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Conserved domains on  [gi|1439168096|emb|STO09949|]
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Bifunctional PGK/TIM [Flavobacterium hibernum]

Protein Classification

triose-phosphate isomerase family protein( domain architecture ID 10785057)

triose-phosphate isomerase (TIM or TPI) family protein such as TIM, a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.-
Gene Ontology:  GO:0005975|GO:0004807|GO:0006094|GO:0006096
PubMed:  12206759|11257493
SCOP:  4003038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-249 1.97e-147

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 411.37  E-value: 1.97e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISA 80
Cdd:COG0149     1 MRKPLIAGNWKMNGTLAEAKALLAALAAALADLADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEISA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  81 DMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESWA 160
Cdd:COG0149    81 AMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAEQAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 161 NVVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKA 240
Cdd:COG0149   161 NVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDA 240


                  ....*....
gi 1439168096 241 DDFLAIVTA 249
Cdd:COG0149   241 EDFLAIVRA 249
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-249 1.97e-147

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 411.37  E-value: 1.97e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISA 80
Cdd:COG0149     1 MRKPLIAGNWKMNGTLAEAKALLAALAAALADLADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEISA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  81 DMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESWA 160
Cdd:COG0149    81 AMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAEQAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 161 NVVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKA 240
Cdd:COG0149   161 NVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDA 240


                  ....*....
gi 1439168096 241 DDFLAIVTA 249
Cdd:COG0149   241 EDFLAIVRA 249
tpiA PRK00042
triosephosphate isomerase; Provisional
 2-249 5.13e-137

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 385.24  E-value: 5.13e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   2 RKKIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISAD 81
Cdd:PRK00042    1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDADGVEVAVAPPFTALASVKEALKGSNIKLGAQNVHPEDSGAFTGEISAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  82 MLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESWAN 161
Cdd:PRK00042   81 MLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQFAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 162 VVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGaDIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKAD 241
Cdd:PRK00042  161 LVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLKAE 239


                  ....*...
gi 1439168096 242 DFLAIVTA 249
Cdd:PRK00042  240 DFLAIVKA 247
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 4-247 4.14e-123

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 349.53  E-value: 4.14e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   4 KIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISADML 83
Cdd:cd00311     1 PLVAGNWKMNGTLAEALELAKALNAVLKDESGVEVVVAPPFTYLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISAEML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  84 TSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHIskESWANVV 163
Cdd:cd00311    81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGV--EDLAPVV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 164 LAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGaDIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKADDF 243
Cdd:cd00311   159 IAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAESF 237


                  ....
gi 1439168096 244 LAIV 247
Cdd:cd00311   238 LDII 241
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 4-250 2.26e-122

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 347.96  E-value: 2.26e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   4 KIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLqAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISADML 83
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADESGVEVVVAPPFTYL-SAVAELLGSNIKVGAQNVDPEESGAFTGEISAEML 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  84 TSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESwANVV 163
Cdd:pfam00121  80 KDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQ-KNLV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 164 LAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFgADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKADDF 243
Cdd:pfam00121 159 IAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELY-KEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEDF 237


                  ....*..
gi 1439168096 244 LAIVTAI 250
Cdd:pfam00121 238 LDIINAA 244
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 5-241 2.62e-46

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 153.42  E-value: 2.62e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   5 IVAGNWKMHKNA-EQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKnttIGVSAQNVHQAEGGAFTGEISADML 83
Cdd:TIGR00419   1 LVIGNWKTYNESrGMRALEVAKIAEEVASEAGVAVAVAPPFVDLPMIKREVE---IPVYAQHVDAVLSGAHTGEISAEML 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  84 TSIGVNTVILGHSERRaiFHESDalIASKVDTALKHDMTVIFCFGeelkdrqsgnhfNIVENQlrdglfhiSKESWANVV 163
Cdd:TIGR00419  78 KDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCTN------------NVLTTA--------AAAALEPDV 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1439168096 164 LAYEPVWAIGTGETASPEQAQEMHEFIREVvrkafgADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKAD 241
Cdd:TIGR00419 134 VAVEPPELIGTGIPVSPAQPEVVHGSVRAV------KEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-249 1.97e-147

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 411.37  E-value: 1.97e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISA 80
Cdd:COG0149     1 MRKPLIAGNWKMNGTLAEAKALLAALAAALADLADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEISA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  81 DMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESWA 160
Cdd:COG0149    81 AMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAEQAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 161 NVVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKA 240
Cdd:COG0149   161 NVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDA 240


                  ....*....
gi 1439168096 241 DDFLAIVTA 249
Cdd:COG0149   241 EDFLAIVRA 249
tpiA PRK00042
triosephosphate isomerase; Provisional
 2-249 5.13e-137

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 385.24  E-value: 5.13e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   2 RKKIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISAD 81
Cdd:PRK00042    1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDADGVEVAVAPPFTALASVKEALKGSNIKLGAQNVHPEDSGAFTGEISAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  82 MLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESWAN 161
Cdd:PRK00042   81 MLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQFAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 162 VVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGaDIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKAD 241
Cdd:PRK00042  161 LVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLKAE 239


