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Conserved domains on  [gi|1437989728|emb|SUG28624|]
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E3 ubiquitin-protein ligase SlrP [Salmonella enterica subsp. arizonae]

Protein Classification

SPI-1 type III secretion system effector E3 ubiquitin transferase SlrP( domain architecture ID 11487756)

SPI-1 type III secretion system effector E3 ubiquitin transferase SlrP is a leucine-rich repeat-containing E3 ubiquitin ligase that interferes with the host's ubiquitination pathway; it can ubiquitinate both ubiquitin and host thioredoxin, which leads to the increase of host cell death

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
51-816 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 1616.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728  51 MFNITNTQSTVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYPAY 130
Cdd:PRK15370    1 MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 131 ADNIQCGREGTNQYCILNENSQEILSIIFNSDSYTVECGGETVTYTRETAGEKASSASGpgSKDAVNYDVIWSEWVKSAP 210
Cdd:PRK15370   81 ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASG--SKDAVNYELIWSEWVKEAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 211 TEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPEKLHANIKEISVRENNLTRLPET 290
Cdd:PRK15370  159 AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 291 LPDTIEIMDLDRNNIIELPERLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTF 370
Cdd:PRK15370  239 LPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 371 LPATLPMNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYIDHNLLINLPENLPAALQYLEASYN 450
Cdd:PRK15370  319 LPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 451 QLARLPESLPSFLSEGPQPARILIEHNPISERTIQNMQMLMSSEGYRGPRVFFAMGEFSNVRVTRPLHEAVQGWLTCLKE 530
Cdd:PRK15370  399 NLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTNLEE 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 531 EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISCEDRVTLAYHQMQ 610
Cdd:PRK15370  479 EDVNQWRAFETEVNAAAFSMFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSALRETAFIIAMDATISCEDRVTLAYHQMQ 558

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 611 EATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 690
Cdd:PRK15370  559 EATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 638

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 691 ITESDLDEAEVRIKVAENSQFNQWLSCWEPWHKVLERIAPDDWQEMMNKRVEYIESNEYQSRVNAKLSALKIAGDSDPer 770
Cdd:PRK15370  639 ITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAECIETDEYQSRVNAELEALGIAGDPDA-- 716

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 1437989728 771 aieiradaERAIGRQVMEEINQSLFTELTEKVLTKQRINSLMTPYW 816
Cdd:PRK15370  717 --------ERMAGMRIMEEINQTLFTEIMENILLKKEVSSLMSAYW 754
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
51-816 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 1616.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728  51 MFNITNTQSTVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYPAY 130
Cdd:PRK15370    1 MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 131 ADNIQCGREGTNQYCILNENSQEILSIIFNSDSYTVECGGETVTYTRETAGEKASSASGpgSKDAVNYDVIWSEWVKSAP 210
Cdd:PRK15370   81 ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASG--SKDAVNYELIWSEWVKEAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 211 TEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPEKLHANIKEISVRENNLTRLPET 290
Cdd:PRK15370  159 AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 291 LPDTIEIMDLDRNNIIELPERLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTF 370
Cdd:PRK15370  239 LPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 371 LPATLPMNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYIDHNLLINLPENLPAALQYLEASYN 450
Cdd:PRK15370  319 LPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 451 QLARLPESLPSFLSEGPQPARILIEHNPISERTIQNMQMLMSSEGYRGPRVFFAMGEFSNVRVTRPLHEAVQGWLTCLKE 530
Cdd:PRK15370  399 NLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTNLEE 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 531 EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISCEDRVTLAYHQMQ 610
Cdd:PRK15370  479 EDVNQWRAFETEVNAAAFSMFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSALRETAFIIAMDATISCEDRVTLAYHQMQ 558

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 611 EATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 690
Cdd:PRK15370  559 EATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 638

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 691 ITESDLDEAEVRIKVAENSQFNQWLSCWEPWHKVLERIAPDDWQEMMNKRVEYIESNEYQSRVNAKLSALKIAGDSDPer 770
Cdd:PRK15370  639 ITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAECIETDEYQSRVNAELEALGIAGDPDA-- 716

