|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
1-393 |
0e+00 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 649.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 1 MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMM 80
Cdd:PRK10473 1 MSRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 81 ASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLF 160
Cdd:PRK10473 81 ASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 161 YTMSAMGIIVCLLSLFILRETRPARlAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRG 240
Cdd:PRK10473 161 YTMAAMGILVLLLSLFILKETRPAR-APAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 241 DYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALG 320
Cdd:PRK10473 240 EYAIIMALTAGVSMTVSFSTPFALGIFKPRTLMLTSQVLFLAAGITLALSPSHAVSLFGITLICAGFSVGFGVAMSQALG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1438323654 321 PFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLLILSVAPNRSISEHEEIHNQS 393
Cdd:PRK10473 320 PFSLRAGVASSTLGIAQVCGSSLWIWLAAVLGISAWNMLIGILIACSIVSLLLILFVAPGRPVAAHEEIPHHA 392
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
5-375 |
1.58e-85 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 264.82 E-value: 1.58e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 5 LLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLL 84
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 85 CSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMS 164
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 165 AMGIIVCLLSLFILRETRPARLAPRDLSRSSHAAESLI-NRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYA 243
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLkNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 244 ITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLA-----HTNTVTLFGLMLICAGFPVGFGVAMSQA 318
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAallggLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 319 LGPFSLRAGVASSTLGIAQVCGSSLWIWLAAIL-GISALNMLIGILIGCSIVSMLLIL 375
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLpNGTALPMGLLILVLGLLALLLLIL 378
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
2-373 |
3.79e-37 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 138.67 E-value: 3.79e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 2 KRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMA 81
Cdd:TIGR00710 4 KAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 82 SLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFY 161
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 162 TMSAMGIIVCLLSLFILRETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGD 241
Cdd:TIGR00710 164 FLSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 242 YAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGV----TLSLAHTNTVTLFGLMLICA-GFPVGFGVAMS 316
Cdd:TIGR00710 244 FGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVlleiTAILGLGSWAMIIGPMMFVGiGNSMISSIAMA 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 317 QALGPFSLRAGVASSTLGIAQ-VCGSSLWIWLAAILGISALNMLIGILIgCSIVSMLL 373
Cdd:TIGR00710 324 YALEDFPHVAGTASALFGTLRlVLGAIVGYLVSLIHGNTAWPMSLSCLV-LAVVSVLA 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-343 |
5.44e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.02 E-value: 5.44e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 2 KRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMA 81
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 82 SLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFY 161
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 162 TMSAMGIIVCLLSLFILRETRPARLAPrdlsRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGD 241
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARAR----LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 242 YAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGP 321
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|...
gi 1438323654 322 FSLRA-GVASSTLGIAQVCGSSL 343
Cdd:COG2814 325 APPEArGRASGLYNSAFFLGGPL 347
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
14-375 |
4.42e-33 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 127.34 E-value: 4.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 14 LYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSL 93
Cdd:PRK11102 2 LMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 94 FLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLL 173
Cdd:PRK11102 82 LIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 174 SLFILRETRPA-RLAPRDLSRSSHAAESLI-NRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAG 251
Cdd:PRK11102 162 VFFFIPETLPKeRRQPFHLRTTIRNFASLFrHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 252 VSMVVSF-----------STPFALGLfkprTLMLVSqGLFLTAGVTLSLAHTNTVtlFGLMLICAGFPVGFGVAMSQALG 320
Cdd:PRK11102 242 FLFVMTIinsrfvrrvgaLNMLRFGL----WIQFIM-GIWLVVSALLDLGFWALV--VGVAAFVGCVSMISSNAMAVILD 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1438323654 321 PFSLRAGVASSTLGIAQV-CGSSLWIWLAAILGISALNMLIGILIgCSIVSMLLIL 375
Cdd:PRK11102 315 EFPHMAGTASSLAGTLRFgIGAIVGALLSLAPFTSAWPMVWSMAF-CSILSILFYL 369
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
21-388 |
3.00e-27 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 111.54 E-value: 3.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFL 100
Cdd:PRK11652 26 IYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 101 QGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRE 180
Cdd:PRK11652 106 QGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 181 TRPARLAPRDLSRSSHAAesLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSrgdyaitmaltagvSMVVS--F 258
Cdd:PRK11652 186 TRPADARRTRVLASYRTL--LSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLS--------------SMTVSilF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 259 STPFALGLF---------KPR-TLMLVSQGLFLTAGVTLSL-AHTNTVTLFGLMLICAGFPVG----FGVAMSQALGPFS 323
Cdd:PRK11652 250 ILPIPAAFFgawfagrpnKRFsTLMWQSVICCLLAGLLMWIpGWFGVMNVWTLLVPAALFFFGagmlFPLATSGAMEPFP 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 324 LRAGVASSTLGIAQVCGSSLWIWLAAIL---GISALNMLigiligCSIVSMLLILSVAPNRSISEHEE 388
Cdd:PRK11652 330 YLAGTAGALLGGLQNIGSGLAALLSAMLpqtGQFSLGLL------MTLMGLLILLCWLPLATRMSHQG 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-375 |
3.11e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 108.43 E-value: 3.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:cd17325 19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 106 GSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPA- 184
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPp 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 185 RLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNAS-PVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFA 263
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFlPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 264 LGLFKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQAL----GPFSLRA---GVASSTLGIA 336
Cdd:cd17325 259 SDRIGRKPLILI--GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALladiVPPEGRGtamGLFNTAFSLG 336
|
330 340 350
....*....|....*....|....*....|....*....