                  ....*...
gi 1439168096 242 DFLAIVTA 249
Cdd:PRK00042  240 DFLAIVKA 247
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 4-247 4.14e-123

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 349.53  E-value: 4.14e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   4 KIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISADML 83
Cdd:cd00311     1 PLVAGNWKMNGTLAEALELAKALNAVLKDESGVEVVVAPPFTYLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISAEML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  84 TSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHIskESWANVV 163
Cdd:cd00311    81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGV--EDLAPVV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 164 LAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGaDIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKADDF 243
Cdd:cd00311   159 IAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAESF 237


                  ....
gi 1439168096 244 LAIV 247
Cdd:cd00311   238 LDII 241
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 4-250 2.26e-122

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 347.96  E-value: 2.26e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   4 KIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLqAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISADML 83
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADESGVEVVVAPPFTYL-SAVAELLGSNIKVGAQNVDPEESGAFTGEISAEML 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  84 TSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESwANVV 163
Cdd:pfam00121  80 KDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQ-KNLV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 164 LAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFgADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKADDF 243
Cdd:pfam00121 159 IAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELY-KEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEDF 237


                  ....*..
gi 1439168096 244 LAIVTAI 250
Cdd:pfam00121 238 LDIINAA 244
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-249 5.27e-103

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 299.14  E-value: 5.27e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAGNWKMHKNAEQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISA 80
Cdd:PTZ00333    3 KRKPFVGGNWKCNGTKASIKELIDSFNKLKFDPNNVDVVVAPPSLHIPLVQEKLKNKNFKISSQNVSLTGSGAFTGEISA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  81 DMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESWA 160
Cdd:PTZ00333   83 EMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDEAWD 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 161 NVVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKA 240
Cdd:PTZ00333  163 NIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASLKP 242


                  ....*....
gi 1439168096 241 dDFLAIVTA 249
Cdd:PTZ00333  243 -DFVDIIKS 250
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 1-250 1.16e-100

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 306.27  E-value: 1.16e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAGNWKMHKNAEQTEELLSELIAKIpAQTTAQVIVAPTFVNLQAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISA 80
Cdd:PRK13962  396 PRKPIIAGNWKMNKTPAEAKEFVNELKKYV-KDAQAEVVVCPPFTALPSVKEAVDGSNIKLGAQNVFYEEKGAYTGEISG 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  81 DMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISKESWA 160
Cdd:PRK13962  475 PMLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAALNGLSAEQVK 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 161 NVVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKA 240
Cdd:PRK13962  555 KVVIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPDIDGGLVGGASLKA 634

                         250
                  ....*....|
gi 1439168096 241 DDFLAIVTAI 250
Cdd:PRK13962  635 QEFAAIANYF 644
PLN02561 PLN02561
triosephosphate isomerase
 2-249 2.95e-73

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 223.55  E-value: 2.95e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   2 RKKIVAGNWKMHKNAEQTEELLSEL-IAKIPAQTTAQVIVAPTFVNLqAAVAKLKNTTIGVSAQNVHQAEGGAFTGEISA 80
Cdd:PLN02561    3 RKFFVGGNWKCNGTVEEVKKIVTTLnEAEVPSEDVVEVVVSPPFVFL-PLVKSLLRPDFQVAAQNCWVKKGGAFTGEISA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  81 DMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFHISkeSWA 160
Cdd:PLN02561   82 EMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKVS--DWA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 161 NVVLAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAFGADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKA 240
Cdd:PLN02561  160 NVVLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGASLKP 239


                  ....*....
gi 1439168096 241 dDFLAIVTA 249
Cdd:PLN02561  240 -EFIDIIKS 247
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 1-250 8.75e-62

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 194.83  E-value: 8.75e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAGNWKMHK-NAEQTEEL--LSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKNTT----IGVSAQNVHQAEGGA 73
Cdd:PRK15492    1 MKKIYFGTNLKMYKgIADATDFLakLSELADDIPADKDIELFVIPSFTAIQDAIAATLAIPhdhpIIIGAQNMNPNDNGQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  74 FTGEISADMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLFH 153
Cdd:PRK15492   81 FTGDISPLMLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGISDEILRTQLKIGLHG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 154 ISKESWANVVLAYEPVWAIGT-GETASPEQAQEMHEFIREVVRKAFGaDIADEVSILYGGSVKPDNAKEIFGKPDVDGGL 232
Cdd:PRK15492  161 INPDQLAKLRIAYEPVWAIGEaGIPASADYADEKHAVIKQCLIELFG-DAGDDIPVFYGGSVNAENANELFGQPHIDGLF 239

                         250
                  ....*....|....*...
gi 1439168096 233 IGGAALKADDFLAIVTAI 250
Cdd:PRK15492  240 IGRSAWDADKFFAIIEGI 257
PLN02429 PLN02429
triosephosphate isomerase
 19-250 5.03e-56

