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Conserved domains on  [gi|14249568|ref|NP_116236|]
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uncharacterized protein C8orf76 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5588 pfam17826
Family of unknown function (DUF5588); This is a family of unknown function found in chordata.
 6-373 0e+00

Family of unknown function (DUF5588); This is a family of unknown function found in chordata.


:

Pssm-ID: 465524  Cd Length: 362  Bit Score: 719.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568     6 WLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLS 85
Cdd:pfam17826   1 WLLGGEFEDSVFEERPERRPGPPAPYRAKLCEPQWFYEETESSDDVEALTIKKFRGDLAYRRQEYQKALQEYSSISEKLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568    86 STNFAMKRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPW 165
Cdd:pfam17826  81 STNFAMKRDVQEGQARCLAHLGRHAEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568   166 NWGKLAEAYLNLGPALSAALASSQKQHSFTSSDKTIKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEKALTNi 245
Cdd:pfam17826 161 NWGKLAEAYLNLGPALSASAASSQKQNSFTSSDKTVKSSSPHSGKDCLLCFPETLPESSVFSVEASSSDSQKNEKALKN- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568   246 qncmaeKRETVLIETQLKACASFIRTRLLLQFTQPQQTSFALERNLRTQQEIEDKMKGFSFKEDTLLLIAEVMGEDI-PE 324
Cdd:pfam17826 240 ------KREAALLETRMKACASFIRTRLLLQLTQSQQTSFALEKNLRTQQEIEDKVKGFGFKEDTLLLIAEVMGEDIvPE 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 14249568   325 KIKDEVHPEVKCVGSVALTALVTVSSEEFEDKWFRKIKDHFCPFENQFH 373
Cdd:pfam17826 314 KIKDEVHSEVKCVGPAALTALVIASSEEFEDKWFRKIKDHFCPFENQFH 362
 
Name Accession Description Interval E-value
DUF5588 pfam17826
Family of unknown function (DUF5588); This is a family of unknown function found in chordata.
 6-373 0e+00

Family of unknown function (DUF5588); This is a family of unknown function found in chordata.


Pssm-ID: 465524  Cd Length: 362  Bit Score: 719.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568     6 WLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLS 85
Cdd:pfam17826   1 WLLGGEFEDSVFEERPERRPGPPAPYRAKLCEPQWFYEETESSDDVEALTIKKFRGDLAYRRQEYQKALQEYSSISEKLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568    86 STNFAMKRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPW 165
Cdd:pfam17826  81 STNFAMKRDVQEGQARCLAHLGRHAEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568   166 NWGKLAEAYLNLGPALSAALASSQKQHSFTSSDKTIKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEKALTNi 245
Cdd:pfam17826 161 NWGKLAEAYLNLGPALSASAASSQKQNSFTSSDKTVKSSSPHSGKDCLLCFPETLPESSVFSVEASSSDSQKNEKALKN- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568   246 qncmaeKRETVLIETQLKACASFIRTRLLLQFTQPQQTSFALERNLRTQQEIEDKMKGFSFKEDTLLLIAEVMGEDI-PE 324
Cdd:pfam17826 240 ------KREAALLETRMKACASFIRTRLLLQLTQSQQTSFALEKNLRTQQEIEDKVKGFGFKEDTLLLIAEVMGEDIvPE 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 14249568   325 KIKDEVHPEVKCVGSVALTALVTVSSEEFEDKWFRKIKDHFCPFENQFH 373
Cdd:pfam17826 314 KIKDEVHSEVKCVGPAALTALVIASSEEFEDKWFRKIKDHFCPFENQFH 362
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
49-178 4.92e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.39  E-value: 4.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  49 DDVEVLTlkkFKGDLAYRRQEYQKALQEYS---SISEKLSSTNFAMkrdvqegqARCLAHLGRHMEALEIAanleNKATN 125
Cdd:COG0457   6 DDAEAYN---NLGLAYRRLGRYEEAIEDYEkalELDPDDAEALYNL--------GLAYLRLGRYEEALADY----EQALE 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 14249568 126 TDHLTTVLYLQLAIC-SSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLG 178
Cdd:COG0457  71 LDPDDAEALNNLGLAlQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELG 124
 
Name Accession Description Interval E-value
DUF5588 pfam17826
Family of unknown function (DUF5588); This is a family of unknown function found in chordata.
 6-373 0e+00

Family of unknown function (DUF5588); This is a family of unknown function found in chordata.