gi 1438323654 337 QVCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLLIL 375
Cdd:cd17325 337 MVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-381 |
3.79e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 102.26 E-value: 3.79e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 4 FLLCSFALVLLYpagIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMA 81
Cdd:COG2271 12 LALLFLAYFLNY---LDRSNLSvaAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 82 SLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFY 161
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 162 TMSAMGIIVCLLSLFILretrparlaprdlsrsshaaeslinrfflsrLAITTLSVSVILTFVNASPVLLMEVMEFSRGD 241
Cdd:COG2271 169 ILGLPGLLLALLRFWLL-------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 242 YAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGF----PVGFGVAMSQ 317
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFglggAFGLLWALAA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1438323654 318 ALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLLILSVAPNR 381
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-345 |
1.07e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 1.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 9 FALVLLYPAGIDMYLVGLPR-IAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQ 87
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 88 ATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMG 167
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 168 IIVCLLSLFILRETRPARLAPR-DLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITM 246
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAeEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 247 ALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSL-AHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSLR 325
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAP 321
|
330 340
....*....|....*....|
gi 1438323654 326 AGVASSTLGIAQVCGSSLWI 345
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGA 341
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
23-343 |
1.36e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 100.71 E-value: 1.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 23 LVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQG 102
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 103 VGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSlfilretr 182
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA-------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 183 parlaprdlsrsshaaeslinRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPF 262
Cdd:cd17321 168 ---------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 263 ALGLFKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLM---LICAGFPVGFGVAMSQALGPFSL---RAGVASSTLGIA 336
Cdd:cd17321 227 LADRFGPRLVLVA--GLLLTAVGLLLLALLGADSSVWLLlpgLVLLGLGLGLFATPLTNAALSSVpkeKAGAASGILNTA 304
|
....*..
gi 1438323654 337 QVCGSSL 343
Cdd:cd17321 305 RQLGGAL 311
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-284 |
3.06e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 95.65 E-value: 3.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 2 KRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMA 81
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 82 SLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFY 161
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 162 TMSAMGIIVCLLSLFILRETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGD 241
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1438323654 242 YAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAG 284
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
2-378 |
8.45e-22 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 96.16 E-value: 8.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 2 KRFLLCSFALVLLYPA---GIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVF 78
Cdd:PRK15402 9 RQALLFPLCLVLFEFAtyiANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 79 MMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQS 158
Cdd:PRK15402 89 ILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 159 LFYTMSAMGiivcLLSLFILRETRP--ARLAPRDLSRSSHAAESLI----NRFFLSRLAITTLSVSvILTFVNASPVLLM 232
Cdd:PRK15402 169 MFVLFAALA----ALSFFGLWRAMPetAGRVGEKLSLKELGRDYKLvlknRRFVAGALALGLVSLP-LLAWIALSPVILI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 233 EVMEFSRGDYA-----ITMALTAGVSMVVSFSTPFALglfkPRTLML----VSQGLFLTAGVTLSLAHTNTVTLFGLMLI 303
Cdd:PRK15402 244 SGEQLSSYEYGllqvpVFGALIAGNLTLARLTSRRPL----RSLIRMglwpMVAGLLLAALATVISSHAYLWLTAGLSLY 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1438323654 304 CAGFPVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLLILSVA 378
Cdd:PRK15402 320 AFGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIF 394
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
1-363 |
4.24e-21 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 94.12 E-value: 4.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 1 MKRFL--LCSFALVLLYPAGI-----------DMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGR 67
Cdd:PRK15403 1 MQRMPrfFARHAATLFFPMALilydfaaylttDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 68 KPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLG 147
Cdd:PRK15403 81 RPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 148 HLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARLAP-RDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNA 226
Cdd:PRK15403 161 AALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPfSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 227 SPVLLMEVMEFSRGDYAITM-----ALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLM 301
Cdd:PRK15403 241 SPVILIDAGGMTTSQFAWTQvpvfgAVIVANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIVGNLLWPHVWLWSVLGTS 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 302 LICAGFPVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSL------WIW----------LAAILGISALNMLIGIL 363
Cdd:PRK15403 321 LYAFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMAVsveigrWLWfnggrlpfhlLAVVAGVIVVFTLAGLL 398
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
19-192 |
7.00e-21 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 93.42 E-value: 7.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 19 IDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGR 98
Cdd:PRK11043 22 TDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 99 FLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFIL 178
Cdd:PRK11043 102 FVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLK 181
|
170
....*....|....
gi 1438323654 179 RETRPARLAPRDLS 192
Cdd:PRK11043 182 PSKKARKQSQDALT 195
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
24-351 |
9.64e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 89.94 E-value: 9.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGV 103
Cdd:cd17503 17 VALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 104 GAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFIlretrP 183
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL-----D 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 184 ARLaprdlsrsshaaesLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFA 263
Cdd:cd17503 172 LRL--------------FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 264 LGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTL---FGLMLICAGFPVGFGVAMSQALGPFSL-RAGVASSTLGIAQVC 339
Cdd:cd17503 238 LDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWliiLPLFIRGLGMGLVFMPLNTLALNSLPPeQIGDATALFNTIRQL 317
|
330
....*....|..
gi 1438323654 340 GSSLWIWLAAIL 351
Cdd:cd17503 318 GGSIGTALLATL 329
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-375 |
1.70e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.02 E-value: 1.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 9 FALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQA 88
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 89 TEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLR--FPWQSLFYTMSAM 166
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 167 GIIVCLLSLFILRETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSV----SVILTFVNASPVLLMEVMEFSRGDY 242
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIflvnLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 243 AITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSqGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPF 322
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI-GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 323 SLRAGVASSTLGIAQVCGSSLWIWLAAILGIS-----ALNMLIGILIGCSIVSMLLIL 375
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlaatfGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-336 |
6.32e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.63 E-value: 6.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 3 RFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMAS 82
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 83 LLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYT 162
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 163 MSAMGIIVCLLSLFILRETrPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDY 242
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDP-PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 243 AITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSqGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPF 322
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV-FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330
....*....|....
gi 1438323654 323 SLRAGVASSTLGIA 336
Cdd:COG2223 323 IFPTKNAGAVYGLV 336
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-310 |
3.99e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.93 E-value: 3.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 9 FALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQA 88
Cdd:cd17474 5 FFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 89 TEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLrFPWQSLFYTMSAMGI 168
Cdd:cd17474 85 DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 169 IVCLLSLFILRETrPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMAL 248
Cdd:cd17474 164 VAFLAILFLLPEP-KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAG 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1438323654 249 TAGVSMVVSFSTPFALGL-FKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVG 310
Cdd:cd17474 243 WSVLLALGSLFVGRLLKKrFGARRILVI--GLLLYALSLLLLGFVPSLALLLIAIVLFGLGLG 303
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-364 |
2.51e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 82.60 E-value: 2.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 106 GSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPAR 185
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 186 LAPRDLSRSSHAAesLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALG 265
Cdd:cd17324 182 PGSLGLLSSLLLL--LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 266 LFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSL-- 343
Cdd:cd17324 260 RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALga 339
|
330 340
....*....|....*....|....*....
