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Conserved domains on  [gi|14285364|sp|Q9NQ11|]
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RecName: Full=Polyamine-transporting ATPase 13A2

Protein Classification

cation-translocating P-type ATPase( domain architecture ID 11492996)

cation-translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations or heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle; similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
39-1117 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


:

Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1466.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364     39 GYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRdkedsswqlftvqvQTEAIGEGSLE 118
Cdd:TIGR01657    8 AYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDP--------------TPNSGSDYIVE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    119 PSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGqkrvlryylfqgqryIWIETQQAFYQVSlldHGRSCDDVH 198
Cdd:TIGR01657   74 LSNKSLSNDLQTENAVEGGEEPIYFDFRKQRFSYHEKELK---------------IFSPLPYLFKEKS---FGVYSTCAG 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    199 RSrHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKT 278
Cdd:TIGR01657  136 HS-NGLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQI 214
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    279 RKQSQTLRDMVKLSMRVCVCRPGgEEEWVDSSELVPGDCLVLP-QEGGLMPCDAALVAGECMVNESSLTGESIPVLKTAL 357
Cdd:TIGR01657  215 RKQMQRLRDMVHKPQSVIVIRNG-KWVTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKFPI 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    358 PEGL----GPYCAETHRRHTLFCGTLILQARAYVGP-HVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAAL 432
Cdd:TIGR01657  294 PDNGdddeDLFLYETSKKHVLFGGTKILQIRPYPGDtGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFILFL 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    433 SVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCF 512
Cdd:TIGR01657  374 AVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCF 453
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    513 DKTGTLTEDGLDVMGVVPLKGQA-FLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEpaA 591
Cdd:TIGR01657  454 DKTGTLTEDGLDLRGVQGLSGNQeFLKIVTEDSSLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEED--D 531
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    592 DSAFGTQVLAVMRpplwepqlqaMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPT 671
Cdd:TIGR01657  532 ESAEPTSILAVVR----------TDDPPQELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPS 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    672 DFAQMLQSYTAAGYRVVALASKPLPTvPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTG 751
Cdd:TIGR01657  602 DYQEVLKSYTREGYRVLALAYKELPK-LTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITG 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    752 DNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMES-PTAVNGVKDPDQAASYTVEPDPRSR-HLALSGPT 829
Cdd:TIGR01657  681 DNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSiPFASTQVEIPYPLGQDSVEDLLASRyHLAMSGKA 760
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    830 FGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSS 909
Cdd:TIGR01657  761 FAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSK 840
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    910 MASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGR 989
Cdd:TIGR01657  841 LASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSK 920
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    990 VRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGA 1069
Cdd:TIGR01657  921 ERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKPENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGP 1000
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*...
gi 14285364   1070 PFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFK 1117
Cdd:TIGR01657 1001 PFREPIYKNKPFVYLLITGLGLLLVLLLDPHPLLGKILQIVPLPQEFR 1048
 
Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
39-1117 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1466.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364     39 GYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRdkedsswqlftvqvQTEAIGEGSLE 118
Cdd:TIGR01657    8 AYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDP--------------TPNSGSDYIVE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    119 PSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGqkrvlryylfqgqryIWIETQQAFYQVSlldHGRSCDDVH 198
Cdd:TIGR01657   74 LSNKSLSNDLQTENAVEGGEEPIYFDFRKQRFSYHEKELK---------------IFSPLPYLFKEKS---FGVYSTCAG 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    199 RSrHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKT 278
Cdd:TIGR01657  136 HS-NGLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQI 214
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    279 RKQSQTLRDMVKLSMRVCVCRPGgEEEWVDSSELVPGDCLVLP-QEGGLMPCDAALVAGECMVNESSLTGESIPVLKTAL 357
Cdd:TIGR01657  215 RKQMQRLRDMVHKPQSVIVIRNG-KWVTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKFPI 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    358 PEGL----GPYCAETHRRHTLFCGTLILQARAYVGP-HVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAAL 432
Cdd:TIGR01657  294 PDNGdddeDLFLYETSKKHVLFGGTKILQIRPYPGDtGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFILFL 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    433 SVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCF 512
Cdd:TIGR01657  374 AVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCF 453
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    513 DKTGTLTEDGLDVMGVVPLKGQA-FLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEpaA 591
Cdd:TIGR01657  454 DKTGTLTEDGLDLRGVQGLSGNQeFLKIVTEDSSLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEED--D 531
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    592 DSAFGTQVLAVMRpplwepqlqaMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPT 671
Cdd:TIGR01657  532 ESAEPTSILAVVR----------TDDPPQELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPS 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    672 DFAQMLQSYTAAGYRVVALASKPLPTvPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTG 751
Cdd:TIGR01657  602 DYQEVLKSYTREGYRVLALAYKELPK-LTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITG 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    752 DNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMES-PTAVNGVKDPDQAASYTVEPDPRSR-HLALSGPT 829
Cdd:TIGR01657  681 DNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSiPFASTQVEIPYPLGQDSVEDLLASRyHLAMSGKA 760
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    830 FGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSS 909
Cdd:TIGR01657  761 FAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSK 840
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    910 MASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGR 989
Cdd:TIGR01657  841 LASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSK 920
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    990 VRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGA 1069
Cdd:TIGR01657  921 ERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKPENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGP 1000
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*...
gi 14285364   1070 PFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFK 1117
Cdd:TIGR01657 1001 PFREPIYKNKPFVYLLITGLGLLLVLLLDPHPLLGKILQIVPLPQEFR 1048
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
207-1046 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1234.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  207 QDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLR 286
Cdd:cd07542    1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  287 DMVKLSMRVCVCRPGgEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGP--- 363
Cdd:cd07542   81 EMVHFTCPVRVIRDG-EWQTISSSELVPGDILVIPDNGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDESNDslw 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  364 --YCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTI 441
Cdd:cd07542  160 siYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIALIGFI 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  442 YSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTED 521
Cdd:cd07542  240 YTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLTED 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  522 GLDVMGVVPLKGQAFLPLVPEPRR------LPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEeepaadsaf 595
Cdd:cd07542  320 GLDLWGVRPVSGNNFGDLEVFSLDldldssLPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWSLE--------- 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  596 gtqvlavmrpplwepqlqameeppvpvsVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQ 675
Cdd:cd07542  391 ----------------------------ILRQFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEMIASLCKPETVPSNFQE 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  676 MLQSYTAAGYRVVALASKPLPTVPSLeaAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQ 755
Cdd:cd07542  443 VLNEYTKQGFRVIALAYKALESKTWL--LQKLSREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLL 520
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  756 TAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFlpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivk 835
Cdd:cd07542  521 TAISVARECGMISPSKKVILIEAVKPEDDDSASLTW-------------------------------------------- 556
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  836 hfpkllpKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIEC 915
Cdd:cd07542  557 -------TLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASVAAPFTSKVPDISC 629
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  916 VPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGA 995
Cdd:cd07542  630 VPTVIKEGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS 709
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|.
gi 14285364  996 LLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYE 1046
Cdd:cd07542  710 LVSPPVLVSLLGQIVLILLFQVIGFLIVRQQPWYIPPEPTVDKANTDNSNE 760
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
190-1101 2.58e-77

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 273.91  E-value: 2.58e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  190 HGRSCDDVHR----SRHGLSLQDQMVRKAIYGPNVISIPVK-SYPQLLVDEALNPyygfqaFSIALWLA-------DHYY 257
Cdd:COG0474    9 HALSAEEVLAelgtSEEGLSSEEAARRLARYGPNELPEEKKrSLLRRFLEQFKNP------LILILLAAavisallGDWV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  258 wYALCIFLISSISICLSL---YKTRKQSQTLRDMVklSMRVCVCRpGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALV 334
Cdd:COG0474   83 -DAIVILAVVLLNAIIGFvqeYRAEKALEALKKLL--APTARVLR-DGKWVEIPAEELVPGDIVLL-EAGDRVPADLRLL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  335 -AGECMVNESSLTGESIPVLKTALPEGLGPYCAEthRRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKG---GLVSS 410
Cdd:COG0474  158 eAKDLQVDESALTGESVPVEKSADPLPEDAPLGD--RGNMVFMGTLVTSGRG------TAVVVATGMNTEFGkiaKLLQE 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  411 ILHPRP-----INfkfykhsmKFVAALSVLAL-LGTIYSIFILYRNRvPLNEIVIRALDLVTVVVPPALPAAMTVCTLYA 484
Cdd:COG0474  230 AEEEKTplqkqLD--------RLGKLLAIIALvLAALVFLIGLLRGG-PLLEALLFAVALAVAAIPEGLPAVVTITLALG 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  485 QSRLRRQGIfcihplrI--------NLGGkLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRrlpVGPLLRALA 556
Cdd:COG0474  301 AQRMAKRNA-------IvrrlpaveTLGS-VTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDPA---LEELLRAAA 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  557 TCHALSRLQDTPVGDPMD---LKMVESTGWVLEEEPAAdsafgtqvlavmrpplwepqlqameeppvpVSVLHRFPFSSA 633
Cdd:COG0474  370 LCSDAQLEEETGLGDPTEgalLVAAAKAGLDVEELRKE------------------------------YPRVDEIPFDSE 419
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  634 LQRMSVVVAWPGAtQPEAYVKGSPELVAGLC-----NPETVP------TDFAQMLQSYTAAGYRVVALASKPLPtvpsle 702
Cdd:COG0474  420 RKRMSTVHEDPDG-KRLLIVKGAPEVVLALCtrvltGGGVVPlteedrAEILEAVEELAAQGLRVLAVAYKELP------ 492
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  703 AAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIivhaTHPE 782
Cdd:COG0474  493 ADPELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDRVL----TGAE 568
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  783 rgqpasLEFLpmesptavngvkdPDQAasytvepdprsrhlalsgptfgiivkhfpklLPKVLVQGTVFARMAPEQKTEL 862
Cdd:COG0474  569 ------LDAM-------------SDEE-------------------------------LAEAVEDVDVFARVSPEHKLRI 598
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  863 VCELQKLQYCVGMCGDGANDCGALKAADVGISLSQA------EAsvvspftSSM-------ASIECvpmVIREGRcsldt 929
Cdd:COG0474  599 VKALQANGHVVAMTGDGVNDAPALKAADIGIAMGITgtdvakEA-------ADIvllddnfATIVA---AVEEGR----- 663
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  930 sfSVF----KYmalysltqfisvlILYTINTNLGD------------------LQFLAIDLVITTTvavlmsrtgPALVL 987
Cdd:COG0474  664 --RIYdnirKF-------------IKYLLSSNFGEvlsvllasllglplpltpIQILWINLVTDGL---------PALAL 719
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  988 G-----------RVRPPGA-LLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAApdnlpnyeNTVVFSlss 1055
Cdd:COG0474  720 GfepvepdvmkrPPRWPDEpILSRFLLLRILLLGLLIAIFTLLTFALALARGASLALARTMAF--------TTLVLS--- 788
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*..
gi 14285364 1056 fQYLILAAAVSKGAP-FRRPLYTNVPFLVALALLSSVLVGLVLVPGL 1101
Cdd:COG0474  789 -QLFNVFNCRSERRSfFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPL 834
E1-E2_ATPase pfam00122
E1-E2 ATPase;
290-491 2.39e-32

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 124.22  E-value: 2.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    290 KLSMRVCVCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKtalpeglgpycaetH 369
Cdd:pfam00122    1 SLLPPTATVLRDGTEEEVPADELVPGD-IVLLKPGERVPADGRIVEGSASVDESLLTGESLPVEK--------------K 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    370 RRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYR 449
Cdd:pfam00122   66 KGDMVYSGTVVVSGSA------KAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLF 139
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 14285364    450 NRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQ 491
Cdd:pfam00122  140 VGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
260-950 2.85e-26

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 116.71  E-value: 2.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   260 ALCIFLISSISICLSLY---KTRKQSQTLRDMVklSMRVCVCRPG---GEEEWVDS--SELVPGDCLVLpQEGGLMPCDA 331
Cdd:PRK10517  125 AGVIALMVAISTLLNFIqeaRSTKAADALKAMV--SNTATVLRVIndkGENGWLEIpiDQLVPGDIIKL-AAGDMIPADL 201
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   332 -ALVAGECMVNESSLTGESIPVLKTALPEGL---GPYCAEThrrhTLFCGTLILQARAyvgphvLAVVTRTGFCTAKGGL 407
Cdd:PRK10517  202 rILQARDLFVAQASLTGESLPVEKFATTRQPehsNPLECDT----LCFMGTNVVSGTA------QAVVIATGANTWFGQL 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   408 VSSILH-PRPINfKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPaaMTVCTLYAQS 486
Cdd:PRK10517  272 AGRVSEqDSEPN-AFQQGISRVSWLLIRFMLVMAPVVLLINGYTKGDWWEAALFALSVAVGLTPEMLP--MIVTSTLARG 348
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   487 --RLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGL------DVMGVvplkgqaflplvPEPRRLPVGPLLRALATc 558
Cdd:PRK10517  349 avKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtDISGK------------TSERVLHSAWLNSHYQT- 415
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   559 hALSRLQDTPVgdpmdLKMVEstgwvLEEEPAADSAFgtqvlavmrpplwepqlQAMEEppvpvsvlhrFPFSSALQRMS 638
Cdd:PRK10517  416 -GLKNLLDTAV-----LEGVD-----EESARSLASRW-----------------QKIDE----------IPFDFERRRMS 457
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   639 VVVAWPGAtQPEAYVKGSPELVAGLC-----NPETVPTDfAQML-------QSYTAAGYRVVALASKPLPtvpsleAAQQ 706
Cdd:PRK10517  458 VVVAENTE-HHQLICKGALEEILNVCsqvrhNGEIVPLD-DIMLrrikrvtDTLNRQGLRVVAVATKYLP------AREG 529
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   707 LTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMvaPQEHLIIvhathpergqP 786
Cdd:PRK10517  530 DYQRADESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLI----------G 597
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   787 ASLEFLpmesptavngvkdPDQAASYTVEpdprsrhlalsgptfgiivkhfpkllpkvlvQGTVFARMAPEQKTELVCEL 866
Cdd:PRK10517  598 SDIETL-------------SDDELANLAE-------------------------------RTTLFARLTPMHKERIVTLL 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   867 QKLQYCVGMCGDGANDCGALKAADVGISLSQA-----EASVVSPFTSSMasiecvpMVIREGRCSLDTSFS-VFKYMALY 940
Cdd:PRK10517  634 KREGHVVGFMGDGINDAPALRAADIGISVDGAvdiarEAADIILLEKSL-------MVLEEGVIEGRRTFAnMLKYIKMT 706
                         730
                  ....*....|...
gi 14285364   941 SLTQF---ISVLI 950
Cdd:PRK10517  707 ASSNFgnvFSVLV 719
 
Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
39-1117 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1466.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364     39 GYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRdkedsswqlftvqvQTEAIGEGSLE 118
Cdd:TIGR01657    8 AYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDP--------------TPNSGSDYIVE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    119 PSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGqkrvlryylfqgqryIWIETQQAFYQVSlldHGRSCDDVH 198
Cdd:TIGR01657   74 LSNKSLSNDLQTENAVEGGEEPIYFDFRKQRFSYHEKELK---------------IFSPLPYLFKEKS---FGVYSTCAG 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    199 RSrHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKT 278
Cdd:TIGR01657  136 HS-NGLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVYQI 214
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    279 RKQSQTLRDMVKLSMRVCVCRPGgEEEWVDSSELVPGDCLVLP-QEGGLMPCDAALVAGECMVNESSLTGESIPVLKTAL 357
Cdd:TIGR01657  215 RKQMQRLRDMVHKPQSVIVIRNG-KWVTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKFPI 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    358 PEGL----GPYCAETHRRHTLFCGTLILQARAYVGP-HVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAAL 432
Cdd:TIGR01657  294 PDNGdddeDLFLYETSKKHVLFGGTKILQIRPYPGDtGCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFILFL 373
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    433 SVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCF 512
Cdd:TIGR01657  374 AVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCF 453
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    513 DKTGTLTEDGLDVMGVVPLKGQA-FLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEpaA 591
Cdd:TIGR01657  454 DKTGTLTEDGLDLRGVQGLSGNQeFLKIVTEDSSLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEED--D 531
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    592 DSAFGTQVLAVMRpplwepqlqaMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPT 671
Cdd:TIGR01657  532 ESAEPTSILAVVR----------TDDPPQELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPS 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    672 DFAQMLQSYTAAGYRVVALASKPLPTvPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTG 751
Cdd:TIGR01657  602 DYQEVLKSYTREGYRVLALAYKELPK-LTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITG 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    752 DNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMES-PTAVNGVKDPDQAASYTVEPDPRSR-HLALSGPT 829
Cdd:TIGR01657  681 DNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSiPFASTQVEIPYPLGQDSVEDLLASRyHLAMSGKA 760
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    830 FGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSS 909
Cdd:TIGR01657  761 FAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSK 840
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    910 MASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGR 989
Cdd:TIGR01657  841 LASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSK 920
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    990 VRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGA 1069
Cdd:TIGR01657  921 ERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKPENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGP 1000
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*...
gi 14285364   1070 PFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFK 1117
Cdd:TIGR01657 1001 PFREPIYKNKPFVYLLITGLGLLLVLLLDPHPLLGKILQIVPLPQEFR 1048
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
207-1046 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1234.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  207 QDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLR 286
Cdd:cd07542    1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  287 DMVKLSMRVCVCRPGgEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGP--- 363
Cdd:cd07542   81 EMVHFTCPVRVIRDG-EWQTISSSELVPGDILVIPDNGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDESNDslw 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  364 --YCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTI 441
Cdd:cd07542  160 siYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIALIGFI 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  442 YSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTED 521
Cdd:cd07542  240 YTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLTED 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  522 GLDVMGVVPLKGQAFLPLVPEPRR------LPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEeepaadsaf 595
Cdd:cd07542  320 GLDLWGVRPVSGNNFGDLEVFSLDldldssLPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWSLE--------- 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  596 gtqvlavmrpplwepqlqameeppvpvsVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQ 675
Cdd:cd07542  391 ----------------------------ILRQFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEMIASLCKPETVPSNFQE 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  676 MLQSYTAAGYRVVALASKPLPTVPSLeaAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQ 755
Cdd:cd07542  443 VLNEYTKQGFRVIALAYKALESKTWL--LQKLSREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLL 520
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  756 TAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFlpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivk 835
Cdd:cd07542  521 TAISVARECGMISPSKKVILIEAVKPEDDDSASLTW-------------------------------------------- 556
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  836 hfpkllpKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIEC 915
Cdd:cd07542  557 -------TLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASVAAPFTSKVPDISC 629
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  916 VPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGA 995
Cdd:cd07542  630 VPTVIKEGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS 709
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|.
gi 14285364  996 LLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYE 1046
Cdd:cd07542  710 LVSPPVLVSLLGQIVLILLFQVIGFLIVRQQPWYIPPEPTVDKANTDNSNE 760
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
212-1011 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 622.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  212 RKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKL 291
Cdd:cd02082    5 LLAYYGKNEIEINVPSFLTLMWREFKKPFNFFQYFGVILWGIDEYVYYAITVVFMTTINSLSCIYIRGVMQKELKDACLN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  292 SMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEgLGP----YCAE 367
Cdd:cd02082   85 NTSVIVQRHGYQEITIASNMIVPGDIVLIKRREVTLPCDCVLLEGSCIVTEAMLTGESVPIGKCQIPT-DSHddvlFKYE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  368 THRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFIL 447
Cdd:cd02082  164 SSKSHTLFQGTQVMQIIPPEDDILKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKFTLLLATLALIGFLYTLIRL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  448 YRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMG 527
Cdd:cd02082  244 LDIELPPLFIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIG 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  528 VVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEPAADSAF---GTQVLAVMR 604
Cdd:cd02082  324 YQLKGQNQTFDPIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMAEASTWDLDYDHEAKQHYsksGTKRFYIIQ 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  605 pplwepqlqameeppvpvsvlhRFPFSSALQRMSVVVAWPGATQPE----AYVKGSPELVAGLCnpETVPTDFAQMLQSY 680
Cdd:cd02082  404 ----------------------VFQFHSALQRMSVVAKEVDMITKDfkhyAFIKGAPEKIQSLF--SHVPSDEKAQLSTL 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  681 TAAGYRVVALASKPLPTVpSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTV 760
Cdd:cd02082  460 INEGYRVLALGYKELPQS-EIDAFLDLSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKV 538
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  761 ARGCGMVAPQEHLIIVHATHPERGQPASLEFlpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivkhfpkl 840
Cdd:cd02082  539 AQELEIINRKNPTIIIHLLIPEIQKDNSTQW------------------------------------------------- 569
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  841 lpKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVI 920
Cdd:cd02082  570 --ILIIHTNVFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISLAEADASFASPFTSKSTSISCVKRVI 647
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  921 REGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLmSRTGPALVLGRVRPPGALLSVP 1000
Cdd:cd02082  648 LEGRVNLSTSVEIFKGYALVALIRYLSFLTLYYFYSSYSSSGQMDWQLLAAGYFLVY-LRLGCNTPLKKLEKDDNLFSIY 726
                        810
                 ....*....|.
gi 14285364 1001 VLSSLLLQMVL 1011
Cdd:cd02082  727 NVTSVLFGFTL 737
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
262-978 1.75e-142

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 441.37  E-value: 1.75e-142
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    262 CIFLISSISICLSLYKTRKQSQTLRDMVK--LSMRVCVCRPGGEEeWVDSSELVPGDCLVLPqEGGLMPCDAALVAGECM 339
Cdd:TIGR01494    1 FILFLVLLFVLLEVKQKLKAEDALRSLKDslVNTATVLVLRNGWK-EISSKDLVPGDVVLVK-SGDTVPADGVLLSGSAF 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    340 VNESSLTGESIPVLKTALPEglgpyCAETHRRHTLFCGTLILQARAYVG---PHVLAVVTRTGFCTakgglvSSILHPRP 416
Cdd:TIGR01494   79 VDESSLTGESLPVLKTALPD-----GDAVFAGTINFGGTLIVKVTATGIlttVGKIAVVVYTGFST------KTPLQSKA 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    417 INFKFykhsMKFVAALSVLALLGTIYSIFILYRNRvPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCI 496
Cdd:TIGR01494  148 DKFEN----FIFILFLLLLALAVFLLLPIGGWDGN-SIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVK 222
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    497 HPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVpeprrlpvgpllralatcHALSRLQDT-PVGDPMDL 575
Cdd:TIGR01494  223 NLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEEASLA------------------LALLAASLEyLSGHPLER 284
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    576 KMVESTGWVLEEepaadsafgtqvlavmrpplwepqlqamEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQpEAYVKG 655
Cdd:TIGR01494  285 AIVKSAEGVIKS----------------------------DEINVEYKILDVFPFSSVLKRMGVIVEGANGSD-LLFVKG 335
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    656 SPELVAGLCNPEtvpTDFAQMLQSYTAAGYRVVALASKPLPtvpsleaaqqltrdtveGDLSLLGLLVMRNLLKPQTTPV 735
Cdd:TIGR01494  336 APEFVLERCNNE---NDYDEKVDEYARQGLRVLAFASKKLP-----------------DDLEFLGLLTFEDPLRPDAKET 395
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    736 IQALRRTRIRAVMVTGDNLQTAVTVARGCGMVapqehliivhathpergqpasleflpmesptavngvkdpdqaasytve 815
Cdd:TIGR01494  396 IEALRKAGIKVVMLTGDNVLTAKAIAKELGID------------------------------------------------ 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    816 pdprsrhlalsgptfgiivkhfpkllpkvlvqgtVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISL 895
Cdd:TIGR01494  428 ----------------------------------VFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAM 473
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    896 SQ---AEASVVSPFTSSmaSIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINtnlgdlqflaidLVITT 972
Cdd:TIGR01494  474 GSgdvAKAAADIVLLDD--DLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVII------------LLPPL 539

                   ....*.
gi 14285364    973 TVAVLM 978
Cdd:TIGR01494  540 LAALAL 545
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
213-1081 9.12e-139

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 440.67  E-value: 9.12e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  213 KAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYAL-CIFLIssISICLSLYKTR-KQSQTLRDMVK 290
Cdd:cd07543    6 KKKYGKNKFDIPVPTFSELFKEHAVAPFFVFQVFCVGLWCLDEYWYYSLfTLFML--VAFEATLVFQRmKNLSEFRTMGN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  291 LSMRVCVCRPGgeeEWV--DSSELVPGDCLVL--PQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALpEGLGP--- 363
Cdd:cd07543   84 KPYTIQVYRDG---KWVpiSSDELLPGDLVSIgrSAEDNLVPCDLLLLRGSCIVNEAMLTGESVPLMKEPI-EDRDPedv 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  364 -YCAETHRRHTLFCGTLILQARA-------YVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVL 435
Cdd:cd07543  160 lDDDGDDKLHVLFGGTKVVQHTPpgkgglkPPDGGCLAYVLRTGFETSQGKLLRTILFSTERVTANNLETFIFILFLLVF 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  436 ALLGTIYsIFI----LYRNRVPLneiVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVC 511
Cdd:cd07543  240 AIAAAAY-VWIegtkDGRSRYKL---FLECTLILTSVVPPELPMELSLAVNTSLIALAKLYIFCTEPFRIPFAGKVDICC 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  512 FDKTGTLTEDGLDVMGVVPLKGQAflPLVPEPRRLPVgPLLRALATCHALSRLQD-TPVGDPMDLKMVESTGWVLE-EEP 589
Cdd:cd07543  316 FDKTGTLTSDDLVVEGVAGLNDGK--EVIPVSSIEPV-ETILVLASCHSLVKLDDgKLVGDPLEKATLEAVDWTLTkDEK 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  590 AADSAFGTQvlavmrpplwepqlqameeppvPVSVLHRFPFSSALQRMSVVVAW--PGATQPE--AYVKGSPELVAGLCn 665
Cdd:cd07543  393 VFPRSKKTK----------------------GLKIIQRFHFSSALKRMSVVASYkdPGSTDLKyiVAVKGAPETLKSML- 449
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  666 pETVPTDFAQMLQSYTAAGYRVVALASKPLPTVpSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIR 745
Cdd:cd07543  450 -SDVPADYDEVYKEYTRQGSRVLALGYKELGHL-TKQQARDYKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHR 527
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  746 AVMVTGDNLQTAVTVARGCGMVApQEHLIIvhaTHPERGQPASLeflpmesptavngvkdpdqaasytvepdprsrhlal 825
Cdd:cd07543  528 VVMITGDNPLTACHVAKELGIVD-KPVLIL---ILSEEGKSNEW------------------------------------ 567
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  826 sgptfgiivkhfpKLLPKVlvqgTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQ-AEASVVS 904
Cdd:cd07543  568 -------------KLIPHV----KVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVALLKlGDASIAA 630
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  905 PFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVIttTVAVLM-SRTGP 983
Cdd:cd07543  631 PFTSKLSSVSCVCHIIKQGRCTLVTTLQMFKILALNCLISAYSLSVLYLDGVKFGDVQATISGLLL--AACFLFiSRSKP 708
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  984 ALVLGRVRPPGALLSVPVLSSLLLQMVLvtgvqlggYFLTLAqpWFVPLNRTVAAPDNLPNYE--------NTVVFSLSS 1055
Cdd:cd07543  709 LETLSKERPLPNIFNLYTILSVLLQFAV--------HFVSLV--YITGEAKELEPPREEVDLEkefepslvNSTVYILSM 778
                        890       900
                 ....*....|....*....|....*.
gi 14285364 1056 FQYLILAAAVSKGAPFRRPLYTNVPF 1081
Cdd:cd07543  779 AQQVATFAVNYKGRPFRESLRENKPL 804
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
190-1101 2.58e-77

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 273.91  E-value: 2.58e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  190 HGRSCDDVHR----SRHGLSLQDQMVRKAIYGPNVISIPVK-SYPQLLVDEALNPyygfqaFSIALWLA-------DHYY 257
Cdd:COG0474    9 HALSAEEVLAelgtSEEGLSSEEAARRLARYGPNELPEEKKrSLLRRFLEQFKNP------LILILLAAavisallGDWV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  258 wYALCIFLISSISICLSL---YKTRKQSQTLRDMVklSMRVCVCRpGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALV 334
Cdd:COG0474   83 -DAIVILAVVLLNAIIGFvqeYRAEKALEALKKLL--APTARVLR-DGKWVEIPAEELVPGDIVLL-EAGDRVPADLRLL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  335 -AGECMVNESSLTGESIPVLKTALPEGLGPYCAEthRRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKG---GLVSS 410
Cdd:COG0474  158 eAKDLQVDESALTGESVPVEKSADPLPEDAPLGD--RGNMVFMGTLVTSGRG------TAVVVATGMNTEFGkiaKLLQE 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  411 ILHPRP-----INfkfykhsmKFVAALSVLAL-LGTIYSIFILYRNRvPLNEIVIRALDLVTVVVPPALPAAMTVCTLYA 484
Cdd:COG0474  230 AEEEKTplqkqLD--------RLGKLLAIIALvLAALVFLIGLLRGG-PLLEALLFAVALAVAAIPEGLPAVVTITLALG 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  485 QSRLRRQGIfcihplrI--------NLGGkLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRrlpVGPLLRALA 556
Cdd:COG0474  301 AQRMAKRNA-------IvrrlpaveTLGS-VTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDPA---LEELLRAAA 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  557 TCHALSRLQDTPVGDPMD---LKMVESTGWVLEEEPAAdsafgtqvlavmrpplwepqlqameeppvpVSVLHRFPFSSA 633
Cdd:COG0474  370 LCSDAQLEEETGLGDPTEgalLVAAAKAGLDVEELRKE------------------------------YPRVDEIPFDSE 419
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  634 LQRMSVVVAWPGAtQPEAYVKGSPELVAGLC-----NPETVP------TDFAQMLQSYTAAGYRVVALASKPLPtvpsle 702
Cdd:COG0474  420 RKRMSTVHEDPDG-KRLLIVKGAPEVVLALCtrvltGGGVVPlteedrAEILEAVEELAAQGLRVLAVAYKELP------ 492
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  703 AAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIivhaTHPE 782
Cdd:COG0474  493 ADPELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDRVL----TGAE 568
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  783 rgqpasLEFLpmesptavngvkdPDQAasytvepdprsrhlalsgptfgiivkhfpklLPKVLVQGTVFARMAPEQKTEL 862
Cdd:COG0474  569 ------LDAM-------------SDEE-------------------------------LAEAVEDVDVFARVSPEHKLRI 598
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  863 VCELQKLQYCVGMCGDGANDCGALKAADVGISLSQA------EAsvvspftSSM-------ASIECvpmVIREGRcsldt 929
Cdd:COG0474  599 VKALQANGHVVAMTGDGVNDAPALKAADIGIAMGITgtdvakEA-------ADIvllddnfATIVA---AVEEGR----- 663
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  930 sfSVF----KYmalysltqfisvlILYTINTNLGD------------------LQFLAIDLVITTTvavlmsrtgPALVL 987
Cdd:COG0474  664 --RIYdnirKF-------------IKYLLSSNFGEvlsvllasllglplpltpIQILWINLVTDGL---------PALAL 719
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  988 G-----------RVRPPGA-LLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAApdnlpnyeNTVVFSlss 1055
Cdd:COG0474  720 GfepvepdvmkrPPRWPDEpILSRFLLLRILLLGLLIAIFTLLTFALALARGASLALARTMAF--------TTLVLS--- 788
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*..
gi 14285364 1056 fQYLILAAAVSKGAP-FRRPLYTNVPFLVALALLSSVLVGLVLVPGL 1101
Cdd:COG0474  789 -QLFNVFNCRSERRSfFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPL 834
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
203-989 1.53e-47

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 181.66  E-value: 1.53e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  203 GLSLQDQMVRKAIYGPN-VISIPVKSYPQLLVDEALNP----YYGFQAFSIALWLadhyYWYALCIFLISSISICLSLYK 277
Cdd:cd02089    1 GLSEEEAERRLAKYGPNeLVEKKKRSPWKKFLEQFKDFmvivLLAAAVISGVLGE----YVDAIVIIAIVILNAVLGFVQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  278 TRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALV-AGECMVNESSLTGESIPVLKTA 356
Cdd:cd02089   77 EYKAEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLL-EAGDYVPADGRLIeSASLRVEESSLTGESEPVEKDA 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  357 LPEgLGPYCAETHRRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKG---GLVSSILHPR-PINFKFYKHSMKFVAAL 432
Cdd:cd02089  156 DTL-LEEDVPLGDRKNMVFSGTLVTYGRG------RAVVTATGMNTEMGkiaTLLEETEEEKtPLQKRLDQLGKRLAIAA 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  433 SVLALLgtiysIFIL--YRNRVPLNEIVIrALDLVTVVVPPALPAAMT-VCTLYAQSRLRRQGIfcIHPLR-INLGGKLQ 508
Cdd:cd02089  229 LIICAL-----VFALglLRGEDLLDMLLT-AVSLAVAAIPEGLPAIVTiVLALGVQRMAKRNAI--IRKLPaVETLGSVS 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  509 LVCFDKTGTLTEDGLDVMGVVplkgqaflplvpeprrlpvgpllralatchalsrlqdtPVGDPMDLKMVEstgwvleee 588
Cdd:cd02089  301 VICSDKTGTLTQNKMTVEKIY--------------------------------------TIGDPTETALIR--------- 333
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  589 paadsafgtqvlAVMRPPLWEPQLQAMEEppvpvsVLHRFPFSSALQRMSVVVAWPGATQpeAYVKGSPELVAGLC---- 664
Cdd:cd02089  334 ------------AARKAGLDKEELEKKYP------RIAEIPFDSERKLMTTVHKDAGKYI--VFTKGAPDVLLPRCtyiy 393
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  665 -NPETVP---TDFAQML---QSYTAAGYRVVALASKPLPTVPSLEAaqqltrDTVEGDLSLLGLLVMRNLLKPQTTPVIQ 737
Cdd:cd02089  394 iNGQVRPlteEDRAKILavnEEFSEEALRVLAVAYKPLDEDPTESS------EDLENDLIFLGLVGMIDPPRPEVKDAVA 467
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  738 ALRRTRIRAVMVTGDNLQTAVTVARGCGMvapqehliivhathpergqpasleflpmesptavngVKDPDQAASyTVEPD 817
Cdd:cd02089  468 ECKKAGIKTVMITGDHKLTARAIAKELGI------------------------------------LEDGDKALT-GEELD 510
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  818 prsrhlALSGPTFGIIVKHFpkllpkvlvqgTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISL-- 895
Cdd:cd02089  511 ------KMSDEELEKKVEQI-----------SVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMgi 573
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  896 -----SQAEASVV---SPFTSSMASiecvpmvIREGRcsldTSFSVFKYMALYSLTQFISVLILYTINTNLG-DLQFLAI 966
Cdd:cd02089  574 tgtdvAKEAADMIltdDNFATIVAA-------VEEGR----TIYDNIRKFIRYLLSGNVGEILTMLLAPLLGwPVPLLPI 642
                        810       820
                 ....*....|....*....|...
gi 14285364  967 DLVITTtvavLMSRTGPALVLGR 989
Cdd:cd02089  643 QLLWIN----LLTDGLPALALGV 661
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
203-1099 5.38e-46

