTYDDKGNVTLASQVPSTGAGIATLAPIAEVPAGDVDLIAPLGTIDAGEAG 3972
Cdd:pfam12545    1 GGDILVWSSEGDIDAGRGAKTALSAPPPRIVYDQDGNVTLEFTGPVSGSGIRTLTASPGGPPGDVDLIAPRGTIDAGEAG 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1440290845 3973 IRVSGNANVAALHVVNAENIQVQGKSTGMPT 4003
Cdd:pfam12545   81 IRSGGNVNIAAPVVVNADNIQVGGSTTGVPT 111
adhes_NPXG TIGR01901
filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain ...
 176-253 1.74e-17

filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain found near the N-terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. Members generally have a signal sequence, then an intervening region, then the region described by this model. Following this region, proteins typically have regions rich in repeats but may show no homology between the repeats of one member and the repeats of another. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, heme/hemopexin-binding protein, etc.


Pssm-ID: 273865  Cd Length: 79  Bit Score: 79.63  E-value: 1.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  176 ILNWETFNVGKNTTLNFAQQKD-WAALNRVNDPQarPSQIQGRIQGDGT--VMIVNRNGIVFTGTSQVDTRNLVAAAANI 252
Cdd:TIGR01901    1 FNNWQQFNVGQGGTVTFNQPPAaSNILNRVTGGS--ASQIQGLLQVNGKanVFLINPNGIIFGGGAQINVGGLVASTTAI 78


                   .
gi 1440290845  253 S 253
Cdd:TIGR01901   79 S 79
TPS pfam05860
TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the ...
 151-401 1.07e-15

TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.


Pssm-ID: 461762 [Multi-domain]  Cd Length: 249  Bit Score: 80.06  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  151 NANAPTQTVADGRTTVNVRQTAD-----KAILNWETFNVGKNTTLNFAQQKDWA-ALNRVNDPQarPSQIQGRIQGDGT- 223
Cdd:pfam05860    8 TLPTNGPTVLQTGNGVPIVNIATpnaggNLFNSFSQFNVGPGGAVLFNSPTDAQnILNRVTGGN--PSQIQGYIEANGTr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  224 --VMIVNRNGIVFTGTSQVDTRNLVAAAANISNDQfqkqgiyGVNAATPSFTDALGKVEVRAGARIATreptsvtqGGGY 301
Cdd:pfam05860   86 anLFLANPNGIIFGGNAFINIGGSFLTTTAPSIKF-------GDGTEFNPSSVPLGTVSVPGGGQFGS--------NGGY 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845  302 VLLMGSTVENAGEIVTHRgQTQLAAGDAFIIRRGVGTDGNAESTTRGNEIA--PQFAVSSTAGAVINrglivaregDVTL 379
Cdd:pfam05860  151 IDLIARAVDNNGQVPAGK-TLALVAGNNDVDGGAPGGRVEIGSVTAAGTVAidAASLGSMYAGNIRL---------IGTD 220

                          250       260
                   ....*....|....*....|..
gi 1440290845  380 GGRDVRQLGVALSSTTVNNRGT 401
Cdd:pfam05860  221 KGAGVRLANGSLVASGGDLNGT 242
Haemagg_act smart00912
haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent ...
 143-256 2.38e-15

haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.


Pssm-ID: 214908 [Multi-domain]  Cd Length: 119  Bit Score: 75.01  E-value: 2.38e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440290845   143 NSLTQGWINANA---PTQTVADGRTTVNvrQTADKAIlNWETFNVGKNTTLNFAQQKD-WAALNRVNDPQarPSQIQGRI 218
Cdd:smart00912    2 NGLPVVNIVTPNshnQYSSFNVGTRGVN--QILNNAI-NWQSFSVGAGETVNFNQPGSaSVILNRVTGGN--PSQINGAL 76

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 1440290845   219 Q----GDGTVMIVNRNGIVFTGTSQVDT-RNLVAAAANISNDQ 256
Cdd:smart00912   77 EvagkAAGVVFLNNPGGIVFGCGAIVNVgGVTVATTLPIIDDG 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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