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 1437989728 771 aieiradaERAIGRQVMEEINQSLFTELTEKVLTKQRINSLMTPYW 816
Cdd:PRK15370  717 --------ERMAGMRIMEEINQTLFTEIMENILLKKEVSSLMSAYW 754
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 524-732 3.78e-78

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 251.49  E-value: 3.78e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 524 WL---TCLKEEDVNQWRAFETEVNAAAFSIFLDRLSDTQNTR--HPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISC 598
Cdd:pfam14496   1 WLqacAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRndAEALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 599 EDRVTLAYHQMQEATLVYDAERGAFDSKFT-ELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLT 677
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNRLaALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1437989728 678 TMTQDMRFYNVSGITESDLDEAEVRIKVAE-NSQFNQWLSCWEPWHKVLERIAPDD 732
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
248-457 1.41e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 248 SIPEQIITLILDKNNLLSLPEKLHANIKEISVRENNLTRLPETLPDTIEIMDLDRNNIIELPERLPSALQTLIVSCNALT 327
Cdd:COG4886    31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 328 ALPDtlpdgLQTLDVYRNNLTALPEHLPS--SIVELFVFNNSLTFLPATLPM--NLEILVADDNALTCLPESLP--PALK 401
Cdd:COG4886   111 NLTN-----LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEELGnlTNLK 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 402 NLSVKNNRITVLPETL--PPTLQELYIDHNLLINLPENLPA--ALQYLEASYNQLARLPE 457
Cdd:COG4886   186 ELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE 245
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 346-455 1.71e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 346 NLTALPE-HLPSSIVELFVFNNSLTFLPA--TLPmNLEILVADDNALTCLP--ESLPpALKNLSVKNNRITVLpETL--P 418
Cdd:cd21340    13 NITKIDNlSLCKNLKVLYLYDNKITKIENleFLT-NLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNRISVV-EGLenL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1437989728 419 PTLQELYIDHNlliNLPENLP------------AALQYLEASYNQLARL 455
Cdd:cd21340    90 TNLEELHIENQ---RLPPGEKltfdprslaalsNSLRVLNISGNNIDSL 135
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
51-816 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 1616.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728  51 MFNITNTQSTVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYPAY 130
Cdd:PRK15370    1 MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 131 ADNIQCGREGTNQYCILNENSQEILSIIFNSDSYTVECGGETVTYTRETAGEKASSASGpgSKDAVNYDVIWSEWVKSAP 210
Cdd:PRK15370   81 ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASG--SKDAVNYELIWSEWVKEAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 211 TEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPEKLHANIKEISVRENNLTRLPET 290
Cdd:PRK15370  159 AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 291 LPDTIEIMDLDRNNIIELPERLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTF 370
Cdd:PRK15370  239 LPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 371 LPATLPMNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYIDHNLLINLPENLPAALQYLEASYN 450
Cdd:PRK15370  319 LPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 451 QLARLPESLPSFLSEGPQPARILIEHNPISERTIQNMQMLMSSEGYRGPRVFFAMGEFSNVRVTRPLHEAVQGWLTCLKE 530
Cdd:PRK15370  399 NLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTNLEE 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 531 EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISCEDRVTLAYHQMQ 610
Cdd:PRK15370  479 EDVNQWRAFETEVNAAAFSMFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSALRETAFIIAMDATISCEDRVTLAYHQMQ 558

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 611 EATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 690
Cdd:PRK15370  559 EATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 638

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 691 ITESDLDEAEVRIKVAENSQFNQWLSCWEPWHKVLERIAPDDWQEMMNKRVEYIESNEYQSRVNAKLSALKIAGDSDPer 770
Cdd:PRK15370  639 ITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAECIETDEYQSRVNAELEALGIAGDPDA-- 716