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 179.00  E-value: 5.38e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  203 GLSLQDQMVRKAIYGPNVISI-PVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIF---LISSISICLSLYKT 278
Cdd:cd02080    1 GLTSEEAAERLERYGPNRLPEkKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHWVDAIVIFgvvLINAIIGYIQEGKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  279 RKQSQTLRDMvkLSMRVCVCRPGGEEEwVDSSELVPGDcLVLPQEGGLMPCDAALV-AGECMVNESSLTGESIPVLKT-- 355
Cdd:cd02080   81 EKALAAIKNM--LSPEATVLRDGKKLT-IDAEELVPGD-IVLLEAGDKVPADLRLIeARNLQIDESALTGESVPVEKQeg 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  356 ALPEGLGpyCAEthRRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVL 435
Cdd:cd02080  157 PLEEDTP--LGD--RKNMAYSGTLVTAGSA------TGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLIV 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  436 AL-LGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRL-RRQGIFCIHPLRINLGGkLQLVCFD 513
Cdd:cd02080  227 ILvLAALTFVFGLLRGDYSLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMaKRNAIIRRLPAVETLGS-VTVICSD 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  514 KTGTLTEDGLDVMGVVPLkgqaflplvpeprrlpvgpllralatCHAlSRLQDtpvgdpmdlkmvESTGWVLEEEPaADS 593
Cdd:cd02080  306 KTGTLTRNEMTVQAIVTL--------------------------CND-AQLHQ------------EDGHWKITGDP-TEG 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  594 AFgtqvLAVMRPPLWEPQLQAmeeppVPVSVLHRFPFSSALQRMSVVVawPGATQPEAYVKGSPELVAGLC-----NPET 668
Cdd:cd02080  346 AL----LVLAAKAGLDPDRLA-----SSYPRVDKIPFDSAYRYMATLH--RDDGQRVIYVKGAPERLLDMCdqellDGGV 414
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  669 VPTD---FAQMLQSYTAAGYRVVALASKPLPtvpslEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIR 745
Cdd:cd02080  415 SPLDrayWEAEAEDLAKQGLRVLAFAYREVD-----SEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIR 489
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  746 AVMVTGDNLQTAVTVARGCGMVAPQEHLiivhathpergQPASLEFLpmesptavngvkDPDQaasytvepdprsrhlal 825
Cdd:cd02080  490 VKMITGDHAETARAIGAQLGLGDGKKVL-----------TGAELDAL------------DDEE----------------- 529
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  826 sgptfgiivkhfpklLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQA------E 899
Cdd:cd02080  530 ---------------LAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGIKgtevakE 594
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  900 ASVVSPFTSSMASIECvpmVIREGRCSLDtsfsvfkymalySLTQFisvlILYTINTNLGD------------------L 961
Cdd:cd02080  595 AADMVLADDNFATIAA---AVEEGRRVYD------------NLKKF----ILFTLPTNLGEglviivailfgvtlpltpV 655
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  962 QFLAIDLVITTTVAV----------LMSRtGPalvlgrvRPPGAllsvPVLSSLLLQMVLVTGVQLGG-----YFLTLAQ 1026
Cdd:cd02080  656 QILWINMVTAITLGLalafepaepgIMKR-PP-------RDPSE----PLLSRELIWRILLVSLLMLGgafglFLWALDR 723
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14285364 1027 PWFVPLNRTVAApdnlpnyeNTVVFslSSFQYLiLAAAVSKGAPFRRPLYTNVPFLVALALLSSVLVGLVLVP 1099
Cdd:cd02080  724 GYSLETARTMAV--------NTIVV--AQIFYL-FNCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLP 785
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
276-976 1.98e-43

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 168.75  E-value: 1.98e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  276 YKTRKQSQ----TLRDMVKLSMRVcVCRPGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAGECM-VNESSLTGESI 350
Cdd:cd07539   75 GVQRLRAEralaALLAQQQQPARV-VRAPAGRTQTVPAESLVPGDVIEL-RAGEVVPADARLLEADDLeVDESALTGESL 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  351 PVLKTALPEGLGPYcAEthRRHTLFCGTLIlqarayVGPHVLAVVTRTGFCTAKG---GLVSSILHPRPINFKFYKHSMK 427
Cdd:cd07539  153 PVDKQVAPTPGAPL-AD--RACMLYEGTTV------VSGQGRAVVVATGPHTEAGraqSLVAPVETATGVQAQLRELTSQ 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  428 FVAAlsVLALLGTIYSIFILyrNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKL 507
Cdd:cd07539  224 LLPL--SLGGGAAVTGLGLL--RGAPLRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRV 299
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  508 QLVCFDKTGTLTEDGLdvmgvvplkgqaflplvpeprrlpvgpllralatchALSRLQDtpvgdpmdlkmvestgwvlee 587
Cdd:cd07539  300 DTICFDKTGTLTENRL------------------------------------RVVQVRP--------------------- 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  588 epaadsafgtqvlavmrpplwepqlqameeppvpvsVLHRFPFSSALQRMSVVVAwPGATQPEAYVKGSPELVAGLC--- 664
Cdd:cd07539  323 ------------------------------------PLAELPFESSRGYAAAIGR-TGGGIPLLAVKGAPEVVLPRCdrr 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  665 ----NPETVPTDFAQML----QSYTAAGYRVVALASKplptvpSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVI 736
Cdd:cd07539  366 mtggQVVPLTEADRQAIeevnELLAGQGLRVLAVAYR------TLDAGTTHAVEAVVDDLELLGLLGLADTARPGAAALI 439
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  737 QALRRTRIRAVMVTGDNLQTAVTVARGCGMvapQEHLIIVHATHPERgqpasleflpmesptavngvkdpdqaasytVEP 816
Cdd:cd07539  440 AALHDAGIDVVMITGDHPITARAIAKELGL---PRDAEVVTGAELDA------------------------------LDE 486
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  817 DPRSRHLAlsgptfgiivkhfpkllpkvlvQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLS 896
Cdd:cd07539  487 EALTGLVA----------------------DIDVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVG 544
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  897 ---QAEASVVSPFTSSMASIECVPMVIREGRcsldtsfsvfkymalySLTQFISVLILYTINTNLGDLQFLAIDLVITTT 973
Cdd:cd07539  545 argSDAAREAADLVLTDDDLETLLDAVVEGR----------------TMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGG 608

                 ...
gi 14285364  974 VAV 976
Cdd:cd07539  609 APL 611
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
624-978 6.29e-42

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 156.46  E-value: 6.29e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  624 VLHRFPFSSALQRMSVVVAWPGatQPEAYVKGSPELVAGLCN---PETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPS 700
Cdd:cd01431   21 FIEEIPFNSTRKRMSVVVRLPG--RYRAIVKGAPETILSRCShalTEEDRNKIEKAQEESAREGLRVLALAYREFDPETS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  701 LEAaqqltrdtVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATH 780
Cdd:cd01431   99 KEA--------VELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGIDTKASGVILGEEAD 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  781 PERGQpasleflpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivkhfpkLLPKVLVQGTVFARMAPEQKT 860
Cdd:cd01431  171 EMSEE------------------------------------------------------ELLDLIAKVAVFARVTPEQKL 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  861 ELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAeASVVSPFTSSMASIE----CVPMVIREGRCSLDTsfsVFKY 936
Cdd:cd01431  197 RIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGST-GTDVAKEAADIVLLDdnfaTIVEAVEEGRAIYDN---IKKN 272
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 14285364  937 MaLYSLTQFISVLILYTINTNLGD------LQFLAIDLVITTTVAVLM 978
Cdd:cd01431  273 I-TYLLANNVAEVFAIALALFLGGplpllaFQILWINLVTDLIPALAL 319
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
212-895 4.09e-40

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 159.68  E-value: 4.09e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  212 RKAIYGPNVISIPV-KSYPQLLVdEALNPYY-------GFQAFSIALWLAD-----HYYWYA-----LCIFLISSISiCL 273
Cdd:cd02081    4 RREVYGKNEIPPKPpKSFLQLVW-EALQDPTliilliaAIVSLGLGFYTPFgegegKTGWIEgvailVAVILVVLVT-AG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  274 SLYKTRKQSQTLRDMVKlSMRVCVCRpGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAG-ECMVNESSLTGESIPV 352
Cdd:cd02081   82 NDYQKEKQFRKLNSKKE-DQKVTVIR-DGEVIQISVFDIVVGDIVQL-KYGDLIPADGLLIEGnDLKIDESSLTGESDPI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  353 LKTALPEGLGPYcaethrrhtLFCGTLILQARAYvgphvlAVVTRTGFCTAKGGLVSSI----LHPRPINFKFYKHSMK- 427
Cdd:cd02081  159 KKTPDNQIPDPF---------LLSGTKVLEGSGK------MLVTAVGVNSQTGKIMTLLraenEEKTPLQEKLTKLAVQi 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  428 -----FVAALSVLALlgTIYSIFILYRNRVP------LNEIV---IRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGi 493
Cdd:cd02081  224 gkvglIVAALTFIVL--IIRFIIDGFVNDGKsfsaedLQEFVnffIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDN- 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  494 fcihplriNLGGKLQ---------LVCFDKTGTLTEDgldVMGVVplkgQAFlplvpeprrlpvgpllralatchalsrl 564
Cdd:cd02081  301 --------NLVRHLDacetmgnatAICSDKTGTLTQN---RMTVV----QGY---------------------------- 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  565 qdtpVGDPMDLKMVestGWVLEeepaadsAFGTQVLAVMRPplwepqlqamEEPpvpvsVLHRFPFSSALQRMSVVVAWP 644
Cdd:cd02081  338 ----IGNKTECALL---GFVLE-------LGGDYRYREKRP----------EEK-----VLKVYPFNSARKRMSTVVRLK 388
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  645 GaTQPEAYVKGSPELVAGLCN------------PETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLT-RDT 711
Cdd:cd02081  389 D-GGYRLYVKGASEIVLKKCSyilnsdgevvflTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPTAERDWDdEED 467
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  712 VEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGmvapqehlIIvhathpergqpaslef 791
Cdd:cd02081  468 IESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECG--------IL---------------- 523
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  792 lpmesptavngvkdpdqaasytvepDPRSRHLALSGPTF-----GIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCEL 866
Cdd:cd02081  524 -------------------------TEGEDGLVLEGKEFrelidEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGL 578
                        730       740
                 ....*....|....*....|....*....
gi 14285364  867 QKLQYCVGMCGDGANDCGALKAADVGISL 895
Cdd:cd02081  579 KDSGEVVAVTGDGTNDAPALKKADVGFAM 607
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
203-950 1.02e-39

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 158.95  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  203 GLSLQDQMVRKAIYGPNVISIPVKSYP-QLLVDEALNPyygfqaFSIALWLAD-----HYYWY---------ALCIFLIS 267
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEISHEKFPSWfKLLLKAFINP------FNIVLLVLAlvsffTDVLLapgefdlvgALIILLMV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  268 SISICLSL---YKTRKQSQTLRDMVKLsmRVCVCRPGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALV-AGECMVNES 343
Cdd:cd02077   75 LISGLLDFiqeIRSLKAAEKLKKMVKN--TATVIRDGSKYMEIPIDELVPGDIVYL-SAGDMIPADVRIIqSKDLFVSQS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  344 SLTGESIPVLKTALPeGLGPYCAETHRRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKGGLVSSILHPRP------- 416
Cdd:cd02077  152 SLTGESEPVEKHATA-KKTKDESILELENICFMGTNVVSGSA------LAVVIATGNDTYFGSIAKSITEKRPetsfdkg 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  417 INfKFYKHSMKFvaalsVLALLGTIYSIFILYRNrvPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIF-- 494
Cdd:cd02077  225 IN-KVSKLLIRF-----MLVMVPVVFLINGLTKG--DWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIvk 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  495 ---CIHplriNLGGkLQLVCFDKTGTLTEDGLDVMGVVPLKGQAflplvpEPRrlpvgpLLRALatchALSRLQDTPVGD 571
Cdd:cd02077  297 nlnAIQ----NFGA-MDILCTDKTGTLTQDKIVLERHLDVNGKE------SER------VLRLA----YLNSYFQTGLKN 355
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  572 PMDLKMVESTGWVLEEEPAADsafgtqvlavmrpplwepqLQAMEEPPvpvsvlhrFPFSSalQRMSVVVAWPGATQpEA 651
Cdd:cd02077  356 LLDKAIIDHAEEANANGLIQD-------------------YTKIDEIP--------FDFER--RRMSVVVKDNDGKH-LL 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  652 YVKGSPELVAGLC-----NPETVP-TDFA-----QMLQSYTAAGYRVVALASKPLPtvpsleaAQQLTRDT-VEGDLSLL 719
Cdd:cd02077  406 ITKGAVEEILNVCthvevNGEVVPlTDTLrekilAQVEELNREGLRVLAIAYKKLP-------APEGEYSVkDEKELILI 478
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  720 GLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMvapqehliivhathpergqpasleflpmesptA 799
Cdd:cd02077  479 GFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--------------------------------D 526
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  800 VNGVKDPDQAAsytvepdprsrhlALSgptfgiivkhfPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDG 879
Cdd:cd02077  527 INRVLTGSEIE-------------ALS-----------DEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDG 582
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  880 ANDCGALKAADVGISLSQA-----EASVVSPFTSSMASIEcvPMVIrEGRcsldTSFS-VFKYMALYSLTQF---ISVLI 950
Cdd:cd02077  583 INDAPALRQADVGISVDSAvdiakEAADIILLEKDLMVLE--EGVI-EGR----KTFGnILKYIKMTASSNFgnvFSVLV 655
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
261-1051 5.28e-35

