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Conserved domains on  [gi|1435071765|ref|NP_001352040|]
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SLIT and NTRK-like protein 4 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 6.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  59 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1435071765 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 8.00e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 8.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 358 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 437
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 438 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                         170
                  ....*....|....
gi 1435071765 518 DQLQSLTQIDLEGN 531
Cdd:COG4886   247 GNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.24e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1435071765  213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 5.15e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1435071765  502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 6.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  59 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1435071765 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 8.00e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 8.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 358 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 437
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 438 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                         170
                  ....*....|....
gi 1435071765 518 DQLQSLTQIDLEGN 531
Cdd:COG4886   247 GNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
402-461 1.03e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.03e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 402 GLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
83-143 7.25e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 7.25e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435071765  83 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 382-464 2.28e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 382 LHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYNLI 461
Cdd:cd21340     7 LYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80


                  ...
gi 1435071765 462 KEI 464
Cdd:cd21340    81 SVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-233 8.14e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  63 HLNFQNNflNILYPNTFVNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 142
Cdd:cd21340     6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 143 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 215
Cdd:cd21340    80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                         170
                  ....*....|....*...
gi 1435071765 216 NCSCDLLPLKAWLENMPY 233
Cdd:cd21340   152 NQISDLEELLDLLSSWPS 169
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1435071765  213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 5.15e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1435071765  502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRRCT smart00082
Leucine rich repeat C-terminal domain;
531-563 3.09e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1435071765  531 NPWDCTCDLVALKLWLEKLNDGIVVKELKCETP 563
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-213 6.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  59 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 138
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1435071765 139 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 213
Cdd:COG4886   190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-214 1.22e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 1.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  63 HLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQADYNL 142
Cdd:COG4886   140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1435071765 143 IKYIERgAFNKLHKLKVLILNDNLISFLPdNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGrvvELQLEDNP 214
Cdd:COG4886   217 LTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-531 8.00e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 8.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 358 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 437
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 438 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 517
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                         170
                  ....*....|....
gi 1435071765 518 DQLQSLTQIDLEGN 531
Cdd:COG4886   247 GNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
402-461 1.03e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.03e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 402 GLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
380-532 7.18e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 7.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 380 KKLHVNGNNIKDVDISdFTEFEGLDLLHLGSNQITLIkGEVFHNLTNLRRLYLNGNQIERLyPEIFSGLHNLQYLYLEYN 459
Cdd:COG4886   162 KSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1435071765 460 LIKEIlaGTFDSMPNlqllylnnnllkslpvyifsgapLARLNLRNNKFMYLPVSGvldQLQSLTQIDLEGNP 532
Cdd:COG4886   239 QLTDL--PELGNLTN-----------------------LEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
83-143 7.25e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 7.25e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435071765  83 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 382-464 2.28e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 382 LHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYNLI 461
Cdd:cd21340     7 LYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80


                  ...
gi 1435071765 462 KEI 464
Cdd:cd21340    81 SVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-550 5.17e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 5.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 359 VNCQEKNIQSMSELTPKPlNAKKLHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIE 438
Cdd:cd21340     7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITK--IENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 439 RLypEIFSGLHNLQYLYLEYNLIKEILAGTFDSmpnlqllylnnnllkslpvyiFSGAPLAR----LNLRNNKFMYLpvs 514
Cdd:cd21340    82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1435071765 515 GVLDQLQSLTQIDLEGNP---WDCTCDLVALKLWLEKLN 550
Cdd:cd21340   136 EPLAPLRNLEQLDASNNQisdLEELLDLLSSWPSLRELD 174
LRR_8 pfam13855
Leucine rich repeat;
378-437 2.41e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.41e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 378 NAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQI 437
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
425-473 2.04e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.04e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1435071765 425 TNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMP 473
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR_8 pfam13855
Leucine rich repeat;
132-190 2.82e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.82e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 132 NLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRI 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
109-167 3.36e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1435071765 109 LKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLI 167
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-233 8.14e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  63 HLNFQNNflNILYPNTFVNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 142
Cdd:cd21340     6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 143 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 215
Cdd:cd21340    80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                         170
                  ....*....|....*...
gi 1435071765 216 NCSCDLLPLKAWLENMPY 233
Cdd:cd21340   152 NQISDLEELLDLLSSWPS 169
LRR_8 pfam13855
Leucine rich repeat;
59-119 6.05e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.05e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1435071765  59 SNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
213-253 8.24e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.24e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1435071765  213 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 253
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-194 1.22e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  63 HLNFQNNFLNILypntfVNFSHAVSL---HLGNNKLQNIEGgaFLGLSALKQLHLNNNELK-----ILRADTFLGI-ENL 133
Cdd:cd21340    50 HLYLQNNQIEKI-----ENLENLVNLkklYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSL 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1435071765 134 EYLQADYNLIKYIErgAFNKLHKLKVLILNDNLISFLPD---NIFRFASLTHLDIRGNRIQKLP 194
Cdd:cd21340   123 RVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
377-531 1.80e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 377 LNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNqitlikgEVFHNLTNLRRLYLNGNQIERLyPEIFSGLHNLQYLYL 456
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1435071765 457 EYNLIKEILAgTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSgvLDQLQSLTQIDLEGN 531
Cdd:COG4886   144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-194 5.41e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 5.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  42 NCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1435071765 122 LRADTFLGIENLEYLQADYNLIKYiERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLP 194
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLS-GNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 502-563 5.15e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1435071765  502 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 563
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
363-532 9.60e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 9.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 363 EKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRL------------ 430
Cdd:COG4886    34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELdlsgneelsnlt 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 431 -----YLNGNQIERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRN 505
Cdd:COG4886   114 nleslDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL------------------------PEPLGNLTNLKSLDLSN 168

                         170       180
                  ....*....|....*....|....*..
gi 1435071765 506 NKFMYLPVSgvLDQLQSLTQIDLEGNP 532
Cdd:COG4886   169 NQLTDLPEE--LGNLTNLKELDLSNNQ 193
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 93-188 9.92e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  93 NKLQNIEGGAFLGLSALKQLHLNNNeLKILRADTFLGIeNLEYLQADYNlIKYIERGAFNKLHKLKVLILNDNLISFlPD 172
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSNLTSI-GS 95

                          90
                  ....*....|....*.
gi 1435071765 173 NIFRFASLTHLDIRGN 188
Cdd:pfam13306  96 YAFSNCSLKSITIPSS 111
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 425-459 1.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1435071765 425 TNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYN 459
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.64e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 156 KLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYiGVLEHIGRVVELQLEDNP 214
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
531-563 3.09e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1435071765  531 NPWDCTCDLVALKLWLEKLNDGIVVKELKCETP 563
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-470 5.75e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765  71 LNILYPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILRADtFLGIENLEYLQADYNLIKYIERgA 150
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-E 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 151 FNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPyigvlehigrvvelqlednpwncscdllplkAWLEN 230
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP-------------------------------EPLAN 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 231 MpyniyigeaicetpsdlygrllketnkqelcpmgtgsdfdvrilppsqqengfttpnghttqTTLHRLvtkppkttnps 310
Cdd:COG4886   227 L--------------------------------------------------------------TNLETL----------- 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 311 kisgivagkalsnrNLSqivsyqtrvppltpcpvpcfckthpsdlglsvNCQEKNIQSMSELTpkplNAKKLHVNGNNIK 390
Cdd:COG4886   234 --------------DLS--------------------------------NNQLTDLPELGNLT----NLEELDLSNNQLT 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435071765 391 DvdISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFD 470
Cdd:COG4886   264 D--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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