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 1437989728 771 aieiradaERAIGRQVMEEINQSLFTELTEKVLTKQRINSLMTPYW 816
Cdd:PRK15370  717 --------ERMAGMRIMEEINQTLFTEIMENILLKKEVSSLMSAYW 754
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
59-816 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 541.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728  59 STVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYPAYADNIQCGR 138
Cdd:PRK15387   12 ATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAYAGWEESIHSGQ 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 139 EGTNQYCILNENSQEILSIIFN-SDSYTVECGG--ETVTYTRETA-GEK----ASSASG-------PGS---KDAVNYDV 200
Cdd:PRK15387   92 HGENYFCILDEDSQEILSVTLDdAGNYTVNCQGysETHRLTLDTAqGEEgtghAEGASGtfrtsflPATtapQTPAEYDA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 201 IWSEWVKSAPTEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPeKLHANIKEISVR 280
Cdd:PRK15387  172 VWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLP-ALPPELRTLEVS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 281 ENNLTRLPETLPDTIEiMDLDRNNIIELPErLPSALQTLIVSCNALTALPdTLPDGLQTLDVYRNNLTALPEhLPSSIVE 360
Cdd:PRK15387  251 GNQLTSLPVLPPGLLE-LSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASLPA-LPSELCK 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 361 LFVFNNSLTFLPaTLPMNLEILVADDNALTCLPE-------------------SLPPALKNLSVKNNRITVLPeTLPPTL 421
Cdd:PRK15387  327 LWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTlpselyklwaynnrltslpALPSGLKELIVSGNRLTSLP-VLPSEL 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 422 QELYIDHNLLINLPEnLPAALQYLEASYNQLARLPESLPSFLSEgpqpARILIEHNPISERTIQNMQMLMSSEGYRGPRV 501
Cdd:PRK15387  405 KELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIHLSSE----TTVNLEGNPLSERTLQALREITSAPGYSGPII 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 502 FFAMGEFSNVRVTRPLHEAVQGWLTCLKEED---VNQWRAFETEVNAAAFSIFLDRLSDTQN-TRHPDFKEQVSAWLMRL 577
Cdd:PRK15387  480 RFDMAGASAPRETRALHLAAADWLVPAREGEpapADRWHMFGQEDNADAFSLFLDRLSETENfIKDAGFKAQISSWLAQL 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 578 AEDSTLRERAFTIAMDATISCEDRVTLAYHQMQEATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFI 657
Cdd:PRK15387  560 AEDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALV 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 658 DEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGITESDLDEAEVRIKVAENSQFNQWLSCWEPWHKVLERIAPDDWQEMM 737
Cdd:PRK15387  640 DEIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALR 719

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1437989728 738 NKRVEYIESNeYQSRVNAKLSALKIAGDSdperaieiraDAERAIGRQVMEEINQSLFTELteKVLTKQRINSLMTPYW 816
Cdd:PRK15387  720 EKQISDYEET-YRMLSDTELRPSGLVGNT----------DAERTIGARAMESAKKTFLDGL--RPLVEEMLGSYLNVQW 785
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 524-732 3.78e-78

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 251.49  E-value: 3.78e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 524 WL---TCLKEEDVNQWRAFETEVNAAAFSIFLDRLSDTQNTR--HPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISC 598
Cdd:pfam14496   1 WLqacAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRndAEALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 599 EDRVTLAYHQMQEATLVYDAERGAFDSKFT-ELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLT 677
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNRLaALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1437989728 678 TMTQDMRFYNVSGITESDLDEAEVRIKVAE-NSQFNQWLSCWEPWHKVLERIAPDD 732
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
248-457 1.41e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 248 SIPEQIITLILDKNNLLSLPEKLHANIKEISVRENNLTRLPETLPDTIEIMDLDRNNIIELPERLPSALQTLIVSCNALT 327
Cdd:COG4886    31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 328 ALPDtlpdgLQTLDVYRNNLTALPEHLPS--SIVELFVFNNSLTFLPATLPM--NLEILVADDNALTCLPESLP--PALK 401
Cdd:COG4886   111 NLTN-----LESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEELGnlTNLK 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 402 NLSVKNNRITVLPETL--PPTLQELYIDHNLLINLPENLPA--ALQYLEASYNQLARLPE 457
Cdd:COG4886   186 ELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPE 245
PRK15372 PRK15372
type III secretion system effector SseI;
81-182 1.82e-21

type III secretion system effector SseI;


