similar to protein kinase C substrate [Homo sapiens]
Protein Classification
PRKCSH domain-containing protein( domain architecture ID 10546062)
PRKCSH domain-containing protein similar to Homo sapiens N-acetylglucosamine-1-phosphotransferase subunit gamma, which is non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| PRKCSH | pfam07915 | Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ... |
85-145 | 2.34e-12 | ||
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain. : Pssm-ID: 400321 Cd Length: 72 Bit Score: 61.40 E-value: 2.34e-12
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| Name | Accession | Description | Interval | E-value | ||
| PRKCSH | pfam07915 | Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ... |
85-145 | 2.34e-12 | ||
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain. Pssm-ID: 400321 Cd Length: 72 Bit Score: 61.40 E-value: 2.34e-12
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| Name | Accession | Description | Interval | E-value | |||
| PRKCSH | pfam07915 | Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ... |
85-145 | 2.34e-12 | |||
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain. Pssm-ID: 400321 Cd Length: 72 Bit Score: 61.40 E-value: 2.34e-12
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| PRKCSH_1 | pfam13015 | Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ... |
76-190 | 1.39e-06 | |||
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit. Pssm-ID: 404038 Cd Length: 154 Bit Score: 47.52 E-value: 1.39e-06
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