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Conserved domains on  [gi|1429752196|emb|SSL56794|]
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transglycosylase [Klebsiella pneumoniae]

Protein Classification

LysM and M23_peptidase domain-containing protein( domain architecture ID 11443402)

LysM and M23_peptidase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 518-670 2.21e-22

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 95.43  E-value: 2.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 518 SATFkGWRTRSN-GRRYQHQGLDIEAAPNTPIFSVADGRIAFIidPPRSDYGRqlCIIVQVDDlplekallcrcndseis 596
Cdd:COG0739    80 TSGF-GYRRHPVtGRRRFHKGIDIAAPTGTPVYAAADGTVVFA--GWNGGYGN--LVIIDHGN----------------- 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1429752196 597 EVYFFYAHLSAIHsgLERGDHVRCGELLGETGCTGNANgmtsialGAHLHFEVRVKERPgpgianrLDPAPFID 670
Cdd:COG0739   138 GYTTLYAHLSSIL--VKVGQRVKAGQVIGYVGNTGRST-------GPHLHFEVRVNGKP-------VDPLPFLP 195
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
4-52 1.26e-13

LysM repeat [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 68.97  E-value: 1.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLltkaEQHIIQPGQVLSLPSK 52
Cdd:COG1388   112 YTVKKGDTLWSIARRYGVSVEELKRWNGL----SSDTIRPGQKLKIPAS 156
MltF super family cl34791
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 221-274 1.49e-10

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG4623:

Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 63.54  E-value: 1.49e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1429752196 221 AEQYRDYIIETAKKYGFQPEGLSALIYAESRWKANATNPTgsGAVGLGQFKPDT 274
Cdd:COG4623   261 LPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPT--GARGLMQLMPAT 312
 
Name Accession Description Interval E-value
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 518-670 2.21e-22

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 95.43  E-value: 2.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 518 SATFkGWRTRSN-GRRYQHQGLDIEAAPNTPIFSVADGRIAFIidPPRSDYGRqlCIIVQVDDlplekallcrcndseis 596
Cdd:COG0739    80 TSGF-GYRRHPVtGRRRFHKGIDIAAPTGTPVYAAADGTVVFA--GWNGGYGN--LVIIDHGN----------------- 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1429752196 597 EVYFFYAHLSAIHsgLERGDHVRCGELLGETGCTGNANgmtsialGAHLHFEVRVKERPgpgianrLDPAPFID 670
Cdd:COG0739   138 GYTTLYAHLSSIL--VKVGQRVKAGQVIGYVGNTGRST-------GPHLHFEVRVNGKP-------VDPLPFLP 195
Peptidase_M23 pfam01551
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ...
 535-655 1.17e-17

Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.


Pssm-ID: 460250 [Multi-domain]  Cd Length: 96  Bit Score: 78.36  E-value: 1.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 535 HQGLDIEAAPNTPIFSVADGRIAFIIdpPRSDYGRqlCIIVQVDDlplekallcrcndseisEVYFFYAHLSAIHsgLER 614
Cdd:pfam01551   3 HKGIDIAAPTGTPVYAAADGVVVFAG--WLGGYGN--LVIIDHGN-----------------GYSTLYAHLSSIL--VKV 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1429752196 615 GDHVRCGELLGETGCTGNANgmtsialGAHLHFEVRVKERP 655
Cdd:pfam01551  60 GQRVKAGQVIGTVGSTGRST-------GPHLHFEIRKNGKP 93
M23_peptidase cd12797
M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; ...
 535-649 2.98e-17

M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity.


Pssm-ID: 410984 [Multi-domain]  Cd Length: 85  Bit Score: 76.86  E-value: 2.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 535 HQGLDIEAAPNTPIFSVADGRIAFIIDppRSDYGRqlCIIVQVDDlplekallcrcndseisEVYFFYAHLSAIHsgLER 614
Cdd:cd12797     1 HNGIDIAAPEGTPVYAAADGTVVFAGW--DGGYGN--YVIIDHGN-----------------GYYTLYAHLSSIL--VKV 57

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1429752196 615 GDHVRCGELLGETGCTGNANgmtsialGAHLHFEV 649
Cdd:cd12797    58 GQRVKKGQVIGTVGNTGRST-------GPHLHFEI 85
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
4-52 1.26e-13

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 68.97  E-value: 1.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLltkaEQHIIQPGQVLSLPSK 52
Cdd:COG1388   112 YTVKKGDTLWSIARRYGVSVEELKRWNGL----SSDTIRPGQKLKIPAS 156
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
 4-50 4.80e-12