Pssm-ID: 185270  Cd Length: 292  Bit Score: 95.57  E-value: 1.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728  81 WNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYPAYADNIQCGREGTNQYCILNENSQEILSIIFN 160
Cdd:PRK15372    4 WEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAYDGWEENIHSGLHGENYFCILDEDSQEILSVTLD 83

                          90       100
                  ....*....|....*....|...
gi 1437989728 161 S-DSYTVECGGETVTYTRETAGE 182
Cdd:PRK15372   84 DvGNYTVNCQGYSETHHLTMATE 106
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
230-486 4.14e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 4.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 230 KNETRLCLDRLKLTTIPHSIPE--QIITLILDKNNLLSLPEKLH--ANIKEISVRENNLTRLPETLPD--TIEIMDLDRN 303
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 304 NIIELPERL--PSALQTLIVSCNALTALPDTLPD--GLQTLDVYRNNLTALPE--HLPSsIVELFVFNNSLTFLPATLPM 377
Cdd:COG4886   193 QITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 378 -NLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYIDHNLLINLPENLPAALQYLEASYNQLARLP 456
Cdd:COG4886   272 tNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260       270
                  ....*....|....*....|....*....|
gi 1437989728 457 ESLPSFLSEGPQPARILIEHNPISERTIQN 486
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
230-446 2.08e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 2.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 230 KNETRLCLDRLKLTTIPHSIPE--QIITLILDKNNLLSLPEKLHA--NIKEISVRENNLTRLPETLPD--TIEIMDLDRN 303
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNltNLEELDLSGNQLTDLPEPLANltNLETLDLSNN 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 304 NIIELPE--RLPSaLQTLIVSCNALTALPDTLP-DGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTFLPATLPMNLE 380
Cdd:COG4886   239 QLTDLPElgNLTN-LEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1437989728 381 ILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYIDHNLLINLPENLPAALQYLE 446
Cdd:COG4886   318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383
PRK15386 PRK15386
type III secretion effector GogB;
297-442 5.24e-09

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 59.11  E-value: 5.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 297 IMDLDRNNIIELPErLPSALQTL-IVSCNALTALPDTLPDGLQTLDV-YRNNLTALPEHLpSSIVELFVFNNSLTFLPAT 374
Cdd:PRK15386   56 RLYIKDCDIESLPV-LPNELTEItIENCNNLTTLPGSIPEGLEKLTVcHCPEISGLPESV-RSLEIKGSATDSIKNVPNG 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1437989728 375 LPmNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQ--ELYIDHNLLINLP-ENLPAAL 442
Cdd:PRK15386  134 LT-SLSINSYNPENQARIDNLISPSLKTLSLTGCSNIILPEKLPESLQsiTLHIEQKTTWNISfEGFPDGL 203
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
230-456 7.72e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 7.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 230 KNETRLCLDRLKLTTIPHSI--PEQIITLILDKNNLLSLPEKLHA--NIKEISVRENNLTRLPE--TLPDtIEIMDLDRN 303
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPElgNLTN-LEELDLSNN 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 304 NIIELPERLP-SALQTLIVSCNALTALpdtlpdGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTFLPATLPMNLEIL 382
Cdd:COG4886   261 QLTDLPPLANlTNLKTLDLSNNQLTDL------KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1437989728 383 VADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYIDHNLLINLPENLPAALQYLEASYNQLARLP 456
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
PRK15381 PRK15381
type III secretion system effector;
55-178 7.29e-07