gi 1438323654 344 --------WIWLAAILGISALNMLIGILI 364
Cdd:cd17324 340 algglvldHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-373 |
3.40e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 82.26 E-value: 3.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 13 LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGS 92
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 93 LFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCL 172
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 173 LSLFILRETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVnasPVLLMEvmefsRG--DYAITMALTA 250
Cdd:cd17489 166 LVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFL---PLYAAE-----RGisNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 251 GVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFpvGFGVAMSQALGPFSL---RAG 327
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF--GLLFPALQALAVDLVpphRRG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1438323654 328 VASSTLGIAQ----VCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLL 373
Cdd:cd17489 316 AANGTFFIFFdlgiGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-190 |
1.03e-16 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 81.66 E-value: 1.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGV 103
Cdd:TIGR00711 23 VAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 104 GAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRP 183
Cdd:TIGR00711 103 GGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKP 182
|
....*..
gi 1438323654 184 ARLAPRD 190
Cdd:TIGR00711 183 AASENFD 189
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-382 |
3.64e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.51 E-value: 3.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 1 MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMM 80
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 81 ASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDtLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLR---FPWQ 157
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 158 SLFYTMSAMGIIVCLLSLFI-LRETRPARLAPRDLSRSSHAAesLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVME 236
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSL--LKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 237 FSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMS 316
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFS 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1438323654 317 QALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILG-ISALNMLIGILIGCSIVSMLLILSVAPNRS 382
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
4-323 |
6.89e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 78.50 E-value: 6.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 4 FLLCSFALVLlypAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMA 81
Cdd:cd17371 1 FWAAFLGWAL---DGFDLLLLGlvLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 82 SLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFP----WQ 157
Cdd:cd17371 78 TLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 158 SLFYTmsamGIIVCLLSLFILRE-TRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNAS--------P 228
Cdd:cd17371 158 VLFLL----GALPALLVLFIRRFvKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGyygittwlP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 229 VLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNtvtlFGLMLIcAGFP 308
Cdd:cd17371 234 SYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLS----PTLILI-LGFP 308
|
330
....*....|....*
gi 1438323654 309 VGFGVAmsqalGPFS 323
Cdd:cd17371 309 LGFFAS-----GPFS 318
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
44-181 |
1.19e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 73.45 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 44 FSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDER 123
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 124 RRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRET 181
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
4-180 |
2.12e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 76.85 E-value: 2.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 4 FLLCSFaLVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASL 83
Cdd:cd17323 1 VFIISF-LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 84 LCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTM 163
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170
....*....|....*..
gi 1438323654 164 SAMGIIVCLLSLFILRE 180
Cdd:cd17323 160 AIISGFCLILIFLFLPI 176
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
17-375 |
3.63e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 72.98 E-value: 3.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 17 AGIDMYLVG--LPRIAADLNASEaQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLF 94
Cdd:cd17502 8 AALDQTIVAtaLPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTML 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 95 LSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYtmsaMGIIVCLLS 174
Cdd:cd17502 87 IVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY----INLPIGGLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 175 LFILREtrparlaprdlsrsshaaeslinrfFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSM 254
Cdd:cd17502 163 LALLRT-------------------------ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 255 VVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSlaHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSLRAGVASSTLG 334
Cdd:cd17502 218 IGSIISGALISKTGRYKPLIVIGTILMSVGAGLL--TTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVG 295
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1438323654 335 IAqVCGSSLWIWLAAILGIsALNMLIGILIGCSIVSMLLIL 375
Cdd:cd17502 296 VA-TATNTFFRSLGGTLGV-AITDVFLVALALAALAFLLSL 334
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-321 |
8.25e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.39 E-value: 8.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 2 KRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMA 81
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 82 SLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFY 161
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 162 TMSAMGIIVCLLSLFILRE--------------TRPARLAPRDLSRSSHAAESLINR----------FFLSRLAITTLSV 217
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFLPEsidflvskrpetvrRIVNAIAPQMQAEAQSALPEQKSTqgtkrsvfkaLFQGKTARITVLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 218 SVILTFVNAS--------PVLLMEV-MEFSRGdyAITMALTAGVSMVVSFSTPFALGLFKPRTLMlvsqGLFLTAGVTLS 288
Cdd:TIGR00895 256 WLLYFMLLVGvyfltnwlPKLMVELgFSLSLA--ATGGALFNFGGVIGSIIFGWLADRLGPRVTA----LLLLLGAVFAV 329
|
330 340 350
....*....|....*....|....*....|....*
gi 1438323654 289 LAHT--NTVTLFGLMLICAGFPVGFGVAMSQALGP 321
Cdd:TIGR00895 330 LVGStlFSPTLLLLLGAIAGFFVNGGQSGLYALMA 364
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-336 |
4.18e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 69.91 E-value: 4.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFL 100
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 101 QGVGaGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFIlre 180
Cdd:cd17504 94 QGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 181 trparlAPRDLSRSSHAAESLInrFFLSRLAITTLSVSVILTFVNASPVLLMevmeFSRGDYAITMALTAGVSMVVSFST 260
Cdd:cd17504 170 ------DLRLLRRRNVLLANIT--ALLAGFGMFMVFQLLPQLLQLPTPTGFG----LGITEAGLLLLPGALVMLIAGPLA 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1438323654 261 PFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLIcagfpVGFGVAMSQALGPFSLRAGVASSTLGIA 336
Cdd:cd17504 238 GRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLL-----IGIGLGLAFASLPNIVVESVPPDRTGIA 308
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-373 |
3.96e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.83 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 25 GLPRIA-ADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGV 103
Cdd:cd17473 21 ALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 104 GAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLImLRFPWQSLFYTMsAMGIIVCLLSLFILRETRP 183
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVY-LLALPVLILVLLFLPEPAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 184 ARlAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNAsPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFA 263
Cdd:cd17473 179 KS-KSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQL-PFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 264 LGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALG--PFSLRA---GVASSTLGIAQV 338
Cdd:cd17473 257 KRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSlvPPELRGramGIVTSAFFLGQF 336
|
330 340 350
....*....|....*....|....*....|....*..
