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Conserved domains on  [gi|143323855|gb|EDE33319|]
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hypothetical protein GOS_1148793, partial [marine metagenome]

Protein Classification

DnaB-like helicase C-terminal domain-containing protein( domain architecture ID 12047422)

DnaB-like helicase C-terminal domain-containing protein contains an ATP-binding site

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 25-278 1.29e-163

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


:

Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 454.57  E-value: 1.29e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDYLQLMTSGKKVENRQQEVSEFSRQ 184
Cdd:pfam03796  81 TGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMSGGSRGENRQQEISEISRS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  185 LKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRSGEADLIVAKHRNGPTRT 264
Cdd:pfam03796 161 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGKAEIIIAKQRNGPTGT 240

                         250
                  ....*....|....
gi 143323855  265 ITVSAQLHLARFTD 278
Cdd:pfam03796 241 VKLAFLGEYTRFEN 254
 
Name Accession Description Interval E-value
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 25-278 1.29e-163

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 454.57  E-value: 1.29e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDYLQLMTSGKKVENRQQEVSEFSRQ 184
Cdd:pfam03796  81 TGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMSGGSRGENRQQEISEISRS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  185 LKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRSGEADLIVAKHRNGPTRT 264
Cdd:pfam03796 161 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGKAEIIIAKQRNGPTGT 240

                         250
                  ....*....|....
gi 143323855  265 ITVSAQLHLARFTD 278
Cdd:pfam03796 241 VKLAFLGEYTRFEN 254
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 1-280 6.24e-161

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 454.57  E-value: 6.24e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855    1 VQLSELLPAAYDEIEKISAGVVG-EGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFS 79
Cdd:TIGR00665 151 KSIKEILKEAVEEIEELYERKGGiTGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFS 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   80 LEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVI 159
Cdd:TIGR00665 231 LEMSAEQLVMRMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVI 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  160 DYLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHRED 239
Cdd:TIGR00665 311 DYLQLMSGSGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDE 390

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 143323855  240 LYD-SQNRSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:TIGR00665 391 YYNpDSEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
1-280 4.67e-160

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 452.22  E-value: 4.67e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   1 VQLSELLPAAYDEIEKI--SAGVVgEGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIF 78
Cdd:COG0305  148 VSISDILKEALERIEELykNGGGI-TGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIF 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  79 SLEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIV 158
Cdd:COG0305  227 SLEMSAEQLVMRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIV 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 159 IDYLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHRE 238
Cdd:COG0305  307 IDYLQLMSGSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRD 386

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 143323855 239 DLYDSQN-RSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:COG0305  387 EYYNPDSeDKGIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
PRK05636 PRK05636
replicative DNA helicase; Provisional
 3-280 1.27e-144

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 416.16  E-value: 1.27e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   3 LSELLPAAYDEIEKISA-GVVGEGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLE 81
Cdd:PRK05636 224 LADILDPTMDELEMLSSqGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKASVIFSLE 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  82 MSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDY 161
Cdd:PRK05636 304 MSKSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKARRLKQKHDLKLIVVDY 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 162 LQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLY 241
Cdd:PRK05636 384 LQLMSSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVMLLYRPDSQ 463

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 143323855 242 DSQN-RSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:PRK05636 464 DKDDeRAGEADIILAKHRGGPIDTVQVAHQLHYSRFVDMA 503
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 25-278 9.36e-140

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 394.19  E-value: 9.36e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:cd00984    1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRH-NLKLIVIDYLQLMTSGKKVENRQQEVSEFSR 183
Cdd:cd00984   81 TGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHgGLGLIVIDYLQLIRGSKRAENRQQEVAEISR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 184 QLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQN-RSGEADLIVAKHRNGPT 262
Cdd:cd00984  161 SLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSeDKGIAEIIIAKNRNGPT 240

                        250
                 ....*....|....*.
gi 143323855 263 RTITVSAQLHLARFTD 278
Cdd:cd00984  241 GTVYLAFNPEYTRFTD 256
 
Name Accession Description Interval E-value
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 25-278 1.29e-163

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 454.57  E-value: 1.29e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDYLQLMTSGKKVENRQQEVSEFSRQ 184
Cdd:pfam03796  81 TGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHGLGLIVIDYLQLMSGGSRGENRQQEISEISRS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  185 LKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRSGEADLIVAKHRNGPTRT 264
Cdd:pfam03796 161 LKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGKAEIIIAKQRNGPTGT 240

                         250
                  ....*....|....
gi 143323855  265 ITVSAQLHLARFTD 278
Cdd:pfam03796 241 VKLAFLGEYTRFEN 254
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 1-280 6.24e-161