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 52.36  E-value: 7.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728  55 TNTQSTVRNQSISHGASKeapPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPE-TVSPEEIKSKFEWLKGLAYPAYADN 133
Cdd:PRK15381   11 TSSISSEKFNAIKESARL---PELSLWEKIKAYFFTTHHAEALECIFNLYHHQElNLTPVQVRGAYIKLRALASQGCKEQ 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1437989728 134 -IQCGREGTNQYCILNENSQEILSIifnsdsyTVECGGETVTYTRE 178
Cdd:PRK15381   88 fIIESQEHADKLIIKDDNGENILSI-------EVECHPEAFGLAKE 126
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 346-455 1.71e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 346 NLTALPE-HLPSSIVELFVFNNSLTFLPA--TLPmNLEILVADDNALTCLP--ESLPpALKNLSVKNNRITVLpETL--P 418
Cdd:cd21340    13 NITKIDNlSLCKNLKVLYLYDNKITKIENleFLT-NLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNRISVV-EGLenL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1437989728 419 PTLQELYIDHNlliNLPENLP------------AALQYLEASYNQLARL 455
Cdd:cd21340    90 TNLEELHIENQ---RLPPGEKltfdprslaalsNSLRVLNISGNNIDSL 135
TTSSLRR pfam12468
Type III secretion system leucine rich repeat protein; This domain family is found in bacteria, ...
 157-222 1.80e-04

Type III secretion system leucine rich repeat protein; This domain family is found in bacteria, and is approximately 50 amino acids in length. There are two completely conserved residues (Y and W) that may be functionally important. This family consists of leucine-rich repeat proteins involved in type III secretion.


Pssm-ID: 432576 [Multi-domain]  Cd Length: 54  Bit Score: 39.84  E-value: 1.80e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1437989728 157 IIFNSDSYTVECGGETVTYTRETAGEKassasgpgskDAVNYDVIWSEWVKSAPTEEapNREKAVQ 222
Cdd:pfam12468   1 INNNFSGSSVSFSNISSDRSVESEREK----------TPADYLRIWDEWEKNAPPGE--QRGEAVR 54
LRR_8 pfam13855
Leucine rich repeat;
398-452 2.92e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1437989728 398 PALKNLSVKNNRITVLPETL---PPTLQELYIDHNLLINLPEN----LPAaLQYLEASYNQL 452
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGafsgLPS-LRYLDLSGNRL 61
sifA PRK09498
type III secretion system effector SifA;
80-178 5.40e-04

type III secretion system effector SifA;


Pssm-ID: 181911  Cd Length: 336  Bit Score: 43.08  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728  80 IWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYPAYADNIQCGREGTNQ----YCILNENSQ-EI 154
Cdd:PRK09498   30 LWEKIKDFFFSTGKAKADRCLHEMLFADRAPTRERLTEIFFELKELACASQRDRFQVHNPHENDatiiLRIMDQNEEnEL 109

                          90       100
                  ....*....|....*....|....
gi 1437989728 155 LSIIFNSDSYTVECGGETVTYTRE 178
Cdd:PRK09498  110 LRITQNTDTFSCEVMGNLYFLMKD 133
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
233-434 7.37e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 7.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 233 TRLCLDRLKLTTIPHSIPE--QIITLILDKNNLLSLPE--KLHaNIKEISVRENNLTRLPETLP-DTIEIMDLDRNNIIE 307
Cdd:COG4886   208 EELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTD 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 308 LPERLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTFLPATLPMNLEILVADDN 387
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1437989728 388 ALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYIDHNLLINL 434
Cdd:COG4886   367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR_8 pfam13855
Leucine rich repeat;
316-368 2.54e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 316 LQTLIVSCNALTALPDTLPDG---LQTLDVYRNNLTALPE----HLPsSIVELFVFNNSL 368
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGlsnLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 254-414 7.13e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 254 ITLILDKNNLLSLpEKLHANIKEISVREN--NLTRLpETLpdtieimDLDRNNiieLPERlpsalQTLIVSCNALTALPD 331
Cdd:cd21340    58 IEKIENLENLVNL-KKLYLGGNRISVVEGleNLTNL-EEL-------HIENQR---LPPG-----EKLTFDPRSLAALSN 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437989728 332 TLpdglQTLDVYRNNLTalpehlpsSIVELFVFNnsltflpatlpmNLEILVADDNALTCLPESLP-----PALKNLSVK 406
Cdd:cd21340   121 SL----RVLNISGNNID--------SLEPLAPLR------------NLEQLDASNNQISDLEELLDllsswPSLRELDLT 176


                  ....*...
gi 1437989728 407 NNRITVLP 414
Cdd:cd21340   177 GNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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