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 60.87  E-value: 4.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLltkAEQHiIQPGQVLSLP 50
Cdd:pfam01476   1 YTVKKGDTLSSIAKRYGITVEQLAELNGL---SSPN-LYVGQKLKIP 43
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
 4-49 5.35e-12

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 60.58  E-value: 5.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLLTKaeqHIIQPGQVLSL 49
Cdd:cd00118     3 YTVKPGDTLWSIAKKYGVTVEELAAANPLINP---DCIYPGQKLKI 45
LysM smart00257
Lysin motif;
4-49 4.44e-11

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 58.23  E-value: 4.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1429752196    4 YTVQKGDSLWKISRKFGIDVNELANINGLLTKAEqhiIQPGQVLSL 49
Cdd:smart00257   2 YTVKKGDTLSSIARRYGISVSDLLELNNILDPDN---LQVGQKLKI 44
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 221-274 1.49e-10

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 63.54  E-value: 1.49e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1429752196 221 AEQYRDYIIETAKKYGFQPEGLSALIYAESRWKANATNPTgsGAVGLGQFKPDT 274
Cdd:COG4623   261 LPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPT--GARGLMQLMPAT 312
spore_safA TIGR02899
spore coat assembly protein SafA; SafA (YrbB) (SafA) of Bacillus subtilis is a protein found ...
 6-51 1.02e-08

spore coat assembly protein SafA; SafA (YrbB) (SafA) of Bacillus subtilis is a protein found at the interface of the spore cortex and spore coat, and is dependent on SpoVID for its localization. This model is based on the N-terminal LysM (lysin motif) domain (see pfamAM model pfam01476) of SafA and, from several other spore-forming species, the protein with the most similar N-terminal region. However, this set of proteins differs greatly in C-terminal of the LysM domaim; blocks of 12-residue and 13-residue repeats are found in the Bacillus cereus group, tandem LysM domains in Thermoanaerobacter tengcongensis MB4, etc. in which one of which is found in most examples of endospore-forming bacteria. [Cellular processes, Sporulation and germination]


Pssm-ID: 131945 [Multi-domain]  Cd Length: 44  Bit Score: 51.34  E-value: 1.02e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1429752196   6 VQKGDSLWKISRKFGIDVNELANINGLLTKAEqhIIQPGQVLSLPS 51
Cdd:TIGR02899   1 VQKGDTLWKIAKKYGVDFDELIQANPQLSNPN--LIYPGMKIKIPS 44
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 228-274 1.23e-07

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 51.77  E-value: 1.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1429752196 228 IIETAKKYGFQPEGLSALIYAESRWKANATNPTgsGAVGLGQFKPDT 274
Cdd:cd13403     1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSPA--GARGLMQLMPST 45
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 228-274 6.40e-07

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 48.46  E-value: 6.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1429752196 228 IIETAKKYGFQPEGLSALIYAESRWKANATNptGSGAVGLGQFKPDT 274
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVS--KSGAVGLMQIMPST 45
PRK06148 PRK06148
hypothetical protein; Provisional
 518-649 1.95e-05

hypothetical protein; Provisional


Pssm-ID: 180426 [Multi-domain]  Cd Length: 1013  Bit Score: 48.10  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196  518 SATFKGwRTRSNGRRYQHQGLDIEAAPNTPIFSVADGRIAFI-IDPPRSDYGrqlCIIVqvddlpLEKAllcrcnDSEIS 596
Cdd:PRK06148   425 DEAFTS-RFIEGERRTVHLGVDLFAPAGTPVYAPLAGTVRSVeIEAVPLGYG---GLVA------LEHE------TPGGD 488

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1429752196  597 EVYFFYAHLSaiHSGLER---GDHVRCGELLGETGCTGNANGMTsialgAHLHFEV 649
Cdd:PRK06148   489 PFYTLYGHLA--HEAVSRlkpGDRLAAGELFGAMGDAHENGGWA-----PHLHFQL 537
PRK11198 PRK11198
LysM domain/BON superfamily protein; Provisional
 4-50 2.17e-04

LysM domain/BON superfamily protein; Provisional


Pssm-ID: 236880 [Multi-domain]  Cd Length: 147  Bit Score: 41.82  E-value: 2.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANI---NG-LLTKAEQhiIQPGQVLSLP 50
Cdd:PRK11198   98 YTVKSGDTLSAIAKKVYGNANKYNKIfeaNKpMLKSPDK--IYPGQVLRIP 146
 
Name Accession Description Interval E-value
NlpD COG0739
Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell ...
 518-670 2.21e-22

Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440502 [Multi-domain]  Cd Length: 196  Bit Score: 95.43  E-value: 2.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 518 SATFkGWRTRSN-GRRYQHQGLDIEAAPNTPIFSVADGRIAFIidPPRSDYGRqlCIIVQVDDlplekallcrcndseis 596
Cdd:COG0739    80 TSGF-GYRRHPVtGRRRFHKGIDIAAPTGTPVYAAADGTVVFA--GWNGGYGN--LVIIDHGN----------------- 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1429752196 597 EVYFFYAHLSAIHsgLERGDHVRCGELLGETGCTGNANgmtsialGAHLHFEVRVKERPgpgianrLDPAPFID 670
Cdd:COG0739   138 GYTTLYAHLSSIL--VKVGQRVKAGQVIGYVGNTGRST-------GPHLHFEVRVNGKP-------VDPLPFLP 195
Peptidase_M23 pfam01551
Peptidase family M23; Members of this family are zinc metallopeptidases with a range of ...
 535-655 1.17e-17

Peptidase family M23; Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.


Pssm-ID: 460250 [Multi-domain]  Cd Length: 96  Bit Score: 78.36  E-value: 1.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 535 HQGLDIEAAPNTPIFSVADGRIAFIIdpPRSDYGRqlCIIVQVDDlplekallcrcndseisEVYFFYAHLSAIHsgLER 614
Cdd:pfam01551   3 HKGIDIAAPTGTPVYAAADGVVVFAG--WLGGYGN--LVIIDHGN-----------------GYSTLYAHLSSIL--VKV 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1429752196 615 GDHVRCGELLGETGCTGNANgmtsialGAHLHFEVRVKERP 655
Cdd:pfam01551  60 GQRVKAGQVIGTVGSTGRST-------GPHLHFEIRKNGKP 93
M23_peptidase cd12797
M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; ...
 535-649 2.98e-17

M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity.


Pssm-ID: 410984 [Multi-domain]  Cd Length: 85  Bit Score: 76.86  E-value: 2.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 535 HQGLDIEAAPNTPIFSVADGRIAFIIDppRSDYGRqlCIIVQVDDlplekallcrcndseisEVYFFYAHLSAIHsgLER 614
Cdd:cd12797     1 HNGIDIAAPEGTPVYAAADGTVVFAGW--DGGYGN--YVIIDHGN-----------------GYYTLYAHLSSIL--VKV 57

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1429752196 615 GDHVRCGELLGETGCTGNANgmtsialGAHLHFEV 649
Cdd:cd12797    58 GQRVKKGQVIGTVGNTGRST-------GPHLHFEI 85
SpoIIQ2 COG5821
Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell ...
 471-669 3.64e-16

Stage II sporulation protein SpoIIQ, clostridial version, metallopeptidase M23 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444523 [Multi-domain]  Cd Length: 200  Bit Score: 77.37  E-value: 3.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 471 NTDLPPVTIMNSQPRNTPSPSVNVEGNTWSNPLSVCRIRTHALPRVRSATFKGWRTrsngrryqHQGLDIEAAPNTPIFS 550
Cdd:COG5821    41 KLEEETVKNKSESNEKSKSKVTASTSNKFLKPVSGKITREFGEDLVYSKTLNEWRT--------HTGIDIAAKEGTPVKA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 551 VADGRIAFIIDPPRsdYGrqlcIIVQVDdlplekallcrcNDSEISEVyffYAHLSaihSGL--ERGDHVRCGELLGETG 628
Cdd:COG5821   113 AADGVVVEVGKDPK--YG----ITVVID------------HGNGIKTV---YANLD---SKIkvKVGQKVKKGQVIGKVG 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1429752196 629 CTGNAngmtSIALGAHLHFEVRVKERPgpgianrLDPAPFI 669
Cdd:COG5821   169 STALF----ESSEGPHLHFEVLKNGKP-------VDPMKYL 198
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 523-669 5.69e-15

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 77.11  E-value: 5.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196 523 GWRTRSNGRryqHQGLDIEAAPNTPIFSVADGRIAFIIdpPRSDYGrqLCIIVQVDDlplekallcrcndseisEVYFFY 602
Cdd:COG4942   268 GERDGGGGR---NKGIDIAAPPGAPVRAVADGTVVYAG--WLRGYG--NLVIIDHGG-----------------GYLTLY 323