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 144.92  E-value: 5.28e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    261 LCIFLISSISIclslYKTRKQSQTLRDmVKLSMRVCVCRpGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAG-ECM 339
Cdd:TIGR01517  142 ILVVLVTAVND----YKKELQFRQLNR-EKSAQKIAVIR-GGQEQQISIHDIVVGDIVSL-STGDVVPADGVFISGlSLE 214
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    340 VNESSLTGESIPVLKTALPEGLgpycaethrrhtLFCGTLILQARAYVgphvlaVVTRTGFCTAKGGLVSSI-------- 411
Cdd:TIGR01517  215 IDESSITGESDPIKKGPVQDPF------------LLSGTVVNEGSGRM------LVTAVGVNSFGGKLMMELrqageeet 276
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    412 ---LHPRPINFKFYKHSMKF-VAALSVLALLGTIYSIFILYRNRVP------LNEIVIRALDLVTVVVPPALPAAMTVCT 481
Cdd:TIGR01517  277 plqEKLSELAGLIGKFGMGSaVLLFLVLSLRYVFRIIRGDGRFEDTeedaqtFLDHFIIAVTIVVVAVPEGLPLAVTIAL 356
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    482 LYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDgldVMGVVplkgQAFLPLVPEPRRLPVGPLLralATCHAL 561
Cdd:TIGR01517  357 AYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQN---VMSVV----QGYIGEQRFNVRDEIVLRN---LPAAVR 426
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    562 SRLQDTPVGDPMDLKMVESTGWVLEEEPAADSA---FGTQVLAVMRPPlwepqlqaMEEPPVpVSVLHRFPFSSALQRMS 638
Cdd:TIGR01517  427 NILVEGISLNSSSEEVVDRGGKRAFIGSKTECAlldFGLLLLLQSRDV--------QEVRAE-EKVVKIYPFNSERKFMS 497
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    639 VVVAWPGATQpEAYVKGSPELVAGLC------NPETVP------TDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAaqq 706
Cdd:TIGR01517  498 VVVKHSGGKY-REFRKGASEIVLKPCrkrldsNGEATPiseddkDRCADVIEPLASDALRTICLAYRDFAPEEFPRK--- 573
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    707 ltrDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEhliivhathpergqp 786
Cdd:TIGR01517  574 ---DYPNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--------------- 635
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    787 asleflpmesptavngvkdpdqaasytvepdprsrhLALSGPTFGIIVKH-FPKLLPKVlvqgTVFARMAPEQKTELVCE 865
Cdd:TIGR01517  636 ------------------------------------LAMEGKEFRSLVYEeMDPILPKL----RVLARSSPLDKQLLVLM 675
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    866 LQKLQYCVGMCGDGANDCGALKAADVGISLSQA------EASVVSPFTSSMASIEcvpMVIREGRCSLDtsfSVFKYMAL 939
Cdd:TIGR01517  676 LKDMGEVVAVTGDGTNDAPALKLADVGFSMGISgtevakEASDIILLDDNFASIV---RAVKWGRNVYD---NIRKFLQF 749
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    940 ySLT--------QFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGAllSVPVLSSLLLQMVL 1011
Cdd:TIGR01517  750 -QLTvnvvavilTFVGSCISSSHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGR--NAPLISRSMWKNIL 826
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|..
gi 14285364   1012 -VTGVQLGGYFLTL-AQPWFVPLNRTVAAPDNLPNYENTVVF 1051
Cdd:TIGR01517  827 gQAGYQLVVTFILLfAGGSIFDVSGPDEITSHQQGELNTIVF 868
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
206-895 5.50e-33

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 136.80  E-value: 5.50e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  206 LQDQMVRKAI--YGPNVISIPVKSYPQLLVDEALN-PYYG--FQAFSIALWLADHYYWYALCIFLISSISICL-SLYKTR 279
Cdd:cd07538    2 LTEAEARRRLesGGKNELPQPKKRTLLASILDVLRePMFLllLAAALIYFVLGDPREGLILLIFVVVIIAIEVvQEWRTE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  280 KQSQTLRDMVklSMRVCVCRpGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAGECM-VNESSLTGESIPVLKTalP 358
Cdd:cd07538   82 RALEALKNLS--SPRATVIR-DGRERRIPSRELVPGDLLIL-GEGERIPADGRLLENDDLgVDESTLTGESVPVWKR--I 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  359 EGLGPYCAETHRRHTLFCGTLILQARAYVgpHVLAVVTRTGFCTAKGGLVSSILHPRPINfkfyKHSMKFVAALSVLALL 438
Cdd:cd07538  156 DGKAMSAPGGWDKNFCYAGTLVVRGRGVA--KVEATGSRTELGKIGKSLAEMDDEPTPLQ----KQTGRLVKLCALAALV 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  439 GTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTL 518
Cdd:cd07538  230 FCALIVAVYGVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTL 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  519 TEDGLDVmgvvplkgqaflplvpeprrlpvgpllralatchalsrlQDTpvgdpmdlkmvestgwvleeepaadsafgtq 598
Cdd:cd07538  310 TKNQMEV---------------------------------------VEL------------------------------- 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  599 vlavmrpplwepqlqameeppvpVSVLHRFPFSSALQRMSVVvaWPGATQPEAYVKGSPELVAGLCNPETVPTDfAQMLQ 678
Cdd:cd07538  320 -----------------------TSLVREYPLRPELRMMGQV--WKRPEGAFAAAKGSPEAIIRLCRLNPDEKA-AIEDA 373
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  679 SYTAA--GYRVVALASKPLPTvpsleaaQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQT 756
Cdd:cd07538  374 VSEMAgeGLRVLAVAACRIDE-------SFLPDDLEDAVFIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPAT 446
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  757 AVTVARGCGMvapqehliivhathPERGQpasleflpMESPTAVNGVKDPDqaasytvepdprsrhlalsgptfgiivkh 836
Cdd:cd07538  447 AKAIAKQIGL--------------DNTDN--------VITGQELDAMSDEE----------------------------- 475
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 14285364  837 fpklLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISL 895
Cdd:cd07538  476 ----LAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAM 530
E1-E2_ATPase pfam00122
E1-E2 ATPase;
290-491 2.39e-32

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 124.22  E-value: 2.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    290 KLSMRVCVCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKtalpeglgpycaetH 369
Cdd:pfam00122    1 SLLPPTATVLRDGTEEEVPADELVPGD-IVLLKPGERVPADGRIVEGSASVDESLLTGESLPVEK--------------K 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    370 RRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYR 449
Cdd:pfam00122   66 KGDMVYSGTVVVSGSA------KAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLF 139
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 14285364    450 NRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQ 491
Cdd:pfam00122  140 VGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
276-924 1.34e-31

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 134.12  E-value: 1.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  276 YKTRKQSQTLRDMVKLSMRVCvcrPGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVagECM---VNESSLTGESIPV 352
Cdd:cd02086   78 YKAEKTMDSLRNLSSPNAHVI---RSGKTETISSKDVVPGDIVLL-KVGDTVPADLRLI--ETKnfeTDEALLTGESLPV 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  353 LKTALPE-GLGPYCAETHRRHTLFCGTLILQARAyvgphvLAVVTRTGFCTAKGGLVSSI------LHPRPINFKFY--- 422
Cdd:cd02086  152 IKDAELVfGKEEDVSVGDRLNLAYSSSTVTKGRA------KGIVVATGMNTEIGKIAKALrgkgglISRDRVKSWLYgtl 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  423 ----KHSMKFVAA---------LSVLALL----GTIYSIFILYRNRVPL-NEIVIRALDLVTVVVPPALPAAMTVCTLYA 484
Cdd:cd02086  226 ivtwDAVGRFLGTnvgtplqrkLSKLAYLlffiAVILAIIVFAVNKFDVdNEVIIYAIALAISMIPESLVAVLTITMAVG 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  485 QSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMgvvplkgQAFLPLvpeprrlpvgpllralATCHALSRL 564
Cdd:cd02086  306 AKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVR-------QVWIPA----------------ALCNIATVF 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  565 QDTpvgdpmdlkmvESTGWVLEEEPA--ADSAFGTQvLAVMRPPLWEPqLQAMEEPpvpvsvLHRFPFSSALQRMSVVVA 642
Cdd:cd02086  363 KDE-----------ETDCWKAHGDPTeiALQVFATK-FDMGKNALTKG-GSAQFQH------VAEFPFDSTVKRMSVVYY 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  643 WPGATQPEAYVKGSPELVAGLC-------NPETVPTDF-----AQMlQSYTAAGYRVVALASKPLPTVP---SLEAAQQL 707
Cdd:cd02086  424 NNQAGDYYAYMKGAVERVLECCssmygkdGIIPLDDEFrktiiKNV-ESLASQGLRVLAFASRSFTKAQfndDQLKNITL 502
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  708 TRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEhliivhathpergqpA 787
Cdd:cd02086  503 SRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNS---------------Y 567
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  788 SLEFLPMES----PTAVNGVKDPdqaasytvEPDprsrhlALsgptfgiivkhfpKLLPKVLvqgtvfARMAPEQKTELV 863
Cdd:cd02086  568 HYSQEIMDSmvmtASQFDGLSDE--------EVD------AL-------------PVLPLVI------ARCSPQTKVRMI 614
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14285364  864 CELQKLQYCVGMCGDGANDCGALKAADVGISLSQaEASVVSPFTSSM-------ASIecvPMVIREGR 924
Cdd:cd02086  615 EALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGL-NGSDVAKDASDIvltddnfASI---VNAIEEGR 678
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
203-954 4.60e-31

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 131.58  E-value: 4.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  203 GLSLQDQMVRKAIYGPNviSIPVKSYPQLLvdEALNPYYGFQAFSI------ALWLADHYYWYALCIFLISSISIclSLY 276
Cdd:cd02076    1 GLTSEEAAKRLKEYGPN--ELPEKKENPIL--KFLSFFWGPIPWMLeaaailAAALGDWVDFAIILLLLLINAGI--GFI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  277 KTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECM-VNESSLTGESIPVLKt 355
Cdd:cd02076   75 EERQAGNAVAALKKSLAPKARVLRDGQWQEIDAKELVPGD-IVSLKIGDIVPADARLLTGDALqVDQSALTGESLPVTK- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  356 alpeglgpycaetHRRHTLFCGTLILQArayvgpHVLAVVTRTGFCTAKG---GLVSSIlhPRPINFKFYKHSMKFVAAL 432
Cdd:cd02076  153 -------------HPGDEAYSGSIVKQG------EMLAVVTATGSNTFFGktaALVASA--EEQGHLQKVLNKIGNFLIL 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  433 SVLALLGTIYsIFILYRNRVPLnEIVIRALDLVTVVVPPALPAAMTVcTLYAQSR-LRRQGIFCIHPLRINLGGKLQLVC 511
Cdd:cd02076  212 LALILVLIIV-IVALYRHDPFL-EILQFVLVLLIASIPVAMPAVLTV-TMAVGALeLAKKKAIVSRLSAIEELAGVDILC 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  512 FDKTGTLTEDGLDVMGVVPLKGqaflplvpeprrLPVGPLLR--ALATchalsrlqDTPVGDPMDLKMVESTGwvleeep 589
Cdd:cd02076  289 SDKTGTLTLNKLSLDEPYSLEG------------DGKDELLLlaALAS--------DTENPDAIDTAILNALD------- 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  590 aadsafgtqvlavmRPPLWEPQLQameeppvpvsVLHRFPFSSALQR-MSVVVAWPGATQpeAYVKGSPELVAGLC-NPE 667
Cdd:cd02076  342 --------------DYKPDLAGYK----------QLKFTPFDPVDKRtEATVEDPDGERF--KVTKGAPQVILELVgNDE 395
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  668 TVPTDFAQMLQSYTAAGYRVVALASKPlptvpsleaaqqltrdtVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAV 747
Cdd:cd02076  396 AIRQAVEEKIDELASRGYRSLGVARKE-----------------DGGRWELLGLLPLFDPPRPDSKATIARAKELGVRVK 458
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  748 MVTGDNLQTAVTVARGCGMvapqehliivhathpergqpasleflpmeSPTAVNgvkdpdqaASYTVEPDPRSRHLalsg 827
Cdd:cd02076  459 MITGDQLAIAKETARQLGM-----------------------------GTNILS--------AERLKLGGGGGGMP---- 497
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  828 ptfgiivkhfPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAE------AS 901
Cdd:cd02076  498 ----------GSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGATdaaraaAD 567
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 14285364  902 VVspFTSSMASIecvpmVIRegrcSLDTSFSVFKYM---ALYSLTQFISVLILYTI 954
Cdd:cd02076  568 IV--LTAPGLSV-----IID----AIKTSRQIFQRMksyVIYRIAETLRILVFFTL 612
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
290-924 1.15e-30

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 129.71  E-value: 1.15e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  290 KLSM----RVCVCRPGGEEEwVDSSELVPGDCLVLpQEGGLMPCDAALVAG-ECMVNESSLTGESIPVLKTAlpeglgpy 364
Cdd:cd02609   85 KLSIlnapKVTVIRDGQEVK-IPPEELVLDDILIL-KPGEQIPADGEVVEGgGLEVDESLLTGESDLIPKKA-------- 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  365 caethrRHTLFCGTLILQARAYvgphvlAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLAL-LGTIYS 443
Cdd:cd02609  155 ------GDKLLSGSFVVSGAAY------ARVTAVGAESYAAKLTLEAKKHKLINSELLNSINKILKFTSFIIIpLGLLLF 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  444 IFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFcIHPLR-INLGGKLQLVCFDKTGTLTEDG 522
Cdd:cd02609  223 VEALFRRGGGWRQAVVSTVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVL-VQELYsIETLARVDVLCLDKTGTITEGK 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  523 LDVMGVVPLkGQAFLPLVPEprrlpvgpllRALATCHALSRLQDTpvgdpmdlkmvestgwvleeepaadsafgTQVLAv 602
Cdd:cd02609  302 MKVERVEPL-DEANEAEAAA----------ALAAFVAASEDNNAT-----------------------------MQAIR- 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  603 mrpplwepqlQAMEEPPvPVSVLHRFPFSSAlqrmsvvVAWPGATQP--EAYVKGSPELVAGlcnpeTVPTDFAQMLQSY 680
Cdd:cd02609  341 ----------AAFFGNN-RFEVTSIIPFSSA-------RKWSAVEFRdgGTWVLGAPEVLLG-----DLPSEVLSRVNEL 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  681 TAAGYRVVALAskplptvpslEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTV 760
Cdd:cd02609  398 AAQGYRVLLLA----------RSAGALTHEQLPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAI 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  761 ARGCGmvapqehliivhathpergqpasleflpmesptaVNGVKDPDQAASYTVEPDprsrhlalsgptfgiivkhfpkl 840
Cdd:cd02609  468 AKRAG----------------------------------LEGAESYIDASTLTTDEE----------------------- 490
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  841 LPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAeasvvSPFTSSMASI------- 913
Cdd:cd02609  491 LAEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASG-----SDATRQVAQVvlldsdf 565
                        650
                 ....*....|.
gi 14285364  914 ECVPMVIREGR 924
Cdd:cd02609  566 SALPDVVFEGR 576
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
203-969 2.57e-30

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 130.13  E-value: 2.57e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    203 GLSLQDQMVRKAIYGPNVISIPVK-SYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQ 281
Cdd:TIGR01523   26 GLTHDEAQHRLKEVGENRLEADSGiDAKAMLLHQVCNAMCMVLIIAAAISFAMHDWIEGGVISAIIALNILIGFIQEYKA 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    282 SQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAGECM-VNESSLTGESIPVLKTA-LPE 359
Cdd:TIGR01523  106 EKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVPGDICLL-KTGDTIPADLRLIETKNFdTDEALLTGESLPVIKDAhATF 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    360 GLGPYCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTA----KGGLVSSILHPRP-----INFKFYKHSMKFVA 430
Cdd:TIGR01523  185 GKEEDTPIGDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAAglqgDGGLFQRPEKDDPnkrrkLNKWILKVTKKVTG 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    431 A-------------LSVLALL----GTIYSIFILYRNRVPL-NEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQG 492
Cdd:TIGR01523  265 AflglnvgtplhrkLSKLAVIlfciAIIFAIIVMAAHKFDVdKEVAIYAICLAISIIPESLIAVLSITMAMGAANMSKRN 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    493 IFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGV-VPLKGQAFLPLVPEPRRLPVG-----PLLRALATCHALSRLQ- 565
Cdd:TIGR01523  345 VIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIwIPRFGTISIDNSDDAFNPNEGnvsgiPRFSPYEYSHNEAADQd 424
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    566 ------------DTPVGDPMDL-----------------KMVESTGWVLEEEPA--ADSAFGTQVLAVMRPPLWE----- 609
Cdd:TIGR01523  425 ilkefkdelkeiDLPEDIDMDLfiklletaalaniatvfKDDATDCWKAHGDPTeiAIHVFAKKFDLPHNALTGEedllk 504
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    610 ------PQLQAMEEPPVPVSVLH--RFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCN-----------PETVP 670
Cdd:TIGR01523  505 snendqSSLSQHNEKPGSAQFEFiaEFPFDSEIKRMASIYEDNHGETYNIYAKGAFERIIECCSssngkdgvkisPLEDC 584
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    671 ---TDFAQMlQSYTAAGYRVVALASKPLPTV---PSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRI 744
Cdd:TIGR01523  585 dreLIIANM-ESLAAEGLRVLAFASKSFDKAdnnDDQLKNETLNRATAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGI 663
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    745 RAVMVTGDNLQTAVTVARGCGMVAPqehliivhathpergqpasleflpmesptavNGVKDPDQAASYTVepdprsrhla 824
Cdd:TIGR01523  664 NVHMLTGDFPETAKAIAQEVGIIPP-------------------------------NFIHDRDEIMDSMV---------- 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    825 LSGPTFGIIVKHFPKLLPKVLVqgtVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQ------A 898
Cdd:TIGR01523  703 MTGSQFDALSDEEVDDLKALCL---VIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGIngsdvaK 779
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14285364    899 EASVVSPFTSSMASIecvPMVIREGRcsldtsfsvfkymalySLTQFISVLILYTINTNLGDLQFLAIDLV 969
Cdd:TIGR01523  780 DASDIVLSDDNFASI---LNAIEEGR----------------RMFDNIMKFVLHLLAENVAEAILLIIGLA 831
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
256-896 7.32e-29