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 454.57  E-value: 6.24e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855    1 VQLSELLPAAYDEIEKISAGVVG-EGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFS 79
Cdd:TIGR00665 151 KSIKEILKEAVEEIEELYERKGGiTGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAFFS 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   80 LEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVI 159
Cdd:TIGR00665 231 LEMSAEQLVMRMLSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHGLGLIVI 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  160 DYLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHRED 239
Cdd:TIGR00665 311 DYLQLMSGSGRSENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDE 390

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 143323855  240 LYD-SQNRSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:TIGR00665 391 YYNpDSEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
1-280 4.67e-160

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 452.22  E-value: 4.67e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   1 VQLSELLPAAYDEIEKI--SAGVVgEGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIF 78
Cdd:COG0305  148 VSISDILKEALERIEELykNGGGI-TGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIF 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  79 SLEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIV 158
Cdd:COG0305  227 SLEMSAEQLVMRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHGLGLIV 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 159 IDYLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHRE 238
Cdd:COG0305  307 IDYLQLMSGSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRD 386

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 143323855 239 DLYDSQN-RSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:COG0305  387 EYYNPDSeDKGIAEIIIAKQRNGPTGTVKLAFDGEYTRFENLA 429
PRK05636 PRK05636
replicative DNA helicase; Provisional
 3-280 1.27e-144

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 416.16  E-value: 1.27e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   3 LSELLPAAYDEIEKISA-GVVGEGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLE 81
Cdd:PRK05636 224 LADILDPTMDELEMLSSqGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKASVIFSLE 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  82 MSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDY 161
Cdd:PRK05636 304 MSKSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKARRLKQKHDLKLIVVDY 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 162 LQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLY 241
Cdd:PRK05636 384 LQLMSSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVMLLYRPDSQ 463

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 143323855 242 DSQN-RSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:PRK05636 464 DKDDeRAGEADIILAKHRGGPIDTVQVAHQLHYSRFVDMA 503
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 25-278 9.36e-140

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 394.19  E-value: 9.36e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:cd00984    1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRH-NLKLIVIDYLQLMTSGKKVENRQQEVSEFSR 183
Cdd:cd00984   81 TGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHgGLGLIVIDYLQLIRGSKRAENRQQEVAEISR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 184 QLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQN-RSGEADLIVAKHRNGPT 262
Cdd:cd00984  161 SLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKDSeDKGIAEIIIAKNRNGPT 240

                        250
                 ....*....|....*.
gi 143323855 263 RTITVSAQLHLARFTD 278
Cdd:cd00984  241 GTVYLAFNPEYTRFTD 256
PRK07773 PRK07773
replicative DNA helicase; Validated
 1-235 8.52e-121

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 366.38  E-value: 8.52e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   1 VQLSELLPAAYDEIEKI-SAGVVGEGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFS 79
Cdd:PRK07773 174 VALEDLLQPTFDEIDAIaSSGGLARGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFS 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  80 LEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVI 159
Cdd:PRK07773 254 LEMSKEQLVMRLLSAEAKIKLSDMRSGRMSDDDWTRLARAMGEISEAPIFIDDTPNLTVMEIRAKARRLRQEANLGLIVV 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 143323855 160 DYLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEqdADVVILL 235
Cdd:PRK07773 334 DYLQLMTSGKKYENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRTDKRPMLSDLRESGCLT--GDTLILR 407
PRK05748 PRK05748
replicative DNA helicase; Provisional
 1-280 6.57e-118

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 345.79  E-value: 6.57e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   1 VQLSELLPAAYDEIEKIS--AGVVgEGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIF 78
Cdd:PRK05748 160 KNIKDVLVKAYDRIEMLHnqTGDI-TGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVAIF 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  79 SLEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRH-NLKLI 157
Cdd:PRK05748 239 SLEMGAESLVMRMLCAEGNIDAQRLRTGQLTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHgGLGLI 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 158 VIDYLQLMT-SGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLH 236
Cdd:PRK05748 319 LIDYLQLIQgSGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLY 398