Pssm-ID: 465524  Cd Length: 362  Bit Score: 719.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568     6 WLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLS 85
Cdd:pfam17826   1 WLLGGEFEDSVFEERPERRPGPPAPYRAKLCEPQWFYEETESSDDVEALTIKKFRGDLAYRRQEYQKALQEYSSISEKLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568    86 STNFAMKRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPW 165
Cdd:pfam17826  81 STNFAMKRDVQEGQARCLAHLGRHAEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568   166 NWGKLAEAYLNLGPALSAALASSQKQHSFTSSDKTIKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEKALTNi 245
Cdd:pfam17826 161 NWGKLAEAYLNLGPALSASAASSQKQNSFTSSDKTVKSSSPHSGKDCLLCFPETLPESSVFSVEASSSDSQKNEKALKN- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568   246 qncmaeKRETVLIETQLKACASFIRTRLLLQFTQPQQTSFALERNLRTQQEIEDKMKGFSFKEDTLLLIAEVMGEDI-PE 324
Cdd:pfam17826 240 ------KREAALLETRMKACASFIRTRLLLQLTQSQQTSFALEKNLRTQQEIEDKVKGFGFKEDTLLLIAEVMGEDIvPE 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 14249568   325 KIKDEVHPEVKCVGSVALTALVTVSSEEFEDKWFRKIKDHFCPFENQFH 373
Cdd:pfam17826 314 KIKDEVHSEVKCVGPAALTALVIASSEEFEDKWFRKIKDHFCPFENQFH 362
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
49-178 4.92e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.39  E-value: 4.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  49 DDVEVLTlkkFKGDLAYRRQEYQKALQEYS---SISEKLSSTNFAMkrdvqegqARCLAHLGRHMEALEIAanleNKATN 125
Cdd:COG0457   6 DDAEAYN---NLGLAYRRLGRYEEAIEDYEkalELDPDDAEALYNL--------GLAYLRLGRYEEALADY----EQALE 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 14249568 126 TDHLTTVLYLQLAIC-SSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLG 178
Cdd:COG0457  71 LDPDDAEALNNLGLAlQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELG 124
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 61-178 1.73e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.33  E-value: 1.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  61 GDLAYRRQEYQKALQEYSSISeKLSSTNFamkrDVQEGQARCLAHLGRHMEALEIAanleNKATNTDHLTTVLYLQLA-I 139
Cdd:COG4783  11 AQALLLAGDYDEAEALLEKAL-ELDPDNP----EAFALLGEILLQLGDLDEAIVLL----HEALELDPDEPEARLNLGlA 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 14249568 140 CSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLG 178
Cdd:COG4783  82 LLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALG 120
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
61-183 2.56e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 2.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  61 GDLAYRRQEYQKALQEYssisEKlsstnfAMKRDVQEGQA-----RCLAHLGRHMEALEIAanleNKATNTDHLTTVLYL 135
Cdd:COG0457  49 GLAYLRLGRYEEALADY----EQ------ALELDPDDAEAlnnlgLALQALGRYEEALEDY----DKALELDPDDAEALY 114

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 14249568 136 QLAIC-SSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLGPALSA 183
Cdd:COG0457 115 NLGLAlLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEA 163
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 61-178 6.41e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 6.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  61 GDLAYRRQEYQKALQEYSSiseklsstnfAMKRDVQEGQARC-LAHL----GRHMEALEIAANLENKAtntDHLTTVLYL 135
Cdd:COG2956  49 GNLYRRRGEYDRAIRIHQK----------LLERDPDRAEALLeLAQDylkaGLLDRAEELLEKLLELD---PDDAEALRL 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 14249568 136 QLAICSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLG 178
Cdd:COG2956 116 LAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG 158
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 62-178 7.40e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 7.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  62 DLAYRRQEYQKALQEYSSISEKLSSTNFAMKRDVQEGQARCLAHLGRHMEALEIAanleNKATNTDHLTTVLYLQLAICS 141
Cdd:COG5010  23 LVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALL----EQALQLDPNNPELYYNLALLY 98

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 14249568 142 SLQ-NLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLG 178
Cdd:COG5010  99 SRSgDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLG 136
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 61-178 1.77e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 1.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  61 GDLAYRRQEYQKALQEYssisEKLSSTNfAMKRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHLttvlYLQLAIC 140
Cdd:COG2956  83 AQDYLKAGLLDRAEELL----EKLLELD-PDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA----YCELAEL 153

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 14249568 141 SSLQ-NLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLG 178
Cdd:COG2956 154 YLEQgDYDEAIEALEKALKLDPDCARALLLLAELYLEQG 192
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 59-178 2.09e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  59 FKGDLAYRRQEYQKALQEYSSISEKLSSTnfamkRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHlttvLYLQLA 138
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPET-----VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE----ALLELA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 14249568 139 -ICSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLG 178
Cdd:COG2956  84 qDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEG 124
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 64-176 8.49e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 35.74  E-value: 8.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14249568  64 AYRRQEYQKALQEYSSISEKLSSTNFAmkRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHLTTVLYlQLAIC-SS 142
Cdd:COG1729   3 LLKAGDYDEAIAAFKAFLKRYPNSPLA--PDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALL-KLGLSyLE 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 14249568 143 LQNLEKTIFCLQKLISLHPFNPwnWGKLAEAYLN 176
Cdd:COG1729  80 LGDYDKARATLEELIKKYPDSE--AAKEARARLA 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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