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 123.12  E-value: 7.32e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    256 YYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVC-VCRPGGEEEWVDSSELVPGDCL-VLPqeGGLMPCDAAL 333
Cdd:TIGR01525   17 LVLEGALLLFLFLLGETLEERAKSRASDALSALLALAPSTArVLQGDGSEEEVPVEELQVGDIViVRP--GERIPVDGVV 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    334 VAGECMVNESSLTGESIPVLKTalpeglgpycaethRRHTLFCGTLILQARAYVgphvlaVVTRTGFCTAKGGLVSSI-- 411
Cdd:TIGR01525   95 ISGESEVDESALTGESMPVEKK--------------EGDEVFAGTINGDGSLTI------RVTKLGEDSTLAQIVELVee 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    412 --LHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRvplnEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLR 489
Cdd:TIGR01525  155 aqSSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWR----EALYRALTVLVVACPCALGLATPVAILVAIGAAA 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    490 RQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGqaflplVPEPRRLpvgpllrALATC------HALSR 563
Cdd:TIGR01525  231 RRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPLDD------ASEEELL-------ALAAAleqsssHPLAR 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    564 lqdtpvgdpmdlkmvestgwvleeepaadsafgtqvlAVMRpplwepQLQAMEEPPVPVSVlhrfpfsSAL--QRMSVVV 641
Cdd:TIGR01525  298 -------------------------------------AIVR------YAKERGLELPPEDV-------EEVpgKGVEATV 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    642 awpgATQPEAYVkGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASkplptvpsleaaqqltrdtvegDLSLLGL 721
Cdd:TIGR01525  328 ----DGGREVRI-GNPRFLGNRELAIEPISASPDLLNEGESQGKTVVFVAV----------------------DGELLGV 380
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    722 LVMRNLLKPQTTPVIQALRRT-RIRAVMVTGDNLQTAVTVARGCGMvapqehliivhathpergqpasleflpmesptav 800
Cdd:TIGR01525  381 IALRDQLRPEAKEAIAALKRAgGIKLVMLTGDNRSAAEAVAAELGI---------------------------------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    801 ngvkdPDQaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqgtVFARMAPEQKTELVCELQKLQYCVGMCGDGA 880
Cdd:TIGR01525  427 -----DDE-----------------------------------------VHAELLPEDKLAIVKKLQEEGGPVAMVGDGI 460
                          650
                   ....*....|....*.
gi 14285364    881 NDCGALKAADVGISLS 896
Cdd:TIGR01525  461 NDAPALAAADVGIAMG 476
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
279-898 8.95e-29

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 124.10  E-value: 8.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  279 RKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDC-LVLPqeGGLMPCDAALVAGECMVNESSLTGESIPVLKTAl 357
Cdd:COG2217  198 GRARAAIRALLSLQPKTARVLRDGEEVEVPVEELRVGDRvLVRP--GERIPVDGVVLEGESSVDESMLTGESLPVEKTP- 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  358 peGlgpycaethrrHTLFCGTLILQARAYVgphvlaVVTRTGfctaKGGLVSSILH--------PRPI-NF--KFykhSM 426
Cdd:COG2217  275 --G-----------DEVFAGTINLDGSLRV------RVTKVG----SDTTLARIIRlveeaqssKAPIqRLadRI---AR 328
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  427 KFVAALSVLALLGTIYSIFILYrnrvPLNEIVIRAldlVTVVV---PPAL----PAAMTVctlyAQSRLRRQGIFcihpL 499
Cdd:COG2217  329 YFVPAVLAIAALTFLVWLLFGG----DFSTALYRA---VAVLViacPCALglatPTAIMV----GTGRAARRGIL----I 393
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  500 R----INLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGqaflplVPEPRrlpvgpLLRALATCHALSrlqdtpvgdpmdl 575
Cdd:COG2217  394 KggeaLERLAKVDTVVFDKTGTLTEGKPEVTDVVPLDG------LDEDE------LLALAAALEQGS------------- 448
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  576 kmvestgwvleEEPAADsafgtqvlAVMRpplwepqlqAMEEPPVPVSVLHRFpfsSALQRMSVVVAWPGATqpeaYVKG 655
Cdd:COG2217  449 -----------EHPLAR--------AIVA---------AAKERGLELPEVEDF---EAIPGKGVEATVDGKR----VLVG 493
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  656 SPELVAGlcNPETVPTDFAQMLQSYTAAGYRVVALAskplptvpsleaaqqltrdtVEGdlSLLGLLVMRNLLKPQTTPV 735
Cdd:COG2217  494 SPRLLEE--EGIDLPEALEERAEELEAEGKTVVYVA--------------------VDG--RLLGLIALADTLRPEAAEA 549
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  736 IQALRRTRIRAVMVTGDNLQTAVTVARgcgmvapqehliivhathpergqpasleflpmesptavngvkdpdqaasytve 815
Cdd:COG2217  550 IAALKALGIRVVMLTGDNERTAEAVAR----------------------------------------------------- 576
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  816 pdprsrhlalsgpTFGIivkhfpkllpkvlvqGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISL 895
Cdd:COG2217  577 -------------ELGI---------------DEVRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAM 628

                 ...
gi 14285364  896 SQA 898
Cdd:COG2217  629 GSG 631
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
212-955 1.39e-28

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 124.05  E-value: 1.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  212 RKAIYGPNVISIP-----VKSYpqllVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLR 286
Cdd:cd02085    1 RRKLHGPNEFKVEdeeplWKKY----LEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  287 DMVKLSMRVCVCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALV-AGECMVNESSLTGESIPVLKT--ALPEGLGP 363
Cdd:cd02085   77 ALNKLVPPECHCLRDGKLEHFLARELVPGD-LVCLSIGDRIPADLRLFeATDLSIDESSLTGETEPCSKTteVIPKASNG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  364 YCaeTHRRHTLFCGTLILQARAYvgphvlAVVTRTGFCTAKGGLV---SSILHPR-PInfkfyKHSM-KFVAALSVLALl 438
Cdd:cd02085  156 DL--TTRSNIAFMGTLVRCGHGK------GIVIGTGENSEFGEVFkmmQAEEAPKtPL-----QKSMdKLGKQLSLYSF- 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  439 GTIYSIFIL--YRNRvPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRL-RRQGIFCIHPLRINLGGkLQLVCFDKT 515
Cdd:cd02085  222 IIIGVIMLIgwLQGK-NLLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMaKRRAIVKKLPIVETLGC-VNVICSDKT 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  516 GTLTEDGLDVMGVVplkgqaflplvpeprrlpvgpllrALATCHALSRLQDTPVGDPMDLKMVEstgwvleeepaadsaf 595
Cdd:cd02085  300 GTLTKNEMTVTKIV------------------------TGCVCNNAVIRNNTLMGQPTEGALIA---------------- 339
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  596 gtqvLAvMRPPLWEPQLQameeppvpVSVLHRFPFSSALQRMSVVVAWPGATQPEA--YVKGSPELVAGLC------NPE 667
Cdd:cd02085  340 ----LA-MKMGLSDIRET--------YIRKQEIPFSSEQKWMAVKCIPKYNSDNEEiyFMKGALEQVLDYCttynssDGS 406
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  668 TVPTDFAQMLQ------SYTAAGYRVVALASKPLptvpsleaaqqltrdtvEGDLSLLGLLVMRNLLKPQTTPVIQALRR 741
Cdd:cd02085  407 ALPLTQQQRSEineeekEMGSKGLRVLALASGPE-----------------LGDLTFLGLVGINDPPRPGVREAIQILLE 469
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  742 TRIRAVMVTGDNLQTAVTVARGCGMvapqehliivhathpergqpasleflpmesptavngvkdpdqaasytvepdPRSR 821
Cdd:cd02085  470 SGVRVKMITGDAQETAIAIGSSLGL---------------------------------------------------YSPS 498
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  822 HLALSGPTFGIIVKHfpkLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQA--- 898
Cdd:cd02085  499 LQALSGEEVDQMSDS---QLASVVRKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTgtd 575
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14285364  899 ---EAS----VVSPFTSSMASIEcvpmvirEG-----------RCSLDTSFSVFKYMALYSLTQFISVL----ILYtIN 955
Cdd:cd02085  576 vckEAAdmilVDDDFSTILAAIE-------EGkgifyniknfvRFQLSTSIAALSLIALSTLFNLPNPLnamqILW-IN 646
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
260-950 2.85e-26

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 116.71  E-value: 2.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   260 ALCIFLISSISICLSLY---KTRKQSQTLRDMVklSMRVCVCRPG---GEEEWVDS--SELVPGDCLVLpQEGGLMPCDA 331
Cdd:PRK10517  125 AGVIALMVAISTLLNFIqeaRSTKAADALKAMV--SNTATVLRVIndkGENGWLEIpiDQLVPGDIIKL-AAGDMIPADL 201
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   332 -ALVAGECMVNESSLTGESIPVLKTALPEGL---GPYCAEThrrhTLFCGTLILQARAyvgphvLAVVTRTGFCTAKGGL 407
Cdd:PRK10517  202 rILQARDLFVAQASLTGESLPVEKFATTRQPehsNPLECDT----LCFMGTNVVSGTA------QAVVIATGANTWFGQL 271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   408 VSSILH-PRPINfKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPaaMTVCTLYAQS 486
Cdd:PRK10517  272 AGRVSEqDSEPN-AFQQGISRVSWLLIRFMLVMAPVVLLINGYTKGDWWEAALFALSVAVGLTPEMLP--MIVTSTLARG 348
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   487 --RLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGL------DVMGVvplkgqaflplvPEPRRLPVGPLLRALATc 558
Cdd:PRK10517  349 avKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtDISGK------------TSERVLHSAWLNSHYQT- 415
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   559 hALSRLQDTPVgdpmdLKMVEstgwvLEEEPAADSAFgtqvlavmrpplwepqlQAMEEppvpvsvlhrFPFSSALQRMS 638
Cdd:PRK10517  416 -GLKNLLDTAV-----LEGVD-----EESARSLASRW-----------------QKIDE----------IPFDFERRRMS 457
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   639 VVVAWPGAtQPEAYVKGSPELVAGLC-----NPETVPTDfAQML-------QSYTAAGYRVVALASKPLPtvpsleAAQQ 706
Cdd:PRK10517  458 VVVAENTE-HHQLICKGALEEILNVCsqvrhNGEIVPLD-DIMLrrikrvtDTLNRQGLRVVAVATKYLP------AREG 529
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   707 LTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMvaPQEHLIIvhathpergqP 786
Cdd:PRK10517  530 DYQRADESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLI----------G 597
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   787 ASLEFLpmesptavngvkdPDQAASYTVEpdprsrhlalsgptfgiivkhfpkllpkvlvQGTVFARMAPEQKTELVCEL 866
Cdd:PRK10517  598 SDIETL-------------SDDELANLAE-------------------------------RTTLFARLTPMHKERIVTLL 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   867 QKLQYCVGMCGDGANDCGALKAADVGISLSQA-----EASVVSPFTSSMasiecvpMVIREGRCSLDTSFS-VFKYMALY 940
Cdd:PRK10517  634 KREGHVVGFMGDGINDAPALRAADIGISVDGAvdiarEAADIILLEKSL-------MVLEEGVIEGRRTFAnMLKYIKMT 706
                         730
                  ....*....|...
gi 14285364   941 SLTQF---ISVLI 950
Cdd:PRK10517  707 ASSNFgnvFSVLV 719
P5-ATPase pfam12409
P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically ...
39-175 2.04e-25

P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.


Pssm-ID: 463565  Cd Length: 123  Bit Score: 102.24  E-value: 2.04e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364     39 GYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIeirdkEDSSWQLFTVQVQTEAIGEgSLe 118
Cdd:pfam12409    9 GYRTSRWRLALYLLLCVLTLGLLYLLFRWLPRWRVRLTGKPCPLAEADWVVI-----EDEFGELSIKKVKKLPYGR-PL- 81
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 14285364    119 pSPQSQAEDGRSQAAVGAVPEgawkdtaqLHKSEeavsvgqKRVLRYYLFQGQRYIW 175
Cdd:pfam12409   82 -STVFPLLVGESSSVISKADE--------DNDPE-------LPQLRYFDYRYIRYIW 122
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
297-960 4.37e-25

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 113.15  E-value: 4.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  297 VCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECM---VNESSLTGESIPVLKTALPEGlGPYCAETHRRHT 373
Cdd:cd02083  125 VLRNGKGVQRIRARELVPGD-IVEVAVGDKVPADIRIIEIKSTtlrVDQSILTGESVSVIKHTDVVP-DPRAVNQDKKNM 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  374 LFCGTLILQARAyvgphvLAVVTRTGFCTAKGGLVSSILH----PRPINFKFYKHSMKFVAALSVLALL----------- 438
Cdd:cd02083  203 LFSGTNVAAGKA------RGVVVGTGLNTEIGKIRDEMAEteeeKTPLQQKLDEFGEQLSKVISVICVAvwainighfnd 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  439 ---------GTIYSIFIlyrnrvplneivirALDLVTVVVPPALPAAMTVCTLYAQSRLRRQG-IFCIHPLRINLGgKLQ 508
Cdd:cd02083  277 pahggswikGAIYYFKI--------------AVALAVAAIPEGLPAVITTCLALGTRRMAKKNaIVRSLPSVETLG-CTS 341
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  509 LVCFDKTGTLTEDGLDV--MGVV------------PLKGQAFLP-----LVPEPRRLPVGPLLRALATCHAL---SRLQD 566
Cdd:cd02083  342 VICSDKTGTLTTNQMSVsrMFILdkveddsslnefEVTGSTYAPegevfKNGKKVKAGQYDGLVELATICALcndSSLDY 421
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  567 TP-------VGDPMD--LK-MVESTGwvleeepaadsAFGTqvlAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQR 636
Cdd:cd02083  422 NEskgvyekVGEATEtaLTvLVEKMN-----------VFNT---DKSGLSKRERANACNDVIEQLWKKEFTLEFSRDRKS 487
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  637 MSVVVAWPGA-TQPEAYVKGSPELVAGLCNPETVPTDFAQML------------QSYTAAGYRVVALASKPLPTVPSLEA 703
Cdd:cd02083  488 MSVYCSPTKAsGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLtaaikililkkvWGYGTDTLRCLALATKDTPPKPEDMD 567
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  704 AQQLTRDT-VEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLiivhATHPE 782
Cdd:cd02083  568 LEDSTKFYkYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDEDT----TGKSY 643
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  783 RGQpaslEF--LPMEsptavngvkdpDQAASYtvepdPRSRhlalsgptfgiivkhfpkllpkvlvqgtVFARMAPEQKT 860
Cdd:cd02083  644 TGR----EFddLSPE-----------EQREAC-----RRAR----------------------------LFSRVEPSHKS 675
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  861 ELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEAsvVSPFTSSM-------ASIEcvpMVIREGRcsldtsfsv 933
Cdd:cd02083  676 KIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGTA--VAKSASDMvladdnfATIV---AAVEEGR--------- 741
                        730       740
                 ....*....|....*....|....*...
gi 14285364  934 fkymALYSLT-QFISvlilYTINTNLGD 960
Cdd:cd02083  742 ----AIYNNMkQFIR----YLISSNIGE 761
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
256-893 1.60e-23

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 106.95  E-value: 1.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  256 YYWY--ALCIFlISSISICLSLYKTRKQSQTLRDMVKLS-MRVCVCRPGGEEEWVDSSELVPGDC-LVLPqeGGLMPCDA 331
Cdd:cd07551   73 GYWAegALLIF-IFSLSHALEDYAMGRSKRAITALMQLApETARRIQRDGEIEEVPVEELQIGDRvQVRP--GERVPADG 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  332 ALVAGECMVNESSLTGESIPVLKTalpeglgpycaethRRHTLFCGTLilqarayVGPHVLAV-VTRtgfcTAKGGLVSS 410
Cdd:cd07551  150 VILSGSSSIDEASITGESIPVEKT--------------PGDEVFAGTI-------NGSGALTVrVTK----LSSDTVFAK 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  411 ILH--------PRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRnrvPLNEIVIRALDLVTVVVPPALPAAMTVCTL 482
Cdd:cd07551  205 IVQlveeaqseKSPTQSFIERFERIYVKGVLLAVLLLLLLPPFLLGW---TWADSFYRAMVFLVVASPCALVASTPPATL 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  483 YAQSRLRRQGIFC---IHPLRInlgGKLQLVCFDKTGTLTEDGLDVMGVVPLKGqaflplVPEPRrlpvgpLLRALATCH 559
Cdd:cd07551  282 SAIANAARQGVLFkggVHLENL---GSVKAIAFDKTGTLTEGKPRVTDVIPAEG------VDEEE------LLQVAAAAE 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  560 ALSrlqdtpvgdpmdlkmvestgwvleEEPAADsafgtqvlAVMRpplwepQLQAMEEPPVPVSVLHrfpfssALQRMSV 639
Cdd:cd07551  347 SQS------------------------EHPLAQ--------AIVR------YAEERGIPRLPAIEVE------AVTGKGV 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  640 VVAWPGATqpeaYVKGSPELVAGLCNPETVPTDFAQMLQSytaaGYRVValaskplptvpsleaaqqltrdTVEGDLSLL 719
Cdd:cd07551  383 TATVDGQT----YRIGKPGFFGEVGIPSEAAALAAELESE----GKTVV----------------------YVARDDQVV 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  720 GLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMvapqehliivhathpergqpasleflpmespta 799
Cdd:cd07551  433 GLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI--------------------------------- 479
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  800 vngvkdpDQaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqgtVFARMAPEQKTELVCELQKLQYCVGMCGDG 879
Cdd:cd07551  480 -------DE-----------------------------------------VVANLLPEDKVAIIRELQQEYGTVAMVGDG 511
                        650
                 ....*....|....
gi 14285364  880 ANDCGALKAADVGI 893
Cdd:cd07551  512 INDAPALANADVGI 525
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
252-904 2.16e-22