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 143323855 237 REDLYD--SQNRsGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:PRK05748 399 RDDYYDeeTENK-NTIEIIIAKQRNGPVGTVELAFQKEYNKFVNLA 443
PRK09165 PRK09165
replicative DNA helicase; Provisional
 25-282 3.65e-102

replicative DNA helicase; Provisional


Pssm-ID: 181676 [Multi-domain]  Cd Length: 497  Bit Score: 307.19  E-value: 3.65e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIA-RYASIHKRET------------SV-IFSLEMSRSEITMR 90
Cdd:PRK09165 199 GISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALATNIAfNAAKAYRREAqpdgskkavnggVVgFFSLEMSAEQLATR 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  91 MLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDYLQLMTSGKK 170
Cdd:PRK09165 279 ILSEQSEISSSKIRRGKISEEDFEKLVDASQELQKLPLYIDDTPALSISQLRARARRLKRQHGLDLLVVDYLQLIRGSSK 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 171 V--ENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLY------- 241
Cdd:PRK09165 359 RssDNRVQEISEITQGLKALAKELNIPVIALSQLSRQVEQRDDKRPQLSDLRESGSIEQDADVVMFVYREEYYlkrkepr 438

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 143323855 242 ----------DSQNR-SGEADLIVAKHRNGPTRTITVSAQLHLARFTDMATN 282
Cdd:PRK09165 439 egtpkheewqEKMEKvHNKAEVIIAKQRHGPTGTVKLAFESEFTRFGDLADR 490
PRK05595 PRK05595
replicative DNA helicase; Provisional
 3-279 2.02e-100

replicative DNA helicase; Provisional


Pssm-ID: 235525 [Multi-domain]  Cd Length: 444  Bit Score: 301.36  E-value: 2.02e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   3 LSELLPAAYDEIEKIsAGVVGE--GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSL 80
Cdd:PRK05595 160 LSNVLERGFEQIENL-FNNKGEttGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  81 EMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVID 160
Cdd:PRK05595 239 EMSKEQLAYKLLCSEANVDMLRLRTGNLEDKDWENIARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIEHGIDMILID 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 161 YLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDL 240
Cdd:PRK05595 319 YLQLMSGGKGSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEY 398

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 143323855 241 YDSQNR-SGEADLIVAKHRNGPTRTITVSAQLHLARFTDM 279
Cdd:PRK05595 399 YNKETEdKNVAECIIAKQRNGPTGTVKLAWLGQYSKFGNL 438
PRK08506 PRK08506
replicative DNA helicase; Provisional
 15-282 1.08e-96

replicative DNA helicase; Provisional


Pssm-ID: 236278 [Multi-domain]  Cd Length: 472  Bit Score: 292.68  E-value: 1.08e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  15 EKISAGVVGegVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYAsIHKRETSVIFSLEMSRSEITMRMLAA 94
Cdd:PRK08506 166 RLGNKDIIG--LDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKA-LNQDKGVAFFSLEMPAEQLMLRMLSA 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  95 EARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHN-LKLIVIDYLQLMTSGKKVEN 173
Cdd:PRK08506 243 KTSIPLQNLRTGDLDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPeIGLAVIDYLQLMSGSGNFKD 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 174 RQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLY------------ 241
Cdd:PRK08506 323 RHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDVYkereekekekka 402

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 143323855 242 ----------DSQNRSGE-ADLIVAKHRNGPTRTITVSAQLHLARFTDMATN 282
Cdd:PRK08506 403 kkegkeerriHFQNKSIEeAEIIIGKNRNGPTGTVKLRFQKEFTRFVDKPIE 454
phage_DnaB TIGR03600
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ...
 1-267 1.04e-95

phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274672 [Multi-domain]  Cd Length: 420  Bit Score: 288.53  E-value: 1.04e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855    1 VQLSELLPAAYDEIEK-ISAGVVGEGVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFS 79
Cdd:TIGR03600 150 VTFGEVLEDVVRDLDKrFNPKGELTGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVALREGKPVLFFS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   80 LEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHN-LKLIV 158
Cdd:TIGR03600 230 LEMSAEQLGERLLASKSGINTGNIRTGRFNDSEFNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKKGgLDLIV 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  159 IDYLQLMTSGKKvENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHRE 238
Cdd:TIGR03600 310 VDYIQLMAPARG-RDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHRE 388

                         250       260       270
                  ....*....|....*....|....*....|
gi 143323855  239 DLYD-SQNRSGEADLIVAKHRNGPTRTITV 267
Cdd:TIGR03600 389 GYYDaREPPAGIAELILAKNRHGPTGTVEL 418
PRK08760 PRK08760
replicative DNA helicase; Provisional
 25-280 8.20e-92

replicative DNA helicase; Provisional


Pssm-ID: 181547 [Multi-domain]  Cd Length: 476  Bit Score: 280.26  E-value: 8.20e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:PRK08760 211 GLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAAIKSKKGVAVFSMEMSASQLAMRLISSNGRINAQRLR 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDYLQLMTSGKKVENRQQEVSEFSRQ 184
Cdd:PRK08760 291 TGALEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLRSKCRRLKREHDLGLIVIDYLQLMSVPGNSENRATEISEISRS 370