gi 1438323654 339 CGSSLWIWLAAIL-GISALNMLIGI-LIGCSIVSMLL 373
Cdd:cd17473 337 LSPLVLGPLVNLTgGLSGAFLILGVlALVLAIVLLLL 373
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
42-303 |
4.76e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 66.86 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 42 IAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCyvVAFAILRDTLD 121
Cdd:cd17472 36 LALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADLTR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 122 ERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARLAPrdLSRSSHAAESL 201
Cdd:cd17472 114 EENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQIS--EKEKKKLKKLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 202 INR-FFLSRLAITTLSVSVILTFVnASPVLLMEVMeFSRGD----YAITMaLTAGVSMVvsFSTPFALGLFKPRTLMLVS 276
Cdd:cd17472 192 KNKrLLRLDFSIFILHFVLMAFFY-ILPLLLTQLG-GGKGQlwkvYLPAI-LIGFILMV--PFVIYAEKKGKMKQVFVSS 266
|
250 260
....*....|....*....|....*..
gi 1438323654 277 QGLFLTAGVTLSLAHTNTVTLFGLMLI 303
Cdd:cd17472 267 ILLIAVGFLLLLFAATSLWLLIIGLII 293
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
6-215 |
8.22e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 66.14 E-value: 8.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 6 LCsFALVLLypAGIDMYLVGL--PRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASL 83
Cdd:PRK11551 19 LC-FLVALL--EGLDLQSAGVaaPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 84 LCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLngiTCIVP---VLAPVLGHLIMLRFPWQSLF 160
Cdd:PRK11551 96 ATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLM---YCGVPfggALASVIGVLAAGDAAWRHIF 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1438323654 161 YTMSAMGIIVCLLSLFILRETRparlAPRDLSRSSHAAESLINRFFLSRLAITTL 215
Cdd:PRK11551 173 YVGGVGPLLLVPLLMRWLPESR----AFAQAAGAGKQRAPVLRALFGEGRATATL 223
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
9-345 |
9.61e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 65.68 E-value: 9.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 9 FALVLLYPAGIDM---YLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLC 85
Cdd:cd17330 2 FLVVFLDALGFGIvfpVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 86 SQATEGSLFLSGRFLQGVGAGsCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSA 165
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 166 MGIIVCLLSLFILRetrparlaprdlsrsshaaeslinrfFLSRLAITTLSVSVILTFVNAS-PVLLMEVMEFSRGDYAI 244
Cdd:cd17330 161 LALLNLVLVLFFLP--------------------------PLRRLLLVYFLIALAFAGLESVfSLFLKDRFGFSPSQIGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 245 TMALTAGVSMVVSFS-TPFALGLFKPRTLMLVSQGLFLTAGVTLSLAhtNTVTLFGLMLICAGFPVGFGVAMSQALGPFS 323
Cdd:cd17330 215 LLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA--SSVPLLVLAAAILAFGTGIVFPALSALLSKS 292
|
330 340
....*....|....*....|..
gi 1438323654 324 LRAGVASSTLGIAQVCGSSLWI 345
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARI 314
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-377 |
1.27e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 65.32 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 32 DLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVV 111
Cdd:cd17316 30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 112 AFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFP----WQSLFYTMSAMGIIVcllslFILRetrparla 187
Cdd:cd17316 110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALLA-----LLLR-------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 188 prdlsrsshaaeslinRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGLF 267
Cdd:cd17316 177 ----------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 268 KPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSLRAGVASSTLGIAQVCG---SSLW 344
Cdd:cd17316 241 GRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGrlgGGGA 320
|
330 340 350
....*....|....*....|....*....|...
gi 1438323654 345 IWLAAILGISALNMLIGILIGCSIVSMLLILSV 377
Cdd:cd17316 321 PPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
42-181 |
4.38e-11 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 63.37 E-value: 4.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 42 IAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLD 121
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 122 ERRRAKVLSLLNGITCIVPVLAPVLGHLIMlrfPWQSLFYTMSAMGIIVCLLSLFILRET 181
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLWWLPRRT 165
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
42-374 |
6.53e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 63.40 E-value: 6.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 42 IAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLD 121
Cdd:cd17329 39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 122 ERRRAKVLSLLNGITCIVPVLAPVLGhLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARLAPRDLSRSSHAAESL 201
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 202 INRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFL 281
Cdd:cd17329 198 RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 282 TAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQA--LGPFSLRA---GVASSTLGIAQVCGSSLWIWLAAILGISAL 356
Cdd:cd17329 278 IGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVaaLAPPDKRGsymGFYALAWGLGRAIGPLVGGLLLDLLGPGLP 357
|
330
....*....|....*...
gi 1438323654 357 NMLIGILIGCSIVSMLLI 374
Cdd:cd17329 358 WLILAALGLIAAALLLGL 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-364 |
9.52e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.59 E-value: 9.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGV 103
Cdd:cd17319 24 VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 104 GAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRetrp 183
Cdd:cd17319 104 AEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR---- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 184 arlaprdlsrsshaaeslinRFFLsrLAITTLSVSVILTFVNA-SPVLLMEVMEFS---RGDYAITMALTAGVSMVVSfs 259
Cdd:cd17319 180 --------------------QVWG--LALGYFGINYALYGLLTwLPTYLKQARGFSlkqVGLLAAIPFLAGAIGMILG-- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 260 TPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSLRAGVASSTLGIAQVC 339
Cdd:cd17319 236 GRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSG 315
|
330 340
....*....|....*....|....*
gi 1438323654 340 GsslwiWLAAILGisalNMLIGILI 364
Cdd:cd17319 316 G-----NLGGFVA----PLLIGYLV 331
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-374 |
1.08e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 62.63 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIV-----GAIVFMMASLLCSQATEGSLFL 95
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 96 SGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTmSAMGIIVCLLSL 175
Cdd:cd06173 97 VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI-NALSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 176 FILRETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNA----SPVLLMEVMEFSRGDYAITMALTAG 251
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAltvlLPLLAKEVLGGGAAGYGLLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 252 VSMVVSFSTPFALGLFKPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQAL----GPFSLRA- 326
Cdd:cd06173 256 GALLGALLLGRLSKRRRRGRLLLI--GALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLlqlrVPDELRGr 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1438323654 327 --GVASSTLGIAQVCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLLI 374
Cdd:cd06173 334 vfSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
5-173 |
3.12e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.06 E-value: 3.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 5 LLCSFALVLlypAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMAS 82
Cdd:cd17365 2 ALCFLIIVL---DGFDLAVMGfvAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 83 LLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYT 162
Cdd:cd17365 79 LLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170
....*....|.