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 102.79  E-value: 2.16e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    252 LADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDA 331
Cdd:TIGR01512   13 VAIGEYLEGALLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGD-VVVVKPGERVPVDG 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    332 ALVAGECMVNESSLTGESIPVLKTalpeglgpycaethRRHTLFCGTLILQARAYVgphvlaVVTRTGFCTAKGGLVSSI 411
Cdd:TIGR01512   92 EVLSGTSSVDESALTGESVPVEKA--------------PGDEVFAGAINLDGVLTI------EVTKLPADSTIAKIVNLV 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    412 LH----PRPINFKFYKHSMKFVAALSVLALLGTIYSIFILyrnRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSR 487
Cdd:TIGR01512  152 EEaqsrKAPTQRFIDRFARYYTPAVLAIALAAALVPPLLG---AGPFLEWIYRALVLLVVASPCALVISAPAAYLSAISA 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    488 LRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKG---QAFLPLVPEPRRLPVGPLLRALATcHALSRL 564
Cdd:TIGR01512  229 AARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTDVHPADGhseSEVLRLAAAAEQGSTHPLARAIVD-YARARE 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    565 QDTPVGDpmdlkmvestgwvLEEEPAAdsafgtqvlavmrpplwepqlqameeppvpvsvlhrfpfssalqrmsvvvawp 644
Cdd:TIGR01512  308 LAPPVED-------------VEEVPGE----------------------------------------------------- 321
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    645 GATqpeAYVKGSpelVAGLCNPETVPTDFAQMLQSYTAAGYRVVALAskplptvpsleaaqqltrdtVEGDlsLLGLLVM 724
Cdd:TIGR01512  322 GVR---AVVDGG---EVRIGNPRSLSEAVGASIAVPESAGKTIVLVA--------------------RDGT--LLGYIAL 373
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    725 RNLLKPQTTPVIQALRR-TRIRAVMVTGDNLQTAVTVARGCGMvapqehliivhathpergqpasleflpmesptavngv 803
Cdd:TIGR01512  374 SDELRPDAAEAIAELKAlGIKRLVMLTGDRRAVAEAVARELGI------------------------------------- 416
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    804 kdpDQaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqgtVFARMAPEQKTELVCELQKLQYCVGMCGDGANDC 883
Cdd:TIGR01512  417 ---DE-----------------------------------------VHAELLPEDKLEIVKELREKAGPVAMVGDGINDA 452
                          650       660
                   ....*....|....*....|.
gi 14285364    884 GALKAADVGISLSQAEASVVS 904
Cdd:TIGR01512  453 PALAAADVGIAMGASGSDVAL 473
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
184-1033 1.02e-21

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 102.18  E-value: 1.02e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    184 QVSLLDHGRSCDDVHRS-----RHGLS---LQDQMVRKaiyGPNVISIP------VKSYPQLlvdealnpyygFQAFSIA 249
Cdd:TIGR01106   12 EVEMDDHKLSLDELERKygtdlSKGLSaarAAEILARD---GPNALTPPpttpewVKFCRQL-----------FGGFSML 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    250 LWLADHYYWYA-----------------LCIFLISSISI--CLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSS 310
Cdd:TIGR01106   78 LWIGAILCFLAygiqasteeepqndnlyLGVVLSAVVIItgCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAE 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    311 ELVPGDcLVLPQEGGLMPCDAALVAGE-CMVNESSLTGESIPvlKTALPEGLGPYCAEThrRHTLFCGTLILQARAyvgp 389
Cdd:TIGR01106  158 QVVVGD-LVEVKGGDRIPADLRIISAQgCKVDNSSLTGESEP--QTRSPEFTHENPLET--RNIAFFSTNCVEGTA---- 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    390 hvLAVVTRTGFCTAKG---GLVSSILHPR-PINFKFyKHSMKFVAALSVLalLGTIYSIFILYRNRVPLnEIVIRALDLV 465
Cdd:TIGR01106  229 --RGIVVNTGDRTVMGriaSLASGLENGKtPIAIEI-EHFIHIITGVAVF--LGVSFFILSLILGYTWL-EAVIFLIGII 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    466 TVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGldvMGVVPL-------------- 531
Cdd:TIGR01106  303 VANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNR---MTVAHMwfdnqiheadtted 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    532 -KGQAFlplvpeprrlpvgplLRALATCHALSRLqdTPVGDPMDLKMVESTGWVLEEEPAADsAFGTQVLAVMRPPLWEP 610
Cdd:TIGR01106  380 qSGVSF---------------DKSSATWLALSRI--AGLCNRAVFKAGQENVPILKRAVAGD-ASESALLKCIELCLGSV 441
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    611 QLQAMEEPPVPvsvlhRFPFSSALQRMSVVVAWPGATQPE--AYVKGSPELVAGLC-----NPETVPTDfAQMLQSYTAA 683
Cdd:TIGR01106  442 MEMRERNPKVV-----EIPFNSTNKYQLSIHENEDPRDPRhlLVMKGAPERILERCssiliHGKEQPLD-EELKEAFQNA 515
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    684 -------GYRVVALASKPLPTVPSLEAAQQLTRD---TVEGdLSLLGLLVMrnlLKPQTTPVIQALRRTR---IRAVMVT 750
Cdd:TIGR01106  516 ylelgglGERVLGFCHLYLPDEQFPEGFQFDTDDvnfPTDN-LCFVGLISM---IDPPRAAVPDAVGKCRsagIKVIMVT 591
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    751 GDNLQTAVTVARGCGmvapqehlIIVHATHPERGQPASLEfLPMES-------PTAVNGVKDPDQAASYTVEpdprsrhl 823
Cdd:TIGR01106  592 GDHPITAKAIAKGVG--------IISEGNETVEDIAARLN-IPVSQvnprdakACVVHGSDLKDMTSEQLDE-------- 654
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    824 alsgptfgiIVKHFPKLlpkvlvqgtVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAeASVV 903
Cdd:TIGR01106  655 ---------ILKYHTEI---------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA-GSDV 715
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    904 SPFTSSM-------ASIecVPMViREGRCSLDTsfsvFKYMALYSLTQFIS------VLILYTINTNLGDLQFLAIDLV- 969
Cdd:TIGR01106  716 SKQAADMillddnfASI--VTGV-EEGRLIFDN----LKKSIAYTLTSNIPeitpflIFIIANIPLPLGTITILCIDLGt 788
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    970 -ITTTVAVLMSRTGPALVLGRVRPP--GALLSVPVLSSLLLQMVLVTGvqLGG---YFLTLAQPWFVPLN 1033
Cdd:TIGR01106  789 dMVPAISLAYEKAESDIMKRQPRNPktDKLVNERLISMAYGQIGMIQA--LGGfftYFVILAENGFLPLH 856
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
251-896 4.62e-21

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 98.89  E-value: 4.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    251 WLADHYYWYALCiFLISSISI--CLSLYKTRKQSQTLRDMVKLSMRVC-VCRPGGEEEWVDSSELVPGDCL-VLPqeGGL 326
Cdd:TIGR01511   47 GLHVHTFFDASA-MLITFILLgrWLEMLAKGRASDALSKLAKLQPSTAtLLTKDGSIEEVPVALLQPGDIVkVLP--GEK 123
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    327 MPCDAALVAGECMVNESSLTGESIPVLKTalpEGlgpycaethrrHTLFCGTLilqarayVGPHVLAV-VTRTGFCT--- 402
Cdd:TIGR01511  124 IPVDGTVIEGESEVDESLVTGESLPVPKK---VG-----------DPVIAGTV-------NGTGSLVVrATATGEDTtla 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    403 --------AKGG---------LVSSILHPrpinfkfykhsmkFVAALSVLALLGTIYSIfilyrnrvplneivIRAldlV 465
Cdd:TIGR01511  183 qivrlvrqAQQSkapiqrladKVAGYFVP-------------VVIAIALITFVIWLFAL--------------EFA---V 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    466 TVVV---PPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLkgqaflplvpe 542
Cdd:TIGR01511  233 TVLIiacPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDVHVF----------- 301
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    543 prrlpvgpllralatchalsrlqdtpvgDPMDlkmvestgwvleeepaadsafGTQVLAVMRpplwepQLQAMEEPPVPV 622
Cdd:TIGR01511  302 ----------------------------GDRD---------------------RTELLALAA------ALEAGSEHPLAK 326
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    623 SVL-----HRFPFSSALQrmsvVVAWPGA-----TQPEAYVKGSPELvaglCNPETVPTDfaqmlqsytaagyrvvalas 692
Cdd:TIGR01511  327 AIVsyakeKGITLVTVSD----FKAIPGIgvegtVEGTKIQLGNEKL----LGENAIKID-------------------- 378
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    693 kplptvpsLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMvapqeh 772
Cdd:TIGR01511  379 --------GKAGQGSTVVLVAVNGELAGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI------ 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    773 liivhathpergqpasleflpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqgTVFA 852
Cdd:TIGR01511  445 ----------------------------------------------------------------------------DVRA 448
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 14285364    853 RMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLS 896
Cdd:TIGR01511  449 EVLPDDKAALIKKLQEKGPVVAMVGDGINDAPALAQADVGIAIG 492
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
245-900 1.07e-20

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 98.06  E-value: 1.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  245 AFSIALWLADH----YYWYA---LCIFLISSIsicLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGD- 316
Cdd:cd02079   72 AFVASLLTPLLggigYFEEAamlLFLFLLGRY---LEERARSRARSALKALLSLAPETATVLEDGSTEEVPVDDLKVGDv 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  317 CLVLPqeGGLMPCDAALVAGECMVNESSLTGESIPVLKTAlpeGlgpycaethrrHTLFCGTLILQArayvgphVLAV-V 395
Cdd:cd02079  149 VLVKP--GERIPVDGVVVSGESSVDESSLTGESLPVEKGA---G-----------DTVFAGTINLNG-------PLTIeV 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  396 TRTGfctaKGGLVSSILH---------PRPINF--KFykhSMKFVAALSVLALLGTIYSIFILyrnrVPLNEIVIRALDL 464
Cdd:cd02079  206 TKTG----EDTTLAKIIRlveeaqsskPPLQRLadRF---ARYFTPAVLVLAALVFLFWPLVG----GPPSLALYRALAV 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  465 VTVVVPPAL----PAAMTVctlyAQSRLRRQGIFcihpLRinlGG-------KLQLVCFDKTGTLTEDGLDVMGVVPLKG 533
Cdd:cd02079  275 LVVACPCALglatPTAIVA----GIGRAARKGIL----IK---GGdvletlaKVDTVAFDKTGTLTEGKPEVTEIEPLEG 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  534 qaflplvpePRRLPVGPLLRALA--TCHALSR-LQDTPVGDPMDLKMVEStgwvLEEEPaadsAFGtqvlavmrpplwep 610
Cdd:cd02079  344 ---------FSEDELLALAAALEqhSEHPLARaIVEAAEEKGLPPLEVED----VEEIP----GKG-------------- 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  611 qlqameeppvpvsvlhrfpfssalqrmsVVVAWPGATqpeaYVKGSPELVAglcnpETVPTDFAQMLQSYTAAGYRVVAL 690
Cdd:cd02079  393 ----------------------------ISGEVDGRE----VLIGSLSFAE-----EEGLVEAADALSDAGKTSAVYVGR 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  691 ASKplptvpsleaaqqltrdtvegdlsLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVArgcgmvapq 770
Cdd:cd02079  436 DGK------------------------LVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVA--------- 482
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  771 ehliivhathpergqpasleflpmesptavngvkdpdqaasytvepdprsRHLALSgptfgiivkhfpkllpkvlvqgTV 850
Cdd:cd02079  483 --------------------------------------------------KELGID----------------------EV 490
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|
gi 14285364  851 FARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEA 900
Cdd:cd02079  491 HAGLLPEDKLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGSGTD 540
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
624-954 1.34e-19

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 94.97  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  624 VLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLE- 702
Cdd:cd07536  393 ILQLLEFTSDRKRMSVIVRDESTGEITLYMKGADVAISPIVSKDSYMEQYNDWLEEECGEGLRTLCVAKKALTENEYQEw 472
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  703 -----AAQQLTRD----------TVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMV 767
Cdd:cd07536  473 esrytEASLSLHDrslrvaevveSLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLV 552
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  768 APQEHLIIVHAThPERGQPASLEflpMESPTAVNGVKDPDQAAsytvepdprsrhLALSGPTFGIIVKHFPKLLPKVLVQ 847
Cdd:cd07536  553 SRTQDIHLLRQD-TSRGERAAIT---QHAHLELNAFRRKHDVA------------LVIDGDSLEVALKYYRHEFVELACQ 616
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  848 --GTVFARMAPEQKTELVCELQKlqyCVG----MCGDGANDCGALKAADVGISLSQAE---ASVVSPFT-SSMASIECVP 917
Cdd:cd07536  617 cpAVICCRVSPTQKARIVTLLKQ---HTGrrtlAIGDGGNDVSMIQAADCGVGISGKEgkqASLAADYSiTQFRHLGRLL 693
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 14285364  918 MVirEGRCSldtsfsvFKYMALYSLTQFISVLILYTI 954
Cdd:cd07536  694 LV--HGRNS-------YNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
260-898 4.24e-18

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 89.79  E-value: 4.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  260 ALCIFLISsISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECM 339
Cdd:cd07545   63 AMVVFLFA-ISEALEAYSMDRARRSIRSLMDIAPKTALVRRDGQEREVPVAEVAVGD-RMIVRPGERIAMDGIIVRGESS 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  340 VNESSLTGESIPVLKTAlpeglgpycaethrRHTLFCGTLilqarayVGPHVLAV-VTRtgfcTAKGGLVSSILH----- 413
Cdd:cd07545  141 VNQAAITGESLPVEKGV--------------GDEVFAGTL-------NGEGALEVrVTK----PAEDSTIARIIHlveea 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  414 --PRPINFKFY-KHSMKFVAALSVLALLGTIYSIFILYRNRVPLneiVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRR 490
Cdd:cd07545  196 qaERAPTQAFVdRFARYYTPVVMAIAALVAIVPPLFFGGAWFTW---IYRGLALLVVACPCALVISTPVSIVSAIGNAAR 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  491 QGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAflplvpEPRrlpvgplLRALATchALSRLQDTPVG 570
Cdd:cd07545  273 KGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVVLGGQT------EKE-------LLAIAA--ALEYRSEHPLA 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  571 DpmdlkmvestgwvleeepaadsafgtqvlAVMRpplwepqlqAMEEPPVPVSVLHRFpfsSALQRMSVVvawpGATQPE 650
Cdd:cd07545  338 S-----------------------------AIVK---------KAEQRGLTLSAVEEF---TALTGRGVR----GVVNGT 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  651 AYVKGSPELV--AGLCNPETvptdFAQMLQSYTAAGYRVVALaskplptvpsleaaqqLTRDTVegdlslLGLLVMRNLL 728
Cdd:cd07545  373 TYYIGSPRLFeeLNLSESPA----LEAKLDALQNQGKTVMIL----------------GDGERI------LGVIAVADQV 426
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  729 KPQTTPVIQALRRTRI-RAVMVTGDNLQTAVTVArgcgmvapqehliivhathpergqpasleflpmesptAVNGVKDpd 807
Cdd:cd07545  427 RPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIA-------------------------------------AQVGVSD-- 467
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  808 qaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqgtVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALK 887
Cdd:cd07545  468 ------------------------------------------IRAELLPQDKLDAIEALQAEGGRVAMVGDGVNDAPALA 505
                        650
                 ....*....|.
gi 14285364  888 AADVGISLSQA 898
Cdd:cd07545  506 AADVGIAMGAA 516
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
253-893 1.41e-17