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 185 LKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRS--GEADLIVAKHRNGPT 262
Cdd:PRK08760 371 LKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADMIVFIYRDDYYNKENSPdkGLAEIIIGKHRGGPT 450

                        250
                 ....*....|....*...
gi 143323855 263 RTITVSAQLHLARFTDMA 280
Cdd:PRK08760 451 GSCKLKFFGEYTRFDNLA 468
PRK07004 PRK07004
replicative DNA helicase; Provisional
 25-289 2.39e-86

replicative DNA helicase; Provisional


Pssm-ID: 235907 [Multi-domain]  Cd Length: 460  Bit Score: 265.62  E-value: 2.39e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:PRK07004 195 GTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAVEYGLPVAVFSMEMPGTQLAMRMLGSVGRLDQHRMR 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRL-KQRHNLKLIVIDYLQLMTSGKKVENRQQEVSEFSR 183
Cdd:PRK07004 275 TGRLTDEDWPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLaRQCGKLGLIIIDYLQLMSGSSQGENRATEISEISR 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 184 QLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLY--DSQNRsGEADLIVAKHRNGP 261
Cdd:PRK07004 355 SLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADVILFIYRDEVYnpDSPDK-GTAEIIIGKQRNGP 433

                        250       260
                 ....*....|....*....|....*...
gi 143323855 262 TRTITVSAQLHLARFtdmaTNFVPTEKF 289
Cdd:PRK07004 434 IGPVRLTFLGQYTKF----DNFAGAQNF 457
PRK08840 PRK08840
replicative DNA helicase; Provisional
 25-280 3.83e-83

replicative DNA helicase; Provisional


Pssm-ID: 181562 [Multi-domain]  Cd Length: 464  Bit Score: 257.61  E-value: 3.83e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:PRK08840 199 GVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQDKPVLIFSLEMPAEQLMMRMLASLSRVDQTKIR 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKMARRMGEISDAP-LFIDDSPNLSLMEIRAKARRLKQRHN-LKLIVIDYLQLMTSGKKVENRQQEVSEFS 182
Cdd:PRK08840 279 TGQLDDEDWARISSTMGILMEKKnMYIDDSSGLTPTEVRSRARRIAREHGgLSMIMVDYLQLMRVPALSDNRTLEIAEIS 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 183 RQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQ-NRSGEADLIVAKHRNGP 261
Cdd:PRK08840 359 RSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYNPDsPLKGTAEIIIGKQRNGP 438

                        250
                 ....*....|....*....
gi 143323855 262 TRTITVSAQLHLARFTDMA 280
Cdd:PRK08840 439 IGSVRLTFQGQYSRFDNYA 457
PRK06904 PRK06904
replicative DNA helicase; Validated
 6-280 1.84e-80

replicative DNA helicase; Validated


Pssm-ID: 136106 [Multi-domain]  Cd Length: 472  Bit Score: 251.07  E-value: 1.84e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   6 LLPAAYDEIEKISA-----GVVGegVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSL 80
Cdd:PRK06904 181 LLENTIDKIENLAAtptnnGVTG--VTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMASEKPVLVFSL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  81 EMSRSEITMRMLAAEARVPLNNIRSGQ-LGEEEWAKMARRMGEISDAP-LFIDDSPNLSLMEIRAKARRL-KQRHNLKLI 157
Cdd:PRK06904 259 EMPAEQIMMRMLASLSRVDQTKIRTGQnLDQQDWAKISSTVGMFKQKPnLYIDDSSGLTPTELRSRARRVyRENGGLSLI 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 158 VIDYLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHR 237
Cdd:PRK06904 339 MVDYLQLMRAPGFEDNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRESGSIEQDADLIMFIYR 418

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 143323855 238 EDLYD--SQNRSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMA 280
Cdd:PRK06904 419 DEVYNetTEDNKGVAEIIIGKQRNGPIGRVRLAFQGQYSRFDNLA 463
PRK08006 PRK08006
replicative DNA helicase DnaB;
25-280 6.90e-80

replicative DNA helicase DnaB;