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1429752196 603 AHLSAIHsgLERGDHVRCGELLGETGCTGNANgmtsialGAHLHFEVRVKERPgpgianrLDPAPFI 669
Cdd:COG4942   324 AHLSSLL--VKVGQRVKAGQPIGTVGSSGGQG-------GPTLYFELRKNGKP-------VDPLPWL 374
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
4-52 1.26e-13

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 68.97  E-value: 1.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLltkaEQHIIQPGQVLSLPSK 52
Cdd:COG1388   112 YTVKKGDTLWSIARRYGVSVEELKRWNGL----SSDTIRPGQKLKIPAS 156
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
 4-50 4.80e-12

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 60.87  E-value: 4.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLltkAEQHiIQPGQVLSLP 50
Cdd:pfam01476   1 YTVKKGDTLSSIAKRYGITVEQLAELNGL---SSPN-LYVGQKLKIP 43
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
 4-49 5.35e-12

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 60.58  E-value: 5.35e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLLTKaeqHIIQPGQVLSL 49
Cdd:cd00118     3 YTVKPGDTLWSIAKKYGVTVEELAAANPLINP---DCIYPGQKLKI 45
LysM smart00257
Lysin motif;
4-49 4.44e-11

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 58.23  E-value: 4.44e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1429752196    4 YTVQKGDSLWKISRKFGIDVNELANINGLLTKAEqhiIQPGQVLSL 49
Cdd:smart00257   2 YTVKKGDTLSSIARRYGISVSDLLELNNILDPDN---LQVGQKLKI 44
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 221-274 1.49e-10

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 63.54  E-value: 1.49e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1429752196 221 AEQYRDYIIETAKKYGFQPEGLSALIYAESRWKANATNPTgsGAVGLGQFKPDT 274
Cdd:COG4623   261 LPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPT--GARGLMQLMPAT 312
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 221-275 2.33e-09

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 58.47  E-value: 2.33e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1429752196 221 AEQYRDYIIETAKKYGFQPEGLSALIYAESRWKANATNPtgSGAVGLGQFKPDTW 275
Cdd:COG0741   100 PLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSP--AGARGLMQLMPATA 152
XkdP COG1652
Cytoplasmic potassium-binding protein Kbp/XkdP/YgaU, contains LysM domain [Inorganic ion ...
 2-53 6.54e-09

Cytoplasmic potassium-binding protein Kbp/XkdP/YgaU, contains LysM domain [Inorganic ion transport and metabolism];


Pssm-ID: 441258 [Multi-domain]  Cd Length: 163  Bit Score: 55.40  E-value: 6.54e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1429752196   2 EQYTVQKGDSLWKISRKF---GIDVNEL--ANINGLltkAEQHIIQPGQVLSLPSKD 53
Cdd:COG1652   110 KTYTVKPGDTLWGIAKRFygdPARWPEIaeANRDQI---KNPDLIYPGQVLRIPALE 163
spore_safA TIGR02899
spore coat assembly protein SafA; SafA (YrbB) (SafA) of Bacillus subtilis is a protein found ...
 6-51 1.02e-08

spore coat assembly protein SafA; SafA (YrbB) (SafA) of Bacillus subtilis is a protein found at the interface of the spore cortex and spore coat, and is dependent on SpoVID for its localization. This model is based on the N-terminal LysM (lysin motif) domain (see pfamAM model pfam01476) of SafA and, from several other spore-forming species, the protein with the most similar N-terminal region. However, this set of proteins differs greatly in C-terminal of the LysM domaim; blocks of 12-residue and 13-residue repeats are found in the Bacillus cereus group, tandem LysM domains in Thermoanaerobacter tengcongensis MB4, etc. in which one of which is found in most examples of endospore-forming bacteria. [Cellular processes, Sporulation and germination]


Pssm-ID: 131945 [Multi-domain]  Cd Length: 44  Bit Score: 51.34  E-value: 1.02e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1429752196   6 VQKGDSLWKISRKFGIDVNELANINGLLTKAEqhIIQPGQVLSLPS 51
Cdd:TIGR02899   1 VQKGDTLWKIAKKYGVDFDELIQANPQLSNPN--LIYPGMKIKIPS 44
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 228-274 1.23e-07

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 51.77  E-value: 1.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1429752196 228 IIETAKKYGFQPEGLSALIYAESRWKANATNPTgsGAVGLGQFKPDT 274
Cdd:cd13403     1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSPA--GARGLMQLMPST 45
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 224-277 3.76e-07

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 49.82  E-value: 3.76e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1429752196 224 YRDYIIETAKKYGFQPEGLSALIYAESRWKANATNPTgsGAVGLGQFKPDT--WLS 277
Cdd:cd16896     4 YREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSK--GAIGLMQIMPETaeWIA 57
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 228-274 6.40e-07