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 87.92  E-value: 1.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  253 ADHYYWYALCiFLISSISI--CLSLYKTRKQSQTLRDMVKLSMRVC-VCRPGGEEEwVDSSELVPGDCL-VLPqeGGLMP 328
Cdd:cd02094   97 APHVYFEAAA-VIITFILLgkYLEARAKGKTSEAIKKLLGLQPKTArVIRDGKEVE-VPIEEVQVGDIVrVRP--GEKIP 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  329 CDAALVAGECMVNESSLTGESIPVLKTalpEGlgpycaethrrHTLFCGTLilqarayVGPHVLAV-VTRTGFCT----- 402
Cdd:cd02094  173 VDGVVVEGESSVDESMLTGESLPVEKK---PG-----------DKVIGGTI-------NGNGSLLVrATRVGADTtlaqi 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  403 ------AKGG---------LVSSILHPrpinfkfykhsmkFVAALSVLALLGTIYsifilyrnrVPLNEIVIRALDL-VT 466
Cdd:cd02094  232 irlveeAQGSkapiqrladRVSGVFVP-------------VVIAIAILTFLVWLL---------LGPEPALTFALVAaVA 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  467 VVV---PPAL----PAAMTVCTlyaqSRLRRQGIFcihplrINLGGKLQL------VCFDKTGTLTEDGLDVMGVVPLKG 533
Cdd:cd02094  290 VLViacPCALglatPTAIMVGT----GRAAELGIL------IKGGEALERahkvdtVVFDKTGTLTEGKPEVTDVVPLPG 359
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  534 QaflplvpEPRRLpvgplLRALATCHALSrlqdtpvgdpmdlkmvestgwvleEEPAAdsafgtqvLAVMRpplwepqlQ 613
Cdd:cd02094  360 D-------DEDEL-----LRLAASLEQGS------------------------EHPLA--------KAIVA--------A 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  614 AMEEPPVPVSVLHrfpfssalqrmsvVVAWPGA-----TQPEAYVKGSPELVAGLCNPetvPTDFAQMLQSYTAAGYRVV 688
Cdd:cd02094  388 AKEKGLELPEVED-------------FEAIPGKgvrgtVDGRRVLVGNRRLMEENGID---LSALEAEALALEEEGKTVV 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  689 ALAskplptvpsleaaqqltrdtVEGdlSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMva 768
Cdd:cd02094  452 LVA--------------------VDG--ELAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI-- 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  769 pqehliivhathpergqpasleflpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqG 848
Cdd:cd02094  508 -------------------------------------------------------------------------------D 508
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*
gi 14285364  849 TVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGI 893
Cdd:cd02094  509 EVIAEVLPEDKAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGI 553
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
197-894 4.63e-17

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 87.00  E-value: 4.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   197 VHRSRHGLSLQDQMVRKAIYGPNVIS--IPVKSYPQLLvdEAL-NPY-YGFQAFSIALWLADhyYWYAL----------- 261
Cdd:PRK15122   39 LNTHRQGLTEEDAAERLQRYGPNEVAheKPPHALVQLL--QAFnNPFiYVLMVLAAISFFTD--YWLPLrrgeetdltgv 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   262 -CIFLISSISICLSL---YKTRKQSQTLRDMVK----LSMRVCVCRPGGEEEwVDSSELVPGDCLVLpQEGGLMPCDAAL 333
Cdd:PRK15122  115 iIILTMVLLSGLLRFwqeFRSNKAAEALKAMVRttatVLRRGHAGAEPVRRE-IPMRELVPGDIVHL-SAGDMIPADVRL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   334 VAG-ECMVNESSLTGESIPVLKTALPEGLGPYCAET---------HRRHTLFCGTLILQARAyvgphvLAVVTRTGFCTA 403
Cdd:PRK15122  193 IESrDLFISQAVLTGEALPVEKYDTLGAVAGKSADAladdegsllDLPNICFMGTNVVSGTA------TAVVVATGSRTY 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   404 KGGLVSSILHPRP-------INfkfykhsmkfvaalSVLALLgtIYSIFILyrnrVP----LN--------EIVIRALDL 464
Cdd:PRK15122  267 FGSLAKSIVGTRAqtafdrgVN--------------SVSWLL--IRFMLVM----VPvvllINgftkgdwlEALLFALAV 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   465 VTVVVPPALPaaMTVCTLYAQSRL---RRQGIFcihpLRINL---GGKLQLVCFDKTGTLTEDG------LDVMGVvplk 532
Cdd:PRK15122  327 AVGLTPEMLP--MIVSSNLAKGAIamaRRKVVV----KRLNAiqnFGAMDVLCTDKTGTLTQDRiilehhLDVSGR---- 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   533 gqaflplvpepRRLPVgpLLRALATCHALSRLQDTpvgdpMDLKMVestgwvleeepaadsAFGTQVLAVmrpplwepql 612
Cdd:PRK15122  397 -----------KDERV--LQLAWLNSFHQSGMKNL-----MDQAVV---------------AFAEGNPEI---------- 433
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   613 qameEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQpEAYVKGSPELVAGLC-----NPETVPTDFA------QMLQSYT 681
Cdd:PRK15122  434 ----VKPAGYRKVDELPFDFVRRRLSVVVEDAQGQH-LLICKGAVEEMLAVAthvrdGDTVRPLDEArrerllALAEAYN 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   682 AAGYRVVALASKPLPTVpslEAAQQLTRDTvEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVA 761
Cdd:PRK15122  509 ADGFRVLLVATREIPGG---ESRAQYSTAD-ERDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTAKIC 584
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   762 RGCGMvapqehliivhathpERGQPasleflpmesptaVNGVKdpdqaasytVEpdprsrhlALSGPTFGIIVKHfpkll 841
Cdd:PRK15122  585 REVGL---------------EPGEP-------------LLGTE---------IE--------AMDDAALAREVEE----- 614
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|...
gi 14285364   842 pkvlvqGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGIS 894
Cdd:PRK15122  615 ------RTVFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRDADVGIS 661
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
301-898 6.30e-15

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 79.24  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  301 GGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTalpEGlgpycaethrrHTLFCGTLI 380
Cdd:cd07550  107 DGVEVEVPADEVQPGDTVVV-GAGDVIPVDGTVLSGEALIDQASLTGESLPVEKR---EG-----------DLVFASTVV 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  381 LQARAYVgphvlaVVTRTGFCTAKGGLV----SSILHPRPINFKFYKHSMKfvAALSVLALLGTIYSIFI-LYRNRVPLN 455
Cdd:cd07550  172 EEGQLVI------RAERVGRETRAARIAelieQSPSLKARIQNYAERLADR--LVPPTLGLAGLVYALTGdISRAAAVLL 243
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  456 eiviraLDLVT---VVVPPALPAAMTVCTlyaqsrlrRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLK 532
Cdd:cd07550  244 ------VDFSCgirLSTPVAVLSALNHAA--------RHGILVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAIITFD 309
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  533 GqaflplvpeprRLPVGPLLRALATchalsrlqdtpvgdpmdlkmvestgwvLEEE---PAAdsafgtqvLAVMRPPLwE 609
Cdd:cd07550  310 G-----------RLSEEDLLYLAAS---------------------------AEEHfphPVA--------RAIVREAE-E 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  610 PQLQAMEEPPVPVSVLHrfPFSSALQRMSVVVawpgatqpeayvkGSPELVA--GLCNPETVptdfAQMLQSYTAAGYRV 687
Cdd:cd07550  343 RGIEHPEHEEVEYIVGH--GIASTVDGKRIRV-------------GSRHFMEeeEIILIPEV----DELIEDLHAEGKSL 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  688 VALASkplptvpsleaaqqltrdtvegDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAV-MVTGDNLQTAVTVARGCGM 766
Cdd:cd07550  404 LYVAI----------------------DGRLIGVIGLSDPLRPEAAEVIARLRALGGKRIiMLTGDHEQRARALAEQLGI 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  767 vapqehliivhathpergqpasleflpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivkhfpkllpkvlv 846
Cdd:cd07550      --------------------------------------------------------------------------------
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|..
gi 14285364  847 qGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQA 898
Cdd:cd07550  462 -DRYHAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISMRGG 512
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
203-968 1.07e-14

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 79.32  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  203 GLSLQDQMVRKAIYGPNVISIP------VKSYPQLlvdealnpyygFQAFSIALWLA--------------------DHY 256
Cdd:cd02608    1 GLTSARAAEILARDGPNALTPPpttpewVKFCKQL-----------FGGFSMLLWIGailcflaygiqaateeepsnDNL 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  257 YwyaLCIFLISSISI--CLSLYKTRKQSQ---TLRDMVklSMRVCVCRpGGEEEWVDSSELVPGDcLVLPQEGGLMPCDA 331
Cdd:cd02608   70 Y---LGIVLAAVVIVtgCFSYYQEAKSSKimdSFKNMV--PQQALVIR-DGEKMQINAEELVVGD-LVEVKGGDRIPADI 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  332 ALV-AGECMVNESSLTGESIPvlKTALPEGLGPYCAEThrRHTLFCGTLILQARAYvgphvlAVVTRTGFCTAKG---GL 407
Cdd:cd02608  143 RIIsAHGCKVDNSSLTGESEP--QTRSPEFTHENPLET--KNIAFFSTNCVEGTAR------GIVINTGDRTVMGriaTL 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  408 VSSI-LHPRPINfKFYKHSMKFVAALSVlaLLGTIYSIFILYRNRVPLnEIVIRALDLVTVVVPPALPAAMTVC-TLYAQ 485
Cdd:cd02608  213 ASGLeVGKTPIA-REIEHFIHIITGVAV--FLGVSFFILSLILGYTWL-EAVIFLIGIIVANVPEGLLATVTVClTLTAK 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  486 sRLRRQgiFCihpLRINLG-----GKLQLVCFDKTGTLTEDGLDV------MGVV------PLKGQAFlplvpeprrlpv 548
Cdd:cd02608  289 -RMARK--NC---LVKNLEavetlGSTSTICSDKTGTLTQNRMTVahmwfdNQIHeadtteDQSGASF------------ 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  549 gplLRALATCHALSRL-------------QDTPV------GDPMD---LKMVE-STGWVLEeepaadsafgtqvlavMR- 604
Cdd:cd02608  351 ---DKSSATWLALSRIaglcnraefkagqENVPIlkrdvnGDASEsalLKCIElSCGSVME----------------MRe 411
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  605 --PPLWEpqlqameeppvpvsvlhrFPFSSAlQRMSVVVAWPGATQPEAYV---KGSPELVAGLC-----NPETVPTDfA 674
Cdd:cd02608  412 rnPKVAE------------------IPFNST-NKYQLSIHENEDPGDPRYLlvmKGAPERILDRCstiliNGKEQPLD-E 471
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  675 QMLQSYTAA-------GYRVVALASKPLPTvPSLEAAQQLTRDTVE---GDLSLLGLLVMrnlLKPQTTPVIQALRRTR- 743
Cdd:cd02608  472 EMKEAFQNAylelgglGERVLGFCHLYLPD-DKFPEGFKFDTDEVNfptENLCFVGLMSM---IDPPRAAVPDAVGKCRs 547
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  744 --IRAVMVTGDNLQTAVTVARGCGmvapqehlIIvhathpergqpasleflpmesptavngvkdpdqaasytvepdprsr 821
Cdd:cd02608  548 agIKVIMVTGDHPITAKAIAKGVG--------II---------------------------------------------- 573
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  822 hlalsgptfgiivkhfpkllpkvlvqgtVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAeAS 901
Cdd:cd02608  574 ----------------------------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA-GS 624
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  902 VVSPFTSSM-------ASIecVPMViREGRCSLDTsfsvFKYMALYSLTQFIS------VLILYTINTNLGDLQFLAIDL 968
Cdd:cd02608  625 DVSKQAADMillddnfASI--VTGV-EEGRLIFDN----LKKSIAYTLTSNIPeitpflIFIIANIPLPLGTITILCIDL 697
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
623-907 2.71e-14

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 77.83  E-value: 2.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  623 SVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNP----ETVPTDFAQmlqsytaAGYRVVALASKPLP-- 696
Cdd:cd07541  362 EILQIFPFTSESKRMGIIVREEKTGEITFYMKGADVVMSKIVQYndwlEEECGNMAR-------EGLRTLVVAKKKLSee 434
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  697 ------------TVPSLEAAQQLTR--DTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVAR 762
Cdd:cd07541  435 eyqafekrynaaKLSIHDRDLKVAEvvESLERELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAK 514
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  763 GCGMVAPQEHlIIVHATHPERGQpASLEFLPMESptavngvkDPDQAasytvepdprsrhLALSGPTFGIIVKHFPKLLP 842
Cdd:cd07541  515 SSKLVSRGQY-IHVFRKVTTREE-AHLELNNLRR--------KHDCA-------------LVIDGESLEVCLKYYEHEFI 571
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14285364  843 KVLVQGT--VFARMAPEQKTELVCELQKL-QYCVGMCGDGANDCGALKAADVGISLSQAE---ASVVSPFT 907
Cdd:cd07541  572 ELACQLPavVCCRCSPTQKAQIVRLIQKHtGKRTCAIGDGGNDVSMIQAADVGVGIEGKEgkqASLAADFS 642
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
624-906 1.97e-13

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 75.11  E-value: 1.97e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    624 VLHRFPFSSALQRMSVVVAWPGAtQPEAYVKGSPELVAGLC--NPETVPTDFAQMLQSYTAAGYRVVALASKPLP----- 696
Cdd:TIGR01652  511 ILNVLEFNSDRKRMSVIVRNPDG-RIKLLCKGADTVIFKRLssGGNQVNEETKEHLENYASEGLRTLCIAYRELSeeeye 589
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    697 --TVPSLEAAQQLTR---------DTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCG 765
Cdd:TIGR01652  590 ewNEEYNEASTALTDreekldvvaESIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIGYSCR 669
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364    766 MVAPQEHLIIVHATH--PERGQPASLEFLPMESPTAVNGVKDPDQAA--------SYTVEPDPRSRHLALSgptfgiivk 835
Cdd:TIGR01652  670 LLSRNMEQIVITSDSldATRSVEAAIKFGLEGTSEEFNNLGDSGNVAlvidgkslGYALDEELEKEFLQLA--------- 740
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14285364    836 hfpKLLPKVLVqgtvfARMAPEQKTELVCELQKLQYCVGMC-GDGANDCGALKAADVGISLSQAE---ASVVSPF 906
Cdd:TIGR01652  741 ---LKCKAVIC-----CRVSPSQKADVVRLVKKSTGKTTLAiGDGANDVSMIQEADVGVGISGKEgmqAVMASDF 807
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
301-893 2.10e-13

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 74.65  E-value: 2.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  301 GGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGpycaethrrhtlfcGTLI 380
Cdd:cd07552  138 DGSIEDVPVSELKVGD-VVLVRAGEKIPADGTILEGESSVNESMVTGESKPVEKKPGDEVIG--------------GSVN 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  381 LQARAYVGphvlavVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFI--LYRNrvpLNEIV 458
Cdd:cd07552  203 GNGTLEVK------VTKTGEDSYLSQVMELVAQAQASKSRAENLADKVAGWLFYIALGVGIIAFIIwlILGD---LAFAL 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  459 IRAldlVTVVV---PPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKgqa 535
Cdd:cd07552  274 ERA---VTVLViacPHALGLAIPLVVARSTSIAAKNGLLIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFD--- 347
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  536 flplvpeprRLPVGPLLRALATCHALSrlqdtpvgdpmdlkmvestgwvleEEPAADSAfgtqVLAVmrpplwepqlQAM 615
Cdd:cd07552  348 ---------EYDEDEILSLAAALEAGS------------------------EHPLAQAI----VSAA----------KEK 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  616 EEPPVPVSVLHRFPfssalqrmSVVVAwpGATQPEAYVKGSPELVA--GLCNPEtvptdfaQMLQSYTAAGYRVVALask 693
Cdd:cd07552  381 GIRPVEVENFENIP--------GVGVE--GTVNGKRYQVVSPKYLKelGLKYDE-------ELVKRLAQQGNTVSFL--- 440
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  694 plptvpsLEAAQqltrdtvegdlsLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMvapqehl 773
Cdd:cd07552  441 -------IQDGE------------VIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGI------- 494
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  774 iivhathPErgqpasleflpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqgtVFAR 853
Cdd:cd07552  495 -------DE-------------------------------------------------------------------YFAE 500
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|
gi 14285364  854 MAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGI 893
Cdd:cd07552  501 VLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGI 540
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
513-899 5.22e-11