Pssm-ID: 181193 [Multi-domain]  Cd Length: 471  Bit Score: 249.54  E-value: 6.90e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:PRK08006 206 GVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMLQDKPVLIFSLEMPGEQIMMRMLASLSRVDQTRIR 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKMARRMGEISDA-PLFIDDSPNLSLMEIRAKARRLKQRHN-LKLIVIDYLQLMTSGKKVENRQQEVSEFS 182
Cdd:PRK08006 286 TGQLDDEDWARISGTMGILLEKrNMYIDDSSGLTPTEVRSRARRIFREHGgLSLIMIDYLQLMRVPSLSDNRTLEIAEIS 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 183 RQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLY-DSQNRSGEADLIVAKHRNGP 261
Cdd:PRK08006 366 RSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYhENSDLKGIAEIIIGKQRNGP 445

                        250
                 ....*....|....*....
gi 143323855 262 TRTITVSAQLHLARFTDMA 280
Cdd:PRK08006 446 IGTVRLTFNGQWSRFDNYA 464
PRK06321 PRK06321
replicative DNA helicase; Provisional
 25-280 1.30e-78

replicative DNA helicase; Provisional


Pssm-ID: 180528 [Multi-domain]  Cd Length: 472  Bit Score: 246.29  E-value: 1.30e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIR 104
Cdd:PRK06321 208 GIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFCFQNRLPVGIFSLEMTVDQLIHRIICSRSEVESKKIS 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDYLQLMTSG---KKVENRQQEVSEF 181
Cdd:PRK06321 288 VGDLSGRDFQRIVSVVNEMQEHTLLIDDQPGLKITDLRARARRMKESYDIQFLIIDYLQLLSGSgnlRNSESRQTEISEI 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 182 SRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRSGEADLIVAKHRNGP 261
Cdd:PRK06321 368 SRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRESGSIEQDSDLVMFLLRREYYDPNDKPGTAELIVAKNRHGS 447

                        250
                 ....*....|....*....
gi 143323855 262 TRTITVSAQLHLARFTDMA 280
Cdd:PRK06321 448 IGSVPLVFEKEFARFRNYA 466
PRK06749 PRK06749
replicative DNA helicase; Provisional
 25-279 5.36e-73

replicative DNA helicase; Provisional


Pssm-ID: 168658 [Multi-domain]  Cd Length: 428  Bit Score: 230.61  E-value: 5.36e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  25 GVKTGFKDLDALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASihKRETSV-IFSLEMSRSEITMRMLAAEARVPLNNI 103
Cdd:PRK06749 168 GIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAA--KSGAAVgLFSLEMSSKQLLKRMASCVGEVSGGRL 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 104 RSGQ--LGEEEWAKMARRMGEISDAPLFIDDSPNLSLMEIRAKARRLKQRHNLK--LIVIDYLQLMTSGKKVE-NRQQEV 178
Cdd:PRK06749 246 KNPKhrFAMEDWEKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDKkiLIIVDYLQLITGDPKHKgNRFQEI 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 179 SEFSRQLKLLAKELNVPVVAISQLNRSPEQRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRSGE-ADLIVAKH 257
Cdd:PRK06749 326 SEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYREDYYDKETMQKEmTEIHVAKH 405

                        250       260
                 ....*....|....*....|..
gi 143323855 258 RNGPTRTITVSAQLHLARFTDM 279
Cdd:PRK06749 406 RNGPVGSFKLRFLKEFGRFVEG 427
PRK07773 PRK07773
replicative DNA helicase; Validated
 225-281 1.70e-20

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 91.35  E-value: 1.70e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 143323855 225 IEQDADVVILLHREDLYDSQN-RSGEADLIVAKHRNGPTRTITVSAQLHLARFTDMAT 281
Cdd:PRK07773 828 IEQDADVVILLYRPDYYDRDDpRGGEAEFIVAKHRNGPTGTVTLAFQLHLSRFANLAR 885
RecA-like_Gp4D_helicase cd19483
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ...
 46-260 2.37e-19

RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410891 [Multi-domain]  Cd Length: 231  Bit Score: 84.54  E-value: 2.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  46 VVLAARPAVGKSTLGLDIARYASIHKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIRSGQLGEEEWAKMARRMGEISD 125
Cdd:cd19483    1 VTIGAGSGIGKSTIVRELAYHLITEHGEKVGIISLEESVEETAKGLAGKHLGKPEPLELPRDDITEEEEDDAFDNELGSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 126 APLFIDDSPNLSLMEIRAKARRLKQRHNLKLIVIDYLQLMTSG--KKVENRQQEvsEFSRQLKLLAKELNVPVVAISQLN 203
Cdd:cd19483   81 RFFLYDHFGSLDWDNLKEKIRYMVKVLGCKVIVLDHLTILVSGldSSDERKELD--EIMTELAALVKELGVTIILVSHLR 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 143323855 204 RsPEQRSD----KKPMLSDLRESGFIEQDADVVILLHRE---DLYDSQNRSgeaDLIVAKHRNG 260
Cdd:cd19483  159 R-PGGGKGheegGEVSESDLRGSSAIAQLSDYVIGLERNkqaDDPVERNTT---RVRVLKNRFT 218
PRK05973 PRK05973
replicative DNA helicase; Provisional
 40-220 8.31e-16