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 48.46  E-value: 6.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1429752196 228 IIETAKKYGFQPEGLSALIYAESRWKANATNptGSGAVGLGQFKPDT 274
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVS--KSGAVGLMQIMPST 45
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 241-288 5.30e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 44.32  E-value: 5.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1429752196 241 GLSALIYAESRWKANATNPTGSGAVGLGQFKPDTWLSLCAESESKIYQ 288
Cdd:cd00442     1 VLAAIIGQESGGNKPANAGSGSGAAGLFQFMPGTWKAYGKNSSSDLND 48
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 242-275 5.34e-06

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 45.67  E-value: 5.34e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1429752196 242 LSALIYAESRWKANATNPtgSGAVGLGQFKPDTW 275
Cdd:cd00254     4 VLAVIRVESGFNPRAVSP--AGARGLMQLMPGTA 35
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 235-275 7.75e-06

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 44.99  E-value: 7.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1429752196 235 YGFQPEGLSALIYAESRWKANAtNPTGSGAVGLGQFKPDTW 275
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNA-GGSPAGAQGIAQFMPSTW 40
PRK06148 PRK06148
hypothetical protein; Provisional
 518-649 1.95e-05

hypothetical protein; Provisional


Pssm-ID: 180426 [Multi-domain]  Cd Length: 1013  Bit Score: 48.10  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1429752196  518 SATFKGwRTRSNGRRYQHQGLDIEAAPNTPIFSVADGRIAFI-IDPPRSDYGrqlCIIVqvddlpLEKAllcrcnDSEIS 596
Cdd:PRK06148   425 DEAFTS-RFIEGERRTVHLGVDLFAPAGTPVYAPLAGTVRSVeIEAVPLGYG---GLVA------LEHE------TPGGD 488

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1429752196  597 EVYFFYAHLSaiHSGLER---GDHVRCGELLGETGCTGNANGMTsialgAHLHFEV 649
Cdd:PRK06148   489 PFYTLYGHLA--HEAVSRlkpGDRLAAGELFGAMGDAHENGGWA-----PHLHFQL 537
PRK11198 PRK11198
LysM domain/BON superfamily protein; Provisional
 4-50 2.17e-04

LysM domain/BON superfamily protein; Provisional


Pssm-ID: 236880 [Multi-domain]  Cd Length: 147  Bit Score: 41.82  E-value: 2.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANI---NG-LLTKAEQhiIQPGQVLSLP 50
Cdd:PRK11198   98 YTVKSGDTLSAIAKKVYGNANKYNKIfeaNKpMLKSPDK--IYPGQVLRIP 146
RPF cd13925
core lysozyme-like domain of resuscitation-promoting factor proteins; Resuscitation-promoting ...
 242-278 5.47e-04

core lysozyme-like domain of resuscitation-promoting factor proteins; Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activity, and has a polysaccharide binding cleft that corresponds to the peptidoglycan binding cleft of lysozyme. Muralytic activity of Rpf in Micrococcus luteus correlates with resuscitation, supporting a mechanism dependent on cleavage of peptidoglycan by RPF.


Pssm-ID: 381607 [Multi-domain]  Cd Length: 71  Bit Score: 38.90  E-value: 5.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1429752196 242 LSALIYAESRWKANATNpTGSGAVGLGQFKPDTWLSL 278
Cdd:cd13925     3 WDAIAQCESGGNWNAVN-TGNGYYGGLQFLQGTWKSV 38
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 3-49 1.80e-03

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 41.19  E-value: 1.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1429752196   3 QYTVQKGDSLWKISRKFGIDVNELANI--NGLLTKAEQHiIQPGQVLSL 49
Cdd:COG3061    71 EYTVQSGDTLSQIFRRLGLSASDLYALlaAEGDAKPLSR-LKPGQELRF 118
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 4-54 2.13e-03

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 41.26  E-value: 2.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1429752196   4 YTVQKGDSLWKISRKFGIDVNELANINGLLTKAeqhiIQPGQVLSLPSKDK 54
Cdd:PRK10783  405 YRVRKGDSLSSIAKRHGVNIKDVMRWNSDTAKN----LQPGDKLTLFVKNN 451
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 3-51 2.30e-03

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 40.87  E-value: 2.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1429752196   3 QYTVQKGDSLWKISRKFGIDVNELANINGLLTKAeqhiIQPGQVLSLPS 51
Cdd:PRK10783  345 SYKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSK----LKVGQTLTIGA 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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