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 67.19  E-value: 5.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  513 DKTGTLTEDgldVMgvvplkgqaflplvpEPRRLPVG----PLLRALATCHALsrlqdTPVGDPMDLKMV---ESTgwvl 585
Cdd:cd02073  361 DKTGTLTEN---IM---------------EFKKCSINgvdyGFFLALALCHTV-----VPEKDDHPGQLVyqaSSP---- 413
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  586 eEEPA---ADSAFG------TQVLAVMRPplwEPQLQAMEeppvpvsVLHRFPFSSALQRMSVVVAWPGAtQPEAYVKGS 656
Cdd:cd02073  414 -DEAAlveAARDLGfvflsrTPDTVTINA---LGEEEEYE-------ILHILEFNSDRKRMSVIVRDPDG-RILLYCKGA 481
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  657 PELVAGLC---NPETVPTDFAQmLQSYTAAGYRVVALASKPLPtvPS---------LEAAQQLT-R--------DTVEGD 715
Cdd:cd02073  482 DSVIFERLspsSLELVEKTQEH-LEDFASEGLRTLCLAYREIS--EEeyeewnekyDEASTALQnReelldevaEEIEKD 558
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  716 LSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQ--EHLIIVHAThpergqpaSLEFlp 793
Cdd:cd02073  559 LILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDmeNLALVIDGK--------TLTY-- 628
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  794 mesptavngvkdpdqaasytvepdprsrhlALSGPTFgiivKHFPKLLpkVLVQGTVFARMAPEQKTELVcELQK--LQY 871
Cdd:cd02073  629 ------------------------------ALDPELE----RLFLELA--LKCKAVICCRVSPLQKALVV-KLVKksKKA 671
                        410       420
                 ....*....|....*....|....*...
gi 14285364  872 CVGMCGDGANDCGALKAADVGISLSQAE 899
Cdd:cd02073  672 VTLAIGDGANDVSMIQEAHVGVGISGQE 699
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
274-895 8.83e-10

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 63.05  E-value: 8.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  274 SLYKTRKQSQTLRdmvklsmrvcvCRPGGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVL 353
Cdd:cd02078   87 SLRKTKTETQAKR-----------LRNDGKIEKVPATDLKKGD-IVLVEAGDIIPADGEVIEGVASVDESAITGESAPVI 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  354 KtalpEGLGPYCAETHrrhtlfcGTLILQARAYVgphvlaVVTRT---GFCTAKGGLV---SSILHPRPInfkfykhsmk 427
Cdd:cd02078  155 R----ESGGDRSSVTG-------GTKVLSDRIKV------RITANpgeTFLDRMIALVegaSRQKTPNEI---------- 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  428 fvaALSVLaLLG-TIysIFILY-RNRVPLNEIVIRALDLVTVVvppalpaAMTVC----TLYA---------QSRLRRQG 492
Cdd:cd02078  208 ---ALTIL-LVGlTL--IFLIVvATLPPFAEYSGAPVSVTVLV-------ALLVCliptTIGGllsaigiagMDRLLRFN 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  493 IFCIHPLRINLGGKLQLVCFDKTGTLTedgldvMGvvplKGQA--FLPLvpeprrlpVGPLLRALATCHALSRLQD-TPV 569
Cdd:cd02078  275 VIAKSGRAVEAAGDVDTLLLDKTGTIT------LG----NRQAteFIPV--------GGVDEKELADAAQLASLADeTPE 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  570 GDPMdLKMVESTGWVLEEEPAADSAFgtqvlavmrpplwepqlqameeppvpvsvlhrFPFsSALQRMSVVVAwPGATQp 649
Cdd:cd02078  337 GRSI-VILAKQLGGTERDLDLSGAEF--------------------------------IPF-SAETRMSGVDL-PDGTE- 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  650 eaYVKGSPELVAGLCNPE--TVPTDFAQMLQsytaagyRVVALASKPLPtvpsleaaqqltrdtVEGDLSLLGLLVMRNL 727
Cdd:cd02078  381 --IRKGAVDAIRKYVRSLggSIPEELEAIVE-------EISKQGGTPLV---------------VAEDDRVLGVIYLKDI 436
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  728 LKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGmvapqehliivhathpergqpasleflpmesptavngvkdpd 807
Cdd:cd02078  437 IKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAG------------------------------------------ 474
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  808 qaasytvepdprsrhlalsgptfgiiVKHFpkllpkvlvqgtvFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALK 887
Cdd:cd02078  475 --------------------------VDDF-------------LAEAKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALA 515

                 ....*...
gi 14285364  888 AADVGISL 895
Cdd:cd02078  516 QADVGVAM 523
PLN03190 PLN03190
aminophospholipid translocase; Provisional
624-956 1.14e-09

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 62.99  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   624 VLHRFPFSSALQRMSVVVAWPGATQpEAYVKGSPELVAGLC----NPETVPTDFAQmLQSYTAAGYRVVALASKPLPTVP 699
Cdd:PLN03190  605 VLGLHEFDSDRKRMSVILGCPDKTV-KVFVKGADTSMFSVIdrslNMNVIRATEAH-LHTYSSLGLRTLVVGMRELNDSE 682
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   700 ------SLEAAQQ-------LTR---DTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARG 763
Cdd:PLN03190  683 feqwhfSFEAASTaligraaLLRkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGYS 762
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   764 CGMVAPQEHLIIVHATHPERGQPASLEFLPM-ESPTAVNGVKDPDQAASYTVEpDPRSrhLALSGPTFGIIV-KHFPKLL 841
Cdd:PLN03190  763 SKLLTNKMTQIIINSNSKESCRKSLEDALVMsKKLTTVSGISQNTGGSSAAAS-DPVA--LIIDGTSLVYVLdSELEEQL 839
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   842 PKVLVQGTVF--ARMAPEQKTELVCELQKLQYCVGMC-GDGANDCGALKAADVGISLSQAE---ASVVSPFtsSMASIE- 914
Cdd:PLN03190  840 FQLASKCSVVlcCRVAPLQKAGIVALVKNRTSDMTLAiGDGANDVSMIQMADVGVGISGQEgrqAVMASDF--AMGQFRf 917
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 14285364   915 CVPMVIREGRCsldtSFSVFKYMALYSLTQ---FISVLILYTINT 956
Cdd:PLN03190  918 LVPLLLVHGHW----NYQRMGYMILYNFYRnavFVLVLFWYVLFT 958
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
302-950 1.15e-09

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 62.53  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  302 GEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAGECMVNESSLTGESIPVLKtalpeglgpycaetHRRHTLFCGTLIL 381
Cdd:cd07553  136 GSRIKTRADQIKSGDVYLV-ASGQRVPVDGKLLSEQASIDMSWLTGESLPRIV--------------ERGDKVPAGTSLE 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  382 QARAYVgpHVLAVVT--RTGFCTAKggLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFIlyrnrvPLNEIVI 459
Cdd:cd07553  201 NQAFEI--RVEHSLAesWSGSILQK--VEAQEARKTPRDLLADKIIHYFTVIALLIAVAGFGVWLAI------DLSIALK 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  460 RALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDgldvmgvvplkGQAFLPL 539
Cdd:cd07553  271 VFTSVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRG-----------KSSFVMV 339
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  540 VPEPRRLPVGPLLRAL--ATCHALSRLqdtpvgdpmdlkmvestgwVLEEEPAADSafgtqvlavMRPPLwepqLQAMEE 617
Cdd:cd07553  340 NPEGIDRLALRAISAIeaHSRHPISRA-------------------IREHLMAKGL---------IKAGA----SELVEI 387
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  618 PPVPVSvlhrfpfssalqrmsvvvawpgatqpeAYVKGSPELVAGLCnpetvptdFAQMLQSYTAAGYRvvalaskplpt 697
Cdd:cd07553  388 VGKGVS---------------------------GNSSGSLWKLGSAP--------DACGIQESGVVIAR----------- 421
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  698 vpsleaaqqltrdtvegDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGmvapqehliivh 777
Cdd:cd07553  422 -----------------DGRQLLDLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLG------------ 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  778 athpergqpasleflpmesptavngvKDPDQaasytvepdprsrhlalsgptfgiivkhfpkllpkvlvqgtVFARMAPE 857
Cdd:cd07553  473 --------------------------LDPRQ-----------------------------------------LFGNLSPE 485
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  858 QKTELVCELQKLQycVGMCGDGANDCGALKAADVGISLS--QAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFK 935
Cdd:cd07553  486 EKLAWIESHSPEN--TLMVGDGANDALALASAFVGIAVAgeVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFA 563
                        650
                 ....*....|....*
gi 14285364  936 YMALYSLTQFISVLI 950
Cdd:cd07553  564 FSLLYNLVAIGLALS 578
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
301-895 1.29e-09

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 62.42  E-value: 1.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  301 GGEEEWVDSSELVPGDCLVLpQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTAlpeglgpycaethrRHTLFCGTLI 380
Cdd:cd07546  106 NGERREVPADSLRPGDVIEV-APGGRLPADGELLSGFASFDESALTGESIPVEKAA--------------GDKVFAGSIN 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  381 LQArayvgphVLAV-VTRtgfcTAKGGLVSSILH--------PRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRnr 451
Cdd:cd07546  171 VDG-------VLRIrVTS----APGDNAIDRILHlieeaeerRAPIERFIDRFSRWYTPAIMAVALLVIVVPPLLFGA-- 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  452 vPLNEIVIRALDLVTVVVPPAL----PAAMTVctlyAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMG 527
Cdd:cd07546  238 -DWQTWIYRGLALLLIGCPCALvistPAAITS----GLAAAARRGALIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVTD 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  528 VVPLKGQAflplvpePRRLpvgpLLRALA----TCHALSRlqdtpvgdpmdlkmvestgwvleeepaadsafgtqvlAVM 603
Cdd:cd07546  313 VVPLTGIS-------EAEL----LALAAAvemgSSHPLAQ-------------------------------------AIV 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  604 RpplwEPQLQAMEEPPvpvsvlhrfpfssALQRMSVV-VAWPGATQPEAYVKGSPELVAglcnpETVPTDFAQMLQSYTA 682
Cdd:cd07546  345 A----RAQAAGLTIPP-------------AEEARALVgRGIEGQVDGERVLIGAPKFAA-----DRGTLEVQGRIAALEQ 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  683 AGYRVVALaskplptvpsleaaqqLTRDTVegdlslLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVAR 762
Cdd:cd07546  403 AGKTVVVV----------------LANGRV------LGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAA 460
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  763 GCGMvapqehliivhathpergqpasleflpmesptavngvkdpdqaasytvepdprsrhlalsgptfgiivkhfpkllp 842
Cdd:cd07546  461 ELGL---------------------------------------------------------------------------- 464
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 14285364  843 kvlvqgTVFARMAPEQKTELVCELQKLQyCVGMCGDGANDCGALKAADVGISL 895
Cdd:cd07546  465 ------DFRAGLLPEDKVKAVRELAQHG-PVAMVGDGINDAPAMKAASIGIAM 510
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
247-582 1.42e-08

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 58.87  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  247 SIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGD-CLVLPQEgg 325
Cdd:cd07544   63 AIVATLLVGEYWASLIILLMLTGGEALEDYAQRRASRELTALLDRAPRIAHRLVGGQLEEVPVEEVTVGDrLLVRPGE-- 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  326 LMPCDAALVAGECMVNESSLTGESIPVLKTALPEGL-GPYCAEThrrhtlfcgTLILQARAYVGPHVLAVVTRtgfctak 404
Cdd:cd07544  141 VVPVDGEVVSGTATLDESSLTGESKPVSKRPGDRVMsGAVNGDS---------ALTMVATKLAADSQYAGIVR------- 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  405 ggLVSSILHPRPinfKFYKHSMKFVAALSVLALLGTIYSIFIlyrnrvplNEIVIRALDLVTVVVPPALPAAMTVCTLYA 484
Cdd:cd07544  205 --LVKEAQANPA---PFVRLADRYAVPFTLLALAIAGVAWAV--------SGDPVRFAAVLVVATPCPLILAAPVAIVSG 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  485 QSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQA---FLPLVPEPRRLPVGPLLRALAtchAL 561
Cdd:cd07544  272 MSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDVVPAPGVDadeVLRLAASVEQYSSHVLARAIV---AA 348
                        330       340
                 ....*....|....*....|.
gi 14285364  562 SRLQDTPVGDPMDLkmVESTG 582
Cdd:cd07544  349 ARERELQLSAVTEL--TEVPG 367
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
301-766 2.20e-06

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 51.92  E-value: 2.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   301 GGEEEWVDSSELVPGDCL-VLPqeGGLMPCDAALVAGECMVNESSLTGESIPVLKTA---LPEGlgpyCAETHRrhtlfc 376
Cdd:PRK11033  250 DGEREEVAIADLRPGDVIeVAA--GGRLPADGKLLSPFASFDESALTGESIPVERATgekVPAG----ATSVDR------ 317
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   377 gtlILQarayvgphvLAVVTRTGfctakGGLVSSILH--------PRPINFKFYKHSMKFVAALSVLALLGTIYSIFILY 448
Cdd:PRK11033  318 ---LVT---------LEVLSEPG-----ASAIDRILHlieeaeerRAPIERFIDRFSRIYTPAIMLVALLVILVPPLLFA 380
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   449 RnrvPLNEIVIRALDLVTVVVPPAL----PAAMTvCTLYAQSrlrRQGIFcihplrINLG------GKLQLVCFDKTGTL 518
Cdd:PRK11033  381 A---PWQEWIYRGLTLLLIGCPCALvistPAAIT-SGLAAAA---RRGAL------IKGGaaleqlGRVTTVAFDKTGTL 447
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   519 TEDGLDVMGVVPLKGQAFLPLVPEPRRLPVG---PLLRALatchalsrlqdtpvgdpmdLKMVESTGWVLeeePAADsaf 595
Cdd:PRK11033  448 TEGKPQVTDIHPATGISESELLALAAAVEQGsthPLAQAI-------------------VREAQVRGLAI---PEAE--- 502
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   596 gtqvlavmrpplwepqlqameeppvpvsvlHRfpfsSALQRMSVvvawpgatqpEAYVKGSPELVAGLCNPETVPTDFAQ 675
Cdd:PRK11033  503 ------------------------------SQ----RALAGSGI----------EGQVNGERVLICAPGKLPPLADAFAG 538
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364   676 MLQSYTAAGYRVVALaskplptvpsLEAAQqltrdtvegdlsLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQ 755
Cdd:PRK11033  539 QINELESAGKTVVLV----------LRNDD------------VLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPR 596
                         490
                  ....*....|.
gi 14285364   756 TAVTVARGCGM 766
Cdd:PRK11033  597 AAAAIAGELGI 607
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
301-533 2.53e-05

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 48.39  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  301 GGEEEWVDSSELVPGDcLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTalpEGlgpycaethrrHTLFCGTLI 380
Cdd:cd07548  116 NNELKDVKPEEVQIGD-IIVVKPGEKIPLDGVVLKGESFLDTSALTGESVPVEVK---EG-----------SSVLAGFIN 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  381 LQArayvgphVLAV-VTRTGFCTAkgglVSSILH---------PRPINF--KFYKHSMKFVAALSVlaLLGTIYSIFILY 448
Cdd:cd07548  181 LNG-------VLEIkVTKPFKDSA----VAKILElvenasarkAPTEKFitKFARYYTPIVVFLAL--LLAVIPPLFSPD 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  449 RNrvpLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGV 528
Cdd:cd07548  248 GS---FSDWIYRALVFLVISCPCALVISIPLGYFGGIGAASRKGILIKGSNYLEALSQVKTVVFDKTGTLTKGVFKVTEI 324

                 ....*
gi 14285364  529 VPLKG 533
Cdd:cd07548  325 VPAPG 329
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
297-582 1.47e-04

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 45.81  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  297 VCRPGGEEEWVDSSELVPGDCLVLPQeGGLMPCDAALVAGECMVNESSLTGESIPVlkTALPEGLgpycaethrrhtLFC 376
Cdd:cd02092  130 RLQADGSREYVPVAEIRPGDRVLVAA-GERIPVDGTVVSGTSELDRSLLTGESAPV--TVAPGDL------------VQA 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  377 GTLILQARAYVgpHVLAVVTRTgFCTAKGGLVSSILHPRpinfKFYKHSMKFVAAL-----SVLALLGTIYSIFIlyrnR 451
Cdd:cd02092  195 GAMNLSGPLRL--RATAAGDDT-LLAEIARLMEAAEQGR----SRYVRLADRAARLyapvvHLLALLTFVGWVAA----G 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14285364  452 VPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTedgldvMGVVPL 531
Cdd:cd02092  264 GDWRHALLIAVAVLIITCPCALGLAVPAVQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLT------LGSPRL 337
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 14285364  532 KGQAflplVPEPRRLPVGPLLrALATCHALSR--LQDTPVGDPMDLKMVESTG 582
Cdd:cd02092  338 VGAH----AISADLLALAAAL-AQASRHPLSRalAAAAGARPVELDDAREVPG 385
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
628-664 4.83e-04

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 40.28  E-value: 4.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 14285364    628 FPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLC 664
Cdd:pfam13246   52 IPFNSDRKRMSTVHKLPDDGKYRLFVKGAPEIILDRC 88
copA PRK10671
copper-exporting P-type ATPase CopA;
850-895 2.52e-03

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 42.04  E-value: 2.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 14285364   850 VFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISL 895
Cdd:PRK10671  692 VIAGVLPDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAM 737
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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