replicative DNA helicase; Provisional


Pssm-ID: 168322 [Multi-domain]  Cd Length: 237  Bit Score: 75.07  E-value: 8.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  40 FHPGNMVVLAARPAVGKSTLGLDIARYASIHKReTSVIFSLEMSRSEITMRMLAaearvplnnirsgqLGEEewakmaRR 119
Cdd:PRK05973  61 LKPGDLVLLGARPGHGKTLLGLELAVEAMKSGR-TGVFFTLEYTEQDVRDRLRA--------------LGAD------RA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 120 mgeiSDAPLFIDDSPNlslmEIRAK--ARRLKQRHNLKLIVIDYLQLMTsgkkvENRQQ-EVSEFSRQLKLLAKELNVPV 196
Cdd:PRK05973 120 ----QFADLFEFDTSD----AICADyiIARLASAPRGTLVVIDYLQLLD-----QRREKpDLSVQVRALKSFARERGLII 186

                        170       180
                 ....*....|....*....|....
gi 143323855 197 VAISQLNRSPEQRSDKKPMLSDLR 220
Cdd:PRK05973 187 VFISQIDRSFDPSAKPLPDIRDVR 210
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
26-261 1.08e-15

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 74.18  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  26 VKTGFKDLDALTN-GFHPGNMVVLAARPAVGKSTLGLDIArYASIHKRETSVIFSLEMSRSEItmrmlaaearvpLNNIR 104
Cdd:COG0467    2 VPTGIPGLDELLGgGLPRGSSTLLSGPPGTGKTTLALQFL-AEGLRRGEKGLYVSFEESPEQL------------LRRAE 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 105 SGQLGEEEWAKmarrMGEISdaplFIDDSP---NLSLMEIRAKARRLKQRHNLKLIVID----YLQLMTSgkkvenrQQE 177
Cdd:COG0467   69 SLGLDLEEYIE----SGLLR----IIDLSPeelGLDLEELLARLREAVEEFGAKRVVIDslsgLLLALPD-------PER 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 178 VSEFSRQLKLLAKELNVPVVAISQlnrspeqrsdkKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRSgeadLIVAKH 257
Cdd:COG0467  134 LREFLHRLLRYLKKRGVTTLLTSE-----------TGGLEDEATEGGLSYLADGVILLRYVELGGELRRA----LSVLKM 198


                 ....
gi 143323855 258 RNGP 261
Cdd:COG0467  199 RGSA 202
RepA COG3598
RecA-family ATPase [Replication, recombination and repair];
43-287 2.46e-12

RecA-family ATPase [Replication, recombination and repair];


Pssm-ID: 442817 [Multi-domain]  Cd Length: 313  Bit Score: 66.08  E-value: 2.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  43 GNMVVLAARPAVGKSTLGLDIARYASI--------HKRETSVIFSLEMSRSEITMRMLAAEARVPLNnirsgqlgeeeWA 114
Cdd:COG3598   13 GGVTLLAGPPGTGKSFLALQLAAAVAAggpwlgrrVPPGKVLYLAAEDDRGELRRRLKALGADLGLP-----------FA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 115 KMARRMGEISDAPLFIDDSpnlSLMEIRAKARrlkqRHNLKLIVIDYLQLMTSGKkvENRQQEVSEFSRQLKLLAKELNV 194
Cdd:COG3598   82 DLDGRLRLLSLAGDLDDTD---DLEALERAIE----EEGPDLVVIDPLARVFGGD--ENDAEEMRAFLNPLDRLAERTGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 195 PVVAISQLNRSpeqrSDKKPMLSDLRESGFIEQDADVVILLHREDlyDSQNRSgeadLIVAKHRNGPTRTITVSAQLHLA 274
Cdd:COG3598  153 AVLLVHHTGKG----GAGKDSGDRARGSSALRGAARSVLVLSREK--GEDLRV----LTRAKSNYGPEIALRWDNGGRLA 222

                        250
                 ....*....|...
gi 143323855 275 RFTDMATNFVPTE 287
Cdd:COG3598  223 LEEVAALTAGAGE 235
AAA_25 pfam13481
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
 46-207 7.48e-12

AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.