gi 1438323654 163 MSAMGIIVCLL 173
Cdd:cd17365 159 GGVPPLILLPL 169
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
26-343 |
4.45e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 60.66 E-value: 4.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 106 GSCYVVAFAILRDTLDeRRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPAR 185
Cdd:COG2807 121 AVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 186 LAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVnasPVLLMEvMEFSRGDYAITMALTAGVSMVVSFSTPFALG 265
Cdd:COG2807 200 AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWL---PPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 266 LFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSlRAGVASSTLGIAQVCGSSL 343
Cdd:COG2807 276 RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR-TPAEAAALSGMAQSVGYLL 352
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
5-181 |
1.46e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 59.11 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 5 LLCSFALVLLYPAGIDMYLVGLPrIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLL 84
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVP-MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 85 CSQATEGSL--FLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYT 162
Cdd:cd17380 81 TPLLAYSSLplLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170
....*....|....*....
gi 1438323654 163 MSAMGIIVCLLSLFILRET 181
Cdd:cd17380 161 FGLLGLLWALVWLIYLPPV 179
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-182 |
5.10e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 5.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 3 RFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGR--KPVAIVGAIVFMM 80
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 81 ASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLF 160
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|..
gi 1438323654 161 YTMSAMGIIVCLLSLFILRETR 182
Cdd:COG2271 341 LLLAALALLAALLALLLLRETR 362
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
29-299 |
5.53e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.28 E-value: 5.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 29 IAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATE-GSLFLSGRFLQGVGAGS 107
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 108 CYVVAFAILRDTLDERRRAKVLSLL-NGITCIVPVLAPVLGHLIMlRFPWQSLFYTMSAMGIIVCLLSLFILReTRPARL 186
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILtAGGGLGSLVFLPLGAALIE-AFGWRTALLVLALLALLVLVPVLLLLR-RRPADL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 187 APRDLSRSSHA------AESLINRFFLsRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFST 260
Cdd:cd17355 187 ALRAYDDASPAspgstlKEALRSASFW-LLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLS 265
|
250 260 270
....*....|....*....|....*....|....*....
gi 1438323654 261 PFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFG 299
Cdd:cd17355 266 GWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLL 304
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-201 |
7.08e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 57.25 E-value: 7.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:cd17328 22 LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 106 GSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLI-MLRFPWQSLFYTMSAMGIIVCLLSLFILREtrPA 184
Cdd:cd17328 102 ASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLLLFVRE--PP 179
|
170
....*....|....*..
gi 1438323654 185 RLAPRDLSRSSHAAESL 201
Cdd:cd17328 180 RGAAEGGVMAKSTATSF 196
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
26-369 |
2.73e-08 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 55.34 E-value: 2.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 106 GSCYvVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGhlIMLRFPWQSLFYTMSAMGIIVCLLSLFILRetrpAR 185
Cdd:cd17393 102 GALD-VAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLG--AAAIGAGVSPGVHLLAAAVLLLLAALVAIR----AL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 186 LAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFV------NASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFS 259
Cdd:cd17393 175 LPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALaegaaaDWSALYLRDVLGASAALAALGYAVFSLAMTVGRLF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 260 TPFALGLFKPRTLMLVSqGLFLTAGVTLSL-AHTNTVTLFGLML----ICAGFPVGFGVAMSQALGPFSLRAGVASSTLG 334
Cdd:cd17393 255 GDRLVDRFGDVAVLRAG-ALLAALGLLLALlAPSVWVALAGFALmglgLSVVVPLAFSAAGALPGLAAGIAVARVATLGY 333
|
330 340 350
....*....|....*....|....*....|....*
gi 1438323654 335 IAQVCGSSLWIWLAAILGISALNMLIGILIGCSIV 369
Cdd:cd17393 334 LGFLVGPPLIGFLADATGLRTAFLVVALLALLVAL 368
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
13-179 |
5.33e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 54.19 E-value: 5.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 13 LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGS 92
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 93 LFLSGRFLQGVGAGSCYVVAFAILRDTLDE-RRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVC 171
Cdd:cd17476 88 FFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVA 167
|
....*...
gi 1438323654 172 LLSLFILR 179
Cdd:cd17476 168 VAAIFWTS 175
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
9-186 |
7.51e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 54.17 E-value: 7.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 9 FALVLLYPAGIDMYL---VGLPRIAADLNASEAQLHIAfSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLC 85
Cdd:cd06179 1 AALCLAYFAQLFGVTlpaAVLPFIVADLGPSSNSTWIS-TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 86 SQATEGSLFLSGRFLQGVGAGSCYVVAFAILrDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFP--WQSLFYTM 163
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQGLGAAVAS-ELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158
|
170 180
....*....|....*....|...
gi 1438323654 164 SAMGIIVCLLSLFILRETRPARL 186
Cdd:cd06179 159 AIFNALALILLFFFYHPPPRPQL 181
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
57-375 |
9.71e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.75 E-value: 9.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 57 FAGKIADRSG-----RKPVAIVGAIVFMMASLLCSQATEGS------LFLSGRFLQGVGAGSCYVVAFAILRD-TLDERR 124
Cdd:COG2211 65 LIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAElTPDYEE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 125 RAKVLSLLNGITCIVPVLAPVLGHLIMLRFP------WQSLFYTMSAMGIIVCLLSLFILRETRPARLAPRDLSRSSHAA 198
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKAL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 199 esLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQG 278
Cdd:COG2211 225 --LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 279 LFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSL----------RAGVASSTLGIAQVCGSSLWIWLA 348
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgrrREGLYFGIFTFAIKLGQALAGALA 382
|
330 340 350
....*....|....*....|....*....|....*....
gi 1438323654 349 AIL------------GISALNMLIGILIGCSIVSMLLIL 375
Cdd:COG2211 383 GLLlalfgyvagaaqSPSALTGIRLLFFLLPAVLLLLAA 421
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
1-160 |
2.29e-07 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 52.81 E-value: 2.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 1 MKRFLLCSFALVLLY-PAGIDMYL--VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIV 77
Cdd:PRK14995 1 MFRQWLTLVIIVLVYiPVAIDATVlhVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 78 FMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDT-LDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPW 156
Cdd:PRK14995 81 FGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATfTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYW 160
|
....
