BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAE-------DENKNVLDLHHVTVTGFIPLLE 87
Cdd:cd18228     4 QELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASprlvlvsPAGKCVLDLHHVTVTGFAPLLE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1435035499  88 YAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILW 130
Cdd:cd18228    84 YAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSILW 126

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1435035499 383 STSSTERPSPNGPDRPFQCPTCGVRFTRIQNLKQHMLIHSGIKPFQCDR--CGKKFTRAYSLKMHRLKH 449
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAE-------DENKNVLDLHHVTVTGFIPLLE 87
Cdd:cd18228     4 QELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASprlvlvsPAGKCVLDLHHVTVTGFAPLLE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1435035499  88 YAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILW 130
Cdd:cd18228    84 YAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSILW 126

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499   32 DITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASYM 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1435035499  112 QMFSVASTCSEFMKSSI 128
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 1435035499 413 NLKQHMLIHSGIKPFQCDRCGKKFTR 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 1435035499 399 FQCPTCGVRFTRIQNLKQHMLIH 421
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAE-------DENKNVLDLHHVTVTGFIPLLE 87
Cdd:cd18228     4 QELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASprlvlvsPAGKCVLDLHHVTVTGFAPLLE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1435035499  88 YAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILW 130
Cdd:cd18228    84 YAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSILW 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  17 MLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLSI 96
Cdd:cd18255     5 LLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTL 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1435035499  97 NTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18255    85 DLDCIQDVLGAAVHLQMLPVVELCEEFLKSAM 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  31 CDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAeDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTENIIDVLAAASY 110
Cdd:cd18955     2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQT-DGDLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                          90
                  ....*....|....
gi 1435035499 111 MQMFSVASTCSEFM 124
Cdd:cd18955    81 LGVHNIEKACFDFL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  16 EMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLS 95
Cdd:cd18242     7 SILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVH 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1435035499  96 INTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18242    87 VTVENVQELLPAACLLQLKGVKQACCEFLES 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18257     3 EQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTV 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1435035499  95 SINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18257    83 FISQATVESLLPAANLLQIKLVLKECCDFLESQL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  21 LNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAedenkNVLDLHHVTVTGFIP-----LLEYAYTATLS 95
Cdd:cd18240     8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGW-----NETEKKVYKIPGVSPemmelIIEYAYTRTVP 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1435035499  96 INTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18240    83 ITAENVEELLPAADQFNIMGIVKACCDFLED 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18256     5 SLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVV 84

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1435035499  95 SINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18256    85 EVTVSNVQELLVAADMLQLTEVVEICCEFLKGQL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  17 MLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTK----LVGQAEDEnknvLDLHHVTVTGFIPLLEYAYTA 92
Cdd:cd18261    15 VLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMfslcMVESEADE----VNLHGVTSLGLKQALDFAYTG 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1435035499  93 TLSINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18261    91 QILLEPGVIQDVLAAGSHLQLLELLSLCSHYL 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVG-QAEDENKNVLDLHHVTVTGFIPLLEYAYTAT 93
Cdd:cd18230     6 RHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQvQKTSDQATVTHLDIVTAQGFKAIIDFMYSAH 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1435035499  94 LSINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18230    86 LALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  17 MLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVgqaEDENKNVLDLHHVTVTGFIPLLEYAYTATLSI 96
Cdd:cd18260     5 LLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTGKLTL 81

                          90       100
                  ....*....|....*....|....*...
gi 1435035499  97 NTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18260    82 SLYTIGSTISAASYLQIHALVKMCCDFL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499   5 TFTHSSSSHSQEMLGKLNMLR-NDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENK-NVLDLHHVTVTGF 82
Cdd:cd18207     1 SYTYQVSQHSADMLHNLNQQRkSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1435035499  83 IPLLEYAYTATLSINTENIIDVLAAASYMQMFSVASTCSEFMKSS 127
Cdd:cd18207    81 GDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQS 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  17 MLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQ--AEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1435035499  95 SINTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18245    81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  21 LNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFR----TKLVGQAEDEnknvldlhhVTVTGFIP-----LLEYAYT 91
Cdd:cd18247    10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHamftHDMVESKQDE---------ITMQGIEPsaleaLINFAYS 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1435035499  92 ATLSINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18247    81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  16 EMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENK-NVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18330     4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDIVTSEAFSIILDFLYSGKL 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1435035499  95 SINTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18330    84 DLCSENVIEVMSAASYLQMTDVVNFCKGYI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  17 MLGKLNMLRNDGHFCDITIRVQD--KIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18239    10 VLQGFDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKL 89

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1435035499  95 SINTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18239    90 SLNMDNLQDTLEAASFLQILPVLDFCKVLLISGV 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  16 EMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAeDENKNVLDL-HHVTVTGFIPLLEYAYTATL 94
Cdd:cd18332     5 DVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRV-GEGVSVLTLpSGLEARGFQLLLDFMYTSRL 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1435035499  95 SINTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18332    84 PLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATL 94
Cdd:cd18235     6 QKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEI 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1435035499  95 SINTENIIDVLAAASYMQMFSVASTCSEFMKS 126
Cdd:cd18235    86 QVTEENVQVLLPAANLLQLTDVRDACCDFLQS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  16 EMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLS 95
Cdd:cd18237     7 DFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARIS 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1435035499  96 INTENIIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18237    87 VNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  17 MLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHV-TVTGFIPLLEYAYTATLS 95
Cdd:cd18329     8 LLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFVYSGKLS 87

                          90       100
                  ....*....|....*....|....*....
gi 1435035499  96 INTENIIDVLAAASYMQMFSVASTCSEFM 124
Cdd:cd18329    88 LTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  17 MLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVgqAEDENKNVL-DLHHVTVtgFIPLLEYAYTATLS 95
Cdd:cd18227    12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVL--LKNSRRIVLpDVMNPRV--FENILLSCYTGRLV 87

                          90       100       110
                  ....*....|....*....|....*....|
gi 1435035499  96 INTENIIDVLAAASYMQMFSVASTCSEFMK 125
Cdd:cd18227    88 LPAPEIVSYLTAASFLQMWHVVDKCTELLE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  21 LNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLDLHHVTVTGFIPLLEYAYTATLSINTEN 100
Cdd:cd18338    12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEEN 91

                          90       100
                  ....*....|....*....|....*...
gi 1435035499 101 IIDVLAAASYMQMFSVASTCSEFMKSSI 128
Cdd:cd18338    92 VQVLLPAAGLLQLQDVKKTCCEFLESQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNV--LDLHHVTVTGFIPLLEYAYTA 92
Cdd:cd18196     6 EQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMiqLDSEVVTAEAFAALIDMMYTS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1435035499  93 TLSINTENIIDVLAAASYMQMFSVASTCSEFMKSSILWNTP 133
Cdd:cd18196    86 TLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSP 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  15 QEMLGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRtkLVGQAEDENKNVLDLHH--VTVTGFIPLLEYAYTA 92
Cdd:cd18194     8 RQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH--LFYRDRLDKRDLVRLNSdiVTAPAFGLLLDFMYEG 85

                          90       100
                  ....*....|....*....|....*...
gi 1435035499  93 TLSINTENIIDVLAAASYMQMFSVASTC 120
Cdd:cd18194    86 RLALRDLPVEDVLAAASYLHMYDIVKVC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1435035499  18 LGKLNMLRNDGHFCDITIRVQDKIFRAHKVVLAACSDFFRTKLVGQAEDENKNVLdLHHVTVTGfiPLLEYAYTATLSIN 97
Cdd:cd18203    13 LRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSL-MHSSRVVA--DLLLSCYTGALEFS 89