Pssm-ID: 463892 [Multi-domain]  Cd Length: 193  Bit Score: 63.17  E-value: 7.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855   46 VVLAARPAVGKSTLGLDIAR-YAS-----IHKRETS----VIFSLEMSRSEITMRMLAAEARVPLNNIRSGQLGEEewak 115
Cdd:pfam13481  36 GLLAGAPGTGKTTLALDLAAaVATgkpwlGGPRVPEqgkvLYVSAEGPADELRRRLRAAGADLDLPARLLFLSLVE---- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  116 marrmgeisDAPLFIDDSPNLSLME-IRAKARRLKQRHNLKLIVIDYLQLMTSGkkVENRQQEVSEFSRQLKLLAKELNV 194
Cdd:pfam13481 112 ---------SLPLFFLDRGGPLLDAdVDALEAALEEVEDPDLVVIDPLARALGG--DENSNSDVGRLVKALDRLARRTGA 180

                         170
                  ....*....|...
gi 143323855  195 PVVAISQLNRSPE 207
Cdd:pfam13481 181 TVLLVHHVGKDGA 193
41 PHA02542
41 helicase; Provisional
 47-230 8.28e-08

41 helicase; Provisional


Pssm-ID: 222864 [Multi-domain]  Cd Length: 473  Bit Score: 53.14  E-value: 8.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  47 VLAARPAVGKSTLGLDIAryASIHKRETSVI-FSLEMSRSEITMRMLAAEARVPLNNIRsgqlgEEEWAKMARRMGEIS- 124
Cdd:PHA02542 194 VLLAGVNVGKSLGLCSLA--ADYLQQGYNVLyISMEMAEEVIAKRIDANLLDVSLDDID-----DLSKAEYKAKMEKLRs 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 125 --DAPLFIDDSPNLS--LMEIRAKARRLKQRHNLK--LIVIDYLQLMTSGK---KVENRQQEVSEFSRQLKLLAKELNVP 195
Cdd:PHA02542 267 ktQGKLIIKQYPTGGahAGHFRALLNELKLKKNFKpdVIIVDYLGICASSRlrvSSENSYTYVKAIAEELRGLAVEHDVV 346

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 143323855 196 VVAISQLNRSPEQRSDkkPMLSDLRESGFIEQDAD 230
Cdd:PHA02542 347 VWTAAQTTRSGWDSSD--VDMSDTAESAGLPATAD 379
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 34-206 1.27e-06

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 48.47  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  34 DALTNGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETS-----VIFSLEMSRSEITMRmLAAEARVPLNNIRSGQL 108
Cdd:cd19493    2 TALAGGLPLGAITEITGASGSGKTQFALTLASSAAMPARKGGldggvLYIDTESKFSAERLA-EIAEARFPEAFSGFMEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 109 GEEEwAKMARRMGEISdaplfiddspNLSLMEIRAKARRLKQ---RHNLKLIVIDYLQLM------TSGKKVENRQQEVS 179
Cdd:cd19493   81 NERA-EEMLKRVAVVR----------VTTLAQLLERLPNLEEhilSSGVRLVVIDSIAALvrrefgGSDGEVTERHNALA 149

                        170       180
                 ....*....|....*....|....*..
gi 143323855 180 EFSRQLKLLAKELNVPVVAISQLNRSP 206
Cdd:cd19493  150 REASSLKRLAEEFRIAVLVTNQATTHF 176
RadA_SMS_N cd01121
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ...
 26-197 1.77e-06

bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.


Pssm-ID: 410866 [Multi-domain]  Cd Length: 268  Bit Score: 48.30  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  26 VKTGFKDLD-ALTNGFHPGNMVVLAARPAVGKSTLGLDIAryASIHKRETSVIF-SLEMSRSEITMRmlaaearvplnni 103
Cdd:cd01121   64 ISTGIGELDrVLGGGLVPGSVVLIGGDPGIGKSTLLLQVA--ARLAQRGGKVLYvSGEESLSQIKLR------------- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 104 rsgqlgeeewakmARRMGEISDaplfiddspNLSLM-EIRAKA-RRLKQRHNLKLIVIDYLQLMTSgKKVENRQQEVS-- 179
Cdd:cd01121  129 -------------AERLGLGSD---------NLYLLaETNLEAiLAEIEELKPSLVVIDSIQTVYS-PELTSSPGSVSqv 185

                        170
                 ....*....|....*....
gi 143323855 180 -EFSRQLKLLAKELNVPVV 197
Cdd:cd01121  186 rECAAELLRLAKETGIPVF 204
RepA_RSF1010_like cd01125
Hexameric Replicative Helicase RepA of plasmid RSF1010 and related proteins; This family ...
 43-252 2.66e-05

Hexameric Replicative Helicase RepA of plasmid RSF1010 and related proteins; This family includes the homo-hexameric replicative helicase RepA encoded by plasmid RSF1010. RSF1010 is found in most Gram-negative bacteria and some Gram-positive bacteria . The RepA protein of Plasmid RSF1010 is a 5'-3' DNA helicase which can utilize ATP, dATP, GTP and dGTP (and CTP and dCTP to a lesser extent).