gi 1438323654 157 QSLF 160
Cdd:PRK14995 161 GSVF 164
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-177 |
5.00e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 5.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 3 RFLLCSFALVLLYPAGIDMYLVGLPRIAAD-LNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMA 81
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 82 SLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFY 161
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 1438323654 162 TMSAMGIIVCLLSLFI 177
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
25-173 |
5.00e-07 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 51.59 E-value: 5.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 25 GLPRIAADLNASEAQlHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVG 104
Cdd:pfam06609 66 ALPNILQDIGQSENQ-GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA 144
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1438323654 105 AGSCYVVAFAIlRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLL 173
Cdd:pfam06609 145 AGPAGASPLFI-GELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLL 212
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
26-374 |
5.97e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.07 E-value: 5.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGS-LFLSGRFLQGVG 104
Cdd:cd17353 26 NPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPlLFLGYGVLGGIG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 105 AGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILR----- 179
Cdd:cd17353 106 AGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDppkgw 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 180 ---ETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSrgdyAITMALTAGVSMVV 256
Cdd:cd17353 186 vppGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLD----AGIAALAVSILSIF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 257 SFSTPFALGLF-----KPRTLMLVsqGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQALGP-------FSL 324
Cdd:cd17353 262 NGGGRPFWGWLsdkigRKNTLSIA--FLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTAdffgtknAGT 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1438323654 325 RAGVASSTLGIAQVCGSSLWIWLAAILGISALNMLIGILIGCSIVSMLLI 374
Cdd:cd17353 340 NYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
26-106 |
7.11e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 50.64 E-value: 7.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:cd17359 24 LPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAV 103
|
.
gi 1438323654 106 G 106
Cdd:cd17359 104 G 104
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-374 |
1.18e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.01 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGV 103
Cdd:cd17333 17 ILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 104 GAGSCYVVAFAILRdTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYtmSAMGIIVCLLSLFILR---- 179
Cdd:cd17333 97 GAGILDTGANTFVG-ALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAY--LIIGLIYLLLAILILLtlfp 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 180 ETRPARLAP-RDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSF 258
Cdd:cd17333 174 ELPSARNPQqSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 259 STPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLI---CAG-FPVGFGVAMSQALGPFSLRAGVASSTLG 334
Cdd:cd17333 254 LGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLglfMAAlFPTILSLGISNLPYAKGKGTSVLLAAGS 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1438323654 335 IAQVCGSSLWIWLAAILGIsALNMLIGILIGCSIVSMLLI 374
Cdd:cd17333 334 IGGAIIPFIMGFIAEAVGI-QTAMLLITILYAIIFVLALL 372
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
39-177 |
1.43e-06 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 49.78 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 39 QLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRD 118
Cdd:cd17377 40 KVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1438323654 119 TLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMlrfPWQSLFYTMSAMGIIVCLLSLFI 177
Cdd:cd17377 120 CVGKSYWALAGSLGGLFFAVGIAQYALLGYFIR---SWRTLAVVVNLQGTLVFLLSLFI 175
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
31-112 |
1.92e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.58 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 31 ADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGS---LFLSGRFLQGVGAGS 107
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGG 118
|
....*
gi 1438323654 108 CYVVA 112
Cdd:pfam00083 119 ASVLA 123
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
32-372 |
3.56e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 48.70 E-value: 3.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 32 DLNASEAQLHIAFSVY-LAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEG-SLFLSGRFLQGVGAgSCY 109
Cdd:cd17471 26 ELGASPLQIGIFMTLSaLSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYwVLLLVGVVLLSLGA-AAF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 110 VVAFAILRDTLDE---RRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARL 186
Cdd:cd17471 105 PQLFALAREYADRssgRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 187 APrdlSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGL 266
Cdd:cd17471 185 KA---TPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 267 FKPRTLMLVSqGLFLTAGVTLSLAHTNTVTLFGLMLICA---GFPVGFGVAMSQALGPfsLRAGVASS----TLGIAQVC 339
Cdd:cd17471 262 FGKRRLLLAG-FLAGVLFYLGLALATSLWQLIALQLLNAifiGITAGLGISYFQDLMP--GQPGLATTlysnASRIGSLL 338
|
330 340 350
....*....|....*....|....*....|...
gi 1438323654 340 GSSLWIWLAAILGISALNMLIGILIGCSIVSML 372
Cdd:cd17471 339 GGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
14-156 |
3.68e-06 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 49.20 E-value: 3.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 14 LYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEG 91
Cdd:TIGR01299 176 LMADGVEVFVVGfvLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGY 255
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1438323654 92 SLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPW 156
Cdd:TIGR01299 256 GFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
35-177 |
4.11e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 48.86 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 35 ASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFA 114
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1438323654 115 ILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMlrfPWQSLFYTMSAMGIIVCLLSLFI 177
Cdd:TIGR00898 204 LNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP---DWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-377 |
6.47e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.65 E-value: 6.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGV 103
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 104 GAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILREtRP 183
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD-SP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 184 ARLAPRdlsrsshaaeSLINRF-FLSRLAITTLsvsviltfvnaSPVLLMEVMEFSR--GDYAITMALTAGV--SMVVSF 258
Cdd:cd17312 183 PYVWVL----------SLAYAFvYIVRYACLDW-----------GPLYLYEVKGYSLidAGWFSSLYEVGGIagTILAGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 259 STPFALGlfKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFPVG-----FGVAMSQALGPfSLRAGVASSTL 333
Cdd:cd17312 242 LSDKLFG--GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGgpinlIGGAAAQDIGR-KEAAGTATGFV 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1438323654 334 GIAQVCGSSLWIWLAA-ILGISALNMLIGILIGCSIVSMLLILSV 377
Cdd:cd17312 319 GLFGYLGASLAGLPLGyIIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
26-173 |
1.54e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.40 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIV-GAIVFMMASLLCSQATEGSLFLSGRFLQGVG 104
Cdd:cd17477 211 LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGcALLGALAALLLPLVPGLPLALLVLLFLWGGA 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1438323654 105 AGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLL 173
Cdd:cd17477 291 AGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-179 |
1.97e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 9 FALVLLYPAGIDMYLVGLPRIAAD-LNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQ 87
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 88 ATEGS--LFLSGRFLQGVGAGSCYVVAFAILRDTLD-------ERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQS 158
Cdd:COG2211 314 LGPGNlwLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
170 180 190
....*....|....*....|....*....|..