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 181.91  E-value: 5.03e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  19 TEELLSELIAKIPAQT---TAQVIVAPTFVNLQAAVAKLKNTtIGVSAQNVHQAEGGAFTGEISADMLTSIGVNTVILGH 95
Cdd:PLN02429   77 TKDSIAKLISDLNSATleaDVDVVVSPPFVYIDQVKSSLTDR-IDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVILGH 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  96 SERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRdgLFHISKESWANVVLAYEPVWAIGTG 175
Cdd:PLN02429  156 SERRHVIGEKDEFIGKKAAYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLK--AFADAVPSWDNIVVAYEPVWAIGTG 233

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1439168096 176 ETASPEQAQEMHEFIREVVRKAFGADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKADDFLAIVTAI 250
Cdd:PLN02429  234 KVASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFATIVNSV 308
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 1-247 2.92e-53

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 175.61  E-value: 2.92e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAG-NWKMHKNAEQTEELLSELIA---KIPAQTTAQVIVAPTFVNLQAAVAKLKNTT----IGVSAQNVHQAEGG 72
Cdd:PRK14905    1 MAKKIYFGtNLKMYKGNAETVDYLSELLAfaeKFKSDYDIELFVIPSYIALKDAVEAAASETghpkIKIGAQNMNAKDKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  73 AFTGEISADMLTSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLF 152
Cdd:PRK14905   81 QFTGEISPLMLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIGLH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 153 HISKESWANVVLAYEPVWAIGTGET-ASPEQAQEMHEFIREVVRKAFGADiADEVSILYGGSVKPDNAKEIFGKPDVDGG 231
Cdd:PRK14905  161 GVSAEQLPHLFIAYEPVWAIGEGGIpASAEYADEKHAIIKQCLFELFAEE-SKKIPVLYGGSVNLENANELIMKPHIDGL 239

                         250
                  ....*....|....*.
gi 1439168096 232 LIGGAALKADDFLAIV 247
Cdd:PRK14905  240 FIGRSAWDAQCFHALI 255
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 5-247 4.33e-52

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 169.17  E-value: 4.33e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   5 IVAgNWKMHKNAEQTEELLSELIAK-IPAQTTAQVIVAPTFVNLQAAVAKLKNTTIGvsAQNVHQAEGGAFTGEISADML 83
Cdd:PRK14565    5 IVA-NWKMNGDFSLFSSFLKELSNKlANNEITLKLVICPPFTAMSSFVECNPNIKLG--AQNCFYGSSGGYTGEISAKML 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  84 TSIGVNTVILGHSERRAIFHESDALIASKVDTALKHDMTVIFCFGEELKDRQSGNHFNIVENQLRDGLfhiskESWANVV 163
Cdd:PRK14565   82 KECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCSNCL-----PKHGEFI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096 164 LAYEPVWAIGTGETASPEQAQEMHEFIREVVRKAfgadiadevSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKADDF 243
Cdd:PRK14565  157 IAYEPVWAIGGSTIPSNDAIAEAFEIIRSYDSKS---------HIIYGGSVNQENIRDLKSINQLSGVLVGSASLDVDSF 227


                  ....
gi 1439168096 244 LAIV 247
Cdd:PRK14565  228 CKII 231
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 5-241 2.62e-46

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 153.42  E-value: 2.62e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   5 IVAGNWKMHKNA-EQTEELLSELIAKIPAQTTAQVIVAPTFVNLQAAVAKLKnttIGVSAQNVHQAEGGAFTGEISADML 83
Cdd:TIGR00419   1 LVIGNWKTYNESrGMRALEVAKIAEEVASEAGVAVAVAPPFVDLPMIKREVE---IPVYAQHVDAVLSGAHTGEISAEML 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096  84 TSIGVNTVILGHSERRaiFHESDalIASKVDTALKHDMTVIFCFGeelkdrqsgnhfNIVENQlrdglfhiSKESWANVV 163
Cdd:TIGR00419  78 KDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCTN------------NVLTTA--------AAAALEPDV 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1439168096 164 LAYEPVWAIGTGETASPEQAQEMHEFIREVvrkafgADIADEVSILYGGSVKPDNAKEIFGKPDVDGGLIGGAALKAD 241
Cdd:TIGR00419 134 VAVEPPELIGTGIPVSPAQPEVVHGSVRAV------KEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 1-126 8.27e-11

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 59.88  E-value: 8.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1439168096   1 MRKKIVAGNWKMHKNAEQTEEL-LSELIAKIPAQTTAQVIVAPTFVNLqAAVAKlkNTTIGVSAQNVHQAEGGAFTGEIS 79
Cdd:PRK04302    1 MKYPIILVNFKTYPEATGKDALeIAKAAEKVSKETGVRIAVAPQALDI-RRVAE--EVDIPVYAQHVDPVEPGSHTGHIL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1439168096  80 ADMLTSIGVNTVILGHSERRAIFHEsdalIASKVDTALKHDMTVIFC 126
Cdd:PRK04302   78 PEAVKDAGAVGTLINHSERRLTLAD----IEAVVERAKKLGLESVVC 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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