Pssm-ID: 410870  Cd Length: 238  Bit Score: 44.68  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  43 GNMVVLAARPAVGKSTLGLDIAryASI-----------HKRETSVIFSLEMSRSEITMRMLAAEARVPLNNIRsgqlgee 111
Cdd:cd01125    1 GTLGMLVGPPGSGKSFLALDLA--VAVatgrdwlgerrVKQGRVVYLAAEDPRDGLRRRLKAIGAHLGDEDAA------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 112 ewakmARRMGEIsdAPLFIDdspNLSLMEIRAKARRLKQRHN-LKLIVIDYLQLMTSGkKVENRQQEVSEFSRQLKLLAK 190
Cdd:cd01125   72 -----LAENLVI--ENLRGK---PVSIDAEAPELERIIEELEgVRLIIIDTLARVLHG-GDENDAADMGAFVAGLDRIAR 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 143323855 191 ELNVPVVAISQLNrspeqRSDKKPMLSDLRESGFIEQDADVVILLHREDLYDSQNRSGEADL 252
Cdd:cd01125  141 ETGAAVLLVHHTG-----KDAAGDSQQAARGSSALRGAADAEINLSKMDATEAEKVGLDKDL 197
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 141-226 6.26e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 35.94  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 141 IRAKARRLKQRHNLKLIVIDYLQLMtSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQlnrSPEQRSDKKPMLSDLR 220
Cdd:cd01120   38 ILEAIEDLIEEKKLDIIIIDSLSSL-ARASQGDRSSELLEDLAKLLRAARNTGITVIATIH---SDKFDIDRGGSSNDER 113


                 ....*.
gi 143323855 221 ESGFIE 226
Cdd:cd01120  114 LLKSLR 119
KaiC-like_C cd19487
C-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 26-135 7.64e-03

C-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410895 [Multi-domain]  Cd Length: 219  Bit Score: 36.89  E-value: 7.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  26 VKTGFKDLDALTNG-FHPGNMVVLAARPAVGKSTLGLDIARyASIHKRETSVIFSLEMS------RSE---ITMRMLAAE 95
Cdd:cd19487    1 VSSGVPELDELLGGgLERGTSTLLIGPAGVGKSTLALQFAK-AAAARGERSVLFSFDESigtlfeRSEalgIDLRAMVEK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 143323855  96 ARVPLNNIRSGQLGEEEWAKMARRMGEISDAPLFIDDSPN 135
Cdd:cd19487   80 GLLSIEQIDPAELSPGEFAQRVRTSVEQEDARVVVIDSLN 119
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 38-216 9.06e-03

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 36.46  E-value: 9.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855  38 NGFHPGNMVVLAARPAVGKSTLGLDIARYASIHKRETSVIF----SLEMSRseitMRMLaaearvplnnIRSGQLGEEEW 113
Cdd:cd19489    2 GGLRTGEITELVGESSSGKTQLCLTAAANVASRSGQNVLYIdtksSFSARR----LAQI----------LKSRAQDAEEI 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143323855 114 AKMARRMG--EISDAPLFIDDspnlsLMEIRAK--ARRLKQRHNLKLIVIDYL----QLMTSGKKVENRQQEVSEFSRQL 185
Cdd:cd19489   68 DKALQRIRvvRVFDPYELLDL-----LEELRNTlsQQQENLYSRLKLVIIDSLsaliSPLLGGSKHSEGHALLASLARLL 142

                        170       180       190
                 ....*....|....*....|....*....|...
gi 143323855 186 KLLAKELNVPVVAISQLNRSPE--QRSDKKPML 216
Cdd:cd19489  143 KKLAAEYQIAVLVTNLTVRGGDggQQGSTKPAL 175
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 143-202 9.65e-03

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 36.18  E-value: 9.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 143323855 143 AKARRLKQRHNLKLIVID---------YLQLMTSGKKVENRQQEVSEFSRQLKLLAKELNVPVVAISQL 202
Cdd:cd01393   84 SLPESLFPPPNTSLVVVDsvsalfrkaFPRGGDGDSSSSLRARLLSQLARALQKLAAQFNLAVVVTNQV 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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