gi 1438323654 159 -----------LFYTMSAMGIIVCLLSLFILR 179
Cdd:COG2211 394 gaaqspsaltgIRLLFFLLPAVLLLLAALLLL 425
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
14-156 |
2.11e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 46.45 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 14 LYPAGIDMYLVG--LPRIAADLNASEAQL-HIAFSVYLAGMATAMLFAGkIADRSGRKPVAIVGAIVFMMASLLCSQATE 90
Cdd:cd17438 8 LMADGVEVFVVGfvLPSAEKDMCLSSSNKgMLGLIVYLGMMAGAFIWGG-LADKLGRKRCLIISLAINASFAFLSSFVQG 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1438323654 91 GSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPW 156
Cdd:cd17438 87 YGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGW 152
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
45-183 |
2.12e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.03 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 45 SVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERR 124
Cdd:cd17315 41 SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1438323654 125 RAKVLSLLNGITCIVPVLAPVLGHLIMLRFP--WQSLFYTMSAMGIIVCLLsLFILRETRP 183
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLL-MFFLPESRA 180
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
21-375 |
4.50e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSG-RKPVAIVGAIVFMMASLLCSQATEGSLFLSGRF 99
Cdd:cd17370 17 MARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 100 LQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIM--LRFPWQSLFYTMSAMGIIVCLLSLFI 177
Cdd:cd17370 97 LERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLylLGGNYRTIFLLAAIPALLALLILLFV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 178 LRETRPARLAPRDLSRSSHAAeslinrffLSRLAITTLSVSVILTFVNAS-PVLLMEVMEFSRGDYAITMALTagVSMVV 256
Cdd:cd17370 177 VKEYPRPPKLRKKSKKTSLKK--------LPKAFWLYLLAVALFALGNFSfAFLILRAQELGLSAALIPLLYA--LFNLV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 257 SFSTPFALGLFKPRT--LMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGfpVGFGV------AMSQALGPFSLRA-- 326
Cdd:cd17370 247 YALAAYPAGRLSDRIgrKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWG--LYMGAqesierAAVADLVPAELRGta 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1438323654 327 -GVASSTLGIAQVCGSSLWIWLAAILGISAlnmLIGILIGCSIVSMLLIL 375
Cdd:cd17370 325 yGLFNTVVGIGWLLASLIAGYLWDLISPSA---AFLFSAVLALIALLLLL 371
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
9-220 |
7.11e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.55 E-value: 7.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 9 FALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMA-TAMLFA---GKIADRSGRKPVAIVGAIVFMMASLL 84
Cdd:cd17388 5 LVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYAlMQFIFApilGALSDRFGRRPVLLLSLAGAALDYLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 85 CSQATEGSLFLSGRFLQGVGAGScYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHL---IMLRFPwqslFY 161
Cdd:cd17388 85 MAFAPTLWWLYLGRIIAGITGAT-GAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLlgeISPRAP----FL 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1438323654 162 TMSAMGIIVCLLSLFILRETRPARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVI 220
Cdd:cd17388 160 VAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLI 218
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
14-156 |
1.00e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 44.25 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 14 LYPAGIDMYLVG--LPRIAADLNASEA-QLHIAFSVYLAGMATAMLFAGkIADRSGRKPVAIVGAIVFMMASLLCSQATE 90
Cdd:cd17439 8 LMADGVEVFVVGfvLPSAEKDMCLSDSnKGMLGLIVYLGMMVGAFLWGG-LADRIGRRQCLLISLSVNSVFAFFSSFVQG 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1438323654 91 GSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPW 156
Cdd:cd17439 87 YGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
14-156 |
1.05e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 44.13 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 14 LYPAGIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEG 91
Cdd:cd17440 8 LMADGVEVFVVGfvLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGY 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1438323654 92 SLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPW 156
Cdd:cd17440 88 GLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-185 |
1.54e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.33 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 2 KRFLLCSFALVLLYPAGIdMYLVGLPRIAAD-LNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMM 80
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFI-GFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 81 ASLLCSQATEG-SLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAP-VLGHLIMLRFPWQS 158
Cdd:COG2223 284 GLLLLALALGSlWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPlLFGALLDATGSYTA 363
|
170 180
....*....|....*....|....*..
gi 1438323654 159 LFYTMSAMGIIVCLLSLFILRETRPAR 185
Cdd:COG2223 364 AFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
26-178 |
1.88e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 43.57 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:PRK10504 33 LPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGG 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1438323654 106 GSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFIL 178
Cdd:PRK10504 113 AMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLM 185
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
48-199 |
2.58e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.95 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 48 LAGMATAmLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAK 127
Cdd:cd17358 52 LGALIGA-LLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGA 130
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1438323654 128 vLSLLNGITCIVPVLapvLGHLIMLRFPWQslfyTMSAMGIIVCL---LSLFILRETrparlaPRDLSRSSHAAE 199
Cdd:cd17358 131 -LGSLNQLLVNIGIL---LGYVLGSFLPWR----TLALIGAIPPVvflILLFFIPES------PRWLAKKGREEE 191
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
27-181 |
4.34e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 42.14 E-value: 4.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 27 PRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAG 106
Cdd:cd17372 23 PAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1438323654 107 SCYVVAfAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRET 181
Cdd:cd17372 103 GGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKTT 176
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
45-177 |
5.35e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 41.85 E-value: 5.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 45 SVYLAGMaTAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERR 124
Cdd:cd17361 59 SLYLAGL-VASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKL 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1438323654 125 RAKVLSLLNGITCIVPVLAPVLGHLI--MLRFPWQSLFYTMSAMGIIVCLLSLFI 177
Cdd:cd17361 138 RGALNIGFQLAITIGILIANLINYGTskIKPNGWRLSLGLAAVPALILLLGSLFL 192
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
26-169 |
6.07e-04 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 41.83 E-value: 6.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:PRK10213 43 LTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLAL 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1438323654 106 GSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGII 169
Cdd:PRK10213 123 GGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVL 186
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
59-374 |
8.01e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 8.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 59 GKIADRSG-RKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAGS--CYVVAFAILRDTLDErrrAKVLSLLNGI 135
Cdd:cd17490 52 GILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATwvSFTVLYASYFPPDEA---AKAMGLINLV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 136 TCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARLAPRDLS--RSSHAAESLInrfFLSRLAIT 213
Cdd:cd17490 129 NNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKelLSVLKDKKLL---FFSLLAIL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 214 TLSVSVILTFvNASPVLLMEVmefsrGDYAITMALTAGVSMVVS-----FSTPFALGLFKPRTLMLVsqGLFLTAGVTLS 288
Cdd:cd17490 206 QQMITFSTTF-GFTPLIAKQL-----GASSFQLGLLSIIYLLPNalaslLSGTLFYKKLGERNTIII--GFLLLGAYCFL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 289 LAHTNTVTLFGLMLICAGFPVGFGVAMSQALGPFSLRAGVASSTLGIAQV---CGSSLWIWLAAIL----GISALNMLIG 361
Cdd:cd17490 278 IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAiyaLGMFLGPVLVGIIseafGLQTGFFVIG 357
|
330
....*....|....
gi 1438323654 362 IL-IGCSIVSMLLI 374
Cdd:cd17490 358 VIaLLAAILSLAYY 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
27-188 |
8.23e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 8.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 27 PRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAG 106
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 107 SCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARL 186
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASA 179
|
..
gi 1438323654 187 AP 188
Cdd:cd17475 180 AT 181
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
18-132 |
1.35e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 40.55 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 18 GIDMYLVG--LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFL 95
Cdd:cd17363 12 GVEVFVVGfvLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFL 91
|
90 100 110
....*....|....*....|....*....|....*..
gi 1438323654 96 SGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLL 132
Cdd:cd17363 92 FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWL 128
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-144 |
1.62e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 2 KRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKP---VAIVGAIVF 78
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1438323654 79 MMASLLCSQATEGSLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRAKVLSLLNGITCIVPVLAP 144
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
138-351 |
1.76e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 138 IVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETRPARLAPRDLSRSSHAAESL----INRFFLsRLAIT 213
Cdd:cd17332 151 LVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLkallKNRPFL-ILLLA 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 214 TLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTN 293
Cdd:cd17332 230 YLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPG 309
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1438323654 294 TVTLFGLMLICAGFPVGFGVAMSQALGPFSL----------RAGVASSTLGIAQVCGSSLWIWLAAIL 351
Cdd:cd17332 310 NLVLILVLAVLAGIGYGGANLLPWAMLADVIdygelktgkrREGIFYSVMTFFRKLGLALAGALVGLI 377
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
29-177 |
2.27e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 29 IAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATE-GSLFLSGRFLQGVGAGS 107
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSlWQLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 108 CYVVAFAILrDTLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFI 177
Cdd:cd17352 109 IYSPAIVIV-GQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL 177
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
44-112 |
4.53e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 38.77 E-value: 4.53e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 44 FSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEG-SLFLSGRFLQGVGAGSCYVVA 112
Cdd:cd17356 51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKwYQLIVGRIIAGLGVGFASVLV 120
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
56-319 |
5.40e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 56 LFAGKIADRSGRKpVAIVGAIVFMMAS-----LLCSQATEG----SLFLSGRFLQGVGAGSCYVVAFAILRDTLDERRRA 126
Cdd:cd17367 58 WLFGRLADRIGRR-AALTLSVSLMAAGslviaVTPTYATIGiwapIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 127 -----KVLSLLNGITC---IVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVcllslFILRETRPARLAPRDLSRSSHAA 198
Cdd:cd17367 137 fyssfQYVTLIGGQLLalgVLLVLQHTLGEDQMAAWGWRIPFLLGGVLAVVV-----LWLRRGLEETESFEAIAESNEAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 199 ESLIN------RFFLSRLAITTLSVSVILTFVNASPVLLMEVMEFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTL 272
Cdd:cd17367 212 AGTLRelrrhpRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPL 291
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1438323654 273 MLVSQGLF--LTAGVTLSLAHTNTVTLFGLMLICAGFPVGFGVAMSQAL 319
Cdd:cd17367 292 LLFFGIGGtlATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVV 340
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
45-106 |
7.41e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.02 E-value: 7.41e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1438323654 45 SVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGAG 106
Cdd:cd17360 42 SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVG 103
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
24-342 |
8.27e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.13 E-value: 8.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 24 VGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGV 103
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 104 GAGSCYVVAFAILRDTLDERRRAKVLSLLN-GITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLSLFILRETR 182
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWNcSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 183 ------------------PARLAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNA-SPVLLMEVMEFSR--GD 241
Cdd:TIGR00881 176 qscglppaeempneepdgDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDwSPLYLTQEKGFSKekAS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 242 YAITMALTAGVSMVVsFSTPFALGLFKPRTLMLvsqGLFLTAGVTLSLA-HTNTVTLFGLMLICAGFPVGFGVAMSQALg 320
Cdd:TIGR00881 256 WAFTLYELGGLVGTL-LAGWLSDKLFNGRRGPL---AVFFMALIIVSLLvYWLNPAANPLMDLICLFALGFLVYGPQML- 330
|
330 340
....*....|....*....|..
gi 1438323654 321 pfslrAGVASSTLGIAQVCGSS 342
Cdd:TIGR00881 331 -----IGVIASELAPKKAAGTA 347
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-375 |
9.09e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 37.92 E-value: 9.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 26 LPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADRSGRKPVAIVGAIVFMMASLLCSQATEGSLFLSGRFLQGVGA 105
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 106 GSCYVVAFAILRDtLDERRRAKVLSLLNGITCIVPVLAPVLGHLIMLRFPWQSLFYTMSAMGIIVCLLsLFILRETRPAR 185
Cdd:cd17478 99 AAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALL-LLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 186 LAPRDLSRSSHAAESLINRFFLSRLAITTLSVSVILTFVNASPVLLMEvmefsRGDYAITMALTAGVSMVVSFSTPFALG 265
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-----RGYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1438323654 266 L----FKPRTLMLVSqgLFLTAGVTLSLAHTNTV-TLFGLMLICAGFPVGFGVAMSQALGPFSLRAGVASS-TLGIAQVC 339
Cdd:cd17478 252 PlsdrFGRRRVIIAS--LLLAAPFLLLFLLTPGIwSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGlMMGLSFGL 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 1438323654 340 GSSlwiwLAAILGISALNMLIGILIGCSIVSMLLIL 375
Cdd:cd17478 330 GGI----GAPVLGALADAFGLESVLLILALLPLLGA